Tretinoin

This page contains recent news articles, when available, and an overview of Tretinoin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Tretinoin (when available)

Pharmacology and use:
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Mechanism Of Action:
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

News Articles on Tretinoin

The creams skin doctors use on their OWN faces  -  ‎Apr 18, 2009‎
Tretinoin was originally developed as a treatment for acne but it wasn't long before doctors started noticing an unusual side effect: patients began to look Daily Mail

Medicis Announces New Notice of Allowance for SOLODYN(R) 90mg  -  ‎Apr 17, 2009‎
ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, BUPHENYL(R) (sodium phenylbutyrate) Tablets and Powder, AMMONUL(R) (sodium phenylacetate GlobeNewsWire (press release)

Pediatricians May Be Underutilizing Topical Retinoids for Acne  -  ‎Apr 1, 2009‎
Dermatologists prescribed topical retinoids, specifically topical adapalene and tretinoin, more commonly than pediatricians (46.1% vs 12.1% of acne visits). AAP Grand Rounds (registration)

Breast boosters without the surgery  -  ‎Mar 30, 2009‎
If you really must, use a prescription retinoid cream such as Obagi System Tretinoin.' Rating: It worked perfectly. £100 consultation patch test. Metro

Vấn đ�? sức kh�?e và nhan sắc: �?NH NẮNG HẠI CHO DA  -  ‎Apr 15, 2009‎
Một thuốc khác có chứa chất tretinoin (Retin-A, hay được dùng để chữa mụn trứng cá trên mặt) cũng được xem có tác dụng tốt đối với da, khiến da trông láng Cali Today

Pickel & Co – vom Leben mit Akne  -  ‎Apr 13, 2009‎
Bei milder Akne werden häufig Salben verwendet (zB Benzoylperoxid oder Tretinoin). Orale Antibiotika (zB Tetrazyklin) kommen bei schweren Formen zum Einsatz MedUNIQA Gesundheitsweb

Quick news about health and medicine  -  ‎Mar 2, 2009‎
A: The active ingredient in Renova, tretinoin, was originally developed as Retin-A to treat acne. Dermatologists discovered that this topical form of Seattle Times

Professional Skin Care Company OrthoNeutrogena Becomes Ortho ...  -  ‎Mar 3, 2009‎
Ortho Dermatologics brands include RETIN-A MICRO(R) (tretinoin gel) microsphere, 0.04% and 0.1%, ERTACZO(R) (sertaconazole nitrate) cream, 2%, PR Newswire (press release)

Medicis Announces 2008 Fourth Quarter and Year-End Conference Call ...  -  ‎Feb 23, 2009‎
LIDEX(R) (fluocinonide) Cream 0.05%, VANOS(R) (fluocinonide) Cream 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, BUPHENYL(R) MSNBC

New Clinical Data Shows That Obagi Medical Products' Condition ...  -  ‎Mar 9, 2009‎
Condition & Enhance is a 4% hydroquinone-based skin care regimen that, together with the use of tretinoin, creates a system that has been specifically MarketWatch (press release)

Redefining Acne Vulgaris as a Chronic Disease  -  ‎Mar 4, 2009‎
Most patients are prescribed a topical retinoid (tretinoin, adapalene, or tazarotene), which acts as a comedolytic agent and therefore helps prevent the Medscape

How to deal with over-40 facial fuzz  -  ‎Mar 3, 2009‎
Also be sure to skip any prescription-strength tretinoin product for at least 10 days prior to prevent possible burns. — Electrolysis is the only hair The State

Photos: Olay(R) Resignals the Future of Skin Care Introducing NEW ...  -  ‎Mar 5, 2009‎
In a clinical study against the leading anti-aging prescription brand (0.02% tretinoin in an emollient base), Olay Professional Pro-X Intensive Wrinkle PR Newswire (press release)

Out, Damned Spot!  -  ‎Mar 9, 2009‎
Products containing tretinoin and adapalene are topical products derived from vitamin A and are available through prescription. They work by increasing skin University Observer Online

