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RisperidoneThis page contains recent news articles, when available, and an overview of Risperidone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Risperidone (when available) Risperidone is an atypical antipsychotic medication. It is most often used to treat delusional psychosis (including schizophrenia), but Risperidone is also used to treat some forms of bipolar disorder and psychotic depression. It also has shown some success in treating symptoms of Asperger's Syndrome and autism. Risperidone is now the most commonly prescribed antipsychotic medication in the United States. For the treatment of schizophrenia Mechanism Of Action: Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and speech. Blockade of serotonergic 5-HT2 receptors in the mesocortical tract, causes an excess of dopamine and an increase in dopamine transmission, resulting in an increase in dopamine transmission and an elimination of core negative symptoms. Dopamine receptors in the nigrostriatal pathway are not affected by risperidone and extrapyramidal effects are avoided. Like other 5-HT2 antagonists, risperidone also binds at alpha(1)-adrenergic receptors and, to a lesser extent, at histamine H1 and alpha(2)-adrenergic receptors. News Articles on Risperidone Antipsychotic drug for dementia have adverse effects - 20 Apr 2009 The effect on weight was significant for olanzapine and quetiapine, but less so for risperidone. Olanzapine was also significantly associated with increased Reuters UK Mentally ill man raped, murdered daughter after warnings ignored - 20 Apr 2009 The judgment revealed he had stopped taking the antipsychotic drug, Risperidone, and resumed smoking large quantities of cannabis. NEWS.com.au FDA Review Questions Cardiac, Suicide Risks for Investigational ... - Apr 6, 2009 But use of the drug was temporarily suspended after an online database indicated that sertindole might cause more deaths than risperidone (Risperdal). MedPage Today J&J Turns to Pipeline as Generics Take Their Toll - Apr 17, 2009 J&J needs new products after Risperdal (risperidone) became subject to generic competition last year and 17 generic competitors for Topamax (topiramate), FDA news (subscription) Successful Smoking Cessation and Improvement of Negative Symptoms ... - Apr 9, 2009 He was then put on depot medication which he received every 14 days (risperidone, 37.5 mg). He smoked cigarettes for 5 years, increasing to 30 cigarettes a Journal of Neuropsychiatry (subscription) Children's use of anti-psychotics increases despite concerns - Apr 13, 2009 Meanwhile, the FDA approved the use of risperidone in children with schizophrenia. The agency is scheduled in June to review AstraZeneca's application to SmartBrief Dr Reddy`s gets tentative nod from USFDA for Ranitidine - Apr 16, 2009 Recently, the company has received a tentative nod for Risperidone in strength of 1 mg/ml from the United States Food and Drug Administration (USFDA). Myiris.com Woman claims Walgreen's dispensed wrong dosage for daughter - Mar 30, 2009 Rama called for .25 milliliters of Risperidone to be taken twice a day. However, when Kiley went to pick up the prescription, Walgreen's instructed her to St. Clair Record Cost-effectiveness model comparing olanzapine and other oral ... - Apr 8, 2009 In addition, olanzapine resulted in more QALYs than risperidone (0.733 vs. 0.719). The base case and multiple sensitivity analyses found olanzapine to be 7thSpace Interactive (press release) Maintenance of Response with Atypical Antipsychotics in the ... - Apr 1, 2009 This post-hoc analysis describes maintenance of response over 24 or 28 weeks in people treated for schizophrenia with olanzapine, risperidone, quetiapine, 7thSpace Interactive (press release) Drugs may raise weight, good cholesterol of Alzheimer's patients - Apr 16, 2009 Another drug, risperidone, wasn't associated with harmful metabolic changes, according to findings from the Clinical Antipsychotic Trials of Intervention USA Today Lundbeck's Serdolect Fails to Win Support, Prove Suicide-Risk ... - Apr 10, 2009 ...antipsychotic Serdolect, which