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TretinoinThis page contains recent news articles, when available, and an overview of Tretinoin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Tretinoin (when available) Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. Mechanism Of Action: Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown. News Articles on Tretinoin Retinoids and Carotenoids in Dermatology - Apr 1, 2008 This includes the topical agents available by prescription (tretinoin, adapalene, and tazarotene) and the cosmeceutical retinaldehyde. Journal of American Medical Association (subscription), Barrier Therapeutics to Release First Quarter 2008 Financial ... - Apr 22, 2008 ...for diaper dermatitis complicated by documented candidiasis; and Solage(r) (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. Primenewswire (press release), Beauty care limitations for the pregnant woman - Mar 28, 2008 MANILA, Philippines -- Retinol, Tretinoin, Salicylic Acid and Hydroquinone - these are supposedly the most potent acne, wrinkle and pigmentation fighters. Asianjournal.com, “Will This Cream Make My Skin Look Better?� - HealthNewsDigest ... - Apr 20, 2008 ...stabilized and at a high enough concentration, studies have proven that you can get similar effects to the prescription strength Retin-A or tretinoin. HealthNewsDigest.com, The Whistleblower of Youth and Beauty - Apr 18, 2008 All you probably need are daily alpha hydroxyacid, and tretinoin cream and youre good to go.� Instead, he got his pentel pen and started plotting the dots Manila Times, Medicis Announces the Early Adoption of Online Proxy Materials for ... - Apr 8, 2008 LIDEX(R) (fluocinonide) Cream, 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, Primenewswire (press release), Are synthetic products good for you? - Apr 8, 2008 For example, tretinoin, the active ingredient in Retin-A and Renova, is a chemically-modified form of vitamin A that's well researched. Sunday Independent, Getting Past the Pain of Common Cosmetic Procedures - Mar 26, 2008 Clobex® shampoo, lotion and spray (clobetasol propionate 0.05%) and Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%). Market Wire (press release) Trisha Tortolani Skin Care launches acne treatment care - Mar 31, 2008 He is a dermatologist and world renowned acne expert, author of Acne Rx and Bio Chemist who co-developed Tretinoin, (Retin A). Napa Valley Register, The Vitamin D Deal - 12 Mar 2008 Both of these compounds are relatives of tretinoin, the active ingredient in Retin A, which is only available by prescription in the US All these compounds Washington Post, Medicis Increases Cash Dividend to $0.04 Per Share - 12 Mar 2008 LIDEX(R) (fluocinonide) Cream, 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, Primenewswire (press release), Acne During Pregnancy - How to treat acne in pregnancy - Mar 10, 2008 ...benzoyl peroxide, azelaic acid, and erythromycin. Retin-A is a cream which is applied on the affected area to reduce acne. It is also known as Tretinoin. Los Angeles Chronicle, Staying indoors for romance - Feb 14, 2008 Those who are trying to conceive must especially stay away from tretinoin, hydroquinone and salicylic acid, which have been linked to birth defects. Inquirer.net, Skin saver: What you need to know about anti-aging treatments - Mar 10, 2008 ...and spend a bit more ($50 to $100 for a tube that lasts one month) can opt for prescription strength retinoids, such as FDA-approved tretinoin cream. Daily Camera, Barrier Therapeutics to Present At the Cowen and Company 28th ... - Mar 10, 2008 ...for diaper dermatitis complicated by documented candidiasis; and Solage(r) (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. Primenewswire (press release), Do Wrinkle Products Work? - Mar 7, 2008 A prescription topical treatment called tretinoin is approved by the FDA for treating wrinkles. "That and Differin have been proven to be effective and are RedOrbit, Barrier Therapeutics Announces Fourth Quarter and Full Year 2007 ... - Feb 28, 2008 ...for diaper dermatitis complicated by documented candidiasis; and Solagé® (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. CNNMoney.com Obagi Medical Products, Inc. Q4 2007 Earnings Call Transcript - Mar 3, 2008 Sales from our core product launch, which include Nu-Derm