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agonist

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agonist - A drug, hormone or transmitter substance that forms a complex with a receptor site. The formation of the complex triggers an active response from a cell. [FAO]

News archive for agonist.

Pharmion, MethylGene Team For $100M Cancer Partnership  -  21 Aug 2007
BioWorld Online,Most study of sirtuins has been in the area of proliferation of cell growth, or the agonist approach, the most well known of which is the agonist effects of

Pharmion, MethylGene Team For $100M Cancer Partnership  -  21 Aug 2007
Therapeutics Daily (subscription) (press release),Most study of sirtuins has been in the area of proliferation of cell growth, or the agonist approach, the most well known of which is the agonist effects of

Children with sleep issues often treated with drugs  -  21 Aug 2007
DetNews.com,Antihistamines (such as Atarax) and alpha-2-agonist drugs (such as Catapres or Tenex) have sedative effects secondary to their intended use.

Agonist, the  -  Aug 20, 2007
The Gauntlet,But it is exactly this unique dynamic that led Century Media Records to sign Montreal’s THE AGONIST (formerly The Tempest) to a worldwide deal.

THE AGONIST: 'Business Suits And Combat Boots' Video Available ...  -  Aug 16, 2007
Blabbermouth.net,..."Business Suits and Combat Boots" comes off THE AGONIST's debut album, "Once Only Imagined", which was released on August 14 through Century Media.

Kosan's Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase ...  -  Aug 6, 2007
CNNMoney.comIn December 2006, Kosan and Pfizer established a worldwide license agreement for Kosan's motilin agonist program, including KOS-2187 and related compounds,

Buy Dr Reddy's Labs; target of Rs 850: DSP ML  -  Aug 20, 2007
Moneycontrol.com,Balaglitazone, DRL’s diabetes NCE (partial PPAR agonist) having recently started Phase III trials is likely to be differentiated by its body weight-neutral

Kosan’s Motilin Receptor Agonist Enters Phase I Clinical Trial  -  Aug 6, 2007
FDA news (subscription),Kosan Biosciences announced that Pfizer has initiated a Phase I clinical trial of motilin receptor agonist PF-04548043, formerly KOS-2187, for the treatment

THE AGONIST Adds Second Guitarist - July 29, 2007  -  Jul 29, 2007
Blabbermouth.net,As previously reported, THE AGONIST shot its first promotional video clip, for the track "Business Suits and Combat Boots", with renowned director David

Dynavax Awarded $3+ Million Universal Flu Vaccine Grant from NIAID  -  Aug 7, 2007
CNNMoney.comThe research at Dynavax, funded by the NIH starting in 2003, focuses on a new vaccine that incorporates a second- generation TLR9 agonist and the conserved

EPIX Pharmaceuticals Achieves Discovery Milestone in Collaboration ...  -  Aug 16, 2007
CombiChem.net (subscription),...“In addition to our joint focus on developing PRX-03140, our proprietary 5-HT4 agonist, for the treatment of Alzheimer’s disease, EPIX and GSK have agreed

Metabasis Therapeutics Presents Preclinical Results Demonstrating ...  -  Aug 20, 2007
Genetic Engineering News (press release),The presentation provided data on MB07811, the Company's liver-targeted, beta-subtype-selective thyroid hormone receptor (TR beta) agonist product candidate

Social Media - The Next Revolution in Human Health  -  Aug 13, 2007
FastForward Blog,Acute administration of corticosterone (the endogenous Type I and Type II receptor agonist), or RU28362 (a specific Type II receptor agonist),

Exacerbation of Schizophrenia by Varenicline  -  Aug 1, 2007
Am J Psychiatry (subscription)The nicotinic agonist varenicline is a new alternative replacement agonist. There are no reports of its use in schizophrenia.

