Toprol-XL

This page contains recent news articles, when available, and an overview of Toprol-XL but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Toprol-XL (when available)

Pharmacology and use:
Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA). For the treatment of hypertension and angina pectoris

Mechanism Of Action:
Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

News Articles on Metoprolol

AstraZeneca Expands Supply of Brand Toprol-XL  -  ‎Apr 17, 2009‎
AstraZeneca has ramped up production of its beta-blocker Toprol-XL and is removing certain restrictions it established for purchases of the drug because FDA news (subscription)

FDA Safety Changes: Toprol XL, Revlimid, Fludara  -  ‎Apr 15, 2009‎
On February 12, the FDA approved safety labeling revisions for metoprolol succinate (Toprol-XL extended-release tablets; AstraZeneca LP) to provide Medscape

AstraZeneca a Hold for Now  -  ‎Apr 13, 2009‎
The company is facing a number of challenges as it enters 2009, most notably generic competition to Toprol-XL, Nexium, Casodex and Pulmicort. Zacks.com

Shortage of pain-relief drug hits region  -  ‎Apr 13, 2009‎
Current drug shortages include two popular cardiac drugs, Toprol XL and Indur, causing cardiologists and heart patients to scramble in recent months to find Pittsburgh Post Gazette

Orbus Announces Signing Of Anda Development, Manufacturing and ...  -  ‎Mar 30, 2009‎
The product is a generic form of Astra Zeneca's branded product, Toprol XL, which had annual sales in the United States of approximately $2.3 billion in FOXBusiness

Zacks Analyst Blog Highlights: Lattice Semiconductor, Moog Inc ...  -  ‎Apr 14, 2009‎
The company is facing a number of challenges as it enters 2009, most notably generic competition to Toprol-XL, Nexium, Casodex and Pulmicort. Business Wire (press release)

Zacks Analyst Blog Highlights: Lattice Semiconductor, Moog Inc ...  -  ‎Apr 14, 2009‎
The company is facing a number of challenges as it enters 2009, most notably generic competition to Toprol-XL, Nexium, Casodex and Pulmicort. Trading Markets (press release)

The People's Pharmacy  -  ‎Mar 4, 2009‎
The doctor prescribed Coumadin and Toprol XL. I would like to... By Joe Graedon and Teresa Graedonâ€š Ph.D. Q: I was recently diagnosed with an irregular Seattle Times

Goldman reaffirms 'Sell' rating on Watson  -  ‎Mar 3, 2009‎
..."Solid management execution and anticipation over approval of generic Toprol XL have led shares 6 percent higher against a 19 percent decline in the S&P 500 MSNBC

AstraZeneca Filling Supply Gap For Blood Pressure Drug  -  ‎Feb 20, 2009‎
Last year, Sandoz, the generic unit of Novartis AG (NVS), recalled 6 million bottles of generic Toprol XL after the Food and Drug Administration sent a EasyBourse.com

Recall of generic blood-pressure drug causing confusion  -  ‎Mar 2, 2009‎
A recall on the generic version of the popular blood-pressure medication Toprol XL has worried patients calling local pharmacies looking for answers. Canton Repository (subscription)

Drug recall leaves shortage of prescriptions  -  ‎Feb 26, 2009‎
ETHEX Corp. recalled dozens of drugs recently as a precautionary measure, including the generic form of the blood pressure medicine Toprol XL that it KTKA.com

Watson Pharmaceuticals Reports Fourth Quarter and Full Year 2008 ...  -  ‎Feb 20, 2009‎
This forecast includes only a modest contribution from Watson's sales of generic Micro-K(R) and generic Toprol XL(R). Due to production issues experienced Lifescience-online

Watson 4th-qtr profit, 2009 view top expectations  -  ‎Feb 19, 2009‎
...products remain similar and should Watson gain timely approval for one of the products, a generic version of AstraZeneca Plc's heart drug Toprol XL. Alibaba News Channel

Metoprololo nell'ipertensione pediatrica  -  ‎Feb 22, 2009‎
Toprol-XL Pediatric Hypertension Investigators. Efficacy and Safety of Extended Release Metoprolol Succinate in Hypertensive Children 6 to 16 Years of Age: Pillole.org

