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morphine sulfateThis page contains recent news articles, when available, and an overview of morphine sulfate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: morphine sulfate (when available) Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. For the relief and treatment of severe pain Mechanism Of Action: The precise mechanism of the analgesic action is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. News Articles on Morphine Myocardial Infarction In Pregnancy - 20 Apr 2009 In the third trimester, morphine sulfate, a pregnancy category B drug, can be used to prevent or relieve chest pain. 2,3 Note that if morphine is used ADVANCE for Physician Assistants Glenmark: To Stop Distribution Of Morphine Sulfate Pdt In US - Mar 31, 2009 BY) said Wednesday it will cease the distribution of its morphine sulfate product in the US, as it is among the nine companies issued warning letters by the Wall Street Journal FDA was wrong to order companies to stop making morphine sulfate ... - Apr 10, 2009 ...has admitted that it was wrong last month when it ordered nine companies to stop producing a extremely concentrated morphine sulfate elixir. eFitnessNow FDA amends opioid action warning - Apr 15, 2009 They were concerned that the original order would cause a shortage of morphine sulfate oral solution. The agency has determined that the 20 milligram dosage McKnight's Long Term Care News FDA amends unapproved opioids action - Apr 13, 2009 ...allow the continued production, marketing and distribution of one particular type of opioid -- a high concentrate morphine sulfate oral solution. United Press International Buckingham Research Maintains a 'Neutral' on Endo Pharma (ENDP ... - Apr 16, 2009 KV's manufacturing problems have led to dramatic growth in Endo's morphine sulfate painkiller while the Endocet painkiller has grown strongly as well due to StreetInsider.com (subscription) Thriving in a time of adversity - Sun Pharma pounces on shortage ... - Apr 14, 2009 Additionally, for short and immediate term extreme pain relief, another schedule II control substance used is Morphine Sulfate. Gerson Lehrman Group Covidien, Boehringer Must Halt Unapproved Drug Sales - Mar 31, 2009 The 14 products targeted today by the Food and Drug Administration include high concentrate morphine sulfate oral solutions and immediate-release tablets Bloomberg Drug and Therapeutics Update - Apr 16, 2009 ...the continued marketing and distribution of one particular type of opioid -- a high concentrate morphine sulfate oral solution -- on an interim basis. OnMedica FDA gives Lannett a reprieve - Apr 11, 2009 On Thursday, the agency said it was extending that period to 180 days "after any firm receives approval for a morphine sulfate oral solution 20 mg/ml Philadelphia Inquirer Glenmark to stop sale of its pain killer in US - Apr 1, 2009 New Delhi: Drug maker Glenmark Pharmaceuticals Ltd said on Wednesday it will stop selling its morphine sulfate drug in the US, complying with a warning by Livemint FDA Reverses Decision on Opoid Availability - Apr 14, 2009 ...the manufacturing of 20 mg/ml morphine sulfate In the original decision, no representatives from hospice or palliative care organizations were included. Associated Content • Bill would empower Michigan patients to sue drug manufacturers - Apr 5, 2009 After three weeks, when she returned to her Rockford home, she found a letter from the pharmaceutical company recalling the morphine sulfate. The Grand Rapids Press - MLive.com FDA Lightens Message to Cody Laboratories - Apr 13, 2009 ...last week received US Food and Drug Administration orders to cease production of painkilling morphine sulfate in a dosage not federally approved. Pharmaceutical Processing Former Ellwood City police chief sues state police over certification - Apr 15, 2009 The lawsuit states the denial was due to McDonald taking Avinza, or morphine sulfate. The prescription pain medicine was