|
 |
SeroquelThis page contains recent news articles, when available, and an overview of Seroquel but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Seroquel (when available) Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. For the treatment of schizophrenia and acute manic episodes associated with bipolar I disorder, as either monotherapy or adjunct therapy to lithium or divalproex. Mechanism Of Action: The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknown. However, it is thought that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) receptor antagonism. Although quetiapine is known to bind other receptors with similar affinity, only the dopamine D2 and serotonin 5HT2 receptor binding is responsible for quetiapine's therapeutic activity in schizophrenia. News Articles on Quetiapine How Big Pharma Distorts Science to Get FDA Approval for Dangerous ... - 20 Apr 2009 In March the Justice Department charged AstraZeneca with knowing and hiding the diabetes side effects of Seroquel. But this month the FDA considers AlterNet The Mother's Act - Mandatory Screening of Moms for Depression is ... - 20 Apr 2009 The rest of the world apparently has not gone mad because the US accounted for over $3 billion of the close to $4.5 billion of worldwide sales of Seroquel, Natural News.com Antipsychotic drug for dementia have adverse effects - 20 Apr 2009 ...treatment with olanzapine (Zyprexa) , quetiapine (Seroquel), and risperidone (Risperdal); they could switch antipsychotic medication during the trial. Reuters UK A minor victory in Seroquel battle - Apr 9, 2009 By Miriam Hill WASHINGTON - A government panel opened the door a crack yesterday toward allowing AstraZeneca PLC to sell its Seroquel XR more widely, Philadelphia Inquirer Conflicts for FDA committee set to weigh risks of Seroquel - Apr 4, 2009 By Miriam Hill AstraZeneca PLC paid Florida child psychiatrist Jorge Armenteros to talk to other doctors about prescribing Seroquel, the company's powerful Philadelphia Inquirer Seroquel Should Not Be First Choice For Depression - Apr 12, 2009 Due to its worrisome side effects, federal health experts declared that Seroquel should not be a first choice to treat depression. Seroquel is made by InjuryBoard.com FDA Panel:Seroquel Safe As Add-On Therapy For Depression - Apr 8, 2009 By Jennifer Corbett Dooren WASHINGTON (Dow Jones)--A Food and Drug Administration panel said Wednesday that Seroquel could be used as add-on therapy for Wall Street Journal Amylin defends Byetta to skittish investors; AstraZeneca awaits ... - Apr 8, 2009 Report > Scientists from British drugmaker AstraZeneca will try to convince an FDA advisory panel today that the schizophrenia drug Seroquel should be FiercePharma FDA Panel Opposes Seroquel for Depression, Anxiety Indications - Apr 10, 2009 Cardiac, metabolic and other risks of AstraZeneca's atypical antipsychotic Seroquel extended release (XR) make the drug generally not safe as a stand-alone FDA news (subscription) BRIEF-AstraZeneca says FDA posts Seroquel XR meeting documents on ... - Apr 3, 2009 Neither the Subscriber nor Thomson Reuters warrants the completeness or accuracy of the Service or the suitability of the Service as a trading aid and Forbes Alzheimer's Patients on Atypical Antipsychotics Experience ... - Apr 17, 2009 HealthDay News reports that in a study of over 400 elderly patients, medications such as Zyprexa (olanzapine) and Seroquel (quetiapine) were both linked to Newsinferno.com Veterans, families mark 'small victory' in drug battle - Apr 11, 2009 Despite testimony from the families of two Charleston veterans who died in their sleep while taking Seroquel, a Food and Drug Administration advisory panel Charleston Gazette Biovail Fires Back At AstraZeneca In Seroquel IP Suit - Apr 6, 2009 2009) -- Biovail Corp. has become the latest generics maker to ask a court to invalidate or rule unenforceable two patents for Seroquel XR — AstraZeneca IP Law360 (subscription) Astra’s Seroquel to get FDA panel meeting - Mar 30, 2009 AstraZeneca Plc's schizophrenia drug Seroquel will be the topic of a US Food and