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Maximum Tolerated Dose
Maximum Tolerated Dose: - The maximum dose that an animal species can tolerate for a major portion of its lifetime without significant impairment or toxic effect other than carcinogenicity. [Environmental Protection Agency] News archive for Maximum Tolerated Dose:: |
CNNMoney.comThe authors concluded that the maximum tolerated dose (MTD) on this schedule for this patient population was 9 mg/m2. The best response observed was stable
Q2 2008 Earnings Call Transcript - Jul 30, 2008
Seeking Alpha,At the last call, we were still conducting a maximum tolerated dose study and if you recall, we have said that the reason we haven't completed that trial
Neurocrine Biosciences Inc. Q2 2008 Earnings Call Transcript - Jul 30, 2008
Seeking Alpha,...modeling tells us should give us some additional efficacy, and I'm anticipating will help me determine whether I've reached a maximum tolerated dose.
Cornerstone to Conduct Phase I/II Cancer Trial - Jul 30, 2008
FDA news (subscription),The open-label, dose-escalation trial will evaluate safety, tolerability, maximum-tolerated dose, efficacy and pharmacokinetics of the drug in various types
Jennerex Publishes Clinical Trial Data With Lead Product JX-594 ... - Jul 22, 2008
MarketWatchTreatment was well-tolerated during dose-escalation up to the maximum-tolerated dose, with the expected mild to moderate flu-like symptoms;
Avigen Reports Second Quarter 2008 Financial Results - Jul 30, 2008
Primenewswire (press release),...treatment * Completed an AV411 Phase I maximum tolerated dose study, showing AV411 to be safe and well tolerated at single oral doses of up to 100mg.
Curis Reports Second Quarter 2008 Financial Results - Jul 30, 2008
Genetic Engineering News (press release),...are to evaluate the safety and tolerability of escalating doses of CUDC-101 and to establish the maximum tolerated dose and dose-limiting toxicities.
Wonder drug? - Jul 28, 2008
Deccan Herald,The drug injected as a single dose of less than one per cent of the maximum tolerated dose at 30 minutes before irradiation, provided excellent survival
BioAlliance Pharma suspends the Phase II/III trial of doxorubicin ... - Jul 15, 2008
MarketWatchThis type of acute pulmonary damage was observed in Phase I/II trial at a dose of 35mg/m2 (the maximum tolerated dose) but had not been observed at 30mg/m2,
Antigenics Reports Second Quarter 2008 Financial Results - Jul 31, 2008
Business Wire (press release),Antigenics reached the maximum tolerated dose of Aroplatin™ in a Phase 1 study in advanced solid malignancies and B cell lymphoma.
OSI initiates Phase I study of lymphoma drug - Jul 16, 2008
Trading Markets (press release),The study is designed to determine the maximum tolerated dose and to establish the recommended dose and dosing schedule for Phase II trials,
Penwest Begins Phase Ia Clinical Trial of A0001, a Compound For ... - Jul 14, 2008
MarketWatchThe trial is also designed to determine if there is a maximum tolerated dose of the drug. The Company plans to enroll a total of 60 healthy volunteers in
Topiramate Safe, Effective for Migraine Prophylaxis in Adolescents - Jul 10, 2008
Medscape (subscription)The first 4 weeks of the double-blind phase was titration of 25 mg weekly to target doses of either 50 mg or 100 mg per day or the maximum tolerated dose.
Cornerstone Pharmaceuticals Announces Approval to Conduct Phase I ... - Jul 24, 2008
Business Wire (press release),The CPI-613 trial is designed as an open label, dose-escalation study to evaluate safety, tolerability, maximum tolerated dose, efficacy,
Penwest initiates dosing in Phase Ia mitochondrial disease trial - Jul 15, 2008
Trading Markets (press release),The trial is also designed to determine if there is a maximum tolerated dose of the drug. The company plans to enroll a total of 60 healthy volunteers in
ImmunoGen, Inc. Announces Start of IMGN388 Clinical Testing - Jul 8, 2008
FOXBusiness...in new cohorts of patients with solid tumors until the maximum tolerated dose (MTD) is established and the dose-limiting toxicities are identified.
