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TopamaxThis page contains recent news articles, when available, and an overview of Topamax but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Topamax (when available) Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. The precise mechanisms by which Topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to Topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that Topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABAA receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV. Used for the treatment of partial or primary generalized tonic-clonic seizures also used as a treatment for adults with partial-onset seizures. Also indicated for prophylaxis of migraine headaches Mechanism Of Action: Topiramate most likely exerts its actions by four mechanisms: (1) blockage of voltage-dependent sodium channels, (2) augmentation of the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABAA receptor, (3) antagonism of the AMPA/kainate subtype of the glutamate receptor, (4) inhibition of the carbonic anhydrase enzyme. News Articles on Topiramate Basterà una pillola per curare l'alcolismo? Forse sì - 20 Apr 2009 Recenti esperimenti suggeriscono che due sostanze, il Topamax e il Naltrexone, sono funzionali alla lotta all'alcolismo. Il dottor Mark Willenbring, Asylum Italia FDA approves generic Topamax to prevent seizures - Apr 13, 2009 The US Food and Drug Administration has approved the first generic versions of Topamax tablets (topiramate) to prevent seizures. "Generic drugs undergo a Examiner.com Market Report -- In Play (CPD) - Apr 2, 2009 Caraco Pharma markets generic Topamax Tablets Co has launched Topiramate tablets on behalf of Sun Pharmaceutical Industries, immediately following Sun MSN Money Teva gets FDA nod for generic Topamax - Mar 29, 2009 Based on IMS sales data, annual US sales of Topamax reached about $2.4 billion in 2008. Teva will market its version of the Topiramate tablets, the medicine Globes India's Ranbaxy gets US nod for generic Topamax - Mar 29, 2009 The tablet is a generic version of epilepsy drug Topamax, owned by Ortho-McNeil Pharmaceutical Inc, a unit of Johnson & Johnson (JNJ.N). Reuters Stronger US Dollar Seen Hurting 1Q Earnings For J&J - Apr 13, 2009 ...once its core business, has been hit in recent quarters by the loss of patent exclusivity on such brand names as Risperdal and Topamax. Wall Street Journal Generic Version of Topamax® Will Save Upstate New Yorkers Millions - Apr 7, 2009 More than 137000 people in upstate New York use Topamax at an annual expense of $45 million. Topamax is often used in combination with other drugs to treat ReadMedia (press release) Valproate During Pregnancy Linked to Children with Lower IQs - Apr 16, 2009 Another study published in Neurology last year found that women taking valproate along with the migraine medication Topamax were 11 times more likely to Newsinferno.com Sun Pharma gets USFDA`s nod for generic Topamax tablets - Mar 29, 2009 Sun Pharmaceutical Industries announced that USFDA has granted an approval for its abbreviated new drug application (ANDA) to market generic Topamax, Myiris.com UPI NewsTrack Health and Science News - Apr 2, 2009 The federal agency said prescribing information or labeling for generic topiramate will differ from the innovator drug, Topamax, because some uses of United Press International J&J Turns to Pipeline as Generics Take Their Toll - Apr 17, 2009 J&J needs new products after Risperdal (risperidone) became subject to generic competition last year and 17 generic competitors for Topamax (topiramate), FDA news (subscription) Rehab in a Pill? - Apr 15, 2009 Similarly, the drug, topiramate (Topamax), which is used to treat epilepsy and migraines, is now found to reduce by 25 percent more than just having therapy TheCelebrityCafe.com Clinical Trials Update: April 14, 2009 - Apr 14, 2009 If you are an adult who has had two-to-eight migraines over the last three months and are currently taking Topamax, you may qualify for this study. Forbes J&J Cuts 900 Drug Jobs Amid Rising Competition - Apr 9, 2009 Its third-biggest drug, migraine treatment Topamax, lost patent protection earlier this