Xenical

This page contains recent news articles, when available, and an overview of Xenical but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Xenical (when available)

Pharmacology and use:
Orlistat is a lipase inhibitor used for obesity management that acts by inhibiting the absorption of dietary fats. For the treatment of Obesity including management of weight loss and weight maintenance

Mechanism Of Action:
Orlistat is a reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. The inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides. As undigested triglycerides are not absorbed, the resulting caloric deficit may have a positive effect on weight control.

News Articles on Orlistat

New diet pill  -  21 Apr 2009
The pill has been available here in the UK on prescription for the last 10 years under the name "Xenical." The over the counter Alli is half the strength of GMTV

Glaxo launches OTC weight-loss drug alli in Europe  -  21 Apr 2009
VX) prescription drug Xenical, has been available without prescription in the United States since 2007. It works by reducing the amount of fat the body Reuters

Placebo Effect Works For Weight Loss Drugs Too  -  21 Apr 2009
Drugs like Xenical and Reductil have been tested by health authorities around the world and subjected to clinical trials alongside men and women who UKMedix Health News

"Alli : le médicament anti-obésité qui engraisse GSK", par Paul ...  -  21 Apr 2009
Au départ, c'est un médicament développé par Roche sous le nom de Xenical et destiné aux obèses. Il était délivré seulement sous ordonnance. Challenges

Dieetpil Alli, eerst BMI controleren dan kopen  -  21 Apr 2009
Er is al een sterkere versie op de markt, namelijk Xenical en dit middel is alleen via de huisarts verkrijgbaar. Een woordvoerder van Beat, jojoclub-afslanken.com

Nunca se es muy delgada ni muy rica  -  21 Apr 2009
La dieta estricta de lechugas aliñadas con limón y vaselina líquida (ya que se me acabó el Xenical), para intentar recuperar la figura deshinchada el día Terra Chile

Buy Xenical Reductil Alli Diet Pills and Diet Drugs Reviews  -  ‎Apr 5, 2009‎
These low resistance to the version of Xenical attaches to the fat content, so that your body absorbs less fat when you eat. Alli Diet Pills Hoodia Gordonii TMCnet

Two Weight-Loss Drugs Will Go on Sale Over-The-Counter in UK This Week  -  ‎Apr 19, 2009‎
Alli, a half-strength version of the prescription-only Xenical, which interferes with the body's ability to digest fat, and Appesat, a seaweed extract, HULIQ

Scottish Doctors Say Reductil And Xenical Are Highly Effective  -  ‎Apr 2, 2009‎
The use of weight loss medication such as Reductil and Xenical therefore can actually end up not only saving lives but even money in the long term. UKMedix Health News

Cashing in on demand for lifestyle drugs  -  ‎Apr 12, 2009‎
In the UAE the two biggest players in the weight-loss pills market are Xenical, produced by Swiss giants Roche, and Reductil, made by US-based Abbott GulfNews

Orlistat's 10 year birthday  -  ‎Apr 14, 2009‎
The XENDOS (Xenical in the Prevention of Diabetes in Obese Subjects study) showed that not only does it help patients lose more that 5% of their body weight OnMedica

Nonalcoholic Fatty Liver Disease: 5 Tips for Treatment, Prevention  -  ‎Apr 10, 2009‎
The small study of 50 patients found that a drug called orlistat (Xenical), which decreases the absorption of fat, did not seem to directly improve the U.S. News & World Report

Hot new diet drug put to the Healthline test  -  ‎Apr 13, 2009‎
Alli contains the same ingredient as the prescription drug Xenical but at half the dose. Dr. Teng says patients should do their homework before taking Alli. KVBC

Hollywood Headaches: Supermodels can cook too  -  ‎Apr 6, 2009‎
Powder blend crunch: Two of the following: Phentermine, Xenical, Bontril and Meridia. Mix with celery, iceberg lettuce and white wine vinegar. Colorado Daily