Drug Administration advisory committee meeting June 9 and 10 on the use of Philadelphia Inquirer Santa Clara County jails cut off prescription-drug pipeline - Apr 6, 2009 But the latest way to get stoned behind bars has been Seroquel and Wellbutrin, expensive psychotropic drugs that inmates obtain by pretending to be San Jose Mercury News Dementia patient given wrong medication - Apr 14, 2009 Dear Dr. Gott: I am writing to thank you for writing the article about Seroquel being risky for elderly patients. My wife is 82 years old and has had The Spokesman Review Seroquel Clinical Trial Documents Should Be Releases . - Mar 29, 2009 Ted Baker of Bastrop, LA was diagnosed with post-traumatic stress disorder and major depressive disorder and prescribed Seroquel in 2001. InjuryBoard.com Legislation requires doctors to get state permission before ... - Apr 1, 2009 Thousands of Texas children under 2 years old have been prescribed anti-psychotics like Seroquel and Risperdal, Turner said – drugs that treat schizophrenia Dallas Morning News Seroquel XR approved for treatment of bipolar disorder - Apr 2, 2009 AstraZeneca wish to announce that the once-daily formulation Seroquel XR (quetiapine) has been approved for new indications in bipolar disorder. Irish Medical Times How insurers secretly blacklist millions with common ailments - Mar 29, 2009 Use the anti-clotting drug Plavix or Seroquel, prescribed for anti-psychotic or sleep problems? Forget about it. What's more, you can discover that if you MiamiHerald.com AstraZeneca, Barclays, Hays, Misys: UK, Irish Equity Preview - Apr 9, 2009 AstraZeneca Plc (AZN LN): The UK's second largest drugmaker's schizophrenia drug Seroquel is safe and effective for treating anxiety and major depression Bloomberg Dillon woman accused of sewing drugs in underwear - Apr 13, 2009 A search of the cells and inmates reportedly produced an additional seven pairs of Hanes boxer shorts all with slits in the waistband and 13 Seroquel Montana's News Station Updated FDA, Clinical Trial Calendars: Myriad Pharma Announces ... - Apr 9, 2009 AstraZeneca (AZN): The Seroquel (quetiapine) XR sNDA is a pending application by AZN to expand the drug's label to treat adults with major depressive Seeking Alpha Can Consumers Also Have Conflicts of Interest? - Apr 13, 2009 ...‘Seroquel was part of his cocktail.' Margy Lawrence sat on the advisory committee panel that recommended against granting Seroquel approval for additional PsychCentral.com Apotex Wins Approval to Copy AstraZeneca’s Pulmicort - Apr 3, 2009 The shares also were hurt by an FDA staff report suggesting the schizophrenia drug Seroquel XR may pose risks with long-term use. Bloomberg US FDA advisory meetings through June 3 - Apr 6, 2009 L) for Seroquel XR for the treatment of major depressive disorder and generalized anxiety disorder. Particular safety issues for discussion on April 8, Reuters Kids and antipsychotics: Prescriptions on the rise - Apr 10, 2009 In June, the FDA will consider a petition by AstraZeneca for permission to promote the use of Seroquel by adolescents (ages 13 to 17) with schizophrenia and Los Angeles Times AstraZeneca a Hold for Now - Apr 13, 2009 Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Zacks.com US sees death concern in schizophrenia drugs - Apr 3, 2009 AstraZeneca has applied to more widely promote its approved blockbuster schizophrenia treatment Seroquel XR for patients with depression and anxiety. Reuters Fewer potent pills go to youngest patients - Apr 2, 2009 Another dramatic change: Nearly 40 percent fewer doctors are even bothering to write prescriptions for these drugs including Risperdal, Abilify, Seroquel Ocala AstraZeneca's "Smoke and Mirrors" Man Has New Job in Medical Writing - Apr 6, 2009 He was the one who, in 1997, wrote a memo about Seroquel that praised the company’s efforts to put a “positive spin� on “this cursed study,� and added: I am BNET Probation given in drug case - Apr 10, 2009 The officer said he also found 12 boxes of Seroquel tablets (a prescription drug that is used to treat a variety of mental illness) and a pipe