Osi Pharmaceuticals initiates Phase I trial of OSI-027 for ... - Jul 15, 2008
Interactive Investor,The study is designed to determine the maximum-tolerated dose, to establish the recommended dose and dosing schedule for Phase II trials, and to evaluate
OSI Pharmaceuticals Begins Clinical Development Program for OSI ... - Jul 15, 2008
Business Wire (press release),The study is designed to determine the maximum tolerated dose (MTD) and to establish the recommended dose and dosing schedule for Phase II trials,
Peregrine Pharmaceuticals Reports Financial Results for Fiscal ... - Jul 14, 2008
CNNMoney.com (press release)The study’s primary objective is to confirm the maximum tolerated dose of Cotara and secondary objectives include estimates of overall patient survival,
Stock Report - Jul 22, 2008
BuysellSignals,The trial is exploring the potential of PG-11047 as a single anti-cancer agent to assess the agent's maximum tolerated dose. Progen Pharmaceuticals Ltd has
Hana Biosciences Presents Alocrest and Menadione Data At the ... - Jul 7, 2008
CNNMoney.com (press release)A maximum tolerated dose (MTD) of 28 mg/m2 administered via a 60-minute IV infusion on days one and eight every 21 days was established in this population.
BioAlliance Pharma Suspends Phase II/III Trial of Doxorubicin ... - Jul 17, 2008
Lifescience-online,This type of acute pulmonary damage was observed in Phase I/II trial at a dose of 35mg/m2 (the maximum tolerated dose) but had not been observed at 30mg/m2,
Immunogen's Wild Swings Due to Lack of Information at ASCO - Jul 14, 2008
Seeking Alpha,...are recruited and treated with higher doses, until there are signs of dose limiting toxicity, and the maximum tolerated dose [MTD] is established.
Proteolix Initiates Dosing in Phase Ib Myeloma Trial - Jul 11, 2008
RedOrbit,The Phase Ib clinical trial is designed to evaluate safety and to establish a maximum-tolerated dose of carfilzomib in combination with lenalidomide and
BioAlliance Stops Doxorubicin Trial After Pulmonary Reactions. - Jul 18, 2008
Therapeutics Daily (subscription) (press release),...in primary liver cancer after two oversight groups noted unexpected pulmonary adverse events in patients administered the maximum tolerated dose.
Market Report -- In Play (HNAB) - Jul 7, 2008
MSN MoneyA maximum tolerated dose of 28 mg/m2 administered via a 60-minute IV infusion on days one and eight every 21 days was established in this population.
Cytokinetics Announces Presentation of Scientific Poster at the ... - 03 Dec 2007
CNNMoney.comThis clinical trial demonstrated that the maximum tolerated dose (MTD) was 0.5 mg/kg/hr for the six-hour infusion in healthy volunteers.
Cyclacel Pharmaceuticals Provides Year End 2007 Pipeline Update ... - Nov 26, 2007
Business Wire (press release),The primary objective of the study is to determine the maximum tolerated dose. Secondary objectives are to evaluate the pharmacokinetic and pharmacodynamic
Possible New Cancer Drug Developed in Buffalo - Nov 29, 2007
WIVB,Professor of Chemistry, "Some toxicity will show up, any drug will show toxicity at some dose., so we look for what's called the maximum tolerated dose.
ArQule shares fall; observes QTc prolongation in Phase I cancer ... - Nov 29, 2007
Trading Markets (press release),...goal of the Phase I trial: to identify the dose-limiting toxicity and the maximum-tolerated dose, thereby enabling recommendation of a Phase II trial.
Medivation's MDV3100 Demonstrates Substantial PSA Reductions in ... - Nov 5, 2007
CNNMoney.comOnce a maximum tolerated dose has been established, treatment at that dose level will be expanded to 20 patients. The study endpoints include safety,
Raven Announces Phase 1 Clinical Trial Results of RAV12 ... - Nov 19, 2007
Earthtimes,The objectives of the study were to define the safety profile and maximum tolerated dose of RAV12, to define the pharmacokinetics and describe preliminary
Thallion Announces Positive Safety and Efficacy Data From ECO-4601 ... - Nov 15, 2007
Market Wire (press release)...study in 14 patients with doses ranging from 30 to 480mg/m2/day to assess the safety, pharmacokinetics and maximum tolerated dose of ECO-4601.
Valeant Pharmaceuticals Starts Phase 2 Retigabine Study For ... - Nov 30, 2007
Medical News Today (press release),Study patients will be titrated to their individually determined maximum tolerated dose within the range of 300 mg to 900 mg per day.
