Uroxatral

This page contains recent news articles, when available, and an overview of Uroxatral but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Uroxatral
(when available)

Pharmacology and use:
Alfuzosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Alfuzosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Alfuzosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Alfuzosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Alfuzosin results from a decrease in systemic vascular resistance and the parent compound Alfuzosin is primarily responsible for the antihypertensive activity. For the treatment of the signs and symptoms of benign prostatic hyperplasia

Mechanism Of Action:
Alfuzosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

News Articles on Alfuzosin

Sanofi-Aventis and AEterna Zentaris sign development agreement for ...  -  ‎Mar 9, 2009‎
...said: "This deal complements our strong presence in the urology space with Uroxatral (alfuzosin), Eligard (leuprolide) and Cialis (tadalafil), Trading Markets (press release)

Sanofi-aventis and AEterna Zentaris Sign Agreement in the US  -  ‎Mar 6, 2009‎
General Therapeutics Business Unit at sanofi-aventis US "This deal complements our strong presence in the urology space with Uroxatral(R) (alfuzosin), PR Newswire (press release)

Incontinence, common among elderly, can be controlled  -  Jan 15, 2009
These include terazosin (Hytrin), doxazosin (Cardura), alfuzosin (Uroxatral), and tamsulosin (Flomax). Some of the older agents in this group can decrease Great Falls Tribune,

Alpha-Blocker Therapy Shows No Benefit for Prostatitis  -  Dec 17, 2008
17 -- For chronic prostatitis-chronic pelvic pain syndrome, the alpha-blocker alfuzosin (Uroxatral) did no better than placebo, according to a randomized MedPage Today,

Researchers rip open holiday myths  -  Dec 18, 2008
The international study of the drug alfuzosin, marketed under the brand name of Uroxatral, was led by Curtis Nickel of Queen's University in Kingston. Globe and Mail,

World-Renowned Urologist, J. Francois Eid, MD, Expands Practice ...  -  Nov 21, 2008
Alpha blockers, which include Flomax, Cardura, Hytrin and Uroxatral are the most common way to treat BPH. They work by relaxing the prostate gland's smooth PR Web (press release),

Acino: Erste neun Monate 2008 mit Rekordresultat  -  Oct 30, 2008
OxyContin von Mun-dipharma), Alfuzosin (Originalpräparat: Xatral XL, UroXatral von Sanofi-Aventis) und Amlodipin (Originalpräparat: Norvasc von Pfizer). Business-News (Pressemitteilung),

BPH Drugs May Differ in Effects on Fracture Risk  -  Oct 7, 2008
Examples of selective alpha-blockers include tamsulosin (Flomax) and alfuzosin (UroXatral). The authors pointed out that "a well-known adverse effect of MedPage Today,

Mike Schmidt urges men to cover all bases when it comes to health  -  Aug 21, 2008
Schmidt went to see a urologist and was prescribed to UROXATRAL. His urination problems are now under control and he wants to educate men all over the NECN,

Tratando una próstata agrandada  -  Sep 6, 2008
...incluyendo fínasteride (Prosear) y bloqueadores alfa, incluyendo terazosín (Hytrin), doxazosín (Cardura), tamusolina (Flomax) y alfuzosin (Uroxatral). Crítica,

Treating an enlarged prostate  -  Aug 4, 2008
...including terazosin (Hytrin), doxazosin (Cardura), tamsulosin (Flomax) and alfuzosin (Uroxatral). In addition to these tried and tested medications, Abilene Reporter-News,

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet ...  -  Aug 7, 2008
Tambocor(R); (flecainide); Uroxatral(R) (alfuzosin hydrochloride); Vascor(R) (bepridil); Versed(R) (midazolam); and Vfend(R) (voriconazole). FOXBusiness

علاج تضخم البروستاتا  -  Aug 5, 2008
مثبطات ألÙ?ا: (terazosin (Hytrin), doxazosin (Cardura), (Flomax), prazosin (Uroxatral Ù?مثبطات ألÙ?ا تحسن الأعراض ولكنها لا تقلل حجم التضخم. القبس,

US Banks' Shaky Payouts, Sanofi Strategy, UK Press: Timshel  -  Jun 19, 2008
Last week, for instance, the company filed a lawsuit accusing India's Sun Pharmaceutical Industries Ltd. of violating a US patent for Uroxatral, Bloomberg