Generic drugs aren't always the best option  -  ‎Mar 29, 2009‎
Others expected to lose their patents this year include Valtrex for herpes, Prevacid for heartburn and Xenical for obesity. Next year look for the patents Fort Worth Star Telegram

Alli - nadzieja na szczupłą sylwetkę?  -  ‎Apr 18, 2009‎
Jak wynika z raportu opublikowanego przez European Medicines Agency, Xenical został dokładnie przebadany. Badania trwały od jednego roku do dwóch lat i Wiadomosci 24

L'Afssaps met en garde contre un nouveau médicament anti-obésité  -  ‎Apr 10, 2009‎
Distribué sans ordonnance à partir du mois de mai et déjà vendu comme un produit miracle sur des sites Internet étrangers, l'Alli -moins dosé que le Xenical nouvelobs.com

Llega a España el primer fármaco sin receta que ayuda a perder peso  -  ‎Apr 16, 2009‎
...para controlar el exceso de peso bajo el nombre comercial de Xenical (con doble dosis), aunque hasta ahora su venta exigía la prescripción médica. La Voz de Galicia

Un nuovo farmaco per dimagrire: Alli  -  ‎Apr 18, 2009‎
...cioè in sovrappeso Il nuovo farmaco possiede lo stesso principio attivo del famoso Xenical, venduto anche in Italia,solo sotto prescrizione medica per Cittadelmonte Pressonline

Cosmética oral: pastillas que embellecen  -  ‎Apr 15, 2009‎
Para las que quieran perder kilos sin mucho esfuerzo existe Xenical, que deberá tomarse siempre bajo prescripción médica. Estas pastillas, combinadas con El Mañana de Nuevo Laredo

解答：女性最困惑的10个�?肥问题(2)  -  ‎Apr 14, 2009‎
...国内现在�?�法的�?肥�?�物�?�有Xenical和Sibutramine，PPA(但是PPA这�?�?�物�?能�?用超过3个月)，大约在几年�?，美国有一个�?�常有�??的�?肥�?�物"phenfen"被列为�?�?�，�?此�? 新浪网

Soyez mince et en forme avec Xenical Orlistat!  -  ‎Mar 30, 2009‎
Il parle également de Xenical Orlistat qui est un médicament de prescription pour le traitement de l'obésité. Ajoutez un commentaire sur Soyez mince et en Pioche.fr

Prevenção evita até 65% de perdas no varejo  -  ‎Apr 17, 2009‎
No segmento farmacêutico são os produtos de Life Style, tais como: Cialis, Viagra, Vivanza e Xenical, além dos principais anticoncepcionais e alguns Portugal Digital

Alli, nueva píldora adelgazante de venta libre  -  ‎Mar 29, 2009‎
Se trata de un principio activo del fármaco orlistat, actualmente se comercializa bajo el nombre de Xenical pero posee el doble de dosis por cápsula y solo Nutricion.pro

旭�?�家医园地新陈代谢症候群之�?�物治疗  -  ‎Apr 1, 2009‎
...分述如下：目�?�?�法的�?�物有罗�?鲜让你酷(xenical )和诺美婷(reductil)。甲�?罗�?鲜让你酷(xenical )�?�?使用会抑制脂肪�?�收造�?腹泻和利尿作用等等�?�将30%食物中的大纪元

> Pilule régime minceur? Les experts débattent les nouvelles ...  -  ‎Apr 1, 2009‎
Dans le rôle-titre, la molécule amaigrissante Orlistat, prescrite depuis dix ans par les médecins sous le nom de Xenical (120 mg par gélule, non remboursé). Marie Claire

Orlistat als rezeptfreies Medikament gegen Übergewicht in Apotheken  -  ‎Apr 16, 2009‎
Arzneimittel mit 120 mg Orlistat (Xenical®) bleiben weiterhin rezeptpflichtig. Der Wirkstoff Orlistat hemmt im Darm Enyzme, die das Fett in der Nahrung Krankenkassenratgeber

