Tramadol

This page contains recent news articles, when available, and an overview of Tramadol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Tramadol
(when available)

Pharmacology and use:
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis. Indicated in the treatment of moderate to severe pain.

Mechanism Of Action:
Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.

News Articles on Tramadol

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce ...  -  20 Apr 2009
...particularly with concomitant use of serotonergic drugs (including triptans and tramadol) and with drugs which impair metabolism of serotonin (including PR Newswire (press release)

Labopharm sees FDA rejecting pain formulation  -  ‎Apr 2, 2009‎
The study related to its twice-daily formulation of tramadol and acetaminophen. It showed results that were not statistically significant when judging Reuters

Discarded cigarette may have caused fire  -  ‎Apr 19, 2009‎
There were also low levels of alcohol and evidence of the painkiller Tramadol. Dr Tijani said Mr Hudson would have passed out quickly due to the toxic fumes Sunderland Echo

CHEAP TRAMADOL  -  ‎Apr 13, 2009‎
Take tramadol exactly as prescribed. If any side effects of your own risk. Buy cialis online druggist. Because the effects from, tramadol. El Aviso Magazine

Cannabis enforcement Vs.Prescription drugs  -  ‎Apr 18, 2009‎
Heavy-duty, industrial strength opioids such as OxyContin and Tramadol are at the forefront of a global epidemic which is without a doubt, being fueled by a PR CannaZine (press release)

Mystery remains over woman's overdose death  -  ‎Apr 15, 2009‎
Dorothy Nappin had 4889mg of tramadol per litre in her blood when she died – eight times above the therapeutic dose and twice as high as the lethal dose. Portsmouth News

Student arrested for giving out prescription drugs  -  ‎Apr 2, 2009‎
Lambertson and the 15 year old both took hydrocodone, tramadol, and Ambien. The 15 year old had a seizure after taking the drugs and was taken to Crouse WTVH

Rxonlinetoday Launch Cyber Shop for FDA Approved Medicines  -  ‎Apr 5, 2009‎
..."I decided to buy Tramadol online without any prior prescription from Rxonlinetoday.com for immediate needs, choosing next day delivery. PR Web (press release)

Finding doctors for online pharmacies  -  ‎Apr 12, 2009‎
Tramadol, Butal and Soma are all painkillers. They are not controlled drugs but still require a doctor's prescription. Over the years, several doctors have Behind Online Pharma

New agreements increase iNova product offerings in Asia  -  ‎Apr 8, 2009‎
This follows registration in Australia where iNova first launched the once daily tramadol product and achieved Government subsidisation in 2008. PharmaLive.com (press release)

iNova Pharmaceuticals signs exclusive distribution and license ...  -  ‎Apr 9, 2009‎
...iNova also has the rights to make available a once daily, extended release tablet formulation containing the active tramadol hydrochloride for pain Trading Markets (press release)

Mr. Ashok Shinkar, Director Corporate Finance, Wanbury Ltd  -  ‎Apr 15, 2009‎
In addition to Metformin, Wanbury boasts of a strong product portfolio which includes Salsalate, Glucosamine, Mefenamic Acid, Tramadol, Amitryiptyline, India Infoline.com

In Brief - Thursday  -  ‎Apr 2, 2009‎
...fell 10.1% to 1.16 after saying a pain drug didn't pass a late-stage trial. The drug is a combination of acetaminophen and the painkiller tramadol. istockAnalyst.com (press release)

Pharmacokinetic Drug Interactions of Synthetic Opiate Analgesics  -  ‎Apr 17, 2009‎
...propoxyphene, levomethadyl, meperidine, other phenylpiperidines (such as fentanyl), pentazocine, diphenoxylate, loperimide, and tramadol. Psychosomatics (subscription)

Man whose sons were killed by their mother arrested in Pasco drug ...  -  ‎Apr 17, 2009‎
She is charged with selling zolpidem tartrate, tramadol and glyburide. Jorden N. Maniatis, 18, of 3123 Merita Drive, Holiday. She is charged with selling Tampabay.com

