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reverse transcriptase

This page contains news and, when available, background information, onreverse transcriptase. Links on this site lead to other sites on the web. If your site is linked from the page and you would like me to remove the link, please contact me.

reverse transcriptase - An enzyme that uses an RNA molecule as a template for the synthesis of a complementary DNA strand. Synonym: RNA-dependent DNA polymerase. [FAO]

News archive for reverse transcriptase.

ANX-201 Combination Therapy Demonstrates Synergistic Inhibition of ...  -  Jul 23, 2007
CNNMoney.comThe poster entitled "Synergistic Antiretroviral Activity of Pyrophosphate Analogue ANX-201 Paired with Nucleoside Reverse Transcriptase Inhibitors In Vitro"

HIV/HBV coinfected patients should not take entecavir unless on ...  -  Aug 17, 2007
Aidsmap,...therapy could lead lead to the development of stains of HIV with resistance to drugs from the nucleoside reverse transcriptase inhibitor (NRTI) class.

Entecavir for HBV May Result in HIV Drug Resistance  -  Aug 16, 2007
Medscape (subscription)Entecavir selected for an M184I substitution in HIV reverse transcriptase at micromolar concentrations in cell culture, indicating inhibitory pressure at

Revised Labeling for Baraclude  -  Aug 17, 2007
Facts and Comparisons,Warnings, and Precautions sections describe potential development of HIV resistance to nucleoside reverse transcriptase inhibitors if Baraclude is used

City OKs biolab, nixes parking lot  -  Aug 20, 2007
Rome News-Tribune,Molecular Biology Resources Inc. of Milwaukee, Wisc., plans to produce reverse transcriptase from the avian myeloblastosis virus at the Coosa Valley

New weapons in AIDS war  -  Jul 23, 2007
Health24.com,There are four classes of ARVs currently available: Nucleoside Reverse Transcriptase Inhibitors (NRTIs). They interfere with the protein Reverse

Analysis: AIDS pipeline bursting  -  Jul 24, 2007
United Press InternationalFrench chemists described a series of compounds called dihydroxytropolones that attack the reverse transcriptase enzyme, one of the three key enzymes of the

IAS: Investigative Drugs Zero in on HIV Vulnerabilities  -  Jul 24, 2007
MedPage Today,A series of compounds called dihydroxytropolones that attack the reverse transcriptase enzyme, one of the three key enzymes of the HIV virus.

Entacavir (Baraclude) Gets Boxed Warning About HIV Resistance  -  Aug 17, 2007
MedPage Today,...suggesting the potential for development of resistance to HIV nuceloside reverse transcriptase inhibitors in hepatitis B patients untreated for HIV.

Frequency and seriousness of lactic acidosis mean that d4T should ...  -  Aug 17, 2007
Aidsmap,Lactic acidosis is a serious side-effect of anti-HIV drugs in the nucleoside reverse transcriptase inhibitor (NRTI) class, particularly ddI and d4T,

Rampant Adoption of qRT-PCR and Next Generation DNA Sequencing ...  -  Aug 20, 2007
Business Wire (press release),...“Among the market segments, quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) technology, including instrumentation and reagents,

IAS: Darunavir Noninferior to Lopinavir in TITAN trial  -  Jul 27, 2007
MedPage Today,He explained that fewer resistance mutations in the nucleoside reverse transcriptase class and in the protease inhibitor class appeared while patients were

Rilpivirine Shows Improved Lipid Profile Compared With Efavirenz ...  -  Jul 26, 2007
DG NewsRilpivirine is a new drug in the non-nucleoside reverse transcriptase inhibitor class of antiretroviral agents. "TMC278 resulted in minimal changes in lipid

IAS: Genetic Test Pinpoints Patients Who'll React to Abacavir  -  Jul 25, 2007
MedPage Today,Often, he noted, patients who are given regimens containing non-nucleoside reverse transcriptase inhibitors - which also can produce a rash as a side effect

Idenix Pharmaceuticals Reports Second Quarter and Six Month ...  -  Aug 2, 2007
CNNMoney.comIn addition to our HIV non-nucleoside reverse transcriptase inhibitor, which entered the clinic this year, we have a comprehensive HCV discovery engine that

Selection of Development Candidate Triggers $0.5 Million Milestone ...  -  Aug 16, 2007
CNNMoney.comThese compounds include RDEA806 and lead compounds from our 900 series, which are non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment

Patients with renal impairment often receive wrong NRTI dose ...  -  Aug 16, 2007
Aidsmap,Nucleoside reverse-transcriptase inhibitor dosing errors in an outpatient HIV clinic in the electronic medical record era. Clin Infect Dis 45: 658 – 661,

Daily Digest  -  Jul 23, 2007
San Diego Daily Transcript (subscription),...spectrum antiviral drug candidate, ANX-201, when combined with approved nucleoside and nucleotide reverse transcriptase inhibitors in preclinical tests.