Obagi-C Rx, Professional C, and Tretinoin products once again provided solid double-digit growth Seeking Alpha, Obagi Medical Products Reports 2007 Financial Results - Mar 3, 2008 This quarter's success reflected: -- Continued strength of Obagi's core products (includes Nu-Derm, Obagi-C Rx, Professional-C and Tretinoin), StreetInsider.com (subscription), Feeling rough - Mar 1, 2008 You doctor may recommend moisturising regularly with creams containing urea, lactic acid, salicylic acid, alpha-hydroxy acid, tretinoin or vitamin D. Avoid Daily Telegraph, Natural beauty for everyone - Feb 27, 2008 For example, tretinoin, the active ingredient in Retin-A and Renova, is a chemically-modified form of vitamin A that's well researched. Cape Times (subscription), How to Get Rid of Stretch Marks - Feb 20, 2008 Tretinoin cream - also called Retin-A. Studies have shown that this may help reduce stretch marks. Do not use this if you are breastfeeding, as there have American Chronicle, Early skin care can minimize aging effects, experts say - Feb 14, 2008 Among them are idebenone, green tea extract, alpha lipoic acid, vitamin C and tretinoin. Stewart said the best anti-oxidant in the market right now is Press-Enterprise, Acne Treatments- Everything You Wanted To Know- Benzoyl Peroxide - 07 Feb 2008 Benzoyl peroxide should not be used with tretinoin because it reduces effect of tretinoin. You should consult with your doctor If you have eczema, American Chronicle, In the Pink for Valentine's Day - 07 Feb 2008 Differin, or adapalene, belongs to a family of acne medications called retinoids, which also includes tretinoin (the active ingredient in RetinA) and Washington Post, OrthoNeutrogena selects Stratagem as agency of record for Renova brand - Feb 5, 2008 ...has selected Stratagem Healthcare Communications to handle the company’s marketing and branding initiatives for RENOVA® (tretinoin cream 0.02%). PharmaLive.com (press release), Advancements in "Gentle" Skin Brightening Drugs - Jan 30, 2008 Besides hydroquinone, tretinoin offers a less heated option for minimizing a variety of skin blemishes like acne, wrinkles and age spots. American Chronicle, Medicis to Present At Merrill Lynch Conference - Feb 5, 2008 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, SYNALAR(R) (fluocinolone acetonide), and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, FOXBusiness What are other things you can do for acne? - Feb 6, 2008 Here are some of the things they can assist with: Retinoids: Retin-A (tretinoin) has been around for years, and has become milder and gentler while still TamilStar.com, Share This Article - Jan 9, 2008 Topical treatments containing Tretinoin are also considered hazardous for the same reasons. If you are trying to conceive and are taking retinoic acid, Press Media Wire (Press Release), Barrier Therapeutics to Present Scientific Posters At the American ... - Feb 1, 2008 ...for diaper dermatitis complicated by documented candidiasis; and Solage(r) (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. CNNMoney.com Beating the Winter Skin and Hair Doldrums - Jan 30, 2008 This is especially important for people using products with tretinoin like Retin-A or Renova. Deep treatments are your hair’s best friend during the winter Papierdoll, Combating dry skin during cold months - Jan 10, 2008 I also tell people that if they are already using skin-care products [for conditions such as acne] with glycolic acid or salicylic acid or tretinoin [used Baltimore Sun, Differin; beter medicijn tegen acne - Jan 25, 2008 This synthetic retinoid, which some find more tolerable than tretinoin (Retin-A), was previously available at only a single concentration of 0.1%. Blog.nl, Wendy Ann Satmary, MD, Kaiser Permanente Medical Center, Woodland ... - Jan 30, 2008 Virgili A, Corazza M, Bianchi A, Mollica G, Califano A. Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. AAFP News Now W. Scott Thompson: A passage to cheaper medicines in India - Nov 16, 2007 ...a "tretinoin" cream with the same chemical ingredients. I know I should have kept my mouth shut to my daughters and other female friends who use it, New Straits Times, Medicis to Present At 2007 Credit Suisse Annual Healthcare Conference - Nov 12, 2007 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, SYNALAR(R) (fluocinolone acetonide), and ZIANA(R) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, CNNMoney.com Obagi Medical Products Q3 2007 Earnings Call Transcript - Nov 13, 2007 Sales from our core product lines, which includes Nu-Derm, C Rx, Vitamin C and tretinoin continues to have strong momentum increasing 20% versus last year. Seeking Alpha, Anti-Wrinkle Cream - Information For The Effects of Wrinkle Creams - Nov 1, 2007 Tretinoin (or retin-A). The effects of retin-A or tretinoin will be similar to vitamin A, as it is a similar ingredient. It can be also be used to treat American Chronicle, Barrier Therapeutics Announces Third Quarter 2007 Financial Results - Oct 30, 2007 ...for diaper dermatitis complicated by documented candidiasis; and Solagé® (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. CNNMoney.com Wrinkle creams put to the test - Nov 8, 2007 ...quit smoking, moisturize, cleanse and protect! *Retin-A is a retinoid (generic name: tretinoin) Other brands of retinoids include Renova, Avage and Tazorac. KING5.com, BTRX: Positive Ph iia Data on Friday Lifts Stock from 52-Week Low ... - Oct 19, 2007 ...and Solage(R)(mequinol 2.0% and tretinoin 0.01%) Topical Solution, a topical solution indicated for the treatment of solar lentigines, commonly known as Trading Markets (press release), Treatment of Mild to Moderate Acne: Presented at AAFP - Oct 11, 2007 Mild treatment includes topical retinoids, tretinoin, adapalene, and tazarotene. Moderate acne is defined as 20 to 100 comedones or 15 to 50 inflammatory DG News Anti Wrinkle Creams Do They Work - Oct 13, 2007 Tretinoin (or retin-A). The effects of retin-A or tretinoin will be similar to vitamin A, as it is a similar ingredient. It can be also be used to treat American Chronicle, Fade Stretch Marks Without Expensive Surgery - Try Lotions For ... - Sep 24, 2007 Popularly known creams derived from Vitamin A are Tretinoin, or Retin-A. These creams can prove to be beneficial but are not recommended to pregnant women American Chronicle, Medicis to Present At Leerink Swann Aesthetics Roundtable Conference - Oct 1, 2007 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, SYNALAR(R) (fluocinolone acetonide), and ZIANA(TM) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, CNNMoney.com Barrier Therapeutics Completes Patient Enrollment for Pivotal ... - Sep 28, 2007 ...for diaper dermatitis complicated by documented candidiasis; and Solagé® (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. CNNMoney.com Can we hold back time? - Sep 22, 2007 Tretinoin, branded Retin-A, is one that I prescribe. In America, tazarotene, another retinoid [brand name Zorac], is also licensed for photo-damage. Times Online, New approaches to the treatment of melasma aim at improving ... - Oct 4, 2007 Pearl Grimes was Tri-Luma® Cream,* *(TC)* *combining hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.01% (a low-potency corticosteroid). PharmaLive.com (press release), Acne – How To Care For Your Skin - Sep 23, 2007 Acne patients who are treating acne with topical tretinoin and benzoyl peroxide should never use foundations on their faces. Even lip products that contain PR-GB.com (press release), Awful Acne Scars - How to Remove Them - Sep 22, 2007 Look for acne medicine that contains a chemical called 'tretinoin', which does exactly this and also gently removes the built-up layers of dead skin which PR-GB.com (press release), Wrinkles and antioxidants - Vitamin A Topical Products - Sep 4, 2007 Topical products containing natural forms of vitamin A (retinol, retinaldehyde) or vitamin A derivatives called retinoids (tretinoin, tazarotene) have SpiritIndia, Skin Care - Wrinkles and Chemical Peels - Sep 4, 2007 In some cases, tretinoin (vitamin A derivative) or alpha hydroxy is applied four to six weeks before and starting one day after the peel. SpiritIndia, Common Acne Treatments for Women - Sep 6, 2007 For basic treatments, women are usually prescribed with topical medications like products with benzoyl peroxide, erythromycin and tretinoin. PR-GB.com (press release), Acne research pushes for new combinations, probes isotretinoin's ... - Aug 28, 2007 ...a combination of clindamycin 1.2 percent and tretinoin 0.025 percent, available in a once-a-day gel formation, according to Diane Thiboutot, MD, Therapeutics Daily (subscription) (press