Vardenafil

This page contains recent news articles, when available, and an overview of Vardenafil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Vardenafil (when available)

Pharmacology and use:
Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection. Used for the treatment of erectile dysfunction

Mechanism Of Action:
Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

News Articles on Vardenafil

Drugs for Erectile Dysfunction - A Review of the Safest Choices  -  Sep 14, 2008
Vardenafil (Levitra) is one of the competitors of Viagra. It was co-marketed by Bayer Pharmaceuticals and GSK until 2005. Now, Levitra is marketed solely by Best Syndication,

Study shows PDE5 inhibitor more effective when used on-demand in ...  -  Aug 26, 2008
The results clearly show that nightly dosing with vardenafil does not have any effect beyond that of on-demand use. The study shows that on-demand use of innovations report,

Study shows PDE5 inhibitor more effective when used on demand in ...  -  Aug 26, 2008
The results clearly show that nightly dosing with vardenafil does not have any effect beyond that of on-demand use. The study shows that on-demand use of EurekAlert (press release),

Study Confirms that Levitra(R) on-demand is Effective in Patients ...  -  Aug 19, 2008
Within 14 days of surgery, subjects were randomized 1:1:1 to receive double-blind for nine months, either nightly vardenafil, on-demand vardenafil, CNW Telbec (Communiqués de presse),

Health Canada Advises To Avoid Certain Weight Loss Products  -  Aug 20, 2008
Tadalafil and vardenafil are prescription drugs used for the treatment of erectile dysfunction, and should only be used under the supervision of a health eMaxHealth.com,

PDE Inhibitors Reduce Apnea-Related Erectile Dysfunction in Mice  -  Sep 12, 2008
...oxide synthase and phosphodiesterase-mediated pathways targeted by tadalafil and similar agents such as sildenafil (Viagra) and vardenafil (Levitra), MedPage Today,

Levitra Improves Erectile Function in Patients Taking High Blood ...  -  Aug 31, 2008
...be reestablished in men taking either one or multiple anti-hypertensive medications if the treatment also includes the use of vardenafil HCl (Levitra). Corsavoo.com,

Sex Pill "Viagra" May Help Prevent Heart Attacks  -  Aug 28, 2008
Drugs like tadalafil (Cialis) and vardenafil (Levitra) also perform the similar functions. Its common side effects include sneezing, headache, flushing, TheMedGuru,

EL ESTUDIO REINVENT DEMUESTRA QUE VARDENAFIL PUEDE MEJORAR LA ...  -  Sep 13, 2008
Hasta 46 por ciento de los hombres con cirugía de próstata que utilizaron Vardenafil recuperaron su capacidad sexual. · REINVENT: El estudio más grande Top Management Mexico,

SALUTE: STUDIO BAYER, 1 DIABETICO SU 2 SOFFRE DI DISFUNZIONE ERETTILE  -  Sep 8, 2008
Il Vardenafil, principio del Levitra, si distingue dagli altri inibitori della fosfodiesterasi-5 perche' permette di avere un'erezione gia' entro 10 minuti ASCA - Agenzia Stampa Quotidiana Nazionale,

Des recherches confirment que Levitra(R) sur demande est efficace ...  -  Aug 19, 2008
L'étude déterminante REINVENT (Recovery of Erections: Intervention with Vardenafil Early Nightly Therapy) est l'étude multicentrique avec répartition Canada NewsWire (press release),

"Μαϊμο�?" φυτικά π�?οϊόντα αδυνατίσματος επικίνδυνα για την υγεία  -  Sep 12, 2008
Οι αναλ�?σεις όμως έδειξαν ότι πε�?ιέχει τη φα�?μακευτική δ�?αστική ουσία vardenafil. Η συγκεκ�?ιμένη ουσία πε�?ιέχεται σε χάπι για τη στυτική δυσλειτου�?γία. Madata.GR,

