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ZofranThis page contains recent news articles, when available, and an overview of Zofran but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Zofran (when available) Ondansetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. For treatment of chemotherapy-induced nausea and vomiting Mechanism Of Action: Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT3 receptors located on vagal efferents to initiate the vomiting reflex. Therefore Ondansetron works by blocking the reception of serotonin at these 5-HT3 receptors. News Articles on Ondansetron Strativa submits NDA for generic Zofran ODT. - Apr 19, 2009 Business & Industry ® is a broad-based business information database which includes coverage from over 900 trade and business publications covering business The Alacra Store (subscription) What’s Going Around: April 1 - Apr 1, 2009 ...ask your doctor about cola syrup, which you can buy at the drugstore -- and if it's severe, there's an effective prescription medicine called Zofran. NewsChannel 9 WSYR FDA, Clinical Trial Calendars Updated: Cardiome (NASDAQ:CRME ... - Apr 10, 2009 A program consisting of three separate pivotal studies comparing the bioequivalence of ondansetron ODFS 8mg to Zofran ODT 8mg was completed in December 2008 istockAnalyst.com (press release) GlaxoSmithKline PLC (NYSE:GSK) - Vaccines and Respiratory products ... - Apr 7, 2009 ...such as Coreg, Imitrex, Lamictal, Paxil, Requip, Wellburtin and Zofran, coupled with decline in sales for its anti-diabetic drug, Avandia. Research Oracle MonoSol Rx and Strativa file NDA for ondansetron orally dissolving ... - Apr 10, 2009 ...studies in which ondansetron orally dissolving film strip (ODFS) demonstrated bioequivalence against GlaxoSmithKline's Zofran ODT anti-emetic product. Trading Markets (press release) Research Oracle roundup for 07 April 2009 - Apr 7, 2009 ...such as Coreg, Imitrex, Lamictal, Paxil, Requip, Wellburtin and Zofran, coupled with decline in sales for its anti-diabetic drug, Avandia. Research Oracle PRX: Submits NDA to FDA for Orally Dissolving Film Strip Form of ... - Apr 9, 2009 The NDA is supported by positive data from completed pivotal studies in which ondansetron ODFS demonstrated bioequivalence against GlaxoSmithKline's Zofran Trading Markets (press release) Will These Drugs Get Past the FDA? - Mar 13, 2009 In its clinical trials, Rezonic substantially reduced vomiting when added to Zofran and a generic drug called dexamethasone. Glaxo already sells Zofran for Motley Fool Breaking the bricks was the easy part for this champion - Mar 15, 2009 ..."He had Zofran to go!" joked his mother, Daphne, about his anti-nausea medication. Dad Mike, also a judo black-belt, had gone ahead to the competition venue Press of Atlantic City Eurand NV Q4 2008 Earnings Call Transcript - Mar 5, 2009 The study achieved its goal of confirming that EUR-1025 had the desired extended release PK profile to Zofran. Zofran is dosed three, four times daily to Seeking Alpha Attempt to legalize marijuana for medical use fails again - Mar 13, 2009 ..."In my opinion the drugs we have such as Zofran and Kytril, they do a wonderful job of controlling nausea," Kurth said. "I don't see great strides in using Le Mars Daily Sentinel Gastrointestinal drug gets 'black box' warning - Mar 6, 2009 Unlike metoclopramide, the antinausea drug Zofran doesn't block dopamine. There are prescription-strength drugs for reflux that reduce gastric acid rather Los Angeles Times MDS Pharma Services Scientist named to Notable People in R&D list - Mar 11, 2009 He was the lead US clinical pharmacology scientist for Glaxo’s Zofran (ondansetron), – an anti-emetic used to control post-operative and PharmaLive.com (press release) Trana Discovery Taps Pharmaceutical Industry Veteran Frank Johnson ... - Feb 24, 2009 Frank managed marketing and research programs for several key brands including Fortaz, Zofran, Zyban, Imitrex, and Relenza. “Trana is most fortunate to dBusinessNews Triangle (press release) Un medicamento para las nauseas promete contra la adicción a los ... - Feb 23, 2009 Las pruebas iniciales en ratones mostraron que ondansetron (Zofran) bloqueaba ciertos receptores 5-HT3 involucrados en los sÃntomas de abstinencia, Info7 Svært friske facebook-takter fra Jan-Aage Torp - Feb 25, 2009 Jeg slutter aldri Ã¥ fÃ¥ periodiske