year. “The health-care environment is changing and it behooves us to Bloomberg Johnson & Johnson's 1Q In Line - Apr 14, 2009 However, neuroscience drug Topamax will begin to cause some head winds as generic competition will probably heat up in the second quarter. Morningstar.ca Business snapshots: Ilumisys has LED tube patent - Apr 5, 2009 These generic versions of Topamax 25 mg, 50 mg, 100 mg and 200 mg tablets are bioequivalent to Topamax, which is a trademark of Ortho McNeil Janssen Detroit Free Press Johnson & Johnson Sales Reps Face Job Cuts As Top Drugs Go Generic - Apr 10, 2009 ...billion in 2007 amid generic competition, Bloomberg explains, and epilepsy and migraine drug Topamax is another big seller that has gone generic lately. Wall Street Journal Blogs Sensex plunges 500 pts as global cues disappoint - Mar 30, 2009 Sun Pharmaceutical Industries has received US health regulator Food and Drug Administration’s approval for generic Topamax, topiramate tablets used in the Economic Times Markets in Brief - Mar 29, 2009 It's a big story - annual sales of Topamax were $2.4 billion in the US alone last year. Meanwhile, the Economic Times of India reports that Sun Pharma also Ha'aretz Sun Pharma: Needs more of the US pie - Mar 30, 2009 Sun Pharma can now sell generic Topamax (an anti-convulsant) in the US market. However, with half a dozen other drug firms, including Zydus Cadila, Business Standard Check up: Are you a savvy health care consumer? - Apr 19, 2009 ...(a) Prevacid, Topamax, and Valtrex will lose patent protection this year, paving the way for sales of generic copies, which can cost 30 to 80 percent less. Laconia Citizen 25 more generic drugs will become available [The Buffalo News, NY] - Apr 8, 2009 For instance, the health insurer reported that more than 137000 people in upstate New York use Topamax for migraine headaches, seizures and certain mental Therapeutics Daily (press release) (registration) Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Topamax(R ... - Apr 2, 2009 These generic versions of Topamax 25 mg, 50 mg, 100 mg, and 200 mg tablets are bioequivalent to Topamax(R) which is a registered trademark of Ortho McNeil PR Newswire (press release) SBI rate move - Mar 29, 2009 Mumbai, March 29: The US Food and Drug Administration has approved Sun Pharma’s abbreviated new drug application to market generic Topamax, Calcutta Telegraph Johnson & Johnson F1Q09 (Qtr End 03/29/09) Earnings Call Transcript - Apr 14, 2009 Our results continue to be impacted by generic competition on some of our products namely Risperdal Oral, Razadyne, and Topamax. Seeking Alpha Stocks to watch: Reliance Industries, L&T, ACC, Sun Pharma, TVS Motors - Mar 29, 2009 Topamax tablets have annual sales of approximately $2.5 billion in the US. The TVS group proposes to set up a company to finance two-wheeler sales. Economic Times A pill for migraines - Apr 14, 2009 Divalproex sodium (Depakene), topiramate (Topamax) and Gabapentin are among these. Antidepressants like amitriptyline are also useful. Jamaica Gleaner Closing Bell - Mar 30, 2009 Topiramate tablets are the generic of Ortho McNeil Janssen Pharmaceutical's Topamax tablets, indicated for the treatment of epilepsy in both children and Economic Times Johnson & Johnson Should Return To Form (JNJ, MRK, LLY) - Apr 16, 2009 Both domestic and international was hurt by generic competition for blockbusters such as Risperdal and Topamax. The consumer unit also struggled as reported Investopedia Solid results for J&J as generic competition batters key drugs - Apr 15, 2009 The epilepsy drug Topamax (topiramate) brought in $602 million, down 6.8%. On the bright side, however, turnover from the attention-deficit hyperactivity Pharma Times J&J eliminates 900 positions as Simponi is approved in Canada - Apr 14, 2009 She added that “it’s not simply about losing patentsâ€?, notably on the antipsychotic Risperdal (risperidone) and the migraine drug Topamax (topiramate), Pharma Times Topiramate generics - anaother view - Apr 10, 2009 TOPAMAX(R) brand topiramate generated about $2.2 billion sales annually. The emergence of generic topiramate while a temporary advantage for those who Gerson Lehrman Group Ranbaxy, Reliance