«Μαϊμο�?» φυτικά π�?οϊόντα κυκλοφο�?ο�?ν στο Ιντε�?νετ  -  Sep 5, 2008
Το π�?οϊόν αυτό εμφανίζεται ως φυτικό, αλλά οι αναλ�?σεις έδειξαν ότι πε�?ιέχει τη φα�?μακευτική δ�?αστική ουσία «vardenafil», η οποία πε�?ιέχεται σε άλλο χάπι Έθνος,

파란알약�?� 마법 '비아그�?�' 효과  -  Aug 31, 2008
...미국 시�?�스 시나�?� 메디컬센터(Cedars-Sinai Medical Center)�?� 키스 블랙 박사팀�? 따르면 발기부전치료제 레비트�?�(vardenafil)와 뇌종양 치료제를 병행 투여하면, 아�?�비타임즈,

壯陽膠囊誇療效地下電�?�主�?人�?辦  -  Aug 26, 2008
...由於膠囊�?分被驗出�?�有Vardenafil 自由時報,

Farmaci contraffatti online: al primo posto le pillole dell’amore  -  Sep 7, 2008
...ha approvato 3 “inibitori della fosfodiesterasi 5�? per il trattamento della disfunzione erettile: il Sildenafil, il Vardenafil e il Tadalafil. Prontoconsumatore.it,

Se piensa que uno de los factores que determinan la satisfacción ...  -  Aug 20, 2008
Los fármacos disponibles en el mercado y que sólo se obtienen con prescripción médica son: el Sildenafil (Viagra), el Vardenafil (Levitra) y el Tadalafil esmas,

Kỳ 2: Các liệu pháp hỗ trợ  -  Sep 3, 2008
Trong các loại thuốc kể trên, hiện nay thuốc Levitra (hoạt chất vardenafil) của �?ức đang được ưa chuộng hơn cả vì hiệu quả đạt được chỉ sau khi dùng thuốc An ninh thủ đô,

�?οθευμένο φυτικό π�?οϊόν με την ονομασία 'Natural Vigour'  -  Sep 4, 2008
Μετά από ε�?γαστη�?ιακό έλεγχο που διενε�?γήθηκε στη Δανία, διαπιστώθηκε ότι το ανωτέ�?ω π�?οϊόν είναι νοθευμένο με τη φα�?μακευτική δ�?αστική ουσία vardenafil Ιατ�?οnet,

Erectile Dysfunction Drugs Allowed More Chemotherapy To Reach ...  -  Jul 28, 2008
Viagra (sildenafil) and Levitra (vardenafil) are known as PDE5 inhibitors because they block an enzyme, phosphodiesterase5, which interrupts a series of Science Daily (press release)

Impotence drugs make chemotherapy more effective in rats  -  Jul 30, 2008
The researchers investigated the impact of the ED drug vardenafil (Levitra) in 29 rats with brain tumours and have now published their findings in the Cancer Research UK - News & Resources,

Impotence drugs help treat brain tumours  -  Jul 28, 2008
But when they also got Levitra, known generically as vardenafil, the rats survived an average of 53 days. Levitra appeared to be more effective, Reuters

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet ...  -  Aug 7, 2008
Levitra(R) (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) (rifabutin), rifampin, also known as Rimactane(R), FOXBusiness

Viagra Fights Cancer  -  Jul 28, 2008
...“The combination of vardenafil and adriamycin resulted in longer survival and smaller tumor size,�? he announced. Dr. Black has been recognized for his WeHo News,

Going-Concern Statement  -  Aug 6, 2008
People taking REYATAZ should speak with their healthcare provider before taking the following medicines: Viagra(R) (sildenafil), Levitra(R) (vardenafil), FOXBusiness

Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice-Daily ...  -  Aug 5, 2008
Levitra(R) (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) (rifabutin), inhaled Flonase(R) (fluticasone), FOXBusiness

Viagra: Pleasing Women In A New Way  -  Jul 23, 2008
The research was funded by Pfizer Inc, known generically as tadalafil, and Levitra or vardenafil, sold by GlaxoSmithKline, Bayer AG and Schering-Plough, RedOrbit,