has a fivefold increased risk for sudden cardiac death and no proven advantage in suicide risk compared with risperidone. FDA news (subscription) Woman robbed of asthma medication - Apr 6, 2009 Police said the purse contained Apo-Risperidone, Apo-Bromocriptine Mesylate, Pulmicort Turbuhaler Budesonide, an asthma puffer and Bricanyl puffer. Winnipeg Sun Biederman's Finances: He Names His Own Price, and It's $550 an Hour - Mar 29, 2009 Risperidone is used in adults as well, as you know. Q: Sure. Would it surprise you to learn that over 20 percent of all the Risperdal that’s used is used in BNET Researcher Alleged to Have Ensured Positive Results To Drug Makers - Apr 3, 2009 One slide referred to a plan to conduct a trial of risperidone, an antipsychotic drug, on preschool children. He allegedly claimed he would support the InjuryBoard.com Senator Grassley Is Looking At Doctor Yes For Big Pharma - Apr 7, 2009 One of the slides offered "critical competitive data on safety and efficacy of risperidone (an antipsychotic) in children" others talked about other ways to InjuryBoard.com Dr. Sikich Replies - Apr 1, 2009 Sikich L, Hamer RM, Bashford RA, Sheitman BB, Lieberman JA: A pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, Am J Psychiatry (subscription) What Are Options for Treating PICA? Part 2 - Apr 16, 2009 Drugs like olanzapine, risperidone, or clozapine have shown to be more easily tolerated and produce relief in many cases. Isolated reports do indicate that EmpowHer FDA Panel Snubs Seroquel as 1st Choice Depression Treatment - Apr 8, 2009 ...clozapine (Clozaril), olanzapine (Zyprexa) and risperidone (Risperdal) -- were probably low, and the drugs remained appropriate for certain patients. Forbes Conflicts for FDA committee set to weigh risks of Seroquel - Apr 4, 2009 In addition to being a paid speaker for AstraZeneca, he proposed research comparing Seroquel to Risperidone, a competing psychotic used to treat aggression Philadelphia Inquirer Kids and antipsychotics: Prescriptions on the rise - Apr 10, 2009 Among the atypical antipsychotics, only risperidone (marketed as Risperdal) has been approved by the Food and Drug Administration for use by children Los Angeles Times Alkermes, Swinging For the Fence, Touts New Anti-Addiction Drug - Apr 7, 2009 It licensed that technology to partners to help improve their products, and it scored a hit with a long-acting version of the schizophrenia drug risperidone Xconomy Solid results for J&J as generic competition batters key drugs - Apr 15, 2009 Turnover from the antipsychotic Risperdal (risperidone) collapsed 66.0% to $275 million, as generic competition tore into US sales of the blockbuster (down Pharma Times Corcept Therapeutics Announces Fourth Quarter and Full Year 2008 ... - Mar 30, 2009 The group of medications known as atypical antipsychotics, including olanzapine, risperidone, clozapine and quetiapine, are widely used to treat FOXBusiness J&J eliminates 900 positions as Simponi is approved in Canada - Apr 14, 2009 She added that “it’s not simply about losing patentsâ€?, notably on the antipsychotic Risperdal (risperidone) and the migraine drug Topamax (topiramate), Pharma Times Schizophrenia - Novel Treatment May Provide Relief - Apr 1, 2009 ...take pregnenolone or placebo for eight weeks in conjunction with a newer antipsychotic medication (aripiprazole, olanzapine, quetiapine or risperidone). HealthNewsDigest.com Some Doctors Looking to Cut Industry Funding - Apr 1, 2009 ...to major drug maker Johnson & Johnson (J&J) before the start of some clinical trials for Risperdal (Risperidone), an atypical antipsychotic medication. Newsinferno.com Lithium Prophylaxis in Kleine-Levin Syndrome - Apr 9, 2009 She had received treatment from the third episode onward with various drugs including risperidone, olanzapine, valproate, carbamazepine, topiramate, Journal of Neuropsychiatry (subscription) What are the side effects of Sizodon? - Apr 1, 2009 Sizodon (risperidone) is a very potent (strong) medicine given for the treatment of Schizophrenia and Mania. Its side effects are: Agitation, anxiety, NDTV.com Haloperidol changes mRNA expression of a QKI splice variant in ... - Mar 31, 2009 ...