Tamsulosin

This page contains recent news articles, when available, and an overview of Tamsulosin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Tamsulosin
(when available)

Pharmacology and use:
Tamsulosin, an alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). Used in the treatment of signs and symptoms of benign prostatic hyperplasia.

Mechanism Of Action:
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

News Articles on Tamsulosin

Benign Prostatic Hyperplasia and LUTS: Highlights From AUA 2008  -  11 Aug 2008
The Combination of Avodart and Tamsulosin (CombAT, which was sponsored by the manufacturer of Avodart [dutasteride], GlaxoSmithKline; Research Triangle Park Medscape (subscription)

Medical Management Of Benign Prostatic Hyperplasia (BPH)/Lower ...  -  11 Aug 2008
The first line of medical treatment is the class of alpha adrenergic inhibitors and include the prostate specific agents: alfuzosin and tamsulosin. Medical News Today (press release),

Treating an enlarged prostate  -  Aug 4, 2008
The two selective alpha blockers, tamsulosin and alfuzosin, are more specific to the prostate and don't lower blood pressure. Abilene Reporter-News,

Boehringer performs well in difficult environment  -  Aug 8, 2008
The blood pressure drug Micardis (telmisartan) saw sales of 603 million euros, up 11.5%, while Flomax/Alna (tamsulosin) for the treatment of benign Pharma Times (subscription),

The medicine cabinet: Exploring prostate options  -  Jul 15, 2008
Newer drugs tamsulosin and alfuzosin have much less effect on blood pressure. Side effects may include nasal stuffiness, headache, dry mouth and decreased Newsday,

Health Talk: Thinking about prostate health  -  Jul 30, 2008
Alpha blockers such as doxazosin, terazosin, alfuzosin, and tamsulosin may also provide symptomatic relief from BPH. Surgery may also be necessary if Rutland Herald,

IMPAX Sued Based on ANDA for Generic Flomax®  -  Jul 22, 2008
...of Abbreviated New Drug Application (“ANDA�) for tamsulosin hydrochloride capsules (0.4 mg), generic of Flomax®, to the Food and Drug Administration. Business Wire (press release),

IPXL: Boehringer Ingelheim and Astellas File Patent Infringement ...  -  Jul 22, 2008
...the Company's submission of Abbreviated New Drug Application ("ANDA") for tamsulosin hydrochloride capsules (0.4 mg), generic of Flomax(R), to the FDA. Trading Markets (press release),

아스텔ë?¼ìФ ‘플로맥스’ 특허침해소송 제기  -  Jul 22, 2008
...�본 아스텔�스제약� �� 베�거�겔하임� 미국�회사와 공�으로 미국�서 배뇨장애개선제 ‘플로맥스’(Flomax, tamsulosin)� 제네릭약 승�� 신청한 임팩스 래 메디파나뉴스,

ASCRS survey details risks of alpha-blockers, IFIS  -  07 Jul 2008
Ninety percent of respondents said, in their experience, IFIS was more likely to occur with Flomax (tamsulosin, Boehringer Ingelheim) than with other OSN SuperSite (subscription),

FDA Approves GlaxoSmithKline's AVODART(R) in Combination with ...  -  Jun 20, 2008
..."The combination of AVODART and tamsulosin at diagnosis allows doctors to simultaneously treat the patient's prostate on two fronts by reducing prostate FOXBusiness

Stone Disease - Randomized Clinic Trials Suggest Lack Of Benefit ...  -  Jul 6, 2008
Abstract 1491 evaluated tamsulosin vs placebo and Abstract 1410 compared alfuzosin to placbo in untreated patients trying to pass a Ureteral stone. Medical News Today (press release),

Consider Cataracts Before Prescribing Alpha Blockers for Your Patients  -  Jul 2, 2008
That's because the use of alpha blockers -- especially tamsulosin, marketed as Flomax -- is associated with an eye condition that makes cataract surgery AAFP News Now

FDA Approves Dutasteride in Combination With Tamsulosin for the ...  -  Jun 23, 2008
PHILADELPHIA -- June 23, 2008 -- The US Food and Drug Administration (FDA) has approved dutasteride (Avodart) in combination with tamsulosin for the DG News

