Tamsulosin

This page contains recent news articles, when available, and an overview of Tamsulosin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Tamsulosin (when available)

Pharmacology and use:
Tamsulosin, an alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). Used in the treatment of signs and symptoms of benign prostatic hyperplasia.

Mechanism Of Action:
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

News Articles on Tamsulosin

Kidney stones can cause intense pain, nausea  -  ‎Apr 19, 2009‎
Tamsulosin (Flomax), a medication that relaxes muscles in the ureter, can help, too. Because kidney stones are among the most painful conditions you're Detroit Free Press

FDA Rules on Drug Ads Sow Confusion as Applied to Web  -  ‎Apr 17, 2009‎
...which results in ads like, “Flomax® (tamsulosin HCl) www.4FLOMAX.com Capsules, 0.4 mg - Official Site for Important Product Information. New York Times

Evaluation of Selective and Non-Selective Alpha-Andrenergic ...  -  ‎Apr 7, 2009‎
Patients in Group 3 were given the selective α 1a -adrenergic receptor blocker Tamsulosin (0.4 mg) once daily in addition to the standard treatment. UroToday International Journal

Postlithotripsy Agents Improve Stone Outcomes  -  ‎Apr 2, 2009‎
MET agents used in the trials were tamsulosin, nifedipine, and Phyllanthus niruri extract. Trevor D. Schuler, MD, and colleagues at St. Michael's Hospital Renal and Urology News

Finasteride's prostate benefits confirmed  -  ‎Apr 14, 2009‎
Of the 23320 men, 1754 men (7.5%) had used finasteride and 3848 (16.5%) had used an alpha blocker (either tamsulosin or alfuzosin). Cortlandt Forum

A Broader Role for 5ARIs in Prostate Disease? Existing Evidence ...  -  ‎Mar 29, 2009‎
...while the ongoing CombAT trial (dutasteride/tamsulosin) has for the first time shown benefit in improving symptoms for combination therapy over UroToday

A Broader Role For 5ARIs In Prostate Disease? Existing Evidence ...  -  ‎Apr 14, 2009‎
Dutasteride in combination with tamsulosin (CombAT trial) is underway and interim analysis suggests similar superiority to either agent alone. Medical News Today (press release)

브랜드 항우울-제네릭 항염제 �?��?  -  ‎Apr 19, 2009‎
...다�?�으로 ‘웰부트린'�?� 21%, ‘루네스타'(Lunesta, eszopiclone)가 20.3%, ‘카타푸레스'가 19.3%, ‘플로맥스'(Flomax, tamsulosin)가 19.1%, ‘리�?�'�?� 19%�?� 순으로 디지틀보사

�?年病用�?�需求�?�?断增长�?列腺用�?�“增生�?  -  ‎Apr 2, 2009‎
...�?�洛新(tamsulosin)�?�洛新由日本山之内公�?�(Yamanouchi)开�?�，1993年以商�?�??“Harnal�?首次上市，在欧洲商�?�??为“Flomax�?。该�?�于1996年投入我国市场，国内商�?�??为“哈搜狐

AOK schlägt weiter zu  -  ‎Apr 17, 2009‎
Die Wirkstoffe Alendronsäure, Tamsulosin und Molsidomin teilen sie sich mit anderen Herstellern. Weitere Rabattverträge über einzelne Wirkstoffe und apotheke-adhoc

Reduce Ranbaxy Laboratories, target of Rs 155: IIFL  -  18 Mar 2009
..."We also expect the management to successfully shift the location of filing for the valacyclovir and tamsulosin exclusivities that are due to come through Moneycontrol.com

Effect Of Tamsulosin On Systemic Blood Pressure And Nonneurogenic ...  -  ‎Mar 16, 2009‎
UroToday.com - A study by Brian VanderBrink et al. evaluated the effect of tamsulosin on systemic blood pressure in children and non-neuropathic Medical News Today (press release)

Adding Tamsulosin Does Not Aid Ureteral Stone Passage  -  ‎Feb 26, 2009‎
Adding tamsulosin to ibuprofen and oxycodone does not improve outcomes in patients treated for ureteral stones in the emergency department (ED), Renal and Urology News

Research and Markets: Gain Insight into the Flomax Case Study ...  -  ‎Mar 9, 2009‎
Prostatic Hyperplasia) indicated product, Flomax/Tamsulosin, to differentiate the product and to boost disease awareness to expand the product market. MarketWatch (press release)