følelser av ekstrem zofran-resistent kvalme. Men det er slik verden fungerer, det lønner seg ikke alltid Ã¥ være snill. Vårt Land Treatments for severe nausea and vomiting in early pregnancy ... - Jan 21, 2009 Some women are given ondansetron (brand name Zofran), which is an anti-nausea drug also given to people having chemotherapy for cancer. guardian.co.uk, Side effects of chemotherapy - Jan 21, 2009 But sickness can be reduced by taking drugs such as ondansetron (brand name Zofran). Lorazepam, a type of tranquilliser, can also help. guardian.co.uk, Late-night call leads to nightmare - Jan 10, 2009 He gave me something called Zofran (ondansetron) in case I felt nauseous from the pain medication,â€? she said, weakly. “Okay,â€? said Ms. J. “It's not uncommon Clinical Advisor, GlaxoSmithKline to slash 6000 jobs - Jan 31, 2009 ...with the closure of a site in Dartford, because the drugs they produce – Zofran, a treatment for chemotherapy-induced nausea, epilepsy drug Lamictal and Telegraph.co.uk, How dangerous is Marijuana? - Jan 18, 2009 This includes 196 deaths caused by taking anti emetics (Compazine, Reglan, Marinol, Zofran, Anzemet, Kytril, Tigan), 118 for taking anti-spasmodics Denver Post, Pregnancy can cause grave illness for some women - Jan 10, 2009 Next came Zofran, a relatively new drug used to combat nausea in chemotherapy. The round-the-clock nausea was paralyzing. The cruel thing was that vomiting, Leader-Telegram, Gyógyszeripari élboly: a Pfizer továbbra is az elsÅ‘ - Jan 9, 2009 ...a Wellbutrin XL (antidepresszáns, bupropion), a Zofran, (hányás elleni ondasetron) és a Coreg IR (alfa/béta adrenerg blokkoló, carvedilol) generikumai. Weborvos, GSK cuts jobs in Durham due to decline in demand for Zofran - Dec 4, 2008 However the site’s principal product is Zofran (ondansetron) for chemotherapy-induced nausea, which is already coming under pressure from generic Pharma Times, Glaxo cuts further 200 UK manufacturing jobs - Dec 3, 2008 L: Quote, Profile, Research, Stock Buzz) is cutting a further 200 jobs at a factory in north east England that makes its anti-nausea drug Zofran, Reuters Drug Firm Cuts Jobs Again - Dec 3, 2008 The redundancies, which affect makers of anti-nausea drug Zofran, follow the firm's announcement of 620 job losses in the south of England last month. Sky News, Squashing a Queasy StomachHow to avoid nausea and vomiting during ... - Dec 23, 2008 The regimen includes a 5-HT3 antagonist—Anzemet (dolasetron), Kytril/Sancuso (granisetron), Zofran (ondansetron), or Aloxi (palonosetron)—given before Curetoday.com (press release), Non-Hodgkin Lymphoma & Supportive CareTreanda and Sancuso patch ... - Dec 23, 2008 Sancuso and other 5-HT3 inhibitors, such as Zofran (ondansetron) and Aloxi (palonosetron), interrupt that signal. Read more about management of nausea and Curetoday.com (press release), Marie Schlachter honored on Tree of Lights - Dec 19, 2008 For example, Zofran, used for severe nausea, equals 91 percent of each day’s $134.62 reimbursement. One Lupron injection for prostate cancer equals 21 days Holyoke Enterprise, Monosol Rx Successfully Completes Pivotal Bioequivalence Studies - Dec 3, 2008 MonoSol Rx's thin film formulation of ondansetron was studied against GlaxoSmithKline's Zofran ODT® product. MonoSol Rx is a specialty pharmaceutical Pharmaceutical Online (press release), Betapharm boost - Dec 14, 2008 North America accounted for 71 per cent of the generic revenues due to the authorised and exclusive launches of Zocor, Proscar, Zofran and Allegra, Business Standard, AG sues drug firms over price - Dec 3, 2008 In another example, GlaxoSmithKline allegedly charged pharmacies and physicians $22 for Zofran, an anti-nausea drug, but Medicaid repaid those providers Topeka Capital Journal, Strativa Pharmaceuticals Announces Successful Completion of ... - Dec 2, 2008 Working with MonoSol Rx we were able to demonstrate that the thin film formulation is bioequivalent to the FDA approved Zofran ODT(R) product in all human PharmaLive.com (press release), Farmacéutica Glaxo despide otros 200 empleados en Gran Bretaña - Dec 3, 2008 Zofran es un fármaco que Glaxo elabora desde hace tiempo y que ahora debe competir con productos genéricos. El mes pasado, en una decisión similar, Reuters América Latina, GlaxoSmithKline anuncia corte de 200 empregos no Reino Unido - Dec 3, 2008 As vendas do remédio Zofran, que já está há tempos no mercado, foram prejudicadas pela dura concorrência de outras farmacêuticas. O diretor da fábrica, G1.com.br, GSK 英 공장 200명 ê°?