FDA Approvals: Avodart and Trivaris  -  Jun 26, 2008
Explain the potential benefits of dutasteride plus tamsulosin combination therapy for benign prostatic hyperplasia. Medscape (subscription)

Avodart With Flomax Approved for Enlarged Prostate  -  Jun 27, 2008
The FDA has approved GlaxoSmithKline’s Avodart in combination with tamsulosin to treat enlarged prostate. Clinical data show the two medicines together FDA news (subscription),

Stone Disease: ESWL And Invasive Therapy, Including Ureteroscopy  -  Jun 23, 2008
The only caveat among these 3 studies is that patients had fewer side effects with either tamsulosin or alfuzosin vs. doxazosin. While use of alpha blockers Medical News Today (press release),

cialis faq  -  Jun 13, 2008
Tamsulosin --A single oral dose of taadlafip 10, 20 mf, or placevo was administered in a 3-period, crossovre design to healthy subjects taking 0.4 mg Journal lycéen,

Alfuzosin Stone Expulsion Therapy For Distal Ureteral Calculi: A ...  -  Jun 19, 2008
...of spontaneous stone passage is interesting in that other authors have shown an improvement in the rate of spontaneous stone passage with tamsulosin. Medical News Today (press release),

Colour confusion  -  Jun 17, 2008
Omeprozole is yellow then grey/blue then pink/cream, Tamsulosin pink/olive then brown/cream, Atenolol white then orange, and it goes on. York Press,

Now, Ranbaxy seeks peace with Takeda  -  Jun 21, 2008
Ranbaxy will be launching these products in 2008 (Sumatriptan), 2009 (Valacyclovir) and 2010 (Tamsulosin) on an exclusive basis. Business Standard,

Preop identification of alpha-blockers helps prevent IFIS ...  -  Jul 3, 2008
The drugs available in Japan, where there is a 1.1% rate of IFIS, are tamsulosin, naftopidil and silodosin, all of which have selective affinity of alpha-1A OSN SuperSite (subscription),

Meet Malav, the charismatic CEO of Ranbaxy  -  Jun 11, 2008
It agreed with Astellas/Boehringer Ingelheim to dismiss their US court case over Flomax (Tamsulosin capsules) and settled with GSK over Sumatriptan Rediff,

GSK's combination vaccine gets approval  -  Jun 26, 2008
GSK recently had its combination of Avodart and tamsulosin for the treatment of enlarged prostates approved by US regulators. Hays Pharma,

GlaxoSmithKline Gains FDA Approval On Enlarged Prostate Treatment  -  Jun 20, 2008
Avodart in combination with tamsulosin for the treatment of symptomatic enlarged prostate. The new indication reflects emerging research showing the Trading Markets (press release),

AUA: New Therapies Show Promise for BPH  -  May 27, 2008
...or to one of three active therapies: elocalcitol 75 or 150 mcg or elocalcitol 150 mcg plus the alpha blocker tamsulosin (Flomax) at a dose of 0.4 mg. MedPage Today,

For the record  -  May 14, 2008
It also said tamsulosin (Flomax) is in a class of drugs called 5-alpha-reductase inhibitors, used to help shrink the prostate. In fact, Flomax is an alpha Los Angeles Times,

Advances in treatments for enlarged prostates  -  May 9, 2008
...a drug in the same class as doxazosin, and tamsulosin (Flomax), which, like finasteride, is in a class of drugs called 5-alpha-reductase inhibitors. Los Angeles Times,

Malav at work  -  May 5, 2008
It agreed with Astellas/Boehringer Ingelheim to dismiss their US court case over Flomax (Tamsulosin capsules) and settled with GSK over Sumatriptan Business Standard,

Recommendations for Primary Care of the Patient With Cancer  -  May 16, 2008
Prostate irradiation may result in obstructive uropathy, which should be treated with α-blockers (eg, terazosin, doxazosin, and tamsulosin) or finasteride. Abkhazia,