Damit die Pfunde leichter purzeln  -  ‎Apr 15, 2009‎
Der Wirkstoff Orlistat wird in einer Dosierung von 120 mg seit mehr als zehn Jahren als rezeptpflichtiges Präparat Xenical® (von Roche) zur ärztlichen Ärzte Zeitung

首推毋須處方減肥藥  -  ‎Apr 6, 2009‎
...醫院藥劑師學會會長蘇曜�?�表示，該新藥�??為Alli，屬於去油丸的一種，其主�?�?分與去油丸賽尼�?�（Xenical）相�?�，�?�樣為奧利�?�他（Orlistat），但分�?�?�由賽尼�?�的一百香港新浪網

Les dangers de la santé via Internet  -  ‎Apr 9, 2009‎
Dénicher du Xenical, cette pilule magique amaigrissante, délivrée uniquement sur ordonnance ? Rien de plus facile. Sur les forums des sites Internet, France Soir

Rezeptfrei abnehmen mit Orlistat  -  ‎Apr 7, 2009‎
Orlistat ist in einer 120-mg-Dosierung seit 1998 als Xenical ® (Roche) auf dem Markt und weiterhin auf Rezept erhältlich. (bmg) Pharmazeutische Zeitung online

Creeping Waistline Speeds Path to Grave, Study Says  -  18 Mar 2009
Most of that went for purchases of Meridia, made by Abbott Park, Illinois-based Abbott Laboratories and Xenical from London-based GlaxoSmithKline Plc, Bloomberg

Illegal Weight Loss Pills Found With Over 2 Times Recommended ...  -  18 Mar 2009
Weight loss medication such as Reductil and Xenical which can be purchased legally online in the United Kingdom can help you to lose weight but you should UKMedix Health News

Weight-loss drug may not inspire diet change  -  ‎Feb 24, 2009‎
Orlistat, sold under the prescription name Xenical, aids weight loss by blocking the absorption of dietary fat in the intestines. Reuters

Don't count on pill to lose weight  -  ‎Mar 3, 2009‎
GlaxoSmithKline's Alli, a lower-strength version of Roche's prescription-only Xenical, created a stir when it was approved 18 months ago. Stuff.co.nz

Drugs Can Help in Battle of the Bulge  -  ‎Feb 25, 2009‎
Obesity and New Pharmaceutical Approaches describes the compounds currently approved for use in the United States (eg, Meridia, Xenical, Alli) and explains American Council on Science and Health

Weight loss reverses fatty liver disease  -  ‎Feb 20, 2009‎
The finding comes from a study of the diet drug orlistat (also known as Xenical and Alli), which did not itself improve liver disease. Times of India

Grabbing the Gorilla: Making adverts sell  -  ‎Mar 3, 2009‎
The award-winning campaign for Xenical, a prescription weight-loss drug, used a consistent approach to visually convey the danger of fat and quickly Pharmafocus

The internet marketing code  -  ‎Mar 16, 2009‎
...discount pharmacy store, internet pharmacy for weight loss pills, impotence treatment, buy Reductil, buy Xenical, buy weight loss pills, buy Viagra . Pharmafocus

Dangerous medicines in drugstores  -  ‎Mar 10, 2009‎
Medicine for losing the weight Xenical (Roche Holding AG) may lead to bleeding, Lamisil (made by Swiss pharmaceutical company Novartis AG), MIGnews.com.ua

Nibbles: Drinking boosts cancer in women, more bariatric surgery ...  -  ‎Feb 25, 2009‎
Finally, people taking the weight loss drug orlistat, sold over the counter in the United States as alli and available as the prescription drug Xenical, CalorieLab Calorie Counter News

The Obesity Time Bomb In UK Is Exploding  -  ‎Feb 28, 2009‎
...from obesity is also up 30 percent and the number of people using weight loss medications Reductil and Xenical has also increased significantly. UKMedix Health News

OFT Launches Its Own Weight Loss Scams  -  ‎Feb 20, 2009‎
If you buy anything for weight loss other than the prescription weight loss medications Reductil and Xenical online you are putting your health at risk. UKMedix Health News