Effect of Discontinuation of 5alpha-Reductase Inhibitors on ...  -  ‎Mar 2, 2009‎
The patients were randomized into 2 groups: group 1 received finasteride 5 mg plus alfuzocin 10 mg or tamsulosin 0.2 mg daily, and group 2 received UroToday

Health column: Reader's craving for ice leads to cancer diagnosis  -  ‎Feb 24, 2009‎
A. Flomax (tamsulosin) relieves prostate problems by helping smooth muscle relax and improving urine flow. In 2005, ophthalmologists reported that patients Pottstown Mercury

�?�?�?藥�?�多胡言亂語籲藥事照護�?入長照體系  -  ‎Mar 12, 2009‎
...症�?心臟病，一天�?�?�必須�?�上�??一種藥�?，北縣執業藥師張玉錦指出，因為�?先生�?�?�進很多藥�?，憂鬱症的錠劑Venlafaxine-xR�?��?護腺肥大的藥�?Tamsulosin�?容易�?� uho優活健康網

Two Drugs Better than One for LUTS  -  Jan 22, 2009
Combination therapy with tamsulosin and extended-release oxybutynin is superior to tamsulosin alone in treating men with lower urinary tract symptoms (LUTS) Renal and Urology News,

NPA Backs Tamsulosin Switch, UK  -  Jan 23, 2009
The NPA supports the proposed POM to P switch of tamsulosin, for the treatment of lower of benign prostatic hyperplasia (BPH) - which causes lower urinary Medical News Today (press release),

Prescription Meds Over-the-Counter  -  Jan 16, 2009
The drugs in question are trimethoprim, an antibiotic often used to treat women with urinary infection cystitis, and tamsulosin (Flomax), used to treat KCEN-TV,

What's the evidence for saw palmetto plant extracts?  -  Jan 21, 2009
Comparison of a phytotherapeutic agent (Permixon) with an a-blocker (tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized guardian.co.uk,

Providing prescription drugs over the counter 'will not help patients'  -  Jan 13, 2009
64.5 per cent, said trimethoprim should not be available in pharmacies without prescription, and 79.7 per cent said the same about tamsulosin. Telegraph.co.uk,

What treatments work for chronic prostatitis?  -  Jan 21, 2009
...[4] But in a larger study, tamsulosin didn't help men who had severe symptoms for many years, and who had tried lots of different treatments. guardian.co.uk,

What's the evidence for alpha-blockers?  -  Jan 21, 2009
Wilt TJ, MacDonald R, Nelson D. Tamsulosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of guardian.co.uk,

Two Thirds Of Doctors Against Moving Antibiotic Trimethoprim To OTC  -  Jan 19, 2009
The survey also found that nearly 80% of doctors opposed the switching of the drug tamsulosin for benign prostatic hyperplasia (BPH), which is also Medical News Today (press release),

savvy senior  -  Jan 26, 2009
GERD drugs Prevacid (lansoprazole) and Aciphex (rabeprazole), and enlarged prostrate drug Flomax (tamsulosin). Many chains like Wal-Mart, Target, Seymour Herald,

Savvy Senior  -  Jan 24, 2009
GERD drugs Prevacid (lansoprazole) and Aciphex (rabeprazole), and enlarged prostrate drug Flomax (tamsulosin). Many chains like Wal-Mart, Target, Fergus Falls Daily Journal,

Incontinence, common among elderly, can be controlled  -  Jan 15, 2009
These include terazosin (Hytrin), doxazosin (Cardura), alfuzosin (Uroxatral), and tamsulosin (Flomax). Some of the older agents in this group can decrease Great Falls Tribune,

Ärzte kritisieren OTC-Freigabe  -  Jan 16, 2009
Berlin - Ärzte in Großbritannien stehen den Plänen der britischen Arzneimittelbehörde MHRA, das Antibiotikum Trimethoprim und den alpha-1-Blocker Tamsulosin apotheke-adhoc,

한국아스텔�?�스제약 ‘EMU 심�?�지엄’  -  Jan 28, 2009
...환�?들�?게 �?� 치료로 얼마나 좋아졌는가를 질문했�?� 때 플�?�시보 군�?서는 61.7%, tolterodine only 군 65.6%, tamsulosin only 군 77.5%, 콤비네�?�션 군�?서는 80% 디지틀보사,

「石�?在惱人談尿路�?石  -  Jan 14, 2009
...研究也發�?�，傳統�?護腺用藥的α-1a甲型阻斷劑（學�??Tamsulosin 中時電�?報,

GlaxoSmithKline Files Duodart Euro Marketing Authorisation  -  Dec 19, 2008
This MAA file is based on positive two year results results from the Combination of AvodartR and Tamsulosin (CombAT) study, and studies showing EasyBourse.com,