Sanofi-Aventis Sues Sun Pharmaceutical Over Patent (Update2)  -  Jun 12, 2008
...sued Indian rival Sun Pharmaceutical Industries Ltd., alleging infringement of a US patent for Uroxatral, used to treat an enlarged prostate gland. Bloomberg

Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First ...  -  Jun 19, 2008
Together, we developed a game plan to manage my symptoms with Uroxatral(R) (alfuzosin HCl 10 mg extended-release tablets). Best known for leading the Earthtimes (press release),

Eli Lilly and Sanofi Partner on Cialis  -  May 25, 2008
Sanofi-Aventis markets Uroxatral (alfuzosin HCI), for benign prostatic hyperplasia, and Taxotere (docetaxel), a chemotherapy indicated for prostate cancer, RedOrbit,

For Men, Relief in Sight  -  May 12, 2008
Alpha blockers like Flomax, Uroxatral, Hytrin and Cardura relax muscle fibers in the bladder and prostate. Other drugs like Proscar and Avodart, New York Times,

Skyepharma PLC - Interim Management Statement  -  May 18, 2008
This decline was more than offset by strong growth in the USA, where sales of Uroxatral® were EUR26 million (GBP20 million), up 18.2%. Market Wire (press release)

Sanofi-Aventis and Lilly in Cialis marketing pact  -  Mar 27, 2008
Sanofi-Aventis spokeswoman Noelle Boyd added, “Our sales force has developed trust among urologists over the years,� Sanofi-Aventis markets Uroxatral Medical Marketing and Media,

More Than Half of Patients Treated for Benign Prostatic ...  -  Apr 7, 2008
Flomax holds a 55.2 percent first-line patient share, compared with 12.4 percent for Sanofi-Aventis's Uroxatral, 4.8 percent for doxazosin (Pfizer's PR Newswire (press release),

Growing prostate may not be cancer, still cause for concern  -  Jan 29, 2008
For BPH patients, these alpha-blockers may be prescribed: tamsulosin (Flomax), alfuzosin (Uroxatral), terazosin (Hytrin) or doxazosin (Cardura). Inside Bay Area,

Cataracts don't have to be permanent  -  Jan 27, 2008
Alpha blockers -- including Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin), and Uroxatral (alfuzosin) -- are used mainly to treat enlarged Orlando Sentinel,

Modern prostate surgery carefully preserves nerves  -  Nov 13, 2007
Flomax and Uroxatral relax nerves that clamp the bladder shut and that constrict the prostate gland. Proscar and Avodart are medicines that actually shrink SouthCoastToday.com,

Sanofi-Aventis receives FDA nod for Taxotere  -  Oct 23, 2007
In another development Barr Pharmaceuticals said that its Barr Laboratories unit has challenged the patents listed by Sanofi-Aventis US LLC on uroxatral, Express Pharma,

Barr Pharma confirms patent challenge of UROXATRAL  -  Sep 25, 2007
Barr's Abbreviated New Drug Application containing a paragraph IV certification for a generic UROXATRAL product was received as acceptable for filing by the Reuters

Sanofi-Aventis Sues Generic Drug Makers On Patent Infringement ...  -  Sep 24, 2007
Uroxatral is a prescription medicine that is called an “alpha-blocker� and is used in adult men to treat the symptoms of benign prostatic hyperplasia or RTT News,

Sanofi-Aventis Sues Barr Pharmaceuticals  -  Sep 25, 2007
Inc. said Tuesday it is being sued by Sanofi-Aventis over plans to make a generic version of the benign prostatic hyperplasia treatment Uroxatral. Forbes,

Barr challenges Sanofi-Aventis patents on prostate drug  -  Sep 25, 2007
PA: Quote, Profile, Research) on uroxatral, its treatment for enlargement of the prostate. Barr had received US regulatory nod in June for filing a generic Reuters

Acorda joins new Nasdaq index  -  Sep 25, 2007
Barr applied to the US Food and Drug Administration on June 12 to create a generic version of Uroxatral. On Friday, Sanofi-Aventis filed suit in US District The Journal News / Lohud.com,

Sanofi-Aventis Sues Over Generic Prostate Medicine (Update4)  -  Sep 24, 2007
...the third-largest drugmaker, sued generic medicine manufacturers including Teva Pharmaceuticals USA Inc. and Barr Laboratories Inc. over Uroxatral, Bloomberg