La petite soeur du Xenical  -  ‎Feb 20, 2009‎
La pilule Alli est la petite soeur du Xenical, un médicament délivré sur ordonnance, autorisé en France depuis dix ans et destiné aux obèses dont l’indice Elle

肥胖治疗新趋势  -  ‎Mar 4, 2009‎
...�?�物：诺美婷(Reductil)�?�罗�?鲜(Xenical)是目�?市�?�上唯一核准用于�?�?的�?�物。我们建议�?�物治疗用于病�?肥胖的�?群者(BMI>27)。 4.胃内水�?�：胃内水�?�是目�?新�?�展的大纪元

Diätunterstützer erstmals rezeptfrei  -  ‎Mar 12, 2009‎
Zwei Schlankheitsmittel sind in Österreich rezeptpflichtig auf dem Markt: Xenical basiert auf dem Wirkstoff Orlistat, der vom Pharmakonzern Roche entwickelt Salzburger Nachrichten

Verzichten Sie auf gefährliche Appetitzügler  -  ‎Feb 25, 2009‎
Enthalten ist der Wirkstoff unter anderem in der bekannten Schlankheitspille "Xenical". Das Mittel soll die fettabbauenden Enzyme im Darm blockieren. Deutsche Wirtschaft AG

Anleihen-Tipp: Roche  -  ‎Mar 5, 2009‎
Zusammen mit erfolgreichen Eigenentwicklungen wie beispielsweise dem durch die Vogelgrippe bekannten Tamiflu oder dem Fettblocker Xenical führte dies bei Finanzen.net

Excès de poids : orlistat (Alli°) sans ordonnance  -  ‎Mar 3, 2009‎
...digestive des graisses, est disponible depuis 1999 sur ordonnance pour le traitement de l'obésité en gélules à 120 mg, sous le nom de Xenical° (Roche). Vie Femme

'제니칼' 환�? 저지방 �?습관 유�?�하지 못해  -  ‎Feb 24, 2009‎
...비만치료제�?� '제니칼(Xenical)'�?� 복용하는 사람들�?� 치료 성공�? 필수�?�?� �?습관 변화를 유지하지 못한다는 연구결과가 2월호 Journal of Human Nutrition and 메디게이트뉴스

Минздрав готовит "черный" �?пи�?ок медицин�?ких препаратов  -  ‎Mar 12, 2009‎
В неблагопри�?тный �?пи�?ок также попал препарат дл�? похудени�? Xenical (Roche Holding AG), по�?кольку при его и�?пользовании очень вы�?ок ри�?к кровотечени�?, Версии.сом

10 bivirkninger du ikke vil ha  -  ‎Mar 11, 2009‎
Brukerne av slankepillen Xenical (også solgt i en mildere versjon under navnet Alli) må nemlig følge en strikt diett for å få utbytte av pillen. DinSide

Nouvelles de la santé (03/09)  -  ‎Mar 1, 2009‎
Alli n'est pas un médicament nouveau : c'est en quelque sorte un demi-cachet de Xenical (orlistat), un médicament contre l'obésité vendu uniquement sur Transversales Sciences Culture

Минздрав �?о�?тавл�?ет "черный" �?пи�?ок лекар�?тв  -  ‎Mar 9, 2009‎
В неблагопри�?тный �?пи�?ок также попал препарат дл�? похудени�? "Xenical" ("Roche Holding AG"), по�?кольку при его и�?пользовании очень вы�?ок ри�?к кровотечени�?; ЛІГА.Новости

Feketelistás gyógyszerek  -  ‎Mar 12, 2009‎
A fogyókúrához alkalmazott Xenical a legújabb kísérletek tanúsága szerint könnyen vérzékenységet okozhat. A svájci gombaellenes Lamisilról kiderült, Kárpáti Igaz Szó