A new mechanism for respiratory syncytial virus-induced 2 ...  -  Jul 31, 2007
AJP-Lung Physiology (subscription)Although a potential benefit of 2 -agonist medication on RSV infection-induced airway obstruction may be expected, the results of clinical studies have not

Athersys Reports Second Quarter 2007 Financial Results  -  Aug 17, 2007
PR Newswire (press release),We recently announced the initiation of our Phase I clinical trial for ATHX-105, the company's oral, selective 5HT2c receptor agonist for treating obesity

Players Still Trying To Widen Market For Migraine Therapy  -  Aug 17, 2007
BioWorld Online,The selective serotonin receptor agonist takes longer to kick in, but has the longest half-life in the triptan class: 26 hours. Endo in-licensed Frova from

Pfizer's GORD therapy enters the clinic  -  Aug 6, 2007
DrugResearcher.com,Erythromycin is a motilin G-protein coupled receptor agonist that mediates the hormone motilin, which is secreted by the small intestine and stimulates GI

Toll-like receptors, endogenous ligands, and constitutive control ...  -  Jul 27, 2007
Journal of Leukocyte Biology (subscription)Of course, our finding that an endogenous substance could activate TLR4 led us to modify the simple, canonical model of an agonist–receptor interaction.

Eli Lilly to Cease Sale of Permax Due to Risk of Cardiac Valvulopathy  -  Aug 16, 2007
DG NewsPermax® (pergolide mesylate) is a dopamine agonist used in the treatment of the signs and symptoms of idiopathic Parkinson's disease.

Tranzyme Pharma Initiates Dosing of Patients in a Multi-National ...  -  Jul 26, 2007
PharmaLive.com (press release),TZP-101 is a potent ghrelin agonist that Tranzyme is developing as a first-in-class prokinetic agent for the treatment of POI and severe gastroparesis.

Rheoscience and Dr. Reddy's Commence the First Phase III Trial of ...  -  Aug 1, 2007
Genetic Engineering News (press release),Balaglitazone is a second generation of PPAR gamma agonist with only partial agonistic properties, which in clinical phase II studies have shown to have

Market Report -- In Play (WIRES)  -  Aug 6, 2007
MSN MoneyOn The Wires Kosan Biosciences (KOSN) announces that Pfizer (PFE) has initiated a Phase 1 clinical trial of motilin receptor agonist PF-04548043,

Kosan Reveals Initiation Of Phase 1 Clinical Trial Of PF ...  -  Aug 6, 2007
Trading Markets,The company noted that PF- 04548043 is a potent motilin receptor agonist intended for the treatment of gastroesophageal reflux disease and other

Top Marketeer Returns to Merck to Promote Diet Drug Acomplia ...  -  Jul 29, 2007
Acomplia Report,While Merck continues to say little about the Phase III trials of taranabant, a cannabinoid-1 (CB-1) receptor inverse agonist that has a mechanism of action

Pharma Blog Watch  -  Aug 2, 2007
FDA news (subscription),In his blog, Chris Morrison writes about Dr. Reddy’s and Rheoscience’s partial peroxisome proliferator-activated receptor (PPAR) gamma agonist balaglitazone

Spectrum Pharmaceuticals, Inc. gets FDA OK on investigational drug  -  Aug 9, 2007
SmallCapInvestorSPI-1620 is a highly selective endothelin-B agonist that has shown in experimental animal models a “transient and selective increase in blood flow�? to

Veneconomy: Pouring oil on the Middle East Fire  -  Aug 1, 2007
Petroleumworld.com,Ian Welsh is a Lecturer in the School of Social Sciences at Cardiff University, is the managin editor of The Agonist. Petroleumworld does not necessarily

Stirling Products Limited ASX: STI - Activities Update - Dr Calvin ...  -  Jul 30, 2007
Asia Corporate News Network (press release),Commercialising patented beta agonist Repartitioning Feed Enhancers ('RFEs') for livestock, which are being positioned as replacement products and

Anadys Pharmaceuticals Announces Strategic Restructuring and ...  -  Aug 1, 2007
CNNMoney.comFocus its resources on the development of ANA598, a direct antiviral compound for the treatment of hepatitis C, and ANA773, a TLR7 agonist prodrug for

Pfizer starts clinical trial of Kosan drug  -  Aug 6, 2007
MSN MoneyPfizer Inc. has started an early stage clinical trial of a drug it licensed from Kosan Biosciences Inc. The drug is a motilin receptor agonist being tested

Indevus Pharmaceuticals Announces Third Quarter Fiscal 2007 ...  -  Aug 7, 2007
CNNMoney.comVANTAS is contraindicated in patients with hypersensitivity to GnRH, GnRH agonist analogs, or any components in VANTAS. SUPPRELIN(R) LA is a subcutaneous

Addex Pharmaceuticals Appoints Head of ADME/PK  -  Aug 17, 2007
PharmaLive.com (press release),Allosteric modulation may offer more sophisticated ways to normalize biological signaling compared to classical "orthosteric" agonist or antagonist drugs.