Pleas taken in Morgan Superior Court  -  ‎Apr 17, 2009‎
...one count manufacture of marijuana, one count possession of Tramadol, one count possession of Psycholbenzaprine, one count possession of marijuana, Morgan County Citizen

US HOT STOCKS: Research In Motion, Micron Active In Late Trading  -  ‎Apr 2, 2009‎
Labopharm Inc. (DDSS, $1.16, -$0.13, -10.08%) shares fell after a pivotal trial of its Tramadol-Acetaminophen pain study fell short of the company's Wall Street Journal

Man arrested for DUI after he drove to jail  -  ‎Apr 8, 2009‎
The white pills were identified as Tramadol, a controlled substance. Brad Owen Collins, 25, of 1000 Oswald Road, Panama City, was arrested and charged with The News Herald

Basic Energy, Schnitzer Steel Help Power Gains  -  ‎Apr 2, 2009‎
Quebec specialty pharmaceutical company Labopharm fell 13 cents, or 10%, to 1.16, after a pivotal trial of its tramadol-acetaminophen pain study fell short Wall Street Journal

Canada Hot Stocks: Bombardier, Labopharm, Sino-Forest, Pacific ...  -  ‎Apr 2, 2009‎
BT) Labopharm (C$1.34, -C$0.30, -18%) said results of its North American Phase III clinical trial of its twice-daily formulation of tramadol and Wall Street Journal

Life Lessons From the Family Dog  -  ‎Mar 31, 2009‎
Bijou’s medicine chest is impressive for a 23-pound dog: A baby dose of amoxicillin for chronic urinary tract infections; prednisone and Tramadol for pain; New York Times

Certified Canadian Pharmacy - generic zoloft  -  ‎Apr 13, 2009‎
For generic pills online buy cheap tramadol as more times during treatment. It is derived from. PTSD and stress can damage liver cells in your system El Aviso Magazine

Former nurse pleads guilty to forgery  -  ‎Apr 4, 2009‎
They included pills such as Hydrocodone-APAP, Vicodin, Tramadol HCL, Methotrexate, Folic Acid, Keflex, Ultram, Prednisone, Azithromycin and others. Albert Lea Tribune

G-20 To Give Another $1.1 Trillion To IMF, World Bank  -  ‎Apr 2, 2009‎
Labopharm's (DDSS) pain medication tramadol failed a late stage clinical trial. In the broad market, advancing issues outpaced decliners by a margin of more World Market Media

Medical board hearing told patient's treatment "an absolute mess"  -  ‎Apr 3, 2009‎
The board inquiry was told the woman, who died in 2002 and named only as Patient B, was on a cocktail of medication, including Panadeine Forte, tramadol and Geelong Advertiser

GP Carl Grace up before board  -  ‎Apr 1, 2009‎
The panel heard that she was on a cocktail of medication from anti-depressants, sleeping tablets, other painkillers including Panadeine Forte and tramadol, Geelong Advertiser

251 drug-related cases exposed in March  -  ‎Apr 10, 2009‎
270.4 kilos of stimulant powder, 25 kilos of Ephedrine, one litre of opium speciosa liquid, 12.7 kilos of Caxin, 600 capsules of tramadol in one case, MRTV-3

09年执业西è?¯å¸ˆè?¯ç?†å­¦è¾…导:第å??八章第三节其他镇痛è?¯  -  ‎Apr 14, 2009‎
...曲马朵(tramadol)为阿片å?—体激动è?¯ï¼Œå…¶é•‡ç—›ä½œç”¨å¼ºåº¦ä¸Žå–·ä»–ä½?辛相似。å?£æœ?易于å?¸æ”¶ï¼Œç”Ÿç‰©åˆ©ç”¨å?Šåº¦çº¦90%,t1/2约6å°?时。ä¸?良å??应和其他镇痛è?¯ç›¸ä¼¼ï¼Œå?¶æœ‰å¤šæ±—ã€?头晕ã€?æ?¶ 青年人