AZZALURE® approved in the UK for Aesthetic Use  -  ‎Mar 12, 2009‎
Clobex® (clobetasol propionate / psoriasis), Tri-Luma® (hydroquinone, tretinoin, fluocinolone acetonide / pigmentary disorders), Loceryl® (amorolfine PipelineReview.com (press release)

*vwd/BUSINESS WIRE: Ipsen: AZZALURE^® Approved in the UK for ...  -  ‎Mar 11, 2009‎
Clobex^® (clobetasol propionate / psoriasis), Tri-Luma^® (hydroquinone, tretinoin, fluocinolone acetonide / pigmentary disorders), Loceryl^® (amorolfine ddp-direkt.de (press release)

السرطان.. القاتل الأول  -  ‎Mar 14, 2009‎
والعلاج الموضعي بخليط خاص من حمض الريتونيك وبودو�?يلم ريزاين podophyllum resin solution and tretinoin (retinoic acid)، بالإضا�?ة الى �?يتامين A الحمضي. القبس

الأسواق خالية من شامبو رولانا الملوث  -  ‎Mar 4, 2009‎
و�?يتامين أ Tretinoin) و(Isotretinoin Retina A.. والهرمونات الاستيرودية مثل: (hydrocortisone, betamethasone, tricinolone) تستخدم بطريقة غير قانونية كمبيضات الرايـة

Excess Deaths in Tretinoin Trial Don't Appear to be Caused by Drug  -  Jan 19, 2009
NEW YORK JAN 19, 2009(Reuters Health) - Although the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial was stopped 6 months short of its Cancerpage.com,

Acne Cream Not Linked to Raised Death Risk  -  Jan 23, 2009
The earlier study was halted six months early, when a increased risk of death was seen in those using retinoid tretinoin cream when compared to those taking Washington Post,

What treatments work for wrinkles?  -  Jan 21, 2009
Creams containing retinoids include the prescription drugs tazarotene and tretinoin. Lots of cosmetics promise to improve or cover up wrinkles. guardian.co.uk,

Halted cream trial may not be cream caused  -  Jan 20, 2009
The trial was testing a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, to prevent skin cancer. Times of the Internet,

VIDEO: Common Skin Cream Ingredient Linked to Increased Risk of ...  -  Jan 19, 2009
...(January 19, 2009 - Insidermedicine) Tretinoin, a common skin cream ingredient, has been linked with an increased risk of death among elderly men in a study Insidermedicine,

Ipsen: The Health Authorities of 15 European Countries Give a ...  -  Feb 1, 2009
Clobex ® (clobetasol propionate, psoriasis), Tri-Luma ® (hydroquinone, tretinoin, fluocinolone acetonide, pigmentary disorders), Loceryl ® (amorolfine, WELT ONLINE,

Aging Skin Doesn't Have to Be Wrinkled  -  Jan 28, 2009
Evidence does support another kind of topical—prescription creams containing retinoic acid, more commonly called tretinoin, which can actually rejuvenate U.S. News & World Report,

Primary Care Management of Skin Pigmentation Disorders Reviewed  -  Jan 29, 2009
Triple therapy is more effective for treatment of epidermal melasma vs treatment with hydroquinone, fluocinonide, or tretinoin alone or in double Medscape

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Vicodin no prescription needed  -  Jan 17, 2009
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Sony ericsson j300c ringtones  -  Jan 17, 2009
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여드름 연고 오래 바르면 '사�?' 위험 ↑  -  Jan 20, 2009
...여드름�?� 비롯한 �?종 피부질환�? 사용�?�는 레티노�?�드(retinoid)�?� 트레티노�?�(Tretinoin) �?�림�?� 사용한 사람들�?� 사�?할 위험�?� 높�?� 것으로 나타났다. Medical Today,

Galderma: Die Gesundheitsbehörden von 15 europäischen Ländern ...  -  Feb 1, 2009
Oracea ® (Doxyzyklin, Rosazea), Clobex ® (Clobetasolpropionat, Psoriasis), Tri-Luma ® (Hydroquinon, Tretinoin, Fluocinolonacetonid, Pigmentstörungen), Business Wire (press release),