Pilule anti-obésité Alli ®, le débat se poursuit  -  ‎Feb 27, 2009‎
Alli ® n'est pas un nouveau produit puisqu'il s'agit d'une version allégée du Xenical 120mg (délivré sous ordonnance depuis plus de 10 ans). Buzz Actu

O fim da gordura trans  -  ‎Feb 25, 2009‎
A substância orlistate, comercialmente conhecida como Xenical, é uma das opções para a perda saudável e manutenção do peso. O medicamento bloqueia a Farol Comunitário

Internet vende de drogas a diplomas  -  ‎Feb 22, 2009‎
...“Dou garantia de tudo�?, ela diz Ela também conta que os mais vendidos são Xenical e Sibutramina. Os preços variam de R$ 150 a R$ 400 a caixa. Jornal A Cidade

Диабетчики денег не хот�?т  -  ‎Feb 20, 2009‎
Також розгл�?даєть�?�? препарат дл�? �?худненн�? Xenical від Roche Holding AG у зв’�?зку з ризиком ректальної кровотечі. “По�?ва препарату в цьому переліку не uapravo.org

Brand Names/Synonyms:
Xenical is also known by the following brand names and/or synonymsOrlipastat; Orlipastatum [Inn-Latin]; Orlistat; Orlistat [Usan:Inn]; Tetrahydrolipstatin; Xenical

Drug Category:
Xenical is categorized under the following by the FDA: Antiobesity Agents; Enzyme Inhibitors; ATC:A08AB01

Dosage Forms:
CAPSULE

Absorption:
Not Available

Interactions:
Interactions for Orlistat:

Alcohol: In a multiple-dose study in 30 normal weight subjects, coadministration of XENICAL and 40 grams of alcohol (e.g., approximately 3 glasses of wine) did not result in alteration of alcohol pharmacokinetics, orlistat pharmacodynamics (fecal fat excretion), or systemic exposure to orlistat.

Cyclosporine: Preliminary data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporine.

Digoxin: In 12 normal-weight subjects receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not alter the pharmacokinetics of a single dose of digoxin.

Fat-soluble Vitamin Supplements and Analogues: A pharmacokinetic interaction study showed a 30% reduction in beta-carotene supplement absorption when concomitantly administered with XENICAL. XENICAL inhibited absorption of a vitamin E acetate supplement by approximately 60%. The effect of orlistat on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time.

Glyburide: In 12 normal-weight subjects receiving orlistat 80 mg three times a day for 5 days, orlistat did not alter the pharmacokinetics or pharmacodynamics (blood glucose-lowering) of glyburide.

Nifedipine (extended-release tablets): In 17 normal-weight subjects receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not alter the bioavailability of nifedipine (extended-release tablets).

Oral Contraceptives: In 20 normal-weight female subjects, the treatment of XENICAL 120 mg three times a day for 23 days resulted in no changes in the ovulation-suppressing action of oral contraceptives.

Phenytoin: In 12 normal-weight subjects receiving XENICAL 120 mg three times a day for 7 days, XENICAL did not alter the pharmacokinetics of a single 300-mg dose of phenytoin.

Pravastatin: In a 2-way crossover study of 24 normal-weight, mildly hypercholesterolemic patients receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not affect the pharmacokinetics of pravastatin.

Warfarin: In 12 normal-weight subjects, administration of XENICAL 120 mg three times a day for 16 days did not result in any change in either warfarin pharmacokinetics (both R- and S-enantiomers) or pharmacodynamics (prothrombin time and serum Factor VII). Although undercarboxylated osteocalcin, a marker of vitamin K nutritional status, was unaltered with XENICAL administration, vitamin K levels tended to decline in subjects taking XENICAL. Therefore, as vitamin K absorption may be decreased with XENICAL, patients on chronic stable doses of warfarin who are prescribed XENICAL should be monitored closely for changes in coagulation parameters.

Chemical IUPAC Name:
1-[(3-hexyl-4-oxo-oxetan-2-yl)methyl]dodecyl2-formylamino-4-methyl-pentanoate

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