needed for a neck and back injury Pittsburgh Tribune-Review Post-Bulletin, Rochester MN - Apr 16, 2009 In Kreye's home, they found Dilaudid, a Fentanyl patch, half an Oxycontin, 29 morphine sulfate tablets, a Percocet, two Lorazapam and 201/2 Darvocet. Post-Bulletin Critical Shortages Of Narcotic Medications Pose Serious Health Risks - Apr 16, 2009 The drug formulation that is most at issue is morphine sulfate 20mg/ml oral concentrate. This drug, which has been on the market for decades, Medical News Today (press release) FDA warning letter ‘stuns’ Cody Labs CEO - Apr 6, 2009 The FDA audited Cody Labs in 2007 when the lab was making the same drug Â-Â-â€â€? morphine sulfate solution â€â€? now in question. “We passed the audit with Cody Enterprise DEA Marijuana Raid Kills Buzz From Obama Administration's New Policy - Mar 31, 2009 I also use 90 mgs of Morphine Sulfate daily. The "pot" surely helps the pain as much as the morphine. But I'm in Sacramento, not The City. AOL News Newsbloggers Alleged burglar in court - Apr 2, 2009 Galunas pleaded innocent to two counts of first-degree criminal possession of a controlled substance _ morphine, morphine sulfate, oxycodone, oxycotin and Oneonta Daily Star Schering to shut vet plant, cut 240; Gilead gets regulatory OK for ... - Apr 1, 2009 FDA release > Glenmark Pharmaceuticals said it will cease distributing its morphine sulfate product in the US, as it is among the nine companies issued FiercePharma Life Sciences: Competition & Antitrust Update - Apr 1, 2009 However, King’s LAO, Avinza, and Alpharma’s LAO, Kadian, are the only two competitively-significant branded drugs in the narrower, morphine sulfate-based Linex Legal Weitz & Luxenberg Alerts Public to Toxic Emissions of Holcim ... - Apr 6, 2009 Digitek, Gadolinium MRI contrast dye, morphine sulfate, Zimmer Durom Cup, Raptiva and Stryker hip implants, and general negligence, among others. MarketWatch (press release) Two plead to trafficking morphine, pot - Mar 14, 2009 Assistant Attorney General David Fisher said police determined that Bernard was selling morphine sulfate pills for $10 apiece. SunJournal.com Two men charged after bail check - Feb 28, 2009 ...by bail conditions and observed hypodermic needles and syringes and crushed tablets, which turned out to be Oxycodone and morphine sulfate, Baril said. SunJournal.com FDA Cracks Down on KV Pharmaceutical, Maker of Defective Generic Drugs - Mar 3, 2009 The KV Pharmaceutical drugs recalled were propafenone HCl, isosorbide mononitrate, morphine sulfate, and dextroamphetamine sulfate. Attorney at Law EKR Therapeutics to Present at the Cowen and Company 29th Annual ... - Mar 12, 2009 Retavase ® (reteplase recombinant), DepoDur ® (morphine sulfate extended-release liposomal injection), and Gelclair ® (bioadherent oral gel). PR-Inside.com (Pressemitteilung) 10-K: KING PHARMACEUTICALS INC - Mar 2, 2009 ...the US Federal Trade Commission, we divested the rights to Alpharma's Kadian(R) (morphine sulfate long-acting) to Actavis Elizabeth, LLC ("Actavis"). MarketWatch (press release) King Pharmaceuticals Reports Year-End and Fourth-Quarter 2008 ... - Feb 26, 2009 Net sales of AVINZA(R) (morphine sulfate extended release) totaled $33 million during the fourth quarter and $135 million for the year ended December 31, Trading Markets (press release) Parent or Nurse-Controlled Analgesia for Pain Control in ... - Mar 2, 2009 All but two children used morphine sulfate PNCA. Mean pain scores for each 12-hour period ranged from 0.7 to 1.1, indicating good analgesia. AAP Grand Rounds (registration) ETHEX Recalls Infant Vitamins, Iron Supplements - 04 Feb 2009 Those medications included various lots and sizes of Propafenone HCl Tablets, Isosorbide Mononitrate Extended Release Tablets, Morphine Sulfate Extended Newsinferno.com, Oxycodone and Morphine Among Dozens of Drug Recalls - Jan 29, 2009 The recalls stem from a series of manufacturing issues which allowed oversized tablets of Morphine Sulfate and