Aptivus (tipranavir) Demonstrates Potent And Durable Treatment ...  -  Aug 6, 2007
Medical News Today (press release),After adjusting for protease inhibitor stratum, enfuvirtide use, and background reverse transcriptase inhibitor sensitivity, mean viral load change at last

HIV Drug Startup Raises $31 Million  -  Aug 2, 2007
Private Equity Hub,This mechanism of action is different from those currently used for treatment of HIV infection such as nucleoside reverse transcriptase inhibitors and

Genetic Test 100% Effective in Screening Patients With Abacavir ...  -  Jul 26, 2007
DG NewsThe test for the HLA-B*5701 allele successfully identifies patients with HIV who should not receive abacavir -- a nucleoside reverse transcriptase inhibitor

Label changes for Baraclude (entecavir) Tablets and Oral Solution  -  Jul 26, 2007
PharmaLive.com (press release),Limited clinical experience suggests there is a potential for the development to resistance HIV nucleoside reverse transcriptase inhibitors if BARCLUDE is

Progenics Presents Additional Positive Clinical Results for HIV ...  -  Jul 26, 2007
PipelineReview.com (press release),...nucleoside analog reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and the fusion inhibitor enfuvirtide.

144-Week Data from Gilead's Study 934 Comparing Truvada to ...  -  Jul 23, 2007
PharmaLive.com (press release),Twenty-two patients with baseline non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations and 31 patients who completed week 48 and week 96 of the

Bird flu: Four Manipuri teens test negative  -  Aug 3, 2007
Times of India,The samples of the children, all under 14 years, from a farm in Chingmeirong village in Manipur was tested by RT-PCR (reverse transcriptase polymerase chain

Uncertainty surrounds cancer vaccine review at FDA  -  Aug 2, 2007
Nature.com (subscription),GRNVAC1 is an RNA product encoding the reverse transcriptase–containing motif of human telomerase (an antigen Okarma says is on the surface of all cancer

Ardea Biosciences, Inc. Reports Second Quarter 2007 Financial Results  -  Aug 13, 2007
Earthtimes.orgThese include RDEA806, the Company's lead non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV, currently in Phase 1 clinical

Positive thinking  -  Jul 28, 2007
The Australian,The first anti-HIV drug, AZT, was licensed in 1987, and works by inhibiting the HIV enzyme reverse transcriptase which the virus uses to convert its single

An Overview of Pulmonary Diseases  -  Aug 13, 2007
Business Wire (press release),New technologies for infectious respiratory diagnosis: target-enriched multiplex polymerase chain reaction assays, multiplex reverse-transcriptase-PCR

Analysis: Genetic test guides AIDS therapy  -  Jul 26, 2007
Science Daily (press release)...not receive abacavir -- a nucleoside reverse transcriptase inhibitor that is one of the top two choices as the backbone for treatment combinations.

Tentative Approval: Lamuvidine and Zidovidine Tablets  -  Aug 9, 2007
PharmaLive.com (press release),Lamuvidine and zidovidine are both Nucleoside Reverse Transcriptase Inhibitors (NRTI) indicated for used in combination with other antiretroviral agents in

HEALTH-INDIA: On War Footing to Stamp Out Bird Flu Outbreak  -  Aug 7, 2007
IPS,...and were quarantined have been declared negative for avian influenza virus by RT-PCR (Reverse Transcriptase Polymerase Chain Reaction) test," he said.

AVIAN INFLUENZA – NO HUMANS AFFECTED – SITUATIONAL REPORT AS ON 5-8-07  -  Aug 6, 2007
Press Information Bureau (press release),Institute of Communicable Diseases, Delhi and found negative for Avian Influenza virus by RT-PCR [Reverse Transcriptase Polymerase Chain Reaction].