that York News-Times St. Petersburg Times Examines Decline in Antipsychotic Drug ... - Mar 31, 2009 In April 2008, the state began to require physicians to seek approval from the state before writing prescriptions for Risperdal, Abilify, Seroquel, Kaiser network.org » Regulatory Affairs Officer/Senior Regulatory Affairs Office - Apr 15, 2009 A US Food and Drug Administration (FDA) panel has ruled that AstraZeneca's Seroquel is safe and... Regulatory Affairs Job Opportunity. Hays Pharma A college student's erratic behavior draws unwanted attention - Apr 1, 2009 Ms. A was admitted and started on oral medications, including quetiapine (Seroquel) 100 mg nightly, thiamine 100 mg daily for seven days, lorazepam (Ativan) Clinical Advisor Marketing to docs might affect what drugs they prescribe - Apr 7, 2009 That article details how drug representatives for Seroquel wheedled and flattered doctors and gave them gifts and highly paid speaking engagements, Vero Beach Press-Journal (subscription) An invasion of privacy - Apr 1, 2009 Also on the list for rejection are people who use certain drugs, including anti-clotting Plavix and sleep aid Seroquel. Ingenix says the information helps Las Vegas Sun Schizophrenic patients denied treatment during drug trials - Mar 31, 2009 The case which surfaced this week involves the testing of Seroquel, a medicine used for treating schizophrenia and several other mental disorders, RT Biotech/Pharma Docket - Apr 15, 2009 The '288 and '437 patents cover Seroquel® XR, which is used to treat schizophrenia and bipolar disorder, and which is AstraZeneca's best selling drug. Patent Docs Statins Dethroned - Mar 30, 2009 A Harvard doctor who argued for their use in kids is under attack, and Astra is being accused of burying bad data on Seroquel. Forbes Does Your Child Have Schizophrenia? - Apr 19, 2009 Despite the billions a year schizophrenia drugs like Seroquel make in off label marketing, schizophrenia is a rare disease affecting only 2.4 million US Scoop.co.nz FDA Weighs Heart Risks of Seroquel for Depression - Apr 6, 2009 TRENTON, NJ (AP) - Drugmaker Bristol-Myers Squibb Co., seeking to bolster revenue during a crucial period, said it has struck a deal with a Japanese partner Drug Discovery & Development AstraZeneca Chief Open to Small Deals - Apr 14, 2009 AstraZeneca, which makes Crestor cholesterol-lowering pills and the antipsychotic Seroquel, largely stayed on the sidelines this year as Pfizer Inc. agreed Wall Street Journal Add-on treatment may reduce treatment-associated weight gain ... - Mar 29, 2009 Antipsychotic drugs, such as olanzapine (Zyprexa), risperidone (Risperdal) and quetiapine (Seroquel), are commonly used to treat psychotic disorders like News-Medical.net UK Stocks Drop, Trim Longest Streak of Weekly Gains Since ’07 - Apr 3, 2009 AstraZeneca Plc fell 3.1 percent as the US Food and Drug Administration requested more safety data for its Seroquel XR drug. The benchmark FTSE 100 Index Bloomberg BRIEF-FDA panel to weigh Astra's Seroquel for youngsters in June - Mar 30, 2009 Interactive Investor Trading Limited, trading as "Interactive Investor", is authorised and regulated by the Financial Services Authority. Interactive Investor UK at a Glance-UK Stocks -- Factors to watch on April 9 - Apr 8, 2009 AstraZeneca's Seroquel XR schizophrenia drug is safe enough for treating some patients with depression, a US Food & Drug Administration advisory panel said Interactive Investor Student arrested on 11 counts of drug charges - Apr 17, 2009 ...a small amount of cocaine, six pills of Ritalin, 47 pills of Adderall, 10 pills of Ativan and one pill of Seroquel from Faulkner's room. UConn Daily Campus Try these tips to save money on medicine - Apr 12, 2009 ...generics as their patents run out, including the cholesterol-lowering statin Lipitor, the asthma medication Advair and the antipsychotic Seroquel. The Tennessean Mothers Act Fuels Multibillion Dollar Industry - Apr 6, 2009 ..."I've taken many medications, including Effexor, Celexa, Seroquel, Risperdal, Wellbutrin, Luvox, Cymbalta, etc. Throughout all of them, I was on