Restoril

This page contains recent news articles, when available, and an overview of Restoril but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Restoril (when available)

Pharmacology and use:
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. For the short-term treatment of insomnia (generally 7-10 days).

Mechanism Of Action:
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

News Articles on Temazepam

US Judge Denies Covidien Effort To Block Generic Sleep Drug  -  ‎Aug 5, 2009‎
At issue is a 7.5 milligram generic version of Restoril, which is the smallest of four available doses. Restoril is not a major product for Covidien, Wall Street Journal

Michael Jackson and his many doctors  -  ‎Aug 29, 2009‎
When investigators searched Michael Jackson's home, they found bottles of Valium, Floxmax, (Lorazepam)Ativan, Restoril, and (Diprivan) Propofol. Examiner.com

Biotech/Pharma Docket  -  ‎Aug 11, 2009‎
...of New Jersey denied Covidien's bid to enjoin URL Pharma from marketing or manufacturing a generic version of Restoril®, Covidien's sleep disorder drug. Patent Docs

Guest opinion: War on drugs picks wrong target in marijuana  -  ‎Aug 7, 2009‎
Upon beginning use of marijuana, the patient was able to discontinue Neurontin (for nerve pain), Flexeril (for muscle spasm), Restoril and Phenergan (for Billings Gazette

Michael Jackson's Final Hours: A Timeline  -  ‎Aug 25, 2009‎
...prescribed by Murray to Jackson, including: diazepam (Valium), prostate medication tamsulosin (Flomax), lorazepam (Ativan) and tempazepam (Restoril). MTV.com

Caregiver gets probation in pill case  -  ‎Aug 26, 2009‎
Claire McKim's doctor at the time, Richard Wacksman, testified in his deposition that Restoril, the medication John McKim gave to his wife, wouldn't have Tampa Tribune

Mylan Receives FDA Approval For Additional Strength Of Generic ...  -  ‎Jun 26, 2009‎
Temazepam Capsules are the generic version of Mallinckrodt's Restoril®, a sleep aid, which had total US sales of approximately $6 million for the 12 months Medical News Today (press release)

Dad blames Ledger for own death  -  ‎Jul 8, 2009‎
Following the actor's death in January 2008, dad appeared to excuse his son after traces of painkiller ibuprofen and sleeping pills, Restoril and Unisom Metro

Stanley C. Bell, 78, scientist  -  ‎Jul 12, 2009‎
They include oxazepam (Serax) and temazepam (Restoril), both used to treat anxiety disorders, and lorazepam (Ativan), used to treat anxiety and reduce Philadelphia Inquirer

Generic ambien  -  ‎Jul 2, 2009‎
Watch video for Answer watch for any purpose is temazepam Restoril. Like ambien and the drug is already available in generic. Stores are used in this case Tiscali.cz

Cancer treatment given the green light  -  ‎Jul 8, 2009‎
The FDA has recently approved Mylan's sleeping therapy Temazepam, which is the generic version of Mallinckrodt's Restoril treatment. Hays Pharma

Fear Jacko Drug Death Was Like Heath Ledger's  -  ‎Jun 27, 2009‎
They are generic names for the narcotic painkiller OxyContin, the anti-anxiety drugs Valium and Xanax, and the sleep aids Restoril and Unisom. Sky News

A Side Effect of Michael Jackson's Tragic Death – Consumer Health ...  -  ‎Jul 1, 2009‎
The passing of Heath Ledger and Anna Nicole Smith also led to increased consumer research on medications such as OxyContin, Xanax, Valium, Ativan, Restoril Advertiser Talk

El coctel de la muerte  -  ‎Jul 4, 2009‎
...(recetado para la neumonía que padecía), valium y xanax (para la ansiedad), restoril y unisom (para ayudarlo a conciliar el sueño) e ibuprofeno. El Espectador (Colombia)

El caso Jackson-Murray: Las sobredosis van en ascenso  -  ‎Jun 27, 2009‎
Otras medicinas de las que generalmente se abusa y que son recetadas están los sedantes Halcion y Restoril, los tranquilizantes Thorazine y Haldol, Urgente 24

La mariguana y la hipocresía de los legisladores  -  ‎Apr 16, 2009‎
Tafil, Lexotan, Librium, Risolid, Valium, Apzepam, Ativan, Restoril, entre otras muchas de este tipo), no necesariamente aumenta su consumo. La Jornada (México)

Live Blogging Top Chef: The Final Episode  -  ‎Feb 25, 2009‎
...while I run through these highlights from last week's live blog: Emeril was so uncharacteristically sedate, his name might as well have been "Restoril. Gawker

Make Some $$$s From Your Lack Of ZZZs (SEPR, SNY)  -  ‎Mar 9, 2009‎
Other players in the sleep aid market include Covidien's (NYSE:COV) Restoril, Japanese pharmaceutical giant Takeda Pharmaceutical's Rozerem and King Investopedia

