fludarabine phosphate

This page contains recent news articles, when available, and an overview of fludarabine phosphate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

fludarabine phosphate (when available)

Pharmacology and use:
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen

Mechanism Of Action:
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

News Articles on Fludarabine

Cephalon’s New CLL Drug Should Please Patients and Investors  -  Mar 30, 2008
...announced on January 3rd of 2008 that it has received FDA orphan drug designation for its fludarabine phosphate oral tablets for the treatment of CLL, Seeking Alpha,

APP Pharmaceuticals Reports Record Net Revenues of $647 Million ...  -  Mar 7, 2008
In the fourth quarter of 2007, APP launched liquid and lyophilized Fludarabine Phosphate as well as four dosage forms of Epirubicin Hydrochloride Injection. FOXBusiness

... Go to the Article  -  Mar 3, 2008
Patients received the chemotherapy drugs fludarabine phosphate, cyclophosphamide (Cytoxan®) and rituximab for three days before transplantation. CancerWise

Xanthus Announces Oral Fludarabine NDA Accepted for Review by US FDA  -  Jan 22, 2008
...today announced that its New Drug Application (NDA) for fludarabine phosphate oral tablets (oral fludarabine) was accepted for filing by the US Food and Business Wire (press release),

Committee for Medicinal Products for Human Use Post-authorisation ...  -  Oct 18, 2007
...have failed to achieve a complete or partial response or achieved only a short remission (less than 6 months) following fludarabine phosphate therapy. PharmaLive.com (press release),

[an error occurred while processing this directive] [an error occurred while processing this directive] Brand Names/Synonyms:
fludarabine phosphate is also known by the following brand names and/or synonymsFAMP; Fludara; Fludarabine; Fludarabine 5'-Monophosphate; Fludarabine Monophosphate; Fludarabine Phosphate; Fludarabine Phosphate [Usan:Ban]; Fludura

Drug Category:
fludarabine phosphate is categorized under the following by the FDA: Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents; ATC:L01BB05

Dosage Forms:
TABLET; POWDER FOR SOLUTION; IV Solution

Absorption:
Not Available

Interactions:
Interactions for Fludarabine:

The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.

Chemical IUPAC Name:
[5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid

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