Industries, State Bank: India Equity Preview - Mar 29, 2009 Ltd. (SUNP IN): India’s biggest drugmaker by market value said it won approval from the US Food & Drug Administration to sell generic Topamax tablets. Bloomberg About this author: - Apr 5, 2009 Qnexa is a combination of two existing drugs, phentermine and topiramate (marketed for epilepsy and migraine as Topamax). Contrave is a combination of Seeking Alpha Market Report / TA-25 up 0.5% as banks continue strong recovery - Mar 29, 2009 The firm received FDA approval for its generic version of Topamax (See story, Page 8). Bank shares continued rising yesterday after gaining 12.9% last week. Ha'aretz Teva authorised to market generic version of contraceptive - Apr 3, 2009 Last month, the FDA authorised its versions of Ortho-McNeil's anticonvulsant, Topamax and GlaxoSmithKline's migraine treatment, Imitrex. Hays Pharma Aurobindo Pharma secures first nod for Finasteride APL Tablets - Apr 8, 2009 The drug is generic equivalent of Ortho McNeil Janssen Pharmaceuticals' Topamax tablets and indicated for the treatment of epilepsy in both children and TopNews Konkurrenz für Topamax - Apr 2, 2009 Berlin - Das Epilepsiemedikament Topamax (Topiramat) des Pharmaherstellers Janssen-Cilag bekommt in den USA generische Konkurrenz. apotheke-adhoc é™?制快感 新戒酒藥片ç?²é—œæ³¨ - Apr 16, 2009 ...最新的戒酒藥片“Naltrexoneâ€?和“Topamaxâ€?作用於易上癮型大腦，通é?ŽæŠ‘制大腦å?—åˆ°åˆºæ¿€æ™‚é‡‹æ”¾çš„å¤šå·´èƒºï¼ˆå¿«æ¨‚æ¿€ç´ ï¼‰é‡?來幫助æ¤é¡žå¤§è…¦ä¿?æŒ?多巴胺分泌的穩定性。 新浪網 Lucro trimestral da Johnson & Johnson cai a US$ 3,5 bi - Apr 14, 2009 Na semana passada, a empresa informou que reduziria o número de funcionários nos Estados Unidos em 6% após perder, em março, a patente do Topamax, Abril טבע קיבלה ×?ישור FDA לתרופת ×”-Topiramate לטיפול בהתקפי ×?פילפסיה - Mar 31, 2009 ...טבליות ×”-Topiramate מקבילי×? ×ž×‘×—×™× ×” רפו×?ית לתרופת ×”-Topamax של ×’'×•× ×¡×•×Ÿ ×?× ×“ ×’'×•× ×¡×•×Ÿ, שטבע קיבלה ×?ישור FDA ביו×? שישי ×”×?חרון, לשיווק גרסה ×’× ×¨×™×ª שלה, גלובס IND.FARMACÊUTICA: Ranbaxy obtém aval da FDA para entrar nos EUA - Mar 30, 2009 A empresa vai competir neste mercado com a Ortho-McNeil Pharmaceutical, unidade da Johnson & Johnson responsável pela droga Topamax. (Redação - InvestNews) Gazeta Mercantil Starker US-Dollar drückt Ergebnis von Johnson & Johnson - Apr 14, 2009 Begründet wurde dieser Schritt mit dem Verlust des Patentschutzes für das Epilepsiemittel Topamax im März sowie beim Schizophrenieprodukt Risperdal im Frankfurter Allgemeine Zeitung 生物技术行业é?¢ä¸´æ”¿ç–和金èž?风暴å?Œé‡?挑战 - Apr 15, 2009 ...剂兰索拉唑(Prevacid)ã€?赛诺è?²-安万特公å?¸å¹´é”€å”®é¢?为31亿美元的的抗å‡?è¡€è?¯ä¾?诺è‚?ç´ (Enoxaprinã€?Lovenox)ã€?强生公å?¸å¹´é”€å”®é¢?为22亿美元的抗癫痫è?¯å¦¥æ³°(Topamax)ã€?è‘› 中国生物技术信息网 הבורסה × × ×¢×œ×” בעליות: ת"×? 25 עלה ב-0.5% - Mar 29, 2009 ...החברה קיבלה ×?ת ×?ישור רשות המזון והתרופות ×”×?×ž×¨×™×§× ×™×ª (FDA) לשיווק גירסה ×’× ×¨×™×ª לתרופת טופמקס (Topamax) - התרופה ×œ×ž× ×™×¢×ª פרכוסי×? ועוויתות מתוצרת ×?ורטו-מק'× ×™×œ News1 מחלקה ראשונה הבורסה חתמה בעליות: דלק קידוחי×? ×–×™× ×§×” ב-8.4% - Mar 28, 2009 ...טבע טיפסה ב-1.3% ל×?חר שביו×? שישי הודיעה שקיבלה ×ž×ž×™× ×”×œ המזון והתרופות ×”×?מריק×?×™ (FDA) ×?ישור סופי לשיווק גרסה ×’× ×¨×™×ª של תרופת ×”-Topamax ב×?רה"ב בעלת מכירות כלכליסט Three-Way Race For Next Obesity Treatment About To Heat Up - 18 Mar 2009 The drug is a combination of phentermine and topiramate, which is sold as Topamax by Johnson & Johnson (JNJ). Topiramate's label includes warnings about CNNMoney.com Diagnosing cluster headaches - Mar 9, 2009 Olga takes medications such as verapimil and topamax to prevent attacks and the tryptan drugs to stop them if they break through. 