Moderate Acne Despite a Reasonable Topical Regimen  -  Dec 23, 2008
Over the past 4 months, I have had her use tretinoin 0.025% cream nightly and benzoyl peroxide in the morning, with approximately 40% improvement. Medscape

Announcing B TO ZINCTM for individuals using ISOTRETINOIN or TRETINOIN  -  Dec 17, 2008
However, for those of you on Isotretinion / Tretinoin therapy, taking any of the standard multivitamins available on the market today can lead to Vitamin A BigNews.biz (press release),

Ask Dr. Herschenfeld  -  Dec 16, 2008
You may also want to consider seeing a dermatologist to get a prescription for a cream containing tretinoin. Also, avoid too much sun exposure. Washington Post,

Eat less meat without missing it; reverse pm slump  -  Dec 21, 2008
Get a prescription for tretinoin cream (Retin A): This cream can actually reverse wrinkles, increasing the skin’s stretchy fibers, rebuilding some damaged Houston Chronicle,

Medicis to Present At RBC Capital Markets Healthcare Conference  -  Dec 8, 2008
LIDEX(R) (fluocinonide) Cream 0.05%, VANOS(R) (fluocinonide) Cream 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, MarketWatch

Medicis and IMPAX Announce R&D Collaboration and Settlement  -  Dec 1, 2008
LIDEX(R) (fluocinonide) Cream 0.05%, VANOS(R) (fluocinonide) Cream 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, MarketWatch

Smoker is hoping to shrink wrinkles  -  Dec 2, 2008
...in your arteries and blood flow to your skin will improve, allowing it to regain some flexibility. u Get a prescription for tretinoin cream (Retin A). Chicago Sun-Times,

Modern Drugs to Treat Acne  -  Dec 1, 2008
Vitamin-A-like compunds (retinoids) - Tretinoin, isotretinoin (Accutane), tazarotene, adapalene and others: These stimulate the cells in the outer skin Best Syndication,

Look what the 'hot' new facial did to me!  -  Dec 3, 2008
...costing £1600, and Dr Lowe also treated my chest with Airol cream (retin-A), with the active ingredient tretinoin, which reduces pigmentation. Daily Mail,

Illegal beauty goods worth Rp 2.5b seized  -  Nov 21, 2008
..."The beauty products contain hydroquinone and tretinoin, chemical substances that are dangerous to the human body. The distribution of these products poses Jakarta Post,

Wrinkle Free Friday: New treatment for stretch marks  -  Nov 21, 2008
The good news is the prescription tretinoin cream, called Retin A, that is used for acne and wrinkles, can make a difference. WWL,

Don't Use O'lynn Beauty Cream, Langsing Alami Slimming Products ...  -  Nov 11, 2008
She said the use of Tretinoin was not allowed in cosmetics as it could cause side effects such as skin irritations, peelings and other skin complications if Bernama,

Obagi Medical Products, Inc. Q3 2008 Earnings Call Transcript  -  Nov 20, 2008
Sales of Obagi C Rx, Professional-C, Tretinoin and others equaled $5.8 million up 13% versus a year ago. Further we completed our direct to consumer Seeking Alpha,

Medicis Announces Third Quarter 2008 Conference Call and Webcast  -  Nov 6, 2008
LIDEX(R) (fluocinonide) Cream 0.05%, VANOS(R) (fluocinonide) Cream 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, MarketWatch

Products containing poison: Vendor claims trial  -  Nov 19, 2008
The products were six boxes of Tretinoin Hydroquinone and four boxes of Clariderm containing Hydroquinone, which is listed in the First Schedule of the Daily Express,

Dr. Jeff Hersh: Treating skin issues  -  Nov 10, 2008
...use of topical medications (eg tretinoin, podophyllin, tincture of iodine or trichloracetic acid) or "burning" the lesions off with silver nitrate. Taunton Daily Gazette,

