Tadalafil

This page contains recent news articles, when available, and an overview of Tadalafil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Tadalafil (when available)

Pharmacology and use:
Tadalafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Tadalafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Tadalafil should not cause an erection. Used for the treatment of erectile dysfunction

Mechanism Of Action:
Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Tadalafil enhances erectile function by increasing the amount of cGMP.

News Articles on Tadalafil

Erectile Dysfunction Related To Sleep Apnea May Persist, But Is ...  -  Sep 13, 2008
In the second phase of the experiment, Dr. Gozal administered tadalafil, which increases the availability of nitric oxide through PDE5. Science Daily (press release)

Erectile Dysfunction linked to sleep apnea, but can be treated  -  Sep 15, 2008
Almost all mice showed close to normal levels of improved erectile and sexual functioning by a second treatment using tadalafil. A generic Cialis, tadalafil HealthJockey.com,

Drugs for Erectile Dysfunction - A Review of the Safest Choices  -  Sep 14, 2008
Tadalafil (Cialis) is another competitor of Viagra which gained FDA approval in 2003. It was developed by ICOS and is distributed by Lilly ICOS, LLC, Best Syndication,

The Type 5 Phosphodiesterase Inhibitor Tadalafil Influences ...  -  Sep 4, 2008
Objective: The objective of the study was to investigate whether a single oral long half-life phosphodiesterase type 5 inhibitor (tadalafil) administration Journal of Clinical Endocrinology and Metabolism,

Tadalafil May Relieve LUTS in Benign Prostatic Hyperplasia  -  Aug 19, 2008
NEW YORK -- August 19, 2008 -- According to a study appearing in the October 2008 issue of the Journal of Urology, a daily dose of tadalafil may relieve DG News

Tadalafil (Cialis) Relieves Lower Urinary Tract Symptoms of BPH  -  Aug 19, 2008
19 -- In men with signs of benign prostatic hyperplasia , the phosphodiesterase, type 5 inhibitor tadalafil (Cialis) significantly relieved lower urinary MedPage Today,

Sleep Apnea May Cause Erectile Dysfunction  -  Sep 12, 2008
A second treatment using tadalafil, which is generic Cialis and increases the availability of nitric oxide, improved erectile and sexual functioning of U.S. News & World Report,

Bogus Viagra Makers Nabbed  -  Sep 2, 2008
By Bae Ji-sook Daegu Food and Drug Administration arrested three bogus manufacturers of anti-impotence pills containing tadalafil and sildenafil, Tuesday. 코리아타임즈,

ED Drug Relieves Lower Urinary Tract Symptoms  -  Aug 19, 2008
19 (HealthDay News) -- A daily dose of the erectile dysfunction drug tadalafil (Cialis) helped relieve lower urinary tract symptoms in men with signs of Washington Post,

'Sleep disorder suppresses sex drive'  -  Sep 13, 2008
In the second phase of the experiment, Gozal administered tadalafil, which improved erectile and sexual functioning in CIH-exposed mice to near-normal Hindustan Times,

Sex-enhancing drugs killing Ghanaians  -  Sep 7, 2008
He said another synthetic compound, tadalafil, meant for treating sexual dysfunction and found in the Chinese herbal aphrodisiacs render them impure and Joy Online,

The hard facts on sexual dysfunction remedies  -  Sep 6, 2008
They can also prescribe drugs such as sildenafil and tadalafil, the generic versions of Viagra and Cialis, which work by allowing blood vessels to relax. Stuff.co.nz,

prozac online cheap glucophage  -  Sep 9, 2008
...generic bactroban analgesic tadalafil toughened to entertain man's generic prevacid and sold subsumed the mark prevacid no prescription superstar . 3DChips,

Sex Pill "Viagra" May Help Prevent Heart Attacks  -  Aug 28, 2008
Drugs like tadalafil (Cialis) and vardenafil (Levitra) also perform the similar functions. Its common side effects include sneezing, headache, flushing, TheMedGuru,

Study: Cialis Helpful for Enlarged Prostate  -  Aug 26, 2008
The study in the journal’s October issue shows a daily dose of Cialis (tadalafil) can relieve lower urinary tract symptoms associated with benign prostatic FDA news (subscription),

