prochlorperazine maleate

This page contains recent news articles, when available, and an overview of prochlorperazine maleate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

prochlorperazine maleate (when available)

Pharmacology and use:
Prochlorperazine, a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine, is used as an antiemetic and antipsychotic agent in the management of nausea and vomiting. It shares many of the actions and adverse effects of the antipsychotics. For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders

Mechanism Of Action:
Prochlorperazine blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. The antiemetic effects of prochlorperazine can be attributed to dopamine blockade in the chemoreceptor trigger zone. Prochlorperazine also blocks anticholinergic and alpha-adrenergic receptors, the blockade of alpha(1)-adrenergic receptors resulting in sedation, muscle relaxation, and hypotension.

News Articles on Prochlorperazine

[an error occurred while processing this directive] [an error occurred while processing this directive] Brand Names/Synonyms:
prochlorperazine maleate is also known by the following brand names and/or synonyms6140 R.P.; 6140 RP; Bayer a 173; Buccastem; COMPAZINE; Capazine; Chlormeprazine; Chlorperazine; Combid; Compazine; Compro; Emelent; Emetiral; Eskatrol; Kronocin; Meterazin; Meterazin Maleate; Meterazine; Nipodal; Novamin; Pasotomin; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazine; Prochlorperazine Edisylate; Prochlorperazine Maleate; Prochlorpromazine; Procloperazine; Proclorperazine; RP-6140; SKF 4657; Stemetil; Tementil; Temetid; Vertigon

Drug Category:
prochlorperazine maleate is categorized under the following by the FDA: Antipsychotics; Antiemetics; Phenothiazines; ATC:N05AB04

Dosage Forms:
Tablets, Spansule, capsules, Vials, Suppositories, Syrup

Absorption:
rapidly absorbed following oral administration

Interactions:
Interactions for Prochlorperazine:

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines.

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concomitantly.

Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs.

Chemical IUPAC Name:
2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine

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