release), Acne Scars- They Need Not Be There For Life - Aug 10, 2007 Tretinoin comes as a cream or gel and it peels the upper layer of the skin. By repeated application, your mild superficial scar will become less prominent. American Chronicle, Medicis to Present At Thomas Weisel Partners Healthcare Conference - Sep 4, 2007 0.05%, VANOS(R) (fluocinonide) Cream, 0.1%, SYNALAR(R) (fluocinolone acetonide), and ZIANA(TM) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, CNNMoney.com Galderma Laboratories Names Brand Pharm Agency of Record for ... - Sep 4, 2007 The third product - TRI-LUMA® (fluocinolone acetonide 0.01 percent, hydroquinone 4 percent, tretinoin 0.05 percent), a treatment for melasma, PharmaLive.com (press release), ROTH 2007 New York Conference Presenter Profiles - Sep 4, 2007 ...for diaper dermatitis complicated by documented candidiasis; and Solage(R) (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. TMC Net, Medicis and Hyperion Therapeutics Announce Strategic Collaboration - Aug 28, 2007 SYNALAR(R) (fluocinolone acetonide), and ZIANA(TM) (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, and the over-the-counter brand ESOTERICA(R). CNNMoney.com Photosensitive medicines listed - Aug 23, 2007 Alferon-N); methotrexate (Mexate); pentostatin (Nipent); procarbazine (Matulane); tretinoin oral (Vesanoid); vinblastine (Velban, Velbe). Biloxi Sun Herald, Skin Color- Keep Your Skin Young Looking With Even Skin Color-2 - Aug 10, 2007 For that AHAs and tretinoin are commonly used. You should consult your doctor and use a formulation that will not only remove the existing color, American Chronicle, Time to face facts on wrinkle creams - 04 Aug 2007 Montreal Gazette (subscription),Topical retinoic acid (tretinoin) turned out to be an effective remedy for acne. Then in the 1980s, Albert Kligman, an American dermatologist regarded as Antiaging Treatments | Restore Your Youth With Antiaging Treatment ... - Jul 25, 2007 American Chronicle,Thus, according to few the ultimate antiaging solution is Tretinoin and vigorous element in Renova and Retins A, which works to restore the youth. Barrier Therapeutics Introduces New Xolegel Duo(TM) Offering at ... - Aug 2, 2007 CNNMoney.com...for diaper dermatitis complicated by documented candidiasis; and Solage® (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. Ask the Doctor: Shari Rudavsky Sun, smoking are biggest threats to ... - Jul 30, 2007 Indianapolis Star,The most effective is tretinoin, a prescription-strength vitamin A derivative. The ones that are available over the counter are about one-twentieth the Barrier Therapeutics to Release Second Quarter 2007 Financial ... - Jul 30, 2007 CNNMoney.com...for diaper dermatitis complicated by documented candidiasis; and Solagé® (mequinol 2.0%, tretinoin 0.01%) Topical Solution, for solar lentigines. Sold Out Boots No7 'Miracle Serum' Lands in One Store Only in ... - Jul 11, 2007 Earthtimes.org..."The Dermatology Department of the University of Manchester has been researching Tretinoin for years," according to the program. "They were convinced that Anti-aging serum causes got-to-have-it frenzy - Jul 29, 2007 The Daily News,The effects can be compared with what you find with prescription creams with Tretinoin, a form of vitamin A, also known commonly as Retin-A. Both products Wrinkle Wars; Wendy Lewis Takes a Fresh Look at Renova, an Old ... - Jul 21, 2007 DentalPlans.com,If you’ve used and loved Retin-A® to treat your acne, you’ll be thrilled to learn that the benefits of tretinoin will carry you through to your golden years & A on looking and feeling good - Jul 9, 2007 Asianjournal.com,Breast stretch marks (if tightened can lift your breasts) can be reduced through the application of tretinoin cream. (Reference: "Age Erasing Secrets" by Brand Names/Synonyms: Tretinoin is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid Drug Category: Tretinoin is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22 Dosage Forms: CAPSULE; CREAM; GEL; LIQUID Absorption: 1-31% (topical); Interactions: Interactions for Tretinoin: Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA. RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity. Chemical IUPAC Name: 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid : |
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