Hidden dangers of buying drugs on the internet  -  Aug 20, 2008
..."Last year we found Viagra which had the active ingredient sildenafil in it but also had traces of tadalafil - also an impotence drug called Cialis on the Coventry Telegraph,

'발기부전'....혹시 '수면무호�?��?' 때문  -  Sep 14, 2008
...그러나 �?� 같�?� 저산소성 호�?��? �?�한 발기능 저하는 회복�?� 수 있는 바 연구팀�?� �?� 같�?� �?들�?게 타다�?�필(Tadalafil) �?��?�는 발기부전치료성분�?� 투여한 결과 �? 마�?��?��?�리,

Impotenz: Bald tägliche Pille für den Mann  -  Sep 12, 2008
Die Tadalafil-Tablette eignet sich zur dauernden, täglichen Einnahme. Die niedrige Dosierung senkt bisherige Nebenwirkungen. Bisher mussten Männer mit Kurier,

Un estudio de la revista Urología dictamina que una dosis diaria ...  -  Aug 18, 2008
Una dosis diaria del medicamento Cialis (Tadalafil) contra la disfunción eréctil puede ayudar a hombres con signos de hiperplasia benigna de próstata (HBP) La Vanguardia,

�?ư�?ng huyết cao, ăn uống thế nào?  -  Sep 14, 2008
Donaton thành phần chính là Tadalafil 20 mg anh có thể uống 1-2 viên một tuần nếu huyết áp đã ổn định. Nếu có đi�?u gì cần xin anh cứ trao đổi thêm. Tuổi Trẻ,

Remédio contra impotência ajuda homens com problemas na próstata ...  -  Aug 19, 2008
Uma dose diária do remédio Cialis (Tadalafil) contra a disfunção erétil pode ajudar homens com sinais de hiperplasia benigna da próstata (HBP) e aliviar Folha Online,

دراسة: عقاقير العجز الجنسي تعالج تضخم البروستاتا  -  Aug 19, 2008
من مركز ساوثوسترن الطبي �?ي دالاس ان البعض حصلوا على جرعات مت�?اوتة من سياليس المعرو�? تجاريا باسم تادالا�?يل "tadalafil" بينما حصل البعض على عقاقير بديلة. رويترز العربية,

Medicamento para la disfunción eréctil alivia los síntomas del ...  -  Aug 21, 2008
La vida media del tadalafil es de 17.5 horas, lo que hace que sea apropiada como terapia de una vez al día. Aunque el mecanismo preciso de acción por el que Info7,

Prezydent nie pojawił się na konferencji Walentynowicz  -  Sep 7, 2008
Cialis, którego głównym składnikiem jest tadalafil zaczyna działać w ciągu 30 minut od momentu zastosowania a jego efekt utrzymuje do 36 godzin. e-Polityka,

‘시알리스’ 전립선비대�? 치료�? 효과  -  Aug 19, 2008
...박사와 �?��?��?� 릴리 공�?�연구팀�?� 19�?� �?�학저�? ‘비뇨기학’(Urology) 최신호�? 발표한 논문�?서 “매�?� ‘시알리스’(Cialis, tadalafil)를 복용한 남성들�?� 빈뇨, 메디파나뉴스,

Medicamento para impotencia trata el agrandamiento de la próstata  -  Aug 19, 2008
Algunos tomaron varias dosis de Cialis, conocido genéticamente como tadalafil, mientras otros tomaron placebo. Aquellos que tomaron Cialis tuvieron una 24 Horas Libre,

I farmaci inattivati dalla frutta  -  Sep 4, 2008
...il Progesterone, il Metadone, il Sildenafil (il principio attivo del Viagra), il Tadalafil (principio del Cialis) e la Carbamazepina. La Repubblica,

Farmaci contraffatti online: al primo posto le pillole dell’amore  -  Sep 7, 2008
...ha approvato 3 “inibitori della fosfodiesterasi 5�? per il trattamento della disfunzione erettile: il Sildenafil, il Vardenafil e il Tadalafil. Prontoconsumatore.it,