Dr. Rachel Herschenfeld  -  Oct 30, 2008
Tretinoin is found in RetinA and Atralin and in generic form. Over the counter fading creams contain hydroquinone. I would recommend seeing a dermatologist Washington Post,

BUYINS.NET: (JNJ) SqueezeTrigger Price is $63.343. There is ...  -  Oct 29, 2008
Prescriptions drugs in the dermatology field include RETIN-A MICRO (tretinoin), a dermatological cream for acne. Prescription drugs in the gastrointestinal Trading Markets (press release),

2化妆瘦身产�?�?�现�?�毒  -  Nov 11, 2008
...�?�生部�?�剂�?务总监爱莎指出，毒�?控制执法当局在�?�现有关护肤霜�?�有维甲酸“Tretinoin 光�?�日报,

O'lynn Skin Lightening Cream�?�Langsing Alami‧兩款瘦身產�?勿用  -  Nov 11, 2008
...她說，藥劑管制局最近發�?�O'lynn美容霜�?�有維生素A酸（Tretinoin 星洲日報,

التنظي�?... الوسيلة المثلى لوجه مشرق!  -  Nov 13, 2008
تقلّص الكريمات التي تحتوي على مشتقات التريتينوين tretinoin حجم الغدد الدهنية وتساعد �?ي تجديد خلايا البشرة، أما الـ eroxyde de benzoyle �?يحارب الالتهاب صوت العراق,

Wrinkles are there Anti - Wrinkle Solutions  -  Oct 20, 2008
Although the exact mode of action of tretinoin is unknown, current evidence suggests that tretinoin decreases cohesiveness of follicular epithelial cells. American Chronicle,

Medicis Announces FDA Approval of PMA Supplement for RESTYLANE  -  Oct 10, 2008
LIDEX(R) (fluocinonide) Cream 0.05%, VANOS(R) (fluocinonide) Cream 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, BUPHENYL(R) Trading Markets (press release),

고혈압치료제 ACE억제제·  -  Oct 15, 2008
...�?�번 지견�?� Department of Veterans Affairs Topical Tretinoin Chemoprevention(VATTC) 시험�? 근거했다. AII�?� 억제는 혈관신�? �? 종양�?�? 억제로 연결�?� 가능성 쿠키뉴스,

BUYINS.NET: (JNJ) SqueezeTrigger Price is $63.343. There is ...  -  Oct 14, 2008
Prescriptions drugs in the dermatology field include RETIN-A MICRO (tretinoin), a dermatological cream for acne. Prescription drugs in the gastrointestinal Trading Markets (press release),

Ethem MERCAN  -  Oct 7, 2008
Bu ürünlerin içerdiği soldurucu ve yenileyici maddeler (hidrokinon ve tretinoin) yavaş bir şekilde lekelerin rengini açar. Tedavi genellikle 2-4 ay sürer. Internet Haber,

Das geht unter die Haut  -  Oct 4, 2008
Dabei gibt es durchaus Substanzen, deren Wirksamkeit mit sauberen klinischen Studien belegt ist: Der Klassiker sind Vitamin-ASäuren wie Tretinoin und NZZ Online,

Ezeket a gyógyszerket ne szedje terhesség idején  -  Oct 7, 2008
Acitretin, etretinát, tretinoin: Alkalmazásuk hasonló az izotretinoinéhoz, valamint még pikkelysömörben is adják ezeket a szereket. WEBBeteg,

Anal Bleaching  -  Oct 7, 2008
Dazu gehören zum Beispiel Cremes mit Hydrochinon (2 bis 5 Prozent), mit Tretinoin (0,05 Prozent), Azelainsäure (20 Prozent) oder Glycolsäure (12 Prozent). Queer.de,

Brand Names/Synonyms:
Tretinoin is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid

Drug Category:
Tretinoin is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22

Dosage Forms:
CAPSULE; CREAM; GEL; LIQUID

Absorption:
1-31% (topical);

Interactions:
Interactions for Tretinoin:

Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA.

RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity.

Chemical IUPAC Name:
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid

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