Firm applies for prostate treatment to be over the counter  -  Dec 2, 2008
Enlarged prostate treatment tamsulosin could be made available over the counter (OTC), following an application by Boehringer-Ingelheim to have Flomax Healthcare Republic (press release),

英 전립선비대약 OTC 전환 고려  -  Dec 3, 2008
...�?국�?서 전립선비대�? 치료제�?� ‘플로맥스’(Flomax, tamsulosin)�? 대한 OTC 전환�?� 고려�?�고 있다. �?국�?� �?�약품 규제당국�?� MHRA는 최근 �?��? 대한 �?�견�?� 듣기 디지틀보사,

Conservative Treatment Is the Answer  -  Nov 21, 2008
Medics considered this fact and suggested using conservative treatment – patients received a drug, which was an improved form of tamsulosin. Russia-InfoCenter,

Recordati SpA SUBMITS FILE FOR APPROVAL OF SILODOSIN TO THE EMEA  -  Nov 21, 2008
Furthermore, in theactive-controlled study conducted in Europe, silodosin 8mg once daily wasnot inferior to tamsulosin 0.4mg once daily, with an adjusted International Business Times,

21/11/08 11:58 Recordati SpA : RECORDATI DEPOSE UNE DEMANDE D ...  -  Nov 21, 2008
Furthermore, in the active-controlled study conducted in Europe, silodosin 8mg once daily was not inferior to tamsulosin 0.4mg once daily, with an adjusted TF1,

Ask the Eye Guy: Medicines can have impact on cataract surgery  -  Nov 9, 2008
The other group of medications are alpha adrenergic blockers such as Flomax (tamsulosin). This dilates blood vessels and also relaxes muscles tissue in the Annapolis Capital,

「氰�?「石�?難安從三�?�氰胺談尿路�?石治療  -  Nov 11, 2008
...若無明顯症狀，�?�多�?水加上�?�當�?�動�?��?律追蹤，待石頭自行排出；若石頭滾�?�至輸尿管，症狀�?��?嚴�?，�?�加上藥物治療（如甲型交感神經阻斷劑Tamsulosin 中時電�?報,

Floppy iris syndrome manageable with the right viscoadaptive OVD  -  Oct 8, 2008
The relaxing effect of tamsulosin on the pupil may cause damage in what might at first appear to be a standard cataract surgery. OSN SuperSite (subscription),

BPH Drugs May Differ in Effects on Fracture Risk  -  Oct 7, 2008
Examples of selective alpha-blockers include tamsulosin (Flomax) and alfuzosin (UroXatral). The authors pointed out that "a well-known adverse effect of MedPage Today,

「一箭雙雕�? �?護腺藥一藥兩用  -  Oct 7, 2008
...症狀，�?��?�增加�?石排出的機會；用於�?石的病患身上，通常以�?�擇�?血壓作用很�?的α-1a甲型阻斷劑（學�??Tamsulosin 中時電�?報,

هل يؤثر التوتر �?ي تضخم البروستاتا؟  -  Oct 4, 2008
...(Hytrin «دوكسازوسين» (كاردورا)(doxazosin (Cardura «تامسولاسين» (�?لوماكس) tamsulosin (Flomax)، «ال�?وزوسين» (يوراكساترول)(alfuzosin (Uroxatrol. الشرق الاوسط,

Suven granted Certificate of Suitability for Tamsulosin Hydrochloride  -  Aug 18, 2008
...the first Certificate of Suitability (CEP) by the European Directorate for the Quality of Medicines (EDQM) for its API product Tamsulosin Hydrochloried. Equity Bulls,

People's pharmacy: Are we overtreated and underinformed?  -  Aug 17, 2008
A. Flomax (tamsulosin) relieves prostate problems by helping smooth muscle relax and improving urine flow. In 2005, ophthalmologists reported that patients Houston Chronicle,

Astellas offers early-out for Norman workers  -  Sep 3, 2008
The restructuring comes in response to the impending patent expiration of Flomax (tamsulosin hydrochloride), a prescription drug used to treat benign Norman Transcript,

Natural remedy offers hope for prostate patients  -  Aug 30, 2008
Alpha-blockers (such as tamsulosin) relax the muscles, and 5-alpha-reductase inhibitors (eg, finasteride) shrink the prostate. Daily Mail,

Older People in Danger from Common Drugs  -  Aug 28, 2008
Safer alternatives could include single-purpose drugs such as tamsulosin (Flomax) for benign enlarged prostate and diuretics to treat high blood pressure. NewsMax.com,