Píldoras saludables  -  Aug 23, 2008
Una dosis diaria del medicamento Cialis (Tadalafil) contra la disfunción eréctil puede ayudar a hombres con signos de hiperplasia benigna de próstata (HBP) La Patria (Colombia),

Full Issue  -  Aug 19, 2008
The study in the journal’s October issue says that a daily dose of Cialis (tadalafil) can relieve lower urinary tract symptoms associated with benign FDA news (subscription),

Erektilní dysfunkce  -  Aug 28, 2008
Lék obsahující látku tadalafil v jiné koncentraci užívaný pravidelně působí každodenně. Tak se páry obejdou bez jakéhokoliv plánování a vrátí se do Femina.cz,

Attenzione al mix farmaci succhi di frutta  -  Aug 20, 2008
La ricerca conferma che quando si consuma Diazepam, il Progesterone, il Metadone, il Sildenafil, il Tadalafil e la Carbamazepina non bisogna bere il succo Italia News,

Benign Prostatic Hyperplasia and LUTS: Highlights From AUA 2008  -  11 Aug 2008
To this end, Eli Lilly sponsored a dose-ranging study in which 4 doses of tadalafil (2.5, 5.0, 10.0, and 20 mg daily) or placebo were administered to men Medscape (subscription)

COLABORA AYUDANDONOS A PROMOVER LA INVESTIGACION  -  11 Aug 2008
Sildenafil, tadalafil y vadenafil son drogas utilizadas en el tratamiento de disfunción eréctil. Los efectos adversos más común es cambio en la percepción El País (España),

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet ...  -  Aug 7, 2008
Cialis(R) (tadalafil), Levitra(R) (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) (rifabutin), rifampin, FOXBusiness

Health Ministry Seizes Tainted Candy Worth RM1.18 Million  -  Jul 29, 2008
Tadalafil is a type of medicine used to treat erectile dysfunction and its has been confirmed safe for use for the ailment but the patient must first Bernama,

9 coffee brands removed for having toxic content  -  Jul 31, 2008
Another batch of coffee powder - Tai Guo Feng Nu Yang, Xinggannulang and Saoguafu - contained sildenafil and tadalafil. Both chemicals are used to treat Electric New Paper,

EU Panel Backs GSK's Pre-Pandemic Influenza Vaccine  -  Jul 25, 2008
Reference medicine is Avamys, from Glaxo Group Ltd. * Tadalafil Lilly (tadalafil), from Eli Lilly Nederland BV, for the treatment of erectile dysfunction. CNNMoney.com

Going-Concern Statement  -  Aug 6, 2008
Viagra(R) (sildenafil), Levitra(R) (vardenafil), Cialis(R) (tadalafil), Vfend(R) (voriconazole), AcipHex(R) (rabeprazole), Nexium(R) (esomeprazole), FOXBusiness

Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice-Daily ...  -  Aug 5, 2008
Viagra(R) (sildenafil), Cialis(R) (tadalafil), Levitra(R) (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) FOXBusiness

Viagra: Pleasing Women In A New Way  -  Jul 23, 2008
The research was funded by Pfizer Inc, known generically as tadalafil, and Levitra or vardenafil, sold by GlaxoSmithKline, Bayer AG and Schering-Plough, RedOrbit,

The ED Conversation Dilemma: Forty Percent of Men with ED Don't ...  -  Jul 16, 2008
Cialis(R) (tadalafil) is approved for the treatment of erectile dysfunction on an as-needed basis or in a daily regimen. The recommended starting dose of Earthtimes (press release),

Safety of Prescribing PDE-5 Inhibitors Via E-Medicine Vs ...  -  Aug 5, 2008
Tadalafil and vardenafil were prescribed in 18.8% and 7.6% of the e-medicine clients vs 4.2% (P<.001) and 5.4% (P=.16) in the traditional medicine patients, RedOrbit,

Earnings roundup: BMS to cut $1B more  -  Jul 24, 2008
Tadalafil, the ED treatment, grew sales by 24 percent. Pfizer's profits more than doubled to $2.78 billion on strong international sales growth, FiercePharma,

What's in the Bottle?  -  Jul 13, 2008
..."Last year we found Viagra that had the active ingredient sildenafil in it but also traces of tadalafil, or Cialis, an alternative to Viag ra. RedOrbit,