(HOG) cell lines were treated with five different antipsychotic drugs including Haloperidol, Aripiprazole, Clozapine, Olanzapine and Risperidone. 7thSpace Interactive (press release) Dr Kamal K Sharma, MD, Lupin Ltd - Mar 31, 2009 The recently launched Amlodipine ‘Amel’ continues to maintain majority market share and Risperidone ‘Amel’, which was launched last year, remains market India Infoline.com Heavy metal detox - Mar 31, 2009 ...aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, and zotep-ine) against the earlier generation of these drugs. What Doctors Don't Tell You Brain-Derived Neurotrophic Factor Val66Met Polymorphism ... - Apr 9, 2009 ...neurotrophic factor and tyrosine kinase receptor TRKB in rat brain are significantly altered after haloperidol and risperidone administration. Journal of Neuropsychiatry (subscription) Mortality and tardive dyskinesia: long-term study using the US ... - Mar 31, 2009 However, the highest rate occurred in those receiving the lowest dose of risperidone, suggesting that this group may have been at higher risk and thus British Journal of Psychiatry Add-on treatment may reduce treatment-associated weight gain ... - Mar 29, 2009 Antipsychotic drugs, such as olanzapine (Zyprexa), risperidone (Risperdal) and quetiapine (Seroquel), are commonly used to treat psychotic disorders like News-Medical.net Antipsicotici atipici di incerto beneficio nell'Alzheimer - Mar 31, 2009 Si tratta di uno studio randomizzato in cieco nel quale sono stati arruolati 421 pazienti, trattati con olanzapina, quetiapina, risperidone o placebo Pillole.org å“ˆä½›åŒ»å¸ˆæ¶‰å«Œæ”¶è´¿é€ å?‡ç¾Žè®®å‘˜æ·±å…¥è°ƒæŸ¥ - Mar 29, 2009 Risperidone（利螺环酮）是专门用æ?¥æ²»ç–—诸如幻觉ã€?妄想ã€?æ•Œæ„?ç‰ç²¾ç¥žå¼‚常现象的精神科用è?¯ã€‚ 比德曼医生在讨论2005å¹´é‡?è¦?ç ”ç©¶è®¡åˆ’çš„ä¸€ä¸ªåŒ»å¦ç®€æŠ¥ä¸ï¼Œä¿?è¯?æ??供强生è?¯ 大纪元 Voorzitter FDA comité dr. Jorge Armenteros werd betaald voor ... - Apr 5, 2009 Naast een betaalde spreker te zijn voor AstraZeneca, stelde hij voor om Seroquel met Risperidone (Risperdal) te vergelijken, een concurerend medicijn dat Medical facts Galantamine Shows Good Efficacy Compared With Risperidone in ... - Mar 16, 2009 By Chris Berrie PRAGUE, Czech Republic -- March 16, 2009 -- Galantamine shows good safety and tolerability and generally equal effects to risperidone in the DG News States Begin Targeting Drug Company Marketing Practices - Mar 12, 2009 A judge fined the company $4.5 million last week, agreeing with McGraw that its marketing of the antipsychotic drug risperidone (Risperdal) and a MedPage Today Dr Reddy`s Lab gets USFDA approval for Risperidone tablet - Feb 24, 2009 Dr Reddy`s Labs has received final approval from the US Food and Drug Administration (USFDA) to market Risperidone tablet in the strength of 0.5 mg and 2 mg Myiris.com Families complain over hospital consultant - Mar 12, 2009 Dr Black diagnosed Mr Gidley with Alzheimer's disease and gave him antipsychotic drug Risperidone. The family say Mr Gidley's health started to decline Express & Echo Mortality With Antipsychotic Use in Alzheimer Disease - Mar 4, 2009 3 Ballard and colleagues reported that atypical antipsychotics other than risperidone had not been included in their study and that treatment with the other Psychiatric Times Police issue warning about lost pills - Mar 7, 2009 3, Rabeprazole, Risperidone, Citalopram, Zopiclone, Diazepam, Amitriptyline and Naproxen. Police advised the tablets can be dangerous if taken by someone Winnipeg Sun RISK: Antipsychotics for Alzheimer's tested - Feb 26, 2009 Caveats: Nearly all participants taking an antipsychotic took risperidone (Risperdal) or haloperidol (Haldol); whether the findings apply to other drugs is Winston-Salem Journal J&J Replies to Complete Response for Invega NDA - Feb 20, 2009 ...maintenance treatment of schizophrenia with less frequent doses. The drug is a metabolite of Risperdal (risperidone), another atypical antipsychotic drug. FDA news (subscription) Dr Reddy`s Lab gets USFDA approval for Buspirone Hydrochloride Tablet - Mar 3, 2009 Recently, the company has received final approval