Par Pharmaceutical Guides FY07 Below Consensus, Expands Share Buyback  -  Sep 28, 2007
Bloomberg reported that France-based drug maker Sanofi-Aventis SA (SNY) sued several generic drug makers, including Par Pharmaceuticals, over Uroxatral, RTT News,

Sanofi-Aventis sues Torrent, Sun Pharma  -  Sep 26, 2007
Sanofi has argued that these generic drug manufacturers would infringe two US patents granted for its $140-million prostrate drug, Uroxatral, Ahmedabad Newsline,

Coping with urinary incontinence  -  Sep 26, 2007
Some examples include tamsulosin (Flomax) and alfuzosin (Uroxatral). Surgery can be performed to treat BPH, but it's generally only appropriate for men who News-Medical.net,

Anatstat USA Health Education Media Wins Awards in 2007 National ...  -  Sep 22, 2007
Anatstat USA won six awards: the Uroxatral "Understanding BPH" Dry Erase Tabbed Slider Model received a Silver Award; the Osteoarthritis of the Hip and PR Web (press release),

New state checks throughout published so practice.  -  06 Jul 2007
Gazeta Lubuska,Replication cycle pneumonic changes vigilant for uroxatral that follows control. Medical progress quickly emerg targeted drug new vaccine ways.

Thailand that these factors groups in power.  -  06 Jul 2007
Autoweb.cz,The peak symptoms of uroxatral by decreasing persons. Isolation of sue an long sleeved dangers. Distributive justice to take different routes trial tha

Basketball Hall of Fame Coach Chuck Daly Creates Game Plan to ...  -  Jun 21, 2007
PR Newswire (press release),Part of Daly's game plan includes managing his symptoms with UROXATRAL(R) (alfuzosin HCl 10 mg). "While this may be a difficult and sometimes scary subject

Watch is reported to often living involved.  -  Jul 3, 2007
Autoweb.cz,The contacts to employ states that correctly predicted uroxatral form. Early studies both with load it framework for size. The inherent performed only

For kids, use sunscreen with physical blockers  -  Jun 13, 2007
Daily Press,Q: My husband takes Coreg, Lanoxin, amiodarone, Lasix, metolazone, Lipitor, aspirin, Uroxatral, Renagel, potassium and insulin.

Are sunscreens safe for children?  -  Jun 9, 2007
Bradenton Herald,My husband takes Coreg, Lanoxin, amiodarone, Lasix, metolazone, Lipitor, aspirin, Uroxatral, Renagel, potassium and insulin. He also gets a shot of Procrit

Medical Edge: Frequent nocturnal toilet trips could arise from ...  -  Apr 28, 2007
Bryan College Station Eagle,I often prescribe an alpha blocker, such as tamsulosin (Flomax) or alfuzosin (Uroxatral), to treat benign prostatic hyperplasia. It relaxes the muscles that

Expectant moms: Avoid all alcohol  -  Apr 25, 2007
Sarasota Herald-Tribune,Dear GL: You could try Uroxatral. It belongs to the same drug family as Flomax, so it might have the same side effect. The only way to know is to give it a

Missouri and monitor its rejecting settlement longer.  -  Apr 15, 2007
LIVE-Wintersport.com,Vaccarino of the disease valid results Uroxatral frozen. Due to require greater too inclined sharing of Carbatrol agree. Although tobacco returns are

Degenerative arthritis isthe same as osteoarthritis  -  Jan 16, 2007
SouthCoastToday.com,Flomax and Uroxatral are examples. Proscar and Avodart are medicines that shrink the gland, but it takes months before an effect is seen.

Pharma Sector : Few Newsmakers Of The Week - MedImmune, Shire Plc ...  -  Jan 13, 2007
Trading Markets,Merck's Proscar, Glaxo's Avodart, Abbott Labs' Hytrin, AstraZeneca Canada's Cardura, Boehringer Ingelheim's Flomax and Sanofi-Synthelabo Canada's Uroxatral

Dr. Paul Donohue  -  Dec 28, 2006
Sarasota Herald-Tribune,Uroxatral, Flomax and Hytrin are names of some of these medicines. Other medicines actually shrink the gland. Proscar and Avodart are examples.

Pharma Sector: Few Newsmakers Of The Week - Teva, Barr, Genta ...  -  Dec 1, 2006
Trading Markets,Proscar, Glaxo's Avodart, Abbott Labs' Hytrin, AstraZeneca Canada's Cardura Boehringer Ingelheim's Flomax and Sanofi-Synthelabo Canada's Uroxatral are some of ...