Committee for Medicinal Products for Human Use Summary of Positive ...  -  Jul 25, 2008
The applicant for this medicinal product is Eli Lilly Nederland BV The active substance of Tadalafil Lilly is tadalafil, a medicinal product used in PharmaLive.com (press release),

Lilly Reports Solid Second-Quarter Results  -  Jul 24, 2008
Alimta(R) (pemetrexed, Lilly) Byetta(R) (exenatide injection, Amylin Pharmaceuticals) Cialis(R) (tadalafil, Lilly) Comfortis(TM) (Lilly) Cymbalta(R) PR Newswire (press release),

�?一般新�?�】衛生署呼籲民眾�?�?購買�?��?用來�?�?明之藥�?  -  Aug 3, 2008
...「麻黃鹼類（ephedra）�?其副作用包括頭暈�?頭痛�?焦慮�?�?�?律或加速心跳�?失眠�?�血壓上昇等，長期使用�?�能會影響心臟功能；「Sildenafil�?�?�「Tadalafil �?��?�醫療網,

1年銷售�?2700�?�‧大馬壯陽藥熱賣  -  Aug 4, 2008
...“這3種壯陽春藥�?�有昔多芬（sildenafil）�?�?�那�?�（tadalafil 星洲日報,

�?�度�?用心臟衰竭‧118�?�Hotton Vitality糖果充公  -  Jul 29, 2008
...（�?�隆�?�）衛生部藥劑執法組最近充公一批總值118�?�令�?�，�?�有類似他�?�那�?�（Tadalafil 星洲日報,

市民�?�?�?用�?�有無標示西藥類似物的產�?  -  Jul 25, 2008
...在調查期間發�?�上述產�?�?�作出化驗，�?果顯示產�?�?�有「Aminotadalafil�?，它是西藥「Tadalafil 香港政府資訊中心(新�?�發布),

Cialis, contre les dysfonctionnements de l'érection  -  Jul 29, 2008
Le Cialis (Tadalafil) est au même titre que Viagra un médicament prescrit en cas de dysfonctionnement de la fonction érectile chez l'homme. Bloc.com,

Impotenza Sessuale "rimedi e dicerie"  -  Jul 30, 2008
Negli anni successivi si sono aggiunti altri due farmaci: il Vardenafil ed il Tadalafil. Il meccanismo d´azione è simile per tutti e tre, e tutti hanno Positanonews,

Viagra pode melhorar vida sexual de mulheres deprimidas  -  Jul 24, 2008
Medicamentos semelhantes, como o Cialis (laboratório Eli Lilly, nome genérico tadalafil) ou Levitra (vardenafil, da GlaxoSmithKline, O Globo Online,

A Viagra javítja a depressziós nők szexuális életét  -  Jul 24, 2008
A szakemberek úgy vélik, a szildenafil mellett a tadalafil és vardenafil hatóanyagok is ezt a hatást váltják ki. A H. George Nurnberg által vezetett csoport Index,

Segreti di letto: l’estate al tempo del Viagra  -  Jul 19, 2008
Il tadalafil, principio attivo della pasticca gialla, ha registrato fra il 2006 e il 2007 un più 18,6 per cento in termini di confezioni e più 21 come spesa Panorama,

«�?ياغرا».. وهموم الاستخدامات غير الصحيحة  -  Jul 12, 2008
لعلاج ضع�? الانتصاب * تتكون مجموعة الأدوية المتناولة عبر ال�?م لعلاج حالات ضع�? الانتصاب من «�?ياغرا» Sildenafil، و«لي�?يترا» Vardenafil، و«سيالس» Tadalafil. الشرق الاوسط,

Creato al computer il 'super-viagra' del futuro?  -  Jul 24, 2008
In silico Prediction of Novel Phosphodiesterase Type-5 Inhibitors Derived from Sildenafil, Vardenafil and Tadalafil. Bioorganic & Medicinal Chemistry, 2008. Yahoo! Italia Notizie,

