Vitamin D2 (Ergocalciferol)

This page contains recent news articles, when available, and an overview of Vitamin D2 (Ergocalciferol) but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Vitamin D2 (Ergocalciferol)
(when available)

Pharmacology and use:
Used in the treatment of hypcalcemia and in dialysis-dependent renal failure. Ergoalcifediol (Vitamin D2) is a fat soluble steroid hormone precursor of vitamin D that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. For the treament of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Mechanism Of Action:
Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vitamin D2 must be transformed (hydroxylated) into one of two active forms via the liver or kidney. Once transformed, it binds to the vitamin D receptor that then leads to a variety of regulatory roles. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma. Vitamin D2 and its analogs appear to promote intestinal absorption of calcium through binding to a specific receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.

News Articles on Vitamin D2 (Ergocalciferol)

Light shines on vitamin D deficiency epidemic  -  Sep 8, 2008
..."Vitamin D3 (cholecalciferol) is up to three times more readily absorbable than Vitamin D2 (ergocalciferol). Vitamin D3 is the form from animal products and Scarlet Scuttlebutt,

Grillo: Researching Vitamin D  -  Aug 4, 2008
Vitamin D is absorbed through the skin from sunlight (ultraviolet B radiation) or can be supplemented by Vitamin D2 (ergocalciferol) or Vitamin D3 Daily Camera,

Lifetime Liquid D3 Targets Vitamin D Deficiencies in US Population  -  Jul 16, 2008
Vitamin D3 is the preferable form of vitamin D (as opposed to vitamin D2, ergocalciferol) due to its higher potency and longer duration of action. Business Wire (press release),

Here comes the sunshine vitamin  -  May 27, 2008
The additive to milk and margarine is actually vitamin D2 (ergocalciferol), which is a commercial product similar in structure and activity to vitamin D3. Huddersfield Examiner,

Let the sunshine in to build vitamin D  -  May 13, 2008
Most of us need 1000 IU of vitamin D a day; both vitamin D2 (ergocalciferol, which is added to milk) and vitamin D3 (cholecalciferol, which is found in some Atlanta Journal Constitution,

The connection between cancer and vitamin D  -  Feb 26, 2008
Vitamin D2 (ergocalciferol) is a less effective form. It takes about 1000 IU of vitamin D3 to increase D blood levels by 10 ng/ml. Gather.com,

The Latest Word on Vitamin D  -  Feb 16, 2008
Vitamin D can be found in supplements as either vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol). The former comes from fungal or plant sources RedOrbit,

Vitamin D2 Supplements May Help Prevent Falls Among High-risk ...  -  Jan 14, 2008
Half were then randomly assigned to take either 1000 international units of vitamin D2 (ergocalciferol) and half took an identical placebo. Science Daily (press release)

Vitamin D2 May Help Prevent Falls Among High-Risk Older Women  -  Jan 14, 2008
Older women with a vitamin D deficiency who were given vitamin D2 (ergocalciferol) and calcium supplements had a 19% lower risk of falls compared with MedPage Today,

Vitamin D2 Supplements Might Lower Risk Of Some Older Women ...  -  Jan 15, 2008
50% of them were then randomly selected to receive either 1000 international units of vitamin D2 (ergocalciferol) while the other 50% received an identical Medical News Today,

Vitamin D may help prevent falls in older women  -  Jan 14, 2008
Half of the women took 1000 international units of vitamin D2 (ergocalciferol) daily and half took a matching placebo. Over the course of 12 months, Reuters India,

Vitamin D May Curb Falls in High-Risk Older Women  -  Jan 16, 2008
Half of the women also received 1000 international units of vitamin D2 (ergocalciferol) while the other half received a placebo. During the study period, U.S. News & World Report,

Vitamin D may help prevent falls in elderly women  -  Jan 17, 2008
Participants were assigned vitamin D2 (ergocalciferol) or a placebo. All subjects were also given 1000 milligrams of calcium citrate per day. Food Consumer,

Smaller babies linked to mental health problems in adult life  -  Jan 18, 2008
They were randomly assigned to take either 1000 international units of vitamin D2 (ergocalciferol) or an inactive placebo, and all received 1000mg of The Australian,

Are you vitamin D-ficient?  -  May 24, 2007
Chicago Tribune,Vitamin D2 (ergocalciferol) is found in fortified cow’s milk, soy milk, orange juice and cereals, fatty fish, fish oil and egg yolk.

How much Vitamin D is too much? Too little?  -  Apr 27, 2007
Fort Wayne News Sentinel,As I noted in the prior column, vitamin D3 (cholecalciferol) is more potent than vitamin D2 (ergocalciferol). Check the "ingredients" section of product

Dissolving pills  -  May 4, 2007
Fort Wayne News Sentinel,Some vitamin D-fortified food products and multivitamins provide vitamin D2 (ergocalciferol). Most people may need higher amounts than previously thought

High doses of vitamin D are sometimes needed  -  26 Apr 2007
SunHerald.com,As I noted in the prior column, vitamin D3 (cholecalciferol) is more potent than vitamin D2 (ergocalciferol). Check the "ingredients" section of product

The Sunshine Vitamin:  -  Jan 5, 2007
The Statesman,Fortified vegan products contain Vitamin D2 (ergocalciferol). Vegetarians have an advantage over vegans as the former do not avoid milk/dairy products which

Brand Names/Synonyms:
Vitamin D2 (Ergocalciferol) is also known by the following brand names and/or synonymsBuco-D; Calciferol; Calciferon 2; Condacaps; Condocaps; Condol; Crtron; Crystallina; D-Arthin; D-Tracetten; Daral; Davitamon D; Davitin; De-Rat Concentrate; Decaps; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual; Deltalin; Deratol; Detalup; Diactol; Divit Urto; Doral; Drisdol; Ercalciol; Ergocalciferol; Ergorone; Ergosterol Activated; Ergosterol, Irradiated; Ertron; Fortodyl; Geltabs; Hi-Deratol; Infron; Metadee; Mulsiferol; Mykostin; Novovitamin-D; Oleovitamin D; Oleovitamin D, Synthetic; Oleovitamin D2; Ostelin; Radiostol; Radstein; Radsterin; Rodine C; Shock-Ferol; Shock-Ferol Sterogyl; Sterogyl; Synthetic Vitamin D; Uvesterol-D; Vigantol; Vio-D; Viostdrol; Viosterol; Viosterol in Oil; Vitamin D; Vitamin D2; Vitavel-D

Drug Category:
Vitamin D2 (Ergocalciferol) is categorized under the following by the FDA: ATC:A11CC01; Antihypocalcemic Agents; Antihypoparathyroid Agents; Essential Vitamin; Vitamins (Vitamin D)

Dosage Forms:
DROPS, CAPSULES, SOLUTION, TABLETS, INJECTION

Absorption:
Readily absorbed from small intestine (proximal or distal), requires presence of bile salts.

Interactions:
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Chemical IUPAC Name:
3-[2-[1-(5,6-dimethylhept-3-en-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol

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