the road to Scoop.co.nz Brand Names/Synonyms: Seroquel is also known by the following brand names and/or synonymsCHEMBANK1802; Quetiapin Hemifumarate; Quetiapine; Quetiapine Fumarate; Quetiapine Hemifumarate; Seroquel; ZD5077 Drug Category: Seroquel is categorized under the following by the FDA: Antipsychotics; ATC:N05AH04 Dosage Forms: TABLET Absorption: Rapidly and well absorbed. Interactions: -->Interactions for Quetiapine: The risks of using SEROQUEL in combination with other drugs have not been extensively evaluated in systematic studies. Given the primary CNS effects of SEROQUEL, caution should be used when it is taken in combination with other centrally acting drugs. SEROQUEL potentiated the cognitive and motor effects of alcohol in a clinical trial in subjects with selected psychotic disorders, and alcoholic beverages should be avoided while taking SEROQUEL. Because of its potential for inducing hypotension, SEROQUEL may enhance the effects of certain antihypertensive agents. SEROQUEL may antagonize the effects of levodopa and dopamine agonists. The Effect of Other Drugs on Quetiapine Phenytoin: Coadministration of quetiapine (250 mg tid) and phenytoin (100 mg tid) increased the mean oral clearance of quetiapine by 5-fold. Increased doses of SEROQUEL may be required to maintain control of symptoms of schizophrenia in patients receiving quetiapine and phenytoin, or other hepatic enzyme inducers (e.g., carbamazepine, barbiturates, rifampin, glucocorticoids). Caution should be taken if phenytoin is withdrawn and replaced with a non-inducer (e.g., valproate). Divalproex: Coadministration of quetiapine (150 mg bid) and divalproex (500 mg bid) increased the mean maximum plasma concentration of quetiapine at steady state by 17% without affecting the extent of absorption or mean oral clearance. Thioridazine: Thioridazine (200 mg bid) increased the oral clearance of quetiapine (300 mg bid) by 65%. Cimetidine: Administration of multiple daily doses of cimetidine (400 mg tid for 4 days) resulted in a 20% decrease in the mean oral clearance of quetiapine (150 mg tid). Dosage adjustment for quetiapine is not required when it is given with cimetidine. P450 3A Inhibitors: Coadministration of ketoconazole (200 mg once daily for 4 days), a potent inhibitor of cytochrome P4503A, reduced oral clearance of quetiapine by 84%, resulting in a 335% increase in maximum plasma concentration of quetiapine. Caution is indicated when SEROQUEL is administered with ketoconazole and other inhibitors of cytochrome P450 3A (e.g., itraconazole, fluconazole, and erythromycin). Fluoxetine, Imipramine, Haloperidol, and Risperidone: Coadministration of fluoxetine (60 mg once daily); imipramine (75 mg bid), haloperidol (7.5 mg bid), or risperidone (3 mg bid) with quetiapine (300 mg bid) did not alter the steady-state pharmacokinetics of quetiapine. Effect of Quetiapine on Other Drugs Lorazepam: The mean oral clearance of lorazepam (2 mg, single dose) was reduced by 20% in the presence of quetiapine administered as 250 mg tid dosing. Divalproex: The mean maximum concentration and extent of absorption of total and free valproic acid at steady state were decreased by 10 to 12% when divalproex (500 mg bid) was administered with quetiapine (150 mg bid). The mean oral clearance of total valproic acid (administered as divalproex 500 mg bid) was increased by 11% in the presence of quetiapine (150 mg bid). The changes were not significant Lithium: Concomitant administration of quetiapine (250 mg tid) with lithium had no effect on any of the steady-state pharmacokinetic parameters of lithium. Antipyrine: Administration of multiple daily doses up to 750 mg/day (on a tid schedule) of quetiapine to subjects with selected psychotic disorders had no clinically relevant effect on the clearance of antipyrine or urinary recovery of antipyrine metabolites. These results indicate that quetiapine does not significantly induce hepatic enzymes responsible for cytochrome P450 mediated metabolism of antipyrine. Chemical IUPAC Name: Not Available : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |