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histone - Group of water-soluble proteins rich in basic amino acids, closely associated with DNA in plant and animal chromatin. Histones are involved in the coiling of DNA in chromosomes and in the regulation of gene activity. [FAO]

News archive for histone.

Washington University becomes member of major cancer research ...  -  21 Aug 2007
News from Washington University in St. Louis,A number of emerging therapies — including novel proteosome inhibitors, immunomodulatory drugs, histone deacetylase inhibitors, heat shock protein

FDA Grants Tikvah Therapeutics, Inc. Orphan Drug Status for Sodium ...  -  21 Aug 2007
PipelineReview.com (press release),Sodium phenylbutyrate, a histone deacetylase (HDAC) inhibitor, currently approved to treat urea cycle deficiency, has been identified in in vitro systems

Business Briefs - Aug. 21  -  21 Aug 2007
Daily Camera,...targeting sirtuins — which are a class of histone deacetylase enzymes (Class 3 HDACs) implicated in cell survival and death — as anti-cancer agents.

Orphan News :: Treatment & Health  -  21 Aug 2007
Checkbiotech.org (press release),Sodium phenylbutyrate, a histone deacetylase (HDAC) inhibitor, currently approved to treat urea cycle deficiency, has been identified in in vitro systems

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin ...  -  Aug 20, 2007
CNNMoney.comSirtuins (including SIRT1) have been shown to deacetylate histone proteins and numerous transcription factors, leading to promotion of normal cell survival

Pharmion, MethylGene Team For $100M Cancer Partnership  -  Aug 20, 2007
Therapeutics Daily (subscription) (press release),Sirtuins, including SIRT1, have been shown to deacetylate histone proteins and numerous transcription factors, leading to promotion of normal cell survival

MethylGene and Pharmion Ink $101M Expansion to Cancer Alliance  -  Aug 20, 2007
Genetic Engineering News (press release),MethylGene and Pharmion have expanded their collaboration related to anticancer treatments based on histone deacetylase enzymes (HDAC) inhibitors.

Market Report -- In Play (PHRM)  -  Aug 20, 2007
MSN Money...novel small molecule inhibitors targeting sirtuins, a separate and distinct class of histone deacetylase enzymes implicated in cell survival and death.

Full Text  -  Aug 2, 2007
Science Magazine (subscription)And a number of histone modifications (known as histone code) have been associated with such states (13). Silenced chromatin, largely heterochromatic,

Blocker of Longevity-associated Protein Cuts Down Parkinson’s in ...  -  Jul 25, 2007
exduco.net,...“This was very exciting for us because this class of histone deacetylase has been implicated in the pathology of both Parkinson’s and Huntington’s diseases

Chromatin Remodeling Complex Connected To DNA Damage Control  -  Aug 9, 2007
Science Daily (press release)DNA is tightly intertwined with proteins known as histones and assembled in histone/DNA units called nucleosomes along the connecting length of a string of

MethylGene to Present at the Canaccord Adams 27th Annual Global ...  -  Jul 31, 2007
Therapeutics Daily (subscription) (press release),Mr. Corcoran will provide a general update on the company including its histone deacetylase and kinase programs. Mr. Corcoran's presentation will be

Full Text  -  Jul 26, 2007
Science Magazine (subscription)The gene encoding SIRT1, a sirtuin histone deacetylase, is widely recognized for its link to aging. SIRT1 activity increases when conditions favor longevity

Vidaza Significantly Extends Overall Survival by 74% in Phase 3 ...  -  Aug 2, 2007
CNNMoney.comEpigenetics refers to changes in the regulation of gene expression, and DNA methylation and histone deacetylation are two of the more studied epigenetic

Recovering Long-lost Memories  -  Jul 31, 2007
Scientific American...activity of genes; a substance that blocks an enzyme called HDAC (histone deacetylase) seemed to have a similar impact on the gene activity involved,

Critiquing the Sirtuin Model of Calorie Restriction  -  Aug 13, 2007
Methuselah Foundation,...the effect of "CR" on "lifespan" in yeast is mediated by activating the histone deacetylase enzyme Sir2 -- the yeast homolog of the mammalian SIRT1.

Gene-transcription Machinery Seen Poised For Action, Held In Check ...  -  Jul 25, 2007
Science Daily (press release)..."When ubiquitin cannot be removed from the histone, the first thing seen is that a particular enzyme normally recruited into the process at the start of

MethylGene Reports Second Quarter 2007 Results  -  Aug 7, 2007
Earthtimes.orgSelected MGCD290 as the Company's clinical candidate for its histone deacetylase antifungal program. MGCD290 potentiates and broadens the spectrum of azole

ASBMB taps 8 scientists and 1 politician for top awards  -  Aug 6, 2007
FirstScience,His research has helped define cause and effect relationships between specific histone modifications and specific gene expression events, as well as defined

Fourth EURYI Award brings 4 young top researchers to Germany  -  Aug 6, 2007
EurekAlert (press release),Fischer found that even after severe damage to the brain, learning behaviour and access to long-term memory can be reinstated by increasing histone

MethylGene Regains Exclusive Rights to Beta-Lactamase Inhibitor ...  -  Aug 1, 2007
WM Experts (press release),...of novel therapeutics for cancer with a focus on some of the most promising areas of oncology such as histone deacetylase (HDAC) and kinase inhibitors.

Intensive Chemotherapy No Benefit in Some Elderly Leukemia Patients  -  Jul 31, 2007
Cancerpage.com,..."Recently," she said, "demethylating agents like decitabine or 5-azacitidine or inhibitors of histone deacetylase like valproic acid have shown promising

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