Bristol-Myers Squibb Company Reports Financial Results for the ...  -  Jul 26, 2007
CNNMoney.comSales of the SUSTIVA(R) Franchise, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV, increased 21%, including a 3% favorable

GeneSearch™ BLN Approved for Detection of Breast Cancer Spread to ...  -  Aug 1, 2007
Cancer Consultants (press release),The GeneSearch BLN uses real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to detect ammoglobin (MG) and cytokeratin 19 (CK 19) in lymph

Biomedical firm eyeing Rome for facility  -  Jul 31, 2007
Rome News-Tribune,MGR, the company’s subsidiary, would produce reverse transcriptase, an enzyme used in medical research, from the avian myeloblastosis virus at the Rome

Several New HIV Treatment Options to Be Available Over Next 12 Months  -  Jul 30, 2007
FDA news (subscription),Johnson & Johnson submitted a new drug application (NDA) for its investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) etravirine,

Applied Biosystems Announces New Tools For Studying Micrornas  -  Jul 30, 2007
Laboratory Network,...researchers add DNA obtained from performing separate reactions that involve use of the Applied Biosystems Multiplex RT (reverse transcriptase) pool

Tibotec submits marketing authorisation application for ...  -  Jul 29, 2007
SpiritIndia,TMC125 is an investigational next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), being studied for use with other antiretroviral agents

First Head to Head Comparison of Tenofovir/ Emtricitabine Versus ...  -  Jul 27, 2007
DG News...antiretroviral therapy (HAART) regimen had their nucleoside reverse transcriptase inhibitor (NRTI) backbone switched to either Truvada® or Kivexa®.

Ardea Biosciences, Inc. Stockholders Approve Company Proposals at ...  -  Jul 27, 2007
Genetic Engineering News (press release),These compounds include RDEA806 and lead compounds from our 900 Series, which are non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment

Ubisol-Aqua(TM): Coenzyme Q10 May Prevent Toxicity of HIV Drug Therapy  -  Jul 26, 2007
CNW Telbec (Communiqués de presse),...(see Zymes.com) Nucleoside reverse transcriptase inhibitors (NRTIs) inhibit replication of HIV and are central to effective HIV therapy.

IAS: Truvada more effective than Kivexa due to drop-outs related ...  -  Jul 26, 2007
Aidsmap,Truvada and Kivexa are fixed-dose combination pills, each of which combines two nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs) into a

Avexa Releases ATC Phase IIb Clinical Trial Update  -  Jul 26, 2007
PharmaLive.com (press release),ATC is a cytidine analogue that is a potent inhibitor of HIV reverse transcriptase (RT) which acts by selective chain termination of the virus.

Raltegravir Efficacy Challenging Current Theories on How HIV ...  -  Jul 25, 2007
DG NewsThis particular process is unaffected by reverse transcriptase inhibitors and protease inhibitors. Part 1 of this protocol included 9 days of monotherapy in

Integrase Inhibitor Raltegravir as Effective as Efavirenz-Based ...  -  Jul 25, 2007
DG News...integrase inhibitor raltegravir or the standard-of-care non-nucleoside reverse transcriptase efavirenz were able to suppress HIV to undetectable levels,

IAS: Maraviroc Called Premature for New HIV Patients  -  Jul 25, 2007
MedPage Today,In a head-to-head trial, the novel entry inhibitor maraviroc "fell just short" of demonstrating noninferiority to non-nucleoside reverse transcriptase

Gilead Sciences Pwned by Nonprofit Activists  -  Jul 25, 2007
Patent Baristas,Tenofovir disoproxil fumarate (also referred to as TDF or bis(POC)PMPA fumarate) is a nucleotide analog reverse transcriptase inhibitor (NtRTI) that is a

IAS: New Drugs Effective Against HIV Resistance  -  Jul 25, 2007
MedPage Today,...darunavir and emtravirine, a new non-nucleoside reverse transcriptase inhibitor (NNRTI). In both arms of the trials, low-dose ritonavir was also given.

Boosted Invirase (saquinavir) 500 Has Similar Efficacy And An ...  -  Jul 25, 2007
Medical News Today (press release),These treatments are given at their approved twice-daily dosages in combination with two nucleoside reverse transcriptase inhibitors (NRTIs;

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