Labopharm annonce les résultats de l'étude de phase III sur sa ...  -  ‎Apr 2, 2009‎
Les résultats de l'étude sont sans incidence sur le lancement à venir du produit tramadol à prise unique quotidienne de Labopharm aux Etats-Unis. CNW Telbec (Communiqué de presse)

Labopharmå?‘表第三阶段临床实验结果  -  ‎Apr 2, 2009‎
...(DDSS) 1.29 : å…¬å?¸å?‘表最近完æˆ?的北美第三阶段临床实验结果,æ¯?天æœ?用两次tramadol与acetaminophen,积æž?治疗组当中,有13%的病人æ??早中断治疗,对照组有5%的病患æ??æ—© 凤凰网

Kit Car Parking Schermo + Camera Retrovisore Visione Notturna + 4 ...  -  ‎Apr 6, 2009‎
E’ provvisto di entrata dedicata video per l’inserimento di una camera esterna per il car parking. by cod tramadol by money order order tramadol by tramadol Mondo Informatico

Quand la psy cause toujours  -  ‎Apr 16, 2009‎
Angie est constamment shootée, entre Néocodion, Tramadol, Derinox et Valium, tout ça sur fond de vodka. Angie a des phrases impeccables comme«Je prends de Libération

Cinq titres à surveiller (10 avril)  -  ‎Apr 10, 2009‎
Lennox Gibbs, de TD Newcrest, doute que ses versions reformulées de l'analgésique Tramadol soient rentables. Il note toutefois que les liquidités de 45 M$ LesAffaires.com

Morphin lindert Atembeschwerden  -  ‎Apr 6, 2009‎
Aber im „Arzneimittel-Report 2008“ der Krankenkasse GEK wird bemängelt, dass zu lange die nur schwach wirksamen opiatähnlichen Medikamente Tramadol und Tagesspiegel

Les "benskinneurs" se shootent au Tramol  -  ‎Apr 7, 2009‎
Son équivalent en pharmacie est le Trabar, fait à base de Tramadol qui est un analgésique, vendu uniquement sur ordonnance médicale. Bonaberi.com

Farlighetsbedömning av ny narkotika samt rekommendation för ...  -  ‎Mar 30, 2009‎
I promemorian ges rekommendationer för farlighetsbedömningar för olika sorters ny narkotika, t.ex. bromodragonfly och tramadol. Newsdesk (pressmeddelande)

Brand Names/Synonyms:
Tramadol is also known by the following brand names and/or synonymsCrispin; Ralivia Er; Ralivia Flashtab; TRAMADOL/HCL; Tramadol; Tramadol Hcl; Tramadol Hcl Bp/Ep; Tramadol Hydrochloride; Tramadolum [Inn-Latin]; Tramal; Tramodol Hcl; Ultram; Zydol

Drug Category:
Tramadol is categorized under the following by the FDA: Narcotics; Analgesics; ATC:N02AX02

Dosage Forms:
TABLET

Absorption:
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.

Interactions:
-->Interactions for Tramadol:

In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Tramadol does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. Tramadol is a mild inducer of selected drug metabolism pathways measured in animals.

Use With Carbamazepine

Patients taking carbamazepine may have a significantly reduced analgesic effect of ULTRAM. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of ULTRAM and carbamazepine is not recommended.

Use With Quinidine

Tramadol is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration of quinidine and ULTRAM results in increased concentrations of tramadol and reduced concentrations of M1.The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism.

Use With Inhibitors of CYP2D6

In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol.

Use With Cimetidine

Concomitant administration of ULTRAM with cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the ULTRAM dosage regimen is recommended.

Use With MAO Inhibitors

Interactions with MAO Inhibitors, due to interference with detoxification mechanisms, have been reported for some centrally acting drugs.

Use With Digoxin and Warfarin

Post-marketing surveillance has revealed rare reports of digoxin toxicity and alteration of warfarin effect, including elevation of prothrombin times.





Chemical IUPAC Name:
2-(dimethylaminomethyl)-1-(3-methoxyphenyl)-cyclohexan-1-ol

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