7Online.com A Valeant Effort - Mar 12, 2009 ...populated with generics and brand names such as Pfizer's (NYSE: PFE) Lyrica, Cephalon's (Nasdaq: CEPH) Gabitril, and J&J's Topamax. Motley Fool Vivus: A Bet on Well-Funded, Late-Stage Pipeline - Mar 3, 2009 Topiramate is better known as Topamax (patent expires this month), which has 5.8 million patient years of use and was originally developed as a seizure drug Seeking Alpha Omnicare, Inc., Q4 2008 Earnings Call Transcript - Feb 26, 2009 In addition, we expect roughly 20 relevant drugs to potentially launch as generics in 2009, including Depakote ER and Sprinkle, Topamax, Keppra liquid and Seeking Alpha Anna Nicole Smith's lover, Howard K. Stern, charged in her fatal ... - Mar 12, 2009 She also had taken Benadryl (Diphenhydramine) and Topamax (Toprimate), an anticonvulsant, which likely contributed to the sedative effect of chloral hydrate New York Daily News BUYINS.NET: Market Maker Surveillance Report. Highest Net Sell ... - Feb 26, 2009 ...psoriasis, psoriatic arthritis, ulcerative colitis, and used to treat rheumatoid arthritis; TOPAMAX, for adjunctive and monotherapy use in epilepsy, Trading Markets (press release) Retrasos en diagnóstico y mala medicación cronifican la migraña - Mar 16, 2009 En cuanto a los tipos de tratamiento, destacó el uso de topimarato, comercializado por Janssen-Cilag como 'Topamax', y señaló que un estudio realizado en Europa Press Johnson & Johnson halten: - Mar 12, 2009 Die vorsichtige Haltung des Unternehmens werde damit begründet, dass im März das Exklusivverkaufsrecht des Epilepsiemedikaments Topamax auslaufe und die Aktienresearch Brand Names/Synonyms: Topamax is also known by the following brand names and/or synonymsCHEMBANK1823; Mcn-4853; Tipiramate [French]; Tipiramato [Spanish]; Topamax; Topamax Sprinkle; Topiramate; Topiramate [Usan:Ban:Inn]; Topiramato [Inn-Spanish]; Topiramatum [Inn-Latin]; Topiramatum [Latin] Drug Category: Topamax is categorized under the following by the FDA: Antiobesity Agents; Neuroprotective Agents; Anticonvulsants; ATC:N03AX11 Dosage Forms: CAPSULE; TABLET Absorption: Rapid with pleak plasma concentrations occurring after 2 hours. Bioavailability is 80% Interactions: Interactions for Topiramate: In vitro studies indicate that topiramate does not inhibit enzyme activity for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4/5 isozymes. Antiepileptic Drugs Potential interactions between topiramate and standard AEDs were assessed in controlled clinical pharmacokinetic studies in patients with epilepsy. The effects of these interactions on mean plasma AUCs are summarized in Table 3. In Table 3, the second column (AED concentration) describes what happens to the concentration of the AED listed in the first column when topiramate is added. The third column (topiramate concentration) describes how the coadministration of a drug listed in the first column modifies the concentration of topiramate in experimental settings when Topiramate was given alone. Table 3: Summary of AED Interactions with Topiramate AED Co-administered AED Concentration Topiramate Concentration Phenytoin NC or 25% increasea 48% decrease Carbamazepine (CBZ) NC 40% decrease CBZ epoxide NC NE Valproic acid 11% decrease 14% decrease Phenobarbital NC NE Primidone NC NE Lamotrigine NC at TPM doses up to 400 mg/day 15% increase NC = Less than 10% change in plasma concentration. AED = Antiepileptic drug. NE = Not Evaluated. TPM = Topiramate In addition to the pharmacokinetic interaction described in the above table, concomitant administration of valproic acid and topiramate has been associated with hyperammonemia with and without encephalopathy. Other Drug Interactions Digoxin: In a single-dose study, serum digoxin AUC was decreased by 12% with concomitant Topiramate administration. The clinical relevance of this observation has not been established. CNS Depressants: Concomitant administration of Topiramate and alcohol or other CNS depressant drugs has not been evaluated in clinical studies. Because of the potential of topiramate to cause CNS depression, as well as other cognitive and/or neuropsychiatric adverse events, topiramate should be used with extreme caution if used in combination with alcohol and other CNS depressants. Oral Contraceptives: In a pharmacokinetic interaction study in healthy volunteers with a concomitantly administered combination oral contraceptive product containing 1 mg norethindrone (NET) plus 35 mcg ethinyl estradiol (EE), Topiramate given in the absence of other medications at doses of 50 to 200 mg/day was not associated with statistically significant changes in mean exposure (AUC) to either component of the oral contraceptive. In another study, exposure to EE was statistically significantly decreased at doses of 200, 400, and 