Safety of Prescribing PDE-5 Inhibitors Via E-Medicine Vs ...  -  Aug 5, 2008
Tadalafil and vardenafil were prescribed in 18.8% and 7.6% of the e-medicine clients vs 4.2% (P<.001) and 5.4% (P=.16) in the traditional medicine patients, RedOrbit,

Drug delivery news in brief  -  Jul 30, 2008
...drugs Viagra (sildenafil) and Levitra (vardenafil) opened the blood-brain tumor barrier, increasing the level of therapeutic reaching the tumour. In-PharmaTechnologist.com,

Bayer sales hit by currency exchange, Xarelto filed in USA  -  Jul 30, 2008
Sales of the hypertension treatment Adalat (nifedipine) were down 2.5% to 158 million euros, and the erectile dysfunction drug Levitra (vardenafil) rose Pharma Times (subscription),

Study Confirms That Levitra® On Demand Is Effective In Patients ...  -  Jul 26, 2008
A study published in the European Urology journal demonstrated that Levitra® (vardenafil, HCI) is highly efficacious in men with erectile dysfunction (ED) Medical News Today (press release),

�?�法輸入�?藥笙普公�?�負責人�?�起訴  -  Aug 8, 2008
...檢方指出，「金百�?�?與「精力康�?膠囊經檢驗後，發�?�其中�?�有「Vardenafil �?��?�新�?�網,

“레비트�?� 등 발기부전치료제, 뇌종양�? 효과�?  -  Aug 4, 2008
...미국 시�?�스 시나�?� 메디컬센터(Cedars-Sinai Medical Center)�?� 키스 블랙 박사는 �? 실험 결과, 발기부전치료제 레비트�?�(vardenafil)와 뇌종양 치료제를 병행 투여 아�?�비타임즈,

Vardenafil-Einnahme bei Bedarf oder einmal täglich?  -  Jul 14, 2008
Die Dauereinnahme von Vardenafil bei Männern mit erektiler Dysfunktion zeigt keine Unterschiede in der nachhaltigen Wirkung gegenüber einer Einnahme bei www.inar.de,

1年銷售�?2700�?�‧大馬壯陽藥熱賣  -  Aug 4, 2008
...“這3種壯陽春藥�?�有昔多芬（sildenafil）�?�?�那�?�（tadalafil）�?��?地那�?�（vardenafil 星洲日報,

Fármacos contra impotencia ayudan a tratar tumores cerebrales  -  Jul 28, 2008
Pero cuando también recibieron Levitra, conocido genéricamente como vardenafil, los animales sobrevivieron un promedio de 53 días. Reuters América Latina,

Wegweisende Studie: Levitra® nach nervschonender Prostatektomie  -  Jul 25, 2008
Eine in European Urology veröffentlichte Studie zeigt, dass Levitra® (Vardenafil-HCl) bei Männern in der Behandlung der operationsbedingten Erektilen inar.de (Pressemitteilung),

Potenzmittel im Kampf gegen Hirntumoren  -  Jul 29, 2008
Der gefäßerweiternde, durchblutungsfördernde Effekt von Sildenafil (Handelsname: Viagra) und Vardenafil (Handelsname: Levitra) lässt sich auch für die Wissenschaft aktuell Nachrichtendienst,

José R. Yunén  -  Jul 12, 2008
...es medicar con algunas de las tres drogas vasoactivas Sildenafil, Vardenafil y Taladafil, cuya función fisiológica es bloquear la 5 Phosphodiesterasa, Listín Diario,

Impotenza Sessuale "rimedi e dicerie"  -  Jul 30, 2008
Negli anni successivi si sono aggiunti altri due farmaci: il Vardenafil ed il Tadalafil. Il meccanismo d´azione è simile per tutti e tre, e tutti hanno Positanonews,

Viagra pode melhorar vida sexual de mulheres deprimidas  -  Jul 24, 2008
Medicamentos semelhantes, como o Cialis (laboratório Eli Lilly, nome genérico tadalafil) ou Levitra (vardenafil, da GlaxoSmithKline, O Globo Online,

A Viagra javítja a depressziós nők szexuális életét  -  Jul 24, 2008
A szakemberek úgy vélik, a szildenafil mellett a tadalafil és vardenafil hatóanyagok is ezt a hatást váltják ki. A H. George Nurnberg által vezetett csoport Index,

La disfunción eréctil puede ser indicador de riesgo cardiovascular  -  Jul 21, 2008
Para el tratamiento de la disfunción eréctil se presentó recientemente en Argentina Vardenafil, que actúa restaurando la mecánica de la erección inhibiendo InfoBAE.com,

Levitra mostra-se eficaz em disfunção eréctil pós-prostatectomia  -  Aug 3, 2008
Estudo realizado pela farmacêutica Bayer Schering Pharma sugere que o fármaco Levitra (vardenafil) é eficaz em indivíduos com disfunção eréctil mesmo após Farmacia,

Segreti di letto: l’estate al tempo del Viagra  -  Jul 19, 2008
La tabella dei principi attivi segna anche un più 3.052,5 per il vardenafil, base del Levitra, fresco di lancio e dunque con performance da primato. Panorama,

«�?ياغرا».. وهموم الاستخدامات غير الصحيحة  -  Jul 12, 2008
أدوية ثلاثة لعلاج ضع�? الانتصاب * تتكون مجموعة الأدوية المتناولة عبر ال�?م لعلاج حالات ضع�? الانتصاب من «�?ياغرا» Sildenafil، و«لي�?يترا» Vardenafil، و«سيالس» الشرق الاوسط,

Fármacos para a disfunção eréctil impulsionam quimioterapia em ...  -  Jul 31, 2008
Os investigadores do Centro Médico Cedars-Sinai do Instituto Neurocirúrgico Maxine Dunitz declararam que o Viagra (sildenafil) eo Levitra (vardenafil) são Farmacia,

Bayer Austria Ges.mbH startet Aufklärungskampagne zum Schutz vor ...  -  Jul 30, 2008
Bei der chemischen Analyse stellte sich bis dato immer heraus: es war oft gar nicht Vardenafil, der eigentliche Wirkstoff des Bayer PDE-5-Hemmers PR-Inside.com (Pressemitteilung),

Viagra có thể giúp đi�?u trị khối u  -  Jul 29, 2008
...trưởng nhóm nghiên cứu, cho biết, “Sự kết hợp giữa vardenafil và adriamycin đã giúp kéo dài sự sống và làm nh�? kích thước khối u�?. �?àn Ông,

Creato al computer il 'super-viagra' del futuro?  -  Jul 24, 2008
In silico Prediction of Novel Phosphodiesterase Type-5 Inhibitors Derived from Sildenafil, Vardenafil and Tadalafil. Bioorganic & Medicinal Chemistry, 2008. Yahoo! Italia Notizie,

Viagra también ayuda a mujeres deprimidas a obtener satisfacción  -  Jul 23, 2008
Otros fármacos que funcionan de un modo similar al Viagrason Cialis de Eli Lilly and Co, conocido genéricamente comotadalafil, y Levitra o vardenafil, EcoDiario.es,

La impotencia como señal de alerta de enfermedades cardiovasculares  -  Jul 22, 2008
Durante la disertación se presentó un nuevo tratamiento de la disfunción eréctil con la droga vardenafil, que inhibe una enzima llamada PDE-5 para lograr InfoBan,

Alert issued on anti-impotence products  -  Jun 18, 2008
Sildenafil and vardenafil are usually used for treating male sexual dysfunction and can cause low blood pressure, headache, vomiting, dizziness and vision News.gov.hk,

APTIVUS Oral Solution Also Approved for Treatment-Experienced ...  -  Jun 24, 2008
Caution should be used when prescribing sildenafil, tadalafil, and vardenafil with APTIVUS/r because concentrations of these drugs may increase. Earthtimes (press release),

Phosphodiesterase Type 5 Inhibitors In Management Of Erectile ...  -  Jun 12, 2008
Two trials evaluated the effects of sildenafil, 2 tadalafil and one vardenafil. Most were at the highest recommended doses of these drugs. Medical News Today (press release),