Target Product Profiles 2008: Physician Insights on Key Attributes ...  -  May 13, 2008
A drug with lower incidence of sexual side effects than tamsulosin for the treatment of benign prostatic hyperplasia. Our Target Product Profiles Business Wire (press release),

GSK buys anti-aging enzyme expert Sirtris for $720 million  -  23 Apr 2008
The green light was based on positive two-year results from the ongoing CombAT study, which showed that combination therapy with dutasteride and tamsulosin Pharma Times (subscription),

Dutasteride Plus Tamsulosin Approved for Benign Prostatic ...  -  Apr 22, 2008
The approval was based on positive 2-year results from the ongoing Combination of Avodart and Tamsulosin (CombAT) study in men with moderate to severe BPH DG News

Efficacy of Tamsulosin as Therapy for Ureteral Stones Questioned  -  Mar 31, 2008
Inform clinicians of the latest medical information on medical therapy for ureteral stones with use of tamsulosin (an alpha-blocker) presented at the Medscape (subscription)

Dutasteride/Tamsulosin Combo Produces Multiple Benefits in Men ...  -  Mar 27, 2008
By Jill Stein MILAN, Italy -- March 27, 2008 -- Combination treatment with the dual 5 alpha-reductase inhibitor dutasteride and the alpha blocker tamsulosin DG News

Ranbaxy's net profit at USD 39mn (Rs 1530 mn), + 19%  -  Apr 22, 2008
Of them, Coltazole-OD (Cilastozole), Contiflo ICON (Tamsulosin) and Storfib Tab (Atorva + Fenofibrate 145) are the new products launched for the first time Moneycontrol.com (press release),

Ranbaxy in out-of-court pact with AstraZeneca for Nexium  -  Apr 15, 2008
In November ’07, Ranbaxy had reached an agreement with Astellas/Boehringer Ingelheim regarding Flomax (tamsulosin capsules), which will allow Ranbaxy to Financial Express,

RECORDATI: 2007 ACCOUNTS APPROVED BY THE BOARD. DIVIDEND PER SHARE ...  -  Mar 9, 2008
The study was designed to show superiority of silodosin over placebo and non-inferiority to tamsulosin in all parameters. Silodosin was found to be PR-USA.net (press release),

Competitive Advantages Position GlaxoSmithKline's Novel ...  -  Feb 26, 2008
Tamsulosin/dutasteride has competitive advantages in efficacy, safety, tolerability and delivery. This novel combination agent will earn a 10% patient share PR Newswire (press release),

New drugs for NHF  -  Mar 3, 2008
In addition, a new controlled release formulation for Tamsulosin for the treatment of benign prostatic hyperplasia was also added under the label Flomax Jamaica Gleaner,

Teva Pharmaceutical Industries Ltd reports receipt of tentative ...  -  Feb 1, 2008
...approval for its Abbreviated New Drug Application (ANDA) for Tamsulosin Hydrochloride Capsules, 0.4 mg from the US Food and Drug Administration (FDA). Trading Markets (press release),

GSK's Avodart effective in combination with Tamsulosin in prostate ...  -  Jan 17, 2008
Tamsulosin is an alpha blocker, a class of medicines that relaxes muscles in the bladder and prostate, GSK said. Ranbaxy Laboratories Ltd manufactures and CNNMoney.com

Enlarged Prostate Treatment Study Shows Combination of AVODART(R ...  -  Jan 17, 2008
The publication will mark the first time the full two-year results of the CombAT (Combination of Avodart and Tamsulosin) study, one of the largest clinical Trading Markets (press release),

Glaxosmithkline Says Combination Of Avodart And Tamsulosin ...  -  Jan 18, 2008
L) on Thursday said that the results of a two-year CombAT (Combination of Avodart and Tamsulosin) study revealed that men with enlarged prostates who were RTT News,

Teva Announces Tentative Approval Of Generic Flomax(R) Capsules  -  Feb 4, 2008
Administration has granted tentative approval for the Company's Abbreviated New Drug Application (ANDA) for Tamsulosin Hydrochloride Capsules, 0.4 mg. Medical News Today (press release),