Toprol-XL Competitors Hampered by Production Issues  -  Feb 2, 2009
AstraZeneca is the only drug company manufacturing its former blockbuster hypertension treatment Toprol-XL because compliance issues related to good FDA news (subscription),

Generic Toprol XL Scarce, After Problems at Novartis and KV  -  Jan 28, 2009
If you take generic Toprol XL for high blood pressure, you may have noticed it’sa little hard to come by these days. AstraZeneca is boosting production of Wall Street Journal Blogs,

Metoprolol Succinate Recalled: Brand Name Drug Scarce But Still ...  -  Jan 30, 2009
The original, brand name version, Toprol XL, is in very low supply. PharmacyChecker.com finds that consumers can obtain Toprol XL from licensed pharmacies PR Web (press release),

US shortage of blood pressure drug affects Tulsans  -  Jan 31, 2009
She was told the warehouse hadn't shipped new supplies of the generic version of Toprol XL she needed. But she wasn't told why. "Seven days went by, Tulsa World,

Manhattan Research Releases Top Pharma Brand Product Sites by ...  -  Feb 3, 2009
Singulair, Strattera, Tamiflu, Topamax, Toprol XL, TriCor, Valtrex, Viagra, Vytorin, Wellbutrin XL, Yasmin, Yaz, Zocor, Zoloft, Zomig, and Zyprexa. PR Web (press release),

MedImmune boosts AstraZeneca profits  -  Jan 29, 2009
The company was hit by soaring sales of competing generic versions of its Toprol-XL drug, which rung up 70 percent fewer sales in the United States from Bizjournals.com,

Clearing the record  -  Jan 31, 2009
Toprol XL is used to treat hypertension and angina, not depression. A Business story yesterday about HF (Gerry) Lenfest's charitable giving incorrectly Philadelphia Inquirer,

Correction: KV Pharmaceutical recall  -  Jan 29, 2009
28 story about KV Pharmaceutical Co., The Associated Press erroneously described Toprol XL as an antidepressant. It is used to treat hypertension and The Associated Press

KV Pharmaceutical recalls dozens of drugs  -  Jan 28, 2009
Products named in the recall include generic versions of the antidepressant Toprol XL, hypertension drugs Norvasc and Cardura, a variety of painkillers International Herald Tribune,

Market Report -- Short Stories (WPI)  -  Jan 22, 2009
Stanford Research upgrades WPI to Buy from Hold and sets target price at $31, based on a new opportunity in generic Toprol XL competitive landscape, MSN Money

Can sex cause a heart attack?  -  Jan 16, 2009
...not to my heart medications," says Saldana, who was on the beta-blocker Toprol-XL (metoprolol) before suffering a heart aneurysm in July. CNN

KV, Novartis problems spawn drug shortage; UK starts stockpiling ...  -  Jan 29, 2009
Generic Toprol XL, a treatment for high blood pressure, is in short supply after manufacturing problems at Novartis and KV Pharma--two big suppliers in the FiercePharma,

AstraZeneca 4Q Net Profit $1.25 Billion, Targets $5.15-$5.45 '09 ...  -  Jan 29, 2009
Sales in the US were up 3%, as the adverse impact from generic competition for Toprol-XL is now annualised. Sales in the Rest of World were up 5%. EasyBourse.com,

BREAKING NEWS: Sales rise but more job cuts at AstraZeneca  -  Jan 29, 2009
In geographic terms, US sales were up 3%, despite the erosion of revenues from the blood pressure drug Toprol XL/Seloken (metoprolol), which has suffered Pharma Times,

AstraZeneca: BPA 2008 'en ligne' de 5,10 dollars.  -  Jan 29, 2009
...l'effet de l'arrivée d'un générique de son traitement de la pression artérielle, Toprol-XL, étant désormais effacé. 'AstraZeneca a délivré une solide BFM radio,

December 2008 Mayo Clinic Health Letter Highlights: Colorectal ...  -  Dec 9, 2008
...legs syndrome -- Toprol-XL (metoprolol succinate) for blood pressure, heart failure and angina -- Zyrtec-D (cetirizine/pseudoephedrine) for allergies. MarketWatch