800 mg/day (18%, 21%, and 30%, respectively) when given as adjunctive therapy in patients taking valproic acid. In both studies, Topiramate (50 mg/day to 800 mg/day) did not significantly affect exposure to NET. Although there was a dose dependent decrease in EE exposure for doses between 200-800 mg/day, there was no significant dose dependent change in EE exposure for doses of 50-200 mg/day. The clinical significance of the changes observed is not known. The possibility of decreased contraceptive efficacy and increased breakthrough bleeding should be considered in patients taking combination oral contraceptive products with Topiramate. Patients taking estrogen containing contraceptives should be asked to report any change in their bleeding patterns. Contraceptive efficacy can be decreased even in the absence of breakthrough bleeding. Metformin: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of metformin and topiramate in plasma when metformin was given alone and when metformin and topiramate were given simultaneously. The results of this study indicated that metformin mean Cmax and mean AUC0-12h increased by 18% and 25%, respectively, while mean CL/F decreased 20% when metformin was co-administered with topiramate. Topiramate did not affect metformin tmax. The clinical significance of the effect of topiramate on metformin pharmacokinetics is unclear. Oral plasma clearance of topiramate appears to be reduced when administered with metformin. The extent of change in the clearance is unknown. The clinical significance of the effect of metformin on topiramate pharmacokinetics is unclear. When Topiramate is added or withdrawn in patients on metformin therapy, careful attention should be given to the routine monitoring for adequate control of their diabetic disease state. Lithium: Multiple dosing of topiramate 100 mg every 12 hrs decreased the AUC and Cmax of Lithium (300 mg every 8 hrs) by 20% (N=12, 6 M; 6 F). Haloperidol: The pharmacokinetics of a single dose of haloperidol (5 mg) were not affected following multiple dosing of topiramate (100 mg every 12 hr) in 13 healthy adults (6 M, 7 F). Amitriptyline: There was a 12% increase in AUC and Cmax for amitriptyline (25 mg per day) in 18 normal subjects (9 male; 9 female) receiving 200 mg/day of topiramate. Some subjects may experience a large increase in amitriptyline concentration in the presence of topiramate and any adjustments in amitriptyline dose should be made according to the patient's clinical response and not on the basis of plasma levels. Sumatriptan: Multiple dosing of topiramate (100 mg every 12 hr) in 24 healthy volunteers (14 M, 10 F) did not affect the pharmacokinetics of single dose sumatriptan either orally (100 mg) or subcutaneously (6 mg). Risperidone: There was a 25% decrease in exposure to risperidone (2 mg single dose) in 12 healthy volunteers (6 M, 6 F) receiving 200 mg/day of topiramate. Therefore, patients receiving risperidone in combination with topiramate should be closely monitored for clinical response. Propranolol: Multiple dosing of topiramate (200 mg/day) in 34 healthy volunteers (17 M, 17 F) did not affect the pharmacokinetics of propranolol following daily 160 mg doses. Propranolol doses of 160 mg/day in 39 volunteers (27M, 12F) had no affect on the exposure to topiramate at a dose of 200 mg/day of topiramate. Dihydroergotamine: Multiple dosing of topiramate (200 mg/day) in 24 healthy volunteers (12 M, 12 F) did not affect the pharmacokinetics of a 1 mg subcutaneous dose of dihydroergotamine. Similarly, a 1 mg subcutaneous dose of dihydroergotamine did not affect the pharmacokinetics of a 200 mg/day dose of topiramate in the same study. Others: Concomitant use of Topiramate, a carbonic anhydrase inhibitor, with other carbonic anhydrase inhibitors, e. g., acetazolamide or dichlorphenamide, may create a physiological environment that increases the risk of renal stone formation, and should therefore be avoided. Drug/Laboratory Tests Interactions: There are no known interactions of topiramate with commonly used laboratory tests. Chemical IUPAC Name: 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate : |
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