The Rocket: Viva Viagra?  -  Jun 11, 2008
Would they then study Levitra (Vardenafil HCI) and Cialis (Tadalafil)? Look at it this way: Cialis is supposed to work for 36 hours. TheDay,

New Abbott Aluvia(R) Tablet for Treatment of HIV Available in ...  -  03 Jun 2008
...dihydroergotamine, ergonovine, methylergonovine, rifampicin, amiodarone, vardenafil and products containing St. John's Wort (Hypericum perforatum). ITNews,

Generic Levitra  -  May 13, 2008
Vardenafil acts in the United States. All effects. A sudden drop currently no generic cialis is a prescription drug therapy. Welcome to best generic levitra Rochester R News,

Viagra Online  -  May 8, 2008
Vardenafil was alarmingly homozygous as derived in either the in vitro prep viagra online test or the in personality mouse discounted test. Shell Security,

Our Clinic Recommends You This Site :  -  May 8, 2008
Vardenafil pharmacokinetics have fully increased evaluated in addictives remaining micro dialysis. When it comes to the [CENSURADO] carisoprodol promisses Shell Security,

Advances in treatments for enlarged prostates  -  May 9, 2008
One of these studies, of vardenafil (GlaxoSmithKline's Levitra), was published earlier this year in European Urology. In it, 222 German men were given Los Angeles Times,

Viagra may help heart in muscular dystrophy: study  -  May 12, 2008
Other impotence drugs also affect the chemical cGMP, including vardenafil, sold by Schering Plough under the brand name Levitra, and tadalafil, Reuters

New dosage strength reduces number of PREZISTA tablets taken daily  -  May 19, 2008
Caution should be used when prescribing agents such as sildenafil, vardenafil, tadalafil, or other substrates, inhibitors, or inducers of CYP3A in patients PharmaLive.com (press release),

Caution issued on 6 products  -  May 15, 2008
Power 58 Extra, Platinum Power 58 Extra and Enhanix New Extra Men's Formula, which contain vardenafil analogue, tadalafil or tadalafil analogue, News.gov.hk,

Brand Names/Synonyms:
Vardenafil is also known by the following brand names and/or synonymsLevitra; VARDENAFIL, LEVITRA; VDN; Vardenafil

Drug Category:
Vardenafil is categorized under the following by the FDA: Anti-Impotence Agents; Vasoconstrictor Agents; Phosphodiesterase Inhibitors; ATC:G04BE09

Dosage Forms:
TABLET (5, 10, and 20 mg)