Letter: Wide prescription choice requires intelligent study  -  Nov 30, 2008
However, many drugs in this tier have a full price that is less than $95, such as Hyzaar, $87; Fosamax, $78; Xalatan, $69; and Toprol XL, $29. TCPalm,

Generic Drugs are as Good as Brand Names for Heart Problems  -  Dec 2, 2008
A long-acting beta-blocker metoprolol also worked as well as brand-name Toprol XL. And Zocor, a statin used to reduce cholesterol, performed no better than HealthNewsDigest.com,

Double Trouble for AstraZeneca  -  Nov 20, 2008
Losing heartburn medication Prilosec, beta blocker Toprol-XL, and now Pulmicort Respules to generic competition wouldn't be so bad if the company wasn't Motley Fool

AstraZeneca posts 29% profit rise  -  Oct 30, 2008
Sales in the US overall were flat in the quarter as the company also integrated a sharp drop in sales of cardiovascular drug Toprol-XL. Toprol-XL quarterly MarketWatch

KV takes 2Q loss on sliding sales and higher costs  -  Nov 17, 2008
Metoprolol is a generic version of AstraZeneca (nyse: AZN - news - people )'s drug Toprol XL. Overall, revenue from KV's Ethex brand products, which include Forbes,

Astra lifts earnings target  -  Oct 30, 2008
...non-US business offsetting flat growth in America after its high blood pressure treatment Toprol-XL was hit by competition from cheaper generic rivals. The Press Association

AstraZeneca reports sizable jump in profits  -  Oct 30, 2008
...which the company attributed to a $141 million decline in sales of its blood pressure drug Toprol-XL due to generic competition. The News Journal,

Drug to Protect Surgery Patients Causes Strokes  -  Nov 17, 2008
Some of the most widely prescribed beta-blockers include atenolol (Tenormin), metoprolol (Lopressor, Toprol-XL) and propranolol (Inderal, Inderal LA) . Natural News.com,

AstraZeneca goes on the hunt  -  Oct 30, 2008
Sales of the Toprol-XL treatment for hypertension, for instance, dropped $141m as a result of competition from generic versions. guardian.co.uk,

Astrazeneca shares up on higher earnings expectation  -  Oct 30, 2008
In the USA, sales of high blood pressure treatment Toprol-XL fell by £85.5m after cheaper generic rivals came on the market. Astrazeneca, which employs 6500 Crain's Manchester Business,

AstraZeneca reports strong third quarter  -  Oct 31, 2008
A $141 million loss of Toprol XL (metoprolol succinate) sales to generic competition counteracted the 5% increase in the rest of the US business Scrip World Pharmaceutical News (subscription),

AstraZeneca 3Q profits up 29 percent  -  Oct 30, 2008
...where the company is facing tough generic competition to its products were unchanged as a $141 million decline in sales of Toprol-XL overshadowed 5 The Associated Press

Zacks Analyst Blog Highlights: Pride International, Lexicon ...  -  Nov 4, 2008
AstraZeneca Plc (NYSE: AZN) is facing a number of challenges, most notably from generic competition to Toprol-XL and Nexium. Management is determined to Business Wire (press release),

Zacks Analyst Blog Highlights: Pride International, Lexicon ...  -  Nov 4, 2008
AstraZeneca Plc (NYSE: AZN | Quote | Chart | News | PowerRating) is facing a number of challenges, most notably from generic competition to Toprol-XL and Trading Markets (press release),

阿斯利康第三季盈利增长29%  -  Oct 30, 2008
...�?过，�?�心血管�?�物Toprol-XL 新浪网,

阿斯利康第三季盈利增長29%  -  Oct 30, 2008
...�?�?�，�?�心血管藥物Toprol-XL 新浪網,

Sandoz Gets Warning Letter for Generic Toprol XL Production Operations  -  Sep 26, 2008
The FDA is questioning a decision by Novartis subsidiary Sandoz to continue distributing generic versions of Toprol XL after it found the company did not FDA news (subscription),

Sandoz Factory Cited in South Africa  -  Oct 17, 2008
NC, facility for various GMP deficiencies, including inadequate validation of the production process for generic Toprol XL (metoprolol succinate). FDA news (subscription),