Going the Distance  -  Aug 16, 2007
ADVANCE for Physician Assistants,Frova should not be taken in combination with other serotonin receptor agonist medications or medications that are ergot derivatives, such as Bellergal (a

Warm Up Before You Work Out!  -  Jul 30, 2007
About - News & Issues,Taking a type of medicine called a beta-2 agonist while performing warm-up exercises reduced the fall in lung function even more. Obviously, this was a tiny

- Pharmaceutical company partners with leading Internet community ...  -  Aug 10, 2007
Web Services Journal,Buprenorphine is a partial opioid agonist, which allows it to be used to treat opioid dependence for two critical reasons: first, it acts on the brain in a

SATHANAS: 'Crowned Infernal' Track Listing, Artwork Revealed - Aug ...  -  Aug 19, 2007
Blabbermouth.net,SATHANAS will open for OVERKILL and DARK FUNERAL on October 18 at Peabody's Downunder in Cleveland, Ohio along with NAGLAFAR, DAATH and THE AGONIST.

MediciNova Reports Phase Ib Clinical Study Results for MN-221, a ...  -  Aug 17, 2007
CNNMoney.comMN-221 is a highly-selective beta2-adrenergic receptor agonist under development by MediciNova for the treatment of status asthmaticus and preterm labor.

Clinical setbacks for toll-like receptor 9 agonists in cancer  -  Aug 2, 2007
Nature.com (subscription),VaxInnate in Cranbury, New Jersey, is set to launch a clinical program for influenza virus that deploys a yet-unnamed agonist for TLR5.

Idera Pharmaceuticals Announces Publication of Preclinical Data on ...  -  Aug 14, 2007
PharmaLive.com (press release),Idera's most advanced clinical candidate, IMO-2055, is an agonist of TLR9 and is currently in a Phase 2 trial in oncology and in a Phase 1/2 chemotherapy

Kosan Announces Second Quarter 2007 Financial Results  -  Aug 2, 2007
CNNMoney.com...solid tumors with our partner Roche; and motilin agonist KOS-2187 which should soon begin Pfizer-sponsored Phase 1 trials in gastrointestinal disorders.

Dynavax Announces Second Quarter 2007 Financial Results  -  Jul 31, 2007
CNNMoney.comClearly, these are accomplishments that underscore the broadly enabling product potential of our TLR9 agonist approach," said Dino Dina, MD, president and

Pig farmers ask for ban on US pork  -  Jul 30, 2007
Taipei Times,Yang added that beta-agonist drugs such as clenbuterol are used to treat some asthma patients because of their bronchial dilating properties.

Dynavax Issued Landmark Patent Covering Second-Generation TLR9 ...  -  Aug 16, 2007
CNNMoney.comDynavax Technologies Corporation discovers, develops, and intends to commercialize innovative TLR9 agonist-based products to treat and prevent infectious

Cephalon Announces Positive Results from a Pivotal Study of ...  -  Aug 16, 2007
CNNMoney.comFENTORA contains fentanyl, an opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.

Sixty-One Percent of Newly Diagnosed Parkinson's Disease Patients ...  -  Aug 13, 2007
PR Newswire (press release),Patient demand for well-tolerated, levodopa-sparing treatments will continue to drive increases in dopamine agonist patient share first line.

Scottish firm targets South Korea for cancer patch  -  Aug 13, 2007
DrugResearcher.com,Granisetron is a well-known 5-HT3 receptor agonist, and a widely-used treatment for chemotherapy-induced nausea and vomiting. According to ProStrakan, sales

Athersys Begins Phase I Trial for ATHX-105 for Treatment of ...  -  Jul 25, 2007
CNNMoney.comThe company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in Phase I clinical trials for the treatment of obesity.

Corrected Version: Addex Pharmaceuticals First Half 2007 Financial ...  -  Jul 25, 2007
CNNMoney.comThus, allosteric modulators bind receptors at sites that are distinct from the binding sites of classical small molecule "orthosteric" agonist and

FDA Advisory Committee Recommends Approval of EVISTA for the ...  -  Jul 24, 2007
CNNMoney.comEVISTA is a selective estrogen receptor modulator, or SERM (recently classified by the FDA as an estrogen agonist/antagonist). EVISTA is currently indicated

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