to market Risperidone tablet in the strength of 0.5 mg and 2 mg. Shares of the company closed down Rs 0.55 Myiris.com Redefining Antipsychotics - Mar 9, 2009 In order of approval, these are risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and paliperidone. Although the degree to which this group of Medscape Speaking out for Autism - Mar 14, 2009 It should be noted that both of these drugs - Ritalin and Risperidone - are also recommended for the `treatment` of children with ADHD – whether you American Chronicle Exclusive: GPs face crackdown on dementia prescribing - Mar 11, 2009 The review was launched after reports that GPs were prescribing risperidone and olanzapine despite safety concerns. The Alzheimer's Society advice, Healthcare Republic Johnson & Johnson To Pay $4.5 Million - Mar 10, 2009 Risperdal is a brand name for risperidone, a drug used in treating bipolar disorder, schizophrenia, Alzheimer's disease, dementia in the elderly and Wheeling Intelligencer Appraising a guideline for preventing acute care falls - Mar 12, 2009 Medications included lorazepam and risperidone for psychiatric symptoms. In the emergency room, the patient was confused and disoriented. Modern Medicine Update on Conflicts of Interest Allegations - Mar 4, 2009 In one e-mail, a company official stated, “The rationale of this center is to generate and disseminate data supporting the use of risperidone in this Psychiatric Times Cardiac Death Risk Rises With Both Antipsychotic Types - Mar 6, 2009 The antipsychotic medications included in the analysis were haloperidol, thioridazine, clozapine, olanzapine, quetiapine, and risperidone. Psychiatric News FDA Considers Pediatric Indications for Antipsychotics - Mar 6, 2009 Drugs included the antipsychotics olanzapine (Zyprexa) and risperidone (Risperdal). Although not yet finding sufficient evidence of safety and efficacy in Psychiatric Times Two nurses at Rockland Psych Center cited, fined - Feb 23, 2009 27, 2007, when another nurse brought to his attention the fact that a patient had not received the prescription drug risperidone between Nov. 7 and Nov. Lower Hudson Journal news Cuban Medical Lab to Increase Production - Mar 10, 2009 MEDILIP will also insert in its industrial line the denominated Risperidone, and micro-crystalline cellulose dedicated to combat basic gastritis. Prensa Latina Ask the Expert: Geriatric Psychiatry - Feb 25, 2009 Early in the decade, the FDA conducted an extensive meta-analysis of the 17 placebo-controlled North American and European trials of risperidone, Focus (subscription) Families of the Wounded Fund to benefifrom auction and gala this ... - Feb 25, 2009 ...age 35 and currently taking one of five medications for schizophrenia, including olanzaphine, risperidone/paliperidone, quetiapine or aripiprazole. Chesterfield Observer (subscription) Data Demonstrates Metabolic Benefits of Adding CORLUX(R) to ... - Feb 23, 2009 Bristol Myers Squibb and Otsuka American Pharmaceutical) Clozaril® (clozapine, Novartis) Geodon® (ziprasidone, Pfizer) Risperdal® (risperidone, Janssen, MSNBC Brand Names/Synonyms: Risperidone is also known by the following brand names and/or synonymsCHEMBANK1795; R118; Remeron; Risperdal; Risperdal Consta; Risperdal M-Tab; Risperidal M-Tab; Risperidona [Spanish]; Risperidone; Risperidone [Usan:Ban:Inn]; Risperidonum [Latin]; Risperin; Rispolept; Rispolin; Sequinan Drug Category: Risperidone is categorized under the following by the FDA: Antipsychotics; Antipsychotics; ATC:N05AX08 Dosage Forms: Tablets and oral solution Absorption: Risperidone is well absorbed. The absolute oral bioavailability of risperidone is 70% (CV=25%). The relative oral bioavailability of risperidone from a tablet is 94% (CV=10%) when compared to a solution. Pharmacokinetic studies showed that RISPERDAL® M-TAB™ Orally Disintegrating Tablets and RISPERDAL® Oral Solution are bioequivalent to RISPERDAL® Tablets Interactions: -->Interactions for Risperidone: The interactions of RISPERDAL® and other drugs have not been systematically evaluated. Given the primary CNS effects of risperidone, caution should be used when RISPERDAL® is