StockProfiler.US: Stock News Briefs - Nov 28, 2007
Trading Markets (press release),According to the announcement, the primary objective of the Phase I/II study is to determine the safety and maximum tolerated dose (MTD) of GRN163L when
Allos Therapeutics Initiates Study of RH1 in Patients with ... - Nov 12, 2007
CNNMoney.comUp to 60 evaluable patients will be enrolled in the study with the objective of determining the maximum tolerated dose (MTD), recommended Phase 2 dose and
Allos Therapeutics Q3 2007 Earnings Call Transcript - Nov 5, 2007
Seeking Alpha,Up to 54 evaluable patients will be enrolled in the Phase 1 portion of the study with the objective of determining the maximum tolerated dose, safety,
Protherics Announces Interim Results For Six Months Ended 30 ... - Nov 19, 2007
CNNMoney.com...the first cohort of three patients in phase 1/2 primary brain cancer (glioblastoma multiforme) study * prolarixtm: maximum tolerated dose determined and
Seattle Genetics Reports Positive Phase I Data with SGN-35 in ... - Nov 5, 2007
Business Wire (press release),SGN-35 has been generally well-tolerated and the maximum tolerated dose has not yet been defined. The majority of adverse events were Grade 1 and 2,
Allos Therapeutics Reports Third Quarter 2007 Financial Results - Nov 5, 2007
CNNMoney.comThe maximum tolerated dose (MTD) was determined to be 270 mg/m2, which is nearly twice that observed in a previous Phase 1 study in which PDX was
Athersys Trial for multistem Authorized - Nov 18, 2007
FDA news (subscription),The open-label, multicenter, dose-escalation study will evaluate the safety and maximum tolerated dose of single or multiple dose administration of
Avigen's AV411 Shows Promising Initial Results for Neuropathic Pain - Nov 3, 2007
Primenewswire (press release),Earlier this year, Avigen initiated US clinical development of AV411 with a Phase I maximum tolerated dose study. In addition, Avigen's AV411 is being
Solana Resources Slips To Loss In Q3; Revenues Decline - Quick ... - Nov 28, 2007
RTT News,Valeant added that the study patients would be titrated to their individually determined maximum tolerated dose within the range of 300 mg to 900 mg per day
Geron Initiates Clinical Trial of Telomerase Inhibitor Drug in ... - Nov 28, 2007
Business Wire (press release),The primary objective of the Phase I/II study is to determine the safety and maximum tolerated dose (MTD) of GRN163L when administered intravenously in
Allos to Study RH1 in Patients With Tumors or NHL - Nov 13, 2007
FDA news (subscription),Up to 60 patients will enroll in the study to determine the maximum tolerated dose, and three to six patients will be in each group, Allos said.
Synta Reaches Agreement on Special Protocol Assessment and ... - Nov 12, 2007
Trading Markets (press release),...including a therapeutic index - the ratio of maximum tolerated dose to efficacious dose - significantly higher than many commonly-used chemotherapies.
Athersys IND for multistem Authorized for Phase I Clinical Trial ... - Nov 15, 2007
Primenewswire (press release),The Phase I study will be an open label, multi-center dose escalation trial evaluating the safety and maximum tolerated dose of single or multiple dose
Exelixis Q3 2007 Earnings Call Transcript - Nov 5, 2007
Seeking Alpha,We have established a maximum tolerated dose of 300 milligrams per day in this study. The pharmacokinetic exposure obtained over a 28 days cycle with this
Synta Pharmaceuticals Initiates Phase 1 Clinical Trial of STA-9090 ... - Nov 8, 2007
Business Wire (press release),The open-label Phase 1 study in patients with solid tumors is designed to identify the maximum tolerated dose of STA-9090 based on a twice-a-week
methylgene Reports Third Quarter 2007 Financial Results - Nov 7, 2007
Market Wire (press release)The maximum tolerated dose was reached and the data demonstrated preliminary evidence of activity in pancreatic cancer. The Phase II portion of the trial
Kosan Biosciences Incorporated R&D Day - Final - Nov 7, 2007
Insurance News Net (press release),And obviously the objectives were determined, a maximum tolerated dose, the dose-limiting toxicities and safety profile, as well as what should be the
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