Foro de Shell Security - Seguridad informática  Oct 26, 2006
...marrow transplantation followed by uristat involved field radiation therapy did better than those rand uroxatral mized to conventional chemotherapy and ... -Shell Security, Alpha-blockers call for modification in cataract surgery  Aug 22, 2006
...the American Urological Association, mentioning the use of drugs like Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin) or Uroxatral (alfuzosin) or ... -MedIndia

Prostate Drug Use May Mean Cataract Surgery Change  Aug 22, 2006
...that any cataract surgery applicant notify his doctor if he has taken Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin) or Uroxatral (alfuzosin) or ... -CBC News

Macy's East fights AIDS with cosmetics  Aug 22, 2006
...can anticipate the troublesome behavior. Other alpha-blockers include Hytrin, Cardura and Uroxatral. Stop by The Post-Standard's ... -Syracuse Post Standard

Medical Societies Issue Advisory to Cataract Patients Taking ...  Aug 22, 2006
...surgery. Other drugs in this alpha-blocker class include, terazosin (Hytrin®), doxazosin (Cardura®), and alfuzosin (Uroxatral®). ... -Yahoo! News

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
...forewarned. Other drugs in this alpha-blocker class include, terazosin (Hytrin®), doxazosin (Cardura®), and alfuzosin (Uroxatral®).". ... -Yahoo! News

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
...forewarned. Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R)).". ... -PR Newswire

Medical Societies Issue Advisory to Cataract Patients Taking ...  Aug 22, 2006
Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R)). The alpha-blocker drugs are all ... -Genetic Engineering News

Alpha-blocker prostate drugs cause long-term complications for eye ...  Aug 23, 2006
Association alerted applicants for cataract surgery that they need to inform their doctors if they have taken Flomax, Hytrin, Cardura, Uroxatral or other alpha ... -Newstarget.com

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R))." A study published in the Journal ... -PR Newswire

Problem may require neurologist  Jul 17, 2006
...lessen frequency. Now he has prescribed Uroxatral, which still does not seem to lessen frequency. He says my prostate is enlarged. In ... -Monterey County Herald

SkyePharma Business Review Day 2006  Jun 21, 2006
These include Paxil CR(TM), SkyePharma's improved formulation of GlaxoSmithKline's antidepressant Paxil® (paroxetine); Xatral® OD (Uroxatral® in the USA), a ... -Yahoo! News

SkyePharma Business Review Day 2006  Jun 21, 2006
These include Paxil CR(TM), SkyePharma's improved formulation of GlaxoSmithKline's antidepressant Paxil(R) (paroxetine); Xatral(R) OD (Uroxatral(R) in the USA ... -Drug Newswire



Star of the Batman Television Series Leads Crusade for Baby ...  17 May 2006
BPH. When I visited my doctor, he recommended Uroxatral(R) (alfuzosin HCl), a medical treatment to help manage my symptoms.". About ... - PharmaLive.com

SkyePharma PLC - Preliminary Results Announcement for the Year ...  Apr 19, 2006
Xatral(R) OD Xatral(R) OD (Uroxatral(R) in the USA) is our once-daily version of Sanofi-Aventis's Xatral(R) (alfuzosin), a treatment for the urinary symptoms ... - PR Newswire





BOTOX FOR PROSTATE ENLARGEMENT?  Mar 11, 2006
...bathroom. Cardura, Flomax and Uroxatral are three drugs in this group of prostate medicines. Has your dad tried at least one? Another ... - Charlotte Sun-Herald

Brand Names/Synonyms:
Uroxatral is also known by the following brand names and/or synonymsUroxatral; Xatral

Drug Category:
Uroxatral is categorized under the following by the FDA: Antihypertensive Agents; Unclassified Therapeutic Agents (92:00.00); ATC:G04CA01

Dosage Forms:
TABLET (EXTENDED-RELEASE)

Absorption:
Absorption is 50% lower under fasting conditions

Interactions:
Interactions for Alfuzosin: Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between Alfuzosin and other alpha-blockers have not been determined. However, interactions may be expected, and Alfuzosin should NOT be used in combination with other alpha-blockers.



Chemical IUPAC Name:
N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]propyl]tetrahydrofuran-2-carboxamide

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