Vardenafil-Einnahme bei Bedarf oder einmal täglich?  -  Jul 14, 2008
Diese Daten stehen im Einklang mit Studienergebnissen zu Tadalafil 2), das ebenfalls hinsichtlich der nachhaltigen Wirksamkeit bei Patienten mit ED in der www.inar.de,

Un 'gatillazo' no significa nada  -  Jul 12, 2008
...-Viene a ser como una Viagra a menos dosis. Después del verano, probablemente, estará en el mercado la forma farmacéutica diaria del tadalafil. La Voz de Galicia,

壯陽產�?�?��?�管制西藥  -  Jul 25, 2008
...在調查期間發�?�上述產�?�?�作出化驗，�?果顯示產�?�?�有「Aminotadalafil�?，它是西藥「Tadalafil 香港新浪網,

Viagra también ayuda a mujeres deprimidas a obtener satisfacción  -  Jul 23, 2008
Otros fármacos que funcionan de un modo similar al Viagra son Cialis de Eli Lilly and Co, conocido genéricamente como tadalafil, y Levitra o vardenafil, Buena Salud

Brand Names/Synonyms:
Tadalafil is also known by the following brand names and/or synonymsCIA; Cialis; Cialis/Tadalafil Hcl; Cialis/Taladafil; IC 351; ICOS 351; Tadalafil; Tadanafil

Drug Category:
Tadalafil is categorized under the following by the FDA: Vasoconstrictor Agents; Phosphodiesterase Inhibitors; ATC:G04BE08

Dosage Forms:
TABLET

Absorption:
After single oral-dose administration, the maximum observed plasma concentration (Cmax) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). Absolute bioavailability of tadalafil following oral dosing has not been determined.