Teva Pharmaceutical gets tentative FDA approval for generic ...  -  Jan 31, 2008
...it received tentative approval from the Food and Drug Administration for its abbreviated new drug application for its tamsulosin hydrochloride capsules. CNNMoney.com

US FDA grants tentative approval to Teva's generic Flomax capsules  -  Feb 1, 2008
The US Food and Drug Administration has granted tentative approval for Teva Pharmaceutical's abbreviated new drug application (ANDA) for tamsulosin domain-B,

Ranbaxy, GSK settle Imitrex patent issue  -  Jan 21, 2008
As per another settlement, with Astellas/BI on Flomax (Tamsulosin), Ranbaxy will enter the US market in March 2, 2010 eight weeks prior to expiration of the Times of India,

Teva Pharma Gets Tentative Approval From FDA For Generic Flomax ...  -  Jan 31, 2008
States Food and Drug Administration, or FDA, for the company's Abbreviated New Drug Application, or ANDA, for Tamsulosin Hydrochloride Capsules, 0.4 mg. Trading Markets (press release),

Market Report -- In Play (TEVA)  -  Jan 31, 2008
US Food and Drug Administration has granted tentative approval for the Abbreviated New Drug Application for Tamsulosin Hydrochloride Capsules, 0.4 mg. MSN Money

India's Ranbaxy Q4 net rises 4.4 pct, beats f'cast  -  Jan 17, 2008
In November, the company said it had resolved a US patent dispute over tamsulosin capsules, a generic equivalent of Flomax, used to treat benign prostatic Reuters

Aveva Says Q3 Was Strong; Sees FY08 Results Significantly Ahead Of ...  -  Jan 17, 2008
Tamsulosin is an alpha blocker, a class of medicines that relaxes muscles in the bladder and prostate. In the CombAT study, male patients with RTT News,

Ranbaxy's net profit increases 53% to Rs 7901mn  -  Jan 17, 2008
These products have a combined market size of around USD 3 .5 Bn. The Company plans to launch these products in 2009 (Valacyclovir) & 2010 (Tamsulosin) on Moneycontrol.com (press release),

Growing prostate may not be cancer, still cause for concern  -  Jan 29, 2008
For BPH patients, these alpha-blockers may be prescribed: tamsulosin (Flomax), alfuzosin (Uroxatral), terazosin (Hytrin) or doxazosin (Cardura). Inside Bay Area,

Brand Names/Synonyms:
Tamsulosin is also known by the following brand names and/or synonymsFlomax; Harnal; Omnic; Pradif; TAMSULOSIN; Tamsolusin; Tamsulosin; Tamsulosina [Inn-Spanish]; Tamsulosine [Inn-French]; Tamsulosinum [Inn-Latin]

Drug Category:
Tamsulosin is categorized under the following by the FDA: Antineoplastic Agents; ATC:G04CA02

Dosage Forms:
CAPSULE (SUSTAINED-RELEASE)

Absorption:
Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.

Interactions:
Interactions for Tamsulosin:

Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between FLOMAX capsules and other alpha-adrenergic blocking agents have not been determined. However, interactions may be expected and FLOMAX capsules should NOT be used in combination with other alpha-adrenergic blocking agents.

The pharmacokinetic interaction between cimetidine and FLOMAX capsules was investigated. The results indicate significant changes in tamsulosin HCI clearance (26% decrease) and AUC (44% increase). Therefore, FLOMAX capsules should be used with caution in combination with cimetidine, particularly at doses higher than 0.4 mg.

Results from limited in vitro and in vivo drug-drug interaction studies between tamsulosin HCI and warfarin are inconclusive. Therefore, caution should be exercised with concomitant administration of warfarin and FLOMAX capsules.

 

 





Chemical IUPAC Name:
5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide

:
 
Web health.mongabay.com


Health Home | Conditions | Cancer | Medications | Surgery | Vaccines

mongabay.com


Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com lead to other sites. health.mongabay.com does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com responsible for dead or misdirected links.


COPYRIGHT 2007 MONGABAY.COM