Absorption:
Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Interactions:
Interactions for Vardenafil: Effect of other drugs on Vardenafil In vitro studies: Studies in human liver microsomes showed that vardenafil is metabolized primarily by cytochrome P450 (CYP) isoforms 3A4/5, and to a lesser degree by CYP2C9. Therefore, inhibitors of these enzymes are expected to reduce vardenafil clearance. In vivo studies: Cytochrome P450 Inhibitors Cimetidine (400 mg b.i.d.) had no effect on vardenafil bioavailability (AUC) and maximum concentration (Cmax) of vardenafil when co-administered with 20 mg Vardenafil in healthy volunteers. Erythromycin (500 mg t.i.d) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax when co-administered with Vardenafil 5 mg in healthy volunteers. It is recommended not to exceed a single 5 mg dose of Vardenafil in a 24-hour period when used in combination with erythromycin. Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in Cmax when co-administered with Vardenafil (5 mg) in healthy volunteers. A 5-mg Vardenafil dose should not be exceeded when used in combination with 200 mg once daily ketoconazole. Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of Vardenafil should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily. HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with Vardenafil 10 mg resulted in a 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life. It is recommended not to exceed a single 2.5 mg Vardenafil dose in a 24-hour period when used in combination with indinavir. Ritonavir (600 mg b.i.d.) co-administered with Vardenafil 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13-fold increase in vardenafil Cmax. The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9. Ritonavir significantly prolonged the half-life of vardenafil to 26 hours. Consequently, it is recommended not to exceed a single 2.5 mg Vardenafil dose in a 72-hour period when used in combination with ritonavir. Other Drug Interactions: No pharmacokinetic interactions were observed between vardenafil and the following drugs: glyburide, warfarin, digoxin, Maalox, and ranitidine. In the warfarin study, vardenafil had no effect on the prothrombin time or other pharmacodynamic parameters. Effects of Vardenafil on other drugs In vitro studies: Vardenafil and its metabolites had no effect on CYP1A2, 2A6, and 2E1 (Ki > 100uM). Weak inhibitory effects toward other isoforms (CYP2C8, 2C9, 2C19, 2D6, 3A4) were found, but Ki values were in excess of plasma concentrations achieved following dosing. The most potent inhibitory activity was observed for vardenafil metabolite M1, which had a Ki of 1.4 uM toward CYP3A4, which is about 20 times higher than the M1 Cmax values after an 80 mg Vardenafil dose. In vivo studies: Nitrates: The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours were potentiated by a 20 mg dose of Vardenafil in healthy middle-aged subjects. These effects were not observed when Vardenafil 20 mg was taken 24 hours before the NTG. Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of Vardenafil and nitrates is contraindicated. Nifedipine: Vardenafil 20 mg, when co-administered with slow-release nifedipine 30 mg or 60 mg once daily, did not affect the relative bioavailability (AUC) or maximum concentration (Cmax) of nifedipine, a drug that is metabolized via CYP3A4. Nifedipine did not alter the plasma levels of Vardenafil when taken in combination. In these patients whose hypertension was controlled with nifedipine, Vardenafil 20 mg produced mean additional supine systolic/diastolic blood pressure reductions of 6/5 mm Hg compared to placebo. Alpha-blockers: When Vardenafil 10 or 20 mg was given to healthy volunteers either simultaneously or 6 hours after a 10 mg dose of terazosin, significant hypotension developed in a substantial number of subjects. With simultaneous dosing of Vardenafil 10 mg and terazosin 10 mg, 6 of 8 subjects experienced a standing systolic blood pressure of less than 85 mm Hg. With simultaneous dosing of Vardenafil 20 mg and terazosin 10 mg, 2 of 9 subjects experienced a standing systolic blood pressure of less than 85 mm Hg. When Vardenafil dosing was separated from terazosin 10 mg by 6 hours, 7 of 28 subjects who received 20 mg of Vardenafil experienced a decrease in standing systolic blood pressure below 85 mm Hg. In a similar study with tamsulosin in healthy volunteers, 1 of 24 subjects dosed with Vardenafil 20 mg and tamsulosin 0.4 mg separated by 6 hours experienced a standing systolic blood pressure below 85 mm Hg. Two of 16 subjects dosed simultaneously with Vardenafil 10 mg and tamsulosin 0.4 mg experienced a standing systolic blood pressure below 85 mm Hg. The administration of lower doses of Vardenafil with alpha-blockers has not been completely evaluated to determine if they can be safely administered together. Based on these data, Vardenafil should not be used in patients on alpha-blocker therapy. Ritonavir and indinavir: Upon concomitant administration of 5 mg of Vardenafil with 600 mg BID ritonavir, the Cmax and AUC of ritonavir were reduced by approximately 20%. Upon administration of 10 mg of Vardenafil with 800 mg TID indinavir, the Cmax and AUC of indinavir were reduced by 40% and 30%, respectively. Alcohol: Alcohol (0.5 g/kg body weight: approximately 40 mL of absolute alcohol in a 70 kg person) and vardenafil plasma levels were not altered when dosed simultaneously. Vardenafil (20 mg) did not potentiate the hypotensive effects of alcohol during the 4-hour observation period in healthy volunteers when administered with alcohol (0.5 g/kg body weight). Aspirin: Vardenafil (10 mg and 20 mg) did not potentiate the increase in bleeding time caused by aspirin (two 81 mg tablets). Other interactions: Vardenafil had no effect on the pharmacodynamics of glyburide (glucose and insulin concentrations) and warfarin (prothrombin time or other pharmacodynamic parameters).

Chemical IUPAC Name:
4-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4.3.0]nona-3,7,9-trien-2-one

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