Urge to eat ice can be a sign of anemia  -  Aug 23, 2008
A. Flomax (tamsulosin) relieves prostate problems by helping smooth muscle relax and improving urine flow. In 2005, ophthalmologists reported that patients Youngstown Vindicator,

當�?護腺肥大�?�上土石�?  -  Sep 14, 2008
...藥物包�?�甲型阻斷劑�?��?�爾蒙治療劑；甲型阻斷劑，如Tamsulosin 中時電�?報,

Terapia combinata per l'ipertrofia prostatica benigna  -  Sep 10, 2008
The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic Pillole.org,

Benign Prostatic Hyperplasia and LUTS: Highlights From AUA 2008  -  11 Aug 2008
The Combination of Avodart and Tamsulosin (CombAT, which was sponsored by the manufacturer of Avodart [dutasteride], GlaxoSmithKline; Research Triangle Park Medscape (subscription)

Medical Management Of Benign Prostatic Hyperplasia (BPH)/Lower ...  -  11 Aug 2008
The first line of medical treatment is the class of alpha adrenergic inhibitors and include the prostate specific agents: alfuzosin and tamsulosin. Medical News Today (press release),

Treating an enlarged prostate  -  Aug 4, 2008
The two selective alpha blockers, tamsulosin and alfuzosin, are more specific to the prostate and don't lower blood pressure. Abilene Reporter-News,

Boehringer performs well in difficult environment  -  Aug 8, 2008
The blood pressure drug Micardis (telmisartan) saw sales of 603 million euros, up 11.5%, while Flomax/Alna (tamsulosin) for the treatment of benign Pharma Times (subscription),

The medicine cabinet: Exploring prostate options  -  Jul 15, 2008
Newer drugs tamsulosin and alfuzosin have much less effect on blood pressure. Side effects may include nasal stuffiness, headache, dry mouth and decreased Newsday,

Health Talk: Thinking about prostate health  -  Jul 30, 2008
Alpha blockers such as doxazosin, terazosin, alfuzosin, and tamsulosin may also provide symptomatic relief from BPH. Surgery may also be necessary if Rutland Herald,

IMPAX Sued Based on ANDA for Generic Flomax®  -  Jul 22, 2008
...of Abbreviated New Drug Application (“ANDA�?) for tamsulosin hydrochloride capsules (0.4 mg), generic of Flomax®, to the Food and Drug Administration. Business Wire (press release),

IPXL: Boehringer Ingelheim and Astellas File Patent Infringement ...  -  Jul 22, 2008
...the Company's submission of Abbreviated New Drug Application ("ANDA") for tamsulosin hydrochloride capsules (0.4 mg), generic of Flomax(R), to the FDA. Trading Markets (press release),

아스텔�?�스 ‘플로맥스’ 특허침해소송 제기  -  Jul 22, 2008
...�?�본 아스텔�?�스제약�?� �?��?� 베�?거�?�겔하임�?� 미국�?회사와 공�?�으로 미국�?서 배뇨장애개선제 ‘플로맥스’(Flomax, tamsulosin)�?� 제네릭약 승�?��?� 신청한 임팩스 래 메디파나뉴스,

Brand Names/Synonyms:
Tamsulosin is also known by the following brand names and/or synonymsFlomax; Harnal; Omnic; Pradif; TAMSULOSIN; Tamsolusin; Tamsulosin; Tamsulosina [Inn-Spanish]; Tamsulosine [Inn-French]; Tamsulosinum [Inn-Latin]

Drug Category:
Tamsulosin is categorized under the following by the FDA: Antineoplastic Agents; ATC:G04CA02

Dosage Forms:
CAPSULE (SUSTAINED-RELEASE)

Absorption:
Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.

Interactions:
Interactions for Tamsulosin:

Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between FLOMAX capsules and other alpha-adrenergic blocking agents have not been determined. However, interactions may be expected and FLOMAX capsules should NOT be used in combination with other alpha-adrenergic blocking agents.

The pharmacokinetic interaction between cimetidine and FLOMAX capsules was investigated. The results indicate significant changes in tamsulosin HCI clearance (26% decrease) and AUC (44% increase). Therefore, FLOMAX capsules should be used with caution in combination with cimetidine, particularly at doses higher than 0.4 mg.

Results from limited in vitro and in vivo drug-drug interaction studies between tamsulosin HCI and warfarin are inconclusive. Therefore, caution should be exercised with concomitant administration of warfarin and FLOMAX capsules.

Chemical IUPAC Name:
5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide

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