taken in combination with other centrally acting drugs and alcohol. Because of its potential for inducing hypotension, RISPERDAL® may enhance the hypotensive effects of other therapeutic agents with this potential. RISPERDAL® may antagonize the effects of levodopa and dopamine agonists. Amytriptyline does not affect the pharmacokinetics of risperidone or the active antipsychotic fraction. Cimetidine and ranitidine increased the bioavailability of risperidone, but only marginally increased the plasma concentration of the active antipsychotic fraction. Chronic administration of clozapine with risperidone may decrease the clearance of risperidone. Carbamazepine and Other Enzyme Inducers In a drug interaction study in schizophrenic patients, 11 subjects received risperidone titrated to 6 mg/day for 3 weeks, followed by concurrent administration of carbamazepine for an additional 3 weeks. During co-administration, the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone, were decreased by about 50%. Plasma concentrations of carbamazepine did not appear to be affected. The dose of risperidone may need to be titrated accordingly for patients receiving carbamazepine, particularly during initiation or discontinuation of carbamazepine therapy. Co-administration of other known enzyme inducers (e.g., phenytoin, rifampin, and phenobarbital) with risperidone may cause similar decreases in the combined plasma concentrations of risperidone and 9-hydroxyrisperidone, which could lead to decreased efficacy of risperidone treatment. Fluoxetine and Paroxetine Fluoxetine (20 mg QD) and paroxetine (20 mg QD) have been shown to increase the plasma concentration of risperidone 2.5-2.8 fold and 3-9 fold respectively. Fluoxetine did not affect the plasma concentration of 9-hydroxyrisperidone. Paroxetine lowered the concentration of 9-hydroxyrisperidone an average of 13%. When either concomitant fluoxetine or paroxetine is initiated or discontinued, the physician should re-evaluate the dosing of RISPERDAL®. The effects of discontinuation of concomitant fluoxetine or paroxetine therapy on the pharmacokinetics of risperidone and 9-hydroxyrisperidone have not been studied. Lithium Repeated oral doses of risperidone (3 mg BID) did not affect the exposure (AUC) or peak plasma concentrations (Cmax) of lithium (n=13). Valproate Repeated oral doses of risperidone (4 mg QD) did not affect the pre-dose or average plasma concentrations and exposure (AUC) of valproate (1000 mg/day in three divided doses) compared to placebo (n=21). However, there was a 20% increase in valproate peak plasma concentration (Cmax) after concomitant administration of risperidone. Digoxin RISPERDAL® (0.25 mg BID) did not show a clinically relevant effect on the pharmacokinetics of digoxin. Drugs That Inhibit CYP 2D6 and Other CYPIsozymes Risperidone is metabolized to 9-hydroxyrisperidone by CYP 2D6, an enzyme that is polymorphic in the population and that can be inhibited by a variety of psychotropic and other drugs. Drug interactions that reduce the metabolism of risperidone to 9-hydroxyrisperidone would increase the plasma concentrations of risperidone and lower the concentrations of 9-hydroxyrisperidone. Analysis of clinical studies involving a modest number of poor metabolizers (n 70) does not suggest that poor and extensive metabolizers have different rates of adverse effects. No comparison of effectiveness in the two groups has been made. In vitro studies showed that drugs metabolized by other CYPisozymes, including 1A1, 1A2, 2C9, 2C19, and 3A4, are only weak inhibitors of risperidone metabolism. There were no significant interactions between risperidone and erythromycin. Drugs Metabolized by CYP 2D6 In vitro studies indicate that risperidone is a relatively weak inhibitor of CYP 2D6. Therefore, RISPERDAL® is not expected to substantially inhibit the clearance of drugs that are metabolized by this enzymatic pathway. In drug interaction studies, risperidone did not significantly affect the pharmacokinetics of donepezil and galantamine, which are metabolized by CYP 2D6. |
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