other generic drugs to be sold with up to AboutLawsuits.com Suit against drug maker claims woman died from too much morphine ... - Jan 21, 2009 Frank Morris Goodman and Misty Sonnier allege Judy Goodman died after an accidental overdose from an extended-release morphine sulfate tablet prescription Southeast Texas Record, Following Morphine Recall and Other Generic Drug Problems, KV ... - Jan 27, 2009 The recalls issued so far have involved Morphine Sulfate Extended Release, Morphine Sulfate Immediate Release, Dextroamphetamine Sulfate, Propafenone HCI, AboutLawsuits.com Walgreens Sends Urgent Drug Recall Information Letter Out to Ethex ... - Jan 9, 2009 The manufacturer of Morphine Sulfate IR tables, Ethex Corp., is recalling several lots of this medication because there is the possibility that some tablets InjuryBoard.com, Preventing Prescription Opioid Abuse: New Formulations—But Who ... - Feb 3, 2009 The opioid in Embeda, which is being developed by Alpharma, is extended-release morphine sulfate, and the opioid in a product currently labeled ELI-216 Psychiatric Times, Drugs Stolen From Livermore Falls Pharmacy - Jan 27, 2009 Police said two cabinets where narcotics were kept were pried open. The medications taken include OxyContin, oxycodone, morphine sulfate and methadone. WMTW, King Pharma says Embeda was safe and well-tolerated for long-term ... - Jan 30, 2009 ...its Phase III 12-month open-label safety and efficacy study evaluating Embeda (morphine sulfate and naltrexone hydrochloride) Extended Release Capsules. RTT News, Woman Busted with Change Purse of Pills - Jan 22, 2009 Kopp was arrested and charged with possession of a controlled dangerous substance, morphine sulfate pills, and possession of drug paraphernalia, Bay Net, Another Ethex and KV Pharma Drug Recall - Feb 2, 2009 ...as many of its prescription drugs, particularly morphine sulfate, have been manufactured twice the size than the product label suggests. InjuryBoard.com, Calvert County Sheriff's Reports - Jan 20, 2009 Kopp was arrested and charged with possession of a controlled dangerous substance, morphine sulfate pills, and possession of drug paraphernalia, Southern Maryland Online, West Side Neighborhood Watch - Jan 15, 2009 7 a vial of morphine sulfate was missing from a hospice patient’s room. Police went to a Montrose discount store Jan. 8 and arrested a Canton man for Akron Leader Publications, Police report - Jan 16, 2009 A 45-year-old Keller woman was arrested on suspicion of possession of 18.6 grams of morphine sulfate liquid and 1.3 grams of oxycontin. Keller Citizen, King Pharmaceuticals Provides Update on EMBEDA? NDA Review - Jan 8, 2009 ...(FDA) is continuing its review of the New Drug Application (NDA) for EMBEDA" (morphine sulfate and naltrexone hydrochloride) extended release capsules. PR-Inside.com (Pressemitteilung), Generic drug firms robust despite economy - Jan 18, 2009 The company recently expanded its specialty drug portfolio in the US when it acquired Kadian, a brand name extended release morphine sulfate for pain ICIS (subscription), EKR Therapeutics to Present at the JPMorgan 2009 Healthcare Conference - Jan 12, 2009 Retavase® (reteplase recombinant), DepoDur® (morphine sulfate extended-release liposomal injection), and Gelclair® (bioadherent oral gel). PR-Inside.com (Pressemitteilung), ETHEX Recalls More Oversized Drugs - 25 Dec 2008 Those medications included various lots and sizes of Propafenone HCl Tablets, Isosorbide Mononitrate Extended Release Tablets, Morphine Sulfate Extended Newsinferno.com, Class Action Lawsuit Following Ethex Recall of Morphine and Other ... - Dec 3, 2008 On June 10, 2008, one lot of 60 mg Morphine Sulfate Extended Release tablets were recalled when it was found that some of the pills sold since April 2008 AboutLawsuits.com Morphine Overdose Killed Army Soldier - Dec 4, 2008 And they have not connected the morphine overdose to the FDA's three recalls on Ethex Morphine Sulfate tablets, which occurred four months after Mr. Baker's InjuryBoard.com, Police await results from lab in Rangeley Pharmacy pills theft - Dec 24, 2008 About 6000 pills, a mix of Oxycodin, OxyContin, Vyvance, Avinza, morphine sulfate tablets and methadone were stolen, police Chief Dennis Leahy said after SunJournal.com, KV Pharmaceutical chief retires amid controversy - Dec 5, 2008 Included were specific dosages of propafenone HCL, isosobide monitrate, morphine sulfate and dextroamphetamine sulfate. St. Louis Post-Dispatch, Can of beer nets suspect in robbery - Dec 9, 2008 100 tablets of Endocet, which is a combination of oxycodone and acetaminophen, and about 400 tablets of morphine sulfate, according to police reports. Bangor Daily News, UCSF's cooling method a first for at-risk babies - Dec 15, 2008 While on the blanket, the babies are put on a morphine-sulfate drip, which sedates them to minimize movement. They are fed through an IV. San Francisco Chronicle, Dangerous Drug Resource Center Provided by Lawyer Central - Dec 3, 2008 A recent instance of dangerous drugs reaching the marketplace involved the Ethex Corporation, a manufacturer of the pain medication Morphine Sulfate. TransWorldNews (press release), EKR Therapeutics Commences Shipments of Premixed Double ... - Dec 10, 2008 Retavase(R) (reteplase recombinant), DepoDur(R) (morphine sulfate extended-release liposomal injection) and Gelclair(R) (bioadherent oral gel). MarketWatch Pain Therapeutics, King Tumble On FDA's Remoxy Rejection - Dec 11, 2008 30, about Embeda (morphine sulfate extended release with sequestered naltrexone hydrochloride), which the firm claims has an abuse-deterrent mechanism. BioWorld Online, Estimate on pilfered pills increases to 6000 - Dec 9, 2008 The missing narcotic medications include Oxycodin, OxyContin, Vyvance, Avinza, morphine sulfate tablets and methodone, Leahy said. SunJournal.com, Brand Names/Synonyms: morphine sulfate is also known by the following brand names and/or synonymsAVINZA; Apokyn; Astramorph Pf; Avinza; Depodur; Diacetylmorphine Hydrochloride; Diamorphine Hydrochloride; Dulcontin; Duramorph; Duramorph Pf; Duromorph; Epimorph; Heroin Hydrochloride; Heroine Hydrochloride; Kadian; L-Morphine; M S Contin; M-Eslon; M.O.S; M.O.S.-S.R; MS IR; MS.IR; MS/L; MS/S; MSIR; Meconium; Morfina; Morphia; Morphin; Morphina; Morphine; Morphine Extra-Forte; Morphine Forte; Morphine H.P; Morphine Sulfate; Morphinism; Morphinum; Morphitec; Morphium; Moscontin; Ms Contin; Ms/L Concentrate; Nepenthe; O,O'-Diacetylmorphine Hydrochloride; Oms Concentrate; Oramorph Sr; Ospalivina; Rescudose; Rms Uniserts; Roxanol; Roxanol 100; Roxanol Ud; Statex; Statex Drops Drug Category: morphine sulfate is categorized under the following by the FDA: Narcotics; Analgesics; Opiate Agonists; ATC:G04BE07; ATC:N02AA01; ATC:N02AA04; ATC:N02AA09; ATC:N04BC07; ATC:R05DA01; ATC:R05DA05; ATC:S01XA06 Dosage Forms: CAPSULE (SUSTAINED-RELEASE); DROPS; LIQUID; SOLUTION; SUPPOSITORY; SUPPOSITORY (SUSTAINED-RELEASE); SYRUP; TABLET; TABLET (EXTENDED-RELEASE); TINCTURE Absorption: Bioavailability is ~30% Interactions: Interactions for Morphine: Use with Other Central Nervous System Depressants: The depressant effects of morphine are potentiated by the presence of other CNS depressants such as alcohol, sedatives, antihistaminics, or psychotropic drugs. Use of neuroleptics in conjunction with oral morphine may increase the risk of respiratory depression, hypotension and profound sedation or coma. Interaction with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (i.e., pentazocine, nalbuphine, butorphanol, or buprenorphine) should NOT be administered to patients who have received or are receiving a course of therapy with a proof opioid agonist analgesic. In these patients, the mixed agonist/antagonist may alter the analgesic effect or may precipitate withdrawal symptoms. Chemical IUPAC Name: (5α,6α)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol : |
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