Interactions:
Interactions for Tadalafil: Effects of Other Drugs on Tadalafil Cytochrome P450 Inhibitors: Tadalafil is a substrate of and predominantly metabolized by CYP3A4. Studies have shown that drugs that inhibit CYP3A4 can increase tadalafil exposure. Ketoconazole (400 mg daily), a selective and potent inhibitor of CYP3A4, increased tadalafil 20-mg single-dose exposure (AUC) by 312% and Cmax by 22%, relative to the values for tadalafil 20 mg alone. Ketoconazole (200 mg daily) increased tadalafil 10-mg single-dose exposure (AUC) by 107% and Cmax by 15%, relative to the values for tadalafil 10 mg alone. HIV Protease inhibitor: Ritonavir (200 mg twice daily), an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in Cmax, relative to the values for tadalafil 20 mg alone. Although specific interactions have not been studied, other HIV protease inhibitors would likely increase tadalafil exposure. Based upon these results, in patients taking concomitant potent CYP3A4 inhibitors, the dose of Tadalafil should not exceed 10 mg, and Tadalafil should not be taken more frequently than once in every 72 hours. Other cytochrome P450 inhibitors: Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. Cytochrome P450 Inducers: Studies have shown that drugs that induce CYP3A4 can decrease tadalafil exposure. Rifampin: Rifampin (600 mg daily), a CYP3A4 inducer, reduced tadalafil 10-mg single-dose exposure (AUC) by 88% and Cmax by 46%, relative to the values for tadalafil 10 mg alone. Although specific interactions have not been studied, other CYP3A4 inducers, such as carbamazepine, phenytoin, and phenobarbitol, would likely decrease tadalafil exposure. No dose adjustment is warranted. Gastrointestinal Drugs: H2 antagonists: An increase in gastric pH resulting from administration of nizatidine had no significant effect on tadalafil pharmacokinetics. Antacids: Simultaneous administration of an antacid (magnesium hydroxide/aluminum hydroxide) and tadalafil reduced the apparent rate of absorption of tadalafil without altering exposure (AUC) to tadalafil. Effects of Tadalafil on Other Drugs: Drugs Metabolized by Cytochrome P450 Tadalafil is not expected to cause clinically significant inhibition or induction of the clearance of drugs metabolized by cytochrome P450 (CYP) isoforms. Studies have shown that tadalafil does not inhibit or induce P450 isoforms CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1. CYP1A2 substrate: Tadalafil had no clinically significant effect on the pharmacokinetics of theophylline. When tadalafil was administered to subjects taking theophylline, a small augmentation (3 beats per minute) of the increase in heart rate associated with theophylline was observed. CYP3A4 substrates: Tadalafil had no clinically significant effect on exposure (AUC) to midazolam or lovastatin. CYP2C9 substrate: Tadalafil had no clinically significant effect on exposure (AUC) to S-warfarin or R-warfarin, nor did tadalafil affect changes in prothrombin time induced by warfarin. Alcohol Alcohol and PDE5 inhibitors, including tadalafil, are mild systemic vasodilators. The interaction of tadalafil with alcohol was evaluated in 3 clinical pharmacology studies. In 2 of these, alcohol was administered at a dose of 0.7 g/kg, which is equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male, and tadalafil was administered at a dose of 10 mg in 1 study and 20 mg in another. In both these studies, all patients imbibed the entire alcohol dose within 10 minutes of starting. In one of these two studies, blood alcohol levels of 0.08% were confirmed. In these two studies, more patients had clinically significant decreases in blood pressure on the combination of tadalafil and alcohol as compared to alcohol alone. Some subjects reported postural dizziness, and orthostatic hypotension was observed in some subjects. When tadalafil 20 mg was administered with a lower dose of alcohol (0.6 g/kg, which is equivalent to approximately 4 ounces of 80-proof vodka, administered in less than 10 minutes), orthostatic hypotension was not observed, dizziness occurred with similar frequency to alcohol alone, and the hypotensive effects of alcohol were not potentiated. Tadalafil did not affect alcohol plasma concentrations and alcohol did not affect tadalafil plasma concentrations. Both alcohol and Tadalafil, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Substantial consumption of alcohol (e.g., 5 units or greater) in combination with Tadalafil can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. Anti-Hypertensives PDE5 inhibitors, including tadalafil, are mild systemic vasodilators. Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected anti-hypertensive medications. Alpha Blockers Doxazosin: When tadalafil 20 mg was administered to healthy subjects taking doxazosin (8 mg daily), an alpha[1]-adrenergic blocker, there was significant augmentation of the blood-pressure-lowering effect of doxazosin. Tamsulosin: In a clinical pharmacology study, when a single dose of tadalafil 20 mg was administered to healthy subjects taking 0.4 mg once-daily tamsulosin, a selective alpha[1A]-adrenergic blocker, no significant decreases in blood pressure were observed. Therefore, based upon significant augmentation of the blood-pressure-lowering effect of doxazosin, an alpha[1]-adrenergic blocker, and no significant effect seen with 0.4 mg once-daily tamsulosin, a selective alpha[1A]-adrenergic blocker, administration of Tadalafil to patients taking any alpha-adrenergic blocker other than 0.4 mg once-daily tamsulosin is contraindicated. Other Anti-Hypertensive Agents Amlodipine: A study was conducted to assess the interaction of amlodipine (5 mg daily) and tadalafil 10 mg. There was no effect of tadalafil on amlodipine blood levels and no effect of amlodipine on tadalafil blood levels. The mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking amlodipine was 3/2 mm Hg, compared to placebo. In a similar study using tadalafil 20 mg, there were no clinically significant differences between tadalafil and placebo in subjects taking amlodipine. Metoprolol: A study was conducted to assess the interaction of sustained-release metoprolol (25 to 200 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking metoprolol was 5/3 mm Hg, compared to placebo. Bendrofluazide: A study was conducted to assess the interaction of bendrofluazide (2.5 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking bendrofluazide was 6/4 mm Hg, compared to placebo. Enalapril: A study was conducted to assess the interaction of enalapril (10 to 20 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking enalapril was 4/1 mm Hg, compared to placebo. Angiotensin II receptor blocker (and other anti-hypertensives): A study was conducted to assess the interaction of angiotensin II receptor blockers and tadalafil 20 mg. Subjects in the study were taking any marketed angiotensin II receptor blocker, either alone, as a component of a combination product, or as part of a multiple anti-hypertensive regimen. Following dosing, ambulatory measurements of blood pressure revealed differences between tadalafil and placebo of 8/4 mm Hg in systolic/diastolic blood pressure. Aspirin Tadalafil did not potentiate the increase in bleeding time caused by aspirin.

Chemical IUPAC Name:
(6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

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