UPDATE 2-US warns Novartis generic unit on plant problems  -  Aug 26, 2008
L: Quote, Profile, Research, Stock Buzz) Toprol XL. "We question the continued distribution of this product until better process controls are implemented Reuters

FDA sends Sandoz warning letter  -  Aug 27, 2008
The manufacturing process in question was for a generic version of Toprol XL, made by AstraZeneca. The FDA said in its letter that it also had concerns FiercePharma,

FDA Warns Novartis About Manufacturing Plant  -  Aug 26, 2008
...validate the manufacturing process for a copycat version of AstraZeneca’s Toprol XL, a blood pressure medication, which it makes a North Carolina plant. Pharmalot,

PEOPLE'S PHARMACY Generic drugs come under scrutiny  -  Aug 31, 2008
Readers of this column have noted some apparent differences in quality among generic drugs: "I was prescribed Toprol-XL 50 mg for high blood pressure and an Houston Chronicle,

N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP ...  -  Sep 5, 2008
Metoprolol reverses left ventricular remodeling in patients with asymptomatic systolic dysfunction: the REversal of VEntricular Remodeling with Toprol-XL RedOrbit,

Daily Briefing  -  Aug 27, 2008
Novartis AG's Sandoz unit didn't properly investigate problems in manufacturing copies of AstraZeneca PLC's heart drug Toprol XL and other generic medicines The News Journal,

NOVARTIS: FDA-VARNING FÖR KOPIEVERSIONEN ASTRAZENECAS TOPROL  -  Aug 26, 2008
Sandoz är en av två bolag som säljer generika av Toprol XL i USA. KV Pharmaceutical är det andra bolaget. Astrazeneca säljer även en egen kopieversion genom Dagens Nyheter,

Novartis/Sandoz erhält Verwarnung von US-Gesundheitsbehörde FDA  -  Aug 26, 2008
Es handelt sich um ein Generikum für Toprol XL von AstraZeneca. Der Jahresumsatz mit Toprol beträgt gemäss IMS Health Data in den USA 643 Mio USD. Swissinfo,

EEUU advierte a unidad de Novartis por problemas en una planta  -  Aug 26, 2008
El medicamento es una forma genérica del fármaco Toprol XL de AstraZeneca . "Cuestionamos la distribución de este producto hasta que se implementen mejores Reuters América Latina,

FDA, 산�?�즈�? �?산관리 부실 경고  -  Aug 27, 2008
...경고 서신�?� FDA�?� 8월 25�?��? 웹사�?�트�? 실린 것으로 제조규정 위반�?� 아스트�?� 제네카 사�?� 토프롤(Toprol XL)�?� 복제약 Metoprolol succinate ER 정제�? 관련 �?� 메디�?�뉴스,

Novartis se aprieta el cinturón  -  Sep 2, 2008
El medicamento es una forma genérica del fármaco Toprol XL de AstraZeneca. La empresa respondió que las preocupaciones del organismo sanitario estaban Excélsior,

Novartis: "Good News" zu Glivec und Lucentis - "Gelbe Karte"in den ...  -  Aug 27, 2008
Es handelt sich um ein Generikum für Toprol XL von AstraZeneca. Die ZKB bewertet die Empfehlung der britischen Behörde NICE als "positiv" für Novartis und Swissinfo,

Brand Names/Synonyms:
Toprol-XL is also known by the following brand names and/or synonymsBeloc; Betaloc; CGP 2175; H 93/26; H-23/96; LOPRESSOR HCT; Lopresor; Lopresoretic; Lopressor; Metoprolol; Metoprolol Tartrate; Metroprolol; Prelis; Selo-Zok; Seloken; Selopral; Toprol; Toprol-Xl

Drug Category:
Toprol-XL is categorized under the following by the FDA: Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB02; ATC:C07AB52

Dosage Forms:
Tablets

Absorption:
rapid and complete, 50%

Interactions:
Interactions for Metoprolol:

Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with extended release metoprolol succinate plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.

Chemical IUPAC Name:
1-[4-(2-methoxyethyl)phenoxy]-3-(1-methylethylamino)propan-2-ol

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