ì›? - Dec 3, 2008 ...ì?´ëŠ” í•êµ¬í† ì œ ‘조프란’(Zofran, ondansetron)ì?´ ì œë„¤ë¦ ê²½ìŸ? 때문ì—? 매출ì?´ 급격히 ê°?소했기 때문ì?´ë‹¤. ì?´ì™€ ê´€ë ¨, GSK는 지난달ì—?ë?„ ‘ë?¼ë¯¹íƒˆâ€™(Lamictal, 디지틀보사, Cost of perscriptions vary widely - Oct 4, 2008 So he shopped around and was surprised at what he learned: CVS was charging about $420 for 30 four-milligram generic Zofran tablets; Walgreens' cost was Pittsburgh Post Gazette, Ten Highest Yielding Pharma Stocks - Oct 20, 2008 GlaxoSmithKline plc (GSK) - Its drugs include Seretide/Advair, Avandia, Lamictal, Wellbutrin, Zofran, Valtrex, Coreg, Imigran/Imitrex, Augmentin, Seeking Alpha, Acupuncture helps ease post-surgical ills - Sep 25, 2008 One group received acupuncture, another group was given an anti-nausea drug called ondansetron, sold by GlaxoSmithKline under the brand name Zofran, The News International, Manistee doctor supporting marijuana initiative - Oct 16, 2008 ...“There was Zofran, and that cost $47 a pill but the good news was I could afford them, but it didn’t work. It helped a little bit but didn’t help her Ludington Daily News, Drug-Delivery Tech Firms Find Bright Spot in the Economy - Oct 13, 2008 GlaxoSmithKline sells the brand-name version of ondansetron, called Zofran, as injections and tablets. The deal with Par Pharmaceutical calls for MonoSol Rx NJBIZ, Mit liv som ufrivillig amazone - Oct 7, 2008 Og naturligvis Zofran, som modvirker den værste kvalme. Til sidst den nye mirakelmedicin Herceptin (trastuzumab), fordi min brystkræft er den særligt Politiken.dk, AP Pharma Reports Experimental CINV Treatment Fails to Show ... - Sep 30, 2008 ...competing with Aloxi, as well as with Merck & Co´s Emend ($ 125 million dollars in 1H 2008) and GlaxoSmithKline´s Zofran ($ 119 million dollars in 1H2008). Network Médica, × ×©×™×?: דיקור מצמצ×? תופעות לוו×?×™ כימותרפיה - Oct 2, 2008 ...מחקר × ×•×¡×£ ×©× ×¢×¨×š ×‘×©× ×ª 2002 ב×?×•× ×™×‘×¨×¡×™×˜×ª דיוק, צפון ×§×¨×•×œ×™×™× ×”, בחן ×?ת מידת ×”×?פקטיביות של התרופה × ×•×’×“×ª הבחילה זורפר×?ן (Zofran) לעומת טיפולי דיקור, בצמצו×? בחילות BeOK פורטל ברי×?ות ויופי, Using drugs to relieve nausea in children - Sep 4, 2008 ...sold by GlaxoSmithKline under the brand name Zofran - generic versions are available - was effective and decreased the risk of vomiting, Philadelphia Inquirer, Young mum battling cancer denied 'too expensive' anti-sickness ... - Aug 27, 2008 Amy, who had gruelling chemotherapy and radiotherapy, was put on Ondansetron, also known as Zofran, at St James's hospital, Leeds, to stop vomiting. Mirror.co.uk, These cures for stock-market symptoms are suffering too - Sep 12, 2008 Dr. Reddy's Laboratories (RDY/NYSE) , meanwhile, is an Indian company that makes a generic version of the anti-nausea drug Zofran. Financial Post, Podcast: Managing nausea and vomiting during chemotherapy - Sep 13, 2008 The brand names for those, respectively, are Zofran, Kytril, Anzemet and Aloxi, and those will decrease nausea and vomiting quite a bit. MayoClinic.com Drug Reduces Vomiting, Hospital Admissions In Children With ... - Sep 3, 2008 A meta-analysis (a statistical way to combine different studies) found that ondansetron, which is sold under the brand name Zofran and is available as an Science Daily (press release) Glaxo Changes Course - Jul 25, 2008 ...the market fast enough to compensate for generic erosion of former blockbuster therapies like heart failure treatment Coreg or oncology therapy Zofran. Motley Fool Pharmaceuticals: New boss recruits dragons to light a fire under Glaxo - Jul 23, 2008 A number of drugs were hit by generic competition, including the antidepressant Wellbutrin, down 27%, and anti-nausea drug Zofran, down 49%. guardian.co.uk, Moms Forum: Morning sickness: How did you make it through? - Jul 14, 2008 Really, I would have been hospitalized for dehydration if I hadn't been prescribed Zofran - the miracle drug. It reduced my sickness by about 70 percent and Centre Daily Times, Eurand Reports Recent Developments and Second Quarter 2008 ... - Aug 7, 2008 ...when normalized for dose, of this formulation to an 8 mg dose of the anti-emetic drug Zofran(r) (ondansetron) administered in two doses. MarketWatch Pfizer, Wyeth Beat Analysts' Estimates; Glaxo Sinks (Update1) - Jul 23, 2008 Glaxo is trying to replace revenue lost after patents expired on antidepressant Wellbutrin, nausea drug Zofran and blood pressure medicine Coreg. Bloomberg Fort Worth Hospital Incorporates Aromatherapy - Jul 28, 2008 Studies already have found that inhaled Mentha piperita reduces the need for Zofran in chemo-induced nausea, she said. Also, the M technique, Nurse.com, Varenicline safety concerns: An interview with Dr Serena Tonstad - Jul 16, 2008 Tonstad: In less than 3% of patients I've prescribed an antiemetic such as Phenergan (promethazine) or Zofran (ondansetron). I also ask them to take it on a TheHeart.Org, Los palmeños comenzarán la preparación para una campaña ilusionante - Aug 3, 2008 Juan AgustÃn Vidal, Juren Jeraj, Zofran Jeftic, Chema Cid, Lubomir Vermirovsky y Marc Navarro vienen a completar una plantilla en la que se mantienen casi Cordobadeporte.com, GlaxoSmithKline Q2 Net Profit Rises - Jul 23, 2008 Sales of Zofran also dropped 49% to GBP31 million, due to the impact of generic competition. Sales of Requip for Parkinson's disease/Restless Legs Syndrome Trading Markets (press release), Medi-Cal cut hits pharmacies - Jul 4, 2008 30 pills of Zofran cost $1090 but the generic equivalent for that number of pills costs just $6.77, she said. Borchert has been contacting doctors and Red Bluff Daily News, David Cavalla, MA PhD, Founder, commercial, general management - Jun 22, 2008 USA, David Cavalla joined Glaxo Group Research, where he was involved with the research projects that led to the marketed drugs Zofran and Imigran. Silicon Fen Business Report, Drug plan's appeals process criticized - Jun 20, 2008 The hospital charged her $218 for the Zofran anti-nausea pill — nearly 10 times what most online pharmacies charge. Then, the Humana plan that covers her Austin American-Statesman, Gastrointestinal Complications of Diabetes - Jun 17, 2008 ...other drugs.7 Antiemetics, such as promethazine (Phenergan) and ondansetron (Zofran), may be prescribed for symptomatic relief of persistent nausea. RedOrbit, State Receives More Money From GlaxoSmithKline Settlement - Jun 13, 2008 ...$145 million in damages and penalties to Medicaid programs across the country to settle such allegations with respect to its drugs Zofran and Kytril. NJBIZ, Asymmetric ketone catalysis gets pharma-scale makeover - Jun 13, 2008 He points out that drugs such as Zofran (marketed by GSK) and Aricept (Esai/Pfizer) are chiral ketones of the sort his method produces, but are marketed in Chemistry World, Cancer's other battlefields - Jun 9, 2008 He tried one anti-nausea drug after another, going through the space-age names that I'd heard on hospital soap operas; Compazine, Zofran, Reglan . Press of Atlantic City, KV Pharmaceutical Company Reports Fiscal 2008 Results - Jun 16, 2008 Product Launches -- Ondansetron Orally Disintegrating Tablets 4 mg and 8 mg (Zofran ODT(R) marketed by GlaxoSmithKline) indicated for the prevention of Earthtimes (press release), Brand Names/Synonyms: Zofran is also known by the following brand names and/or synonymsZophren; Zofran; Zudan; Zofran ODT Drug Category: Zofran is categorized under the following by the FDA: Anti-anxiety Agents; Antipsychotics; Antipruritics; Antiemetics; Serotonin Antagonists; ATC:A04AA01 Dosage Forms: TABLET; LIQUID Absorption: Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism. Interactions: Interactions for Ondansetron: Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. On the basis of limited available data, no dosage adjustment is recommended for patients on these drugs. Phenytoin, Carbamazepine, and Rifampicin: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampicin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs.1,3 Tramadol: Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small studies indicate that ondansetron may be associated with an increase in patient controlled administration of tramadol.4,5 Chemotherapy: Tumor response to chemotherapy in the P 388 mouse leukemia model is not affected by ondansetron. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron. In a crossover study in 76 pediatric patients, I.V. ondansetron did not increase blood levels of high-dose methotrexate. Chemical IUPAC Name: 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydrocarbazol-4-one : |
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