Elusive pulmonary symptoms prove difficult to pin down  -  Jan 30, 2009
Medications included lorazepam (Ativan), docusate sodium (Colace), temazepam (Restoril), aspirin, valsartan, metformin, glimepiride (Amaryl), Clinical Advisor,

Looking for treatment or just drugs?  -  Jan 29, 2009
...hydrocodone and acetaminophen (Vicodin), and hydromorphone (Dilaudid) for pain; temazepam (Restoril) for insomnia; and lorazepam (Ativan) for anxiety. Clinical Advisor,

What About Pain Pills and Similar Medications?  -  Jan 17, 2009
Valium, Xanax, Ativan, Librium, Paxipam, Restoril, Serax, Tranxene, and Centrax are older versions of medications often prescribed to resolve all kinds of NewsReleaseWire.com (press release)

What Killed Heath Ledger Could Kill You, Too!  -  Dec 17, 2008
Temazepam, sold under such names as Restoril and Euhypnos, is a sleeping agent. Doxylamine, an antihistamine, can be obtained over the counter as a sleep Single Minded Women,

Seven False Starts About the Death of Wallace  -  Dec 4, 2008
...attempts,�? and two weeks earlier had been prescribed a regimen of Nardil, Klonopin and Restoril to treat depression, panic attacks and sleeplessness. LA City Beat,

Your date with destiny - Strategies to finding your soulmate  -  Nov 28, 2008
...the benzodiazepines such as flunizatrazepam called rohypnol or roofies and ruffies, temazepam (restoril), midazolam (Versed), clonazepam (Klonopin), Jamaica Gleaner,

As some sleeping pills double your risk of a car crash, the ...  -  Dec 1, 2008
Types include: diazepam (under the brand name Valium), temazepam (Restoril), loprazolam (Ativan) or nitrazepam (Apodorm and Mogadon). Daily Mail,

Heath Ledger murió de una sobredosis de varias medicinas controladas.  -  Dec 19, 2008
Las drogas fueron las pastillas para el dolor OxyContin; ansiolíticos, Valium y TXanax; para dormir, Restoril y Unismo; y Hydrocone, otro nombre usado para ENEWSPAPER,

الحبوب المنومة أضرار أكثر من �?وائد  -  Dec 13, 2008
وتتضمن انواع هذه المجموعة: ديازيبام (diazepam) والذي يباع بالاسم المعرو�? �?اليوم (Valium)، وتيمازيبام Temazepam (ريستوريل Restoril)، ولوبرازولام Loprazolam الخليج,

Husband changed mind about killing spouse and self, authorities say  -  Nov 12, 2008
His arrest report says he gave his wife Restoril, a prescription sleep aid on the morning of Nov. 3 at their home on Hearthstone Court in Gulf Trace. Tampabay.com,

I've had insomnia for years. Is there a biological cause?  -  Nov 2, 2008
The fact that low GABA levels may be linked to insomnia fits with the fact that many sleeping pills such as Ambien, Halcion, Restoril, Lunesta, Boston Globe (registration),

Economic Downturn Claims A Gay Man's Life  -  Nov 7, 2008
With his body purged, it appeared the combination of Valium and Restoril were not enough to take his life, and the pair went off to sleep. On Top Magazine,

His Job at Bear Gone, Mr. Fox Chose Suicide  -  Nov 5, 2008
State medical records indicate that large concentrations of the tranquilizer Valium and the sleep aid Restoril were in his system that night, Wall Street Journal

The Wall Street Journal helps to Find Your Inner Scrooge  -  Nov 10, 2008
We learn that Fox went home on the day he received the bad news and overdosed on Valium and Restoril, and later jumped off his balcony to his death. Huffington Post,

Tres metralletas de `rap´ «con salud, dinero y amor»  -  Nov 6, 2008
...`Nunca´, `Restoril´, `Quemando billetes´, `Yo me tiro rap hasta las tantas´ o `Rapeaba antes peor´ son algunas de las canciones que completarán su actuación Diario de Ibiza,

Heath Ledger insurance claim  -  Sep 30, 2008
He took among other drugs some painkillers like OxyContin and Vicodinalong with Valium and Xanax which are anti anxiety drugs and the sleeping pill Restoril WiredPRNews.com (press release),

Benzodiazepines- Prescription Drugs Deadly If Abused  -  Oct 1, 2008
Shorter-acting benzodiazepines used to manage insomnia include estazolam (ProSom®), flurazepam (Dalmane®), temazepam (Restoril®), and triazolam (Halcion®). TransWorldNews (press release),

长期�?用安眠�?�病情会�?�化对�?�康有害无益  -  Oct 19, 2008
...标志的。20世纪70年代，一个巨大的�?破�?�自于当时引进的苯二氮类（benzodiazepine）�?�物——如海�?神（Halcion）�?三唑安定（Xanax）�?替马西泮胶囊（Restoril 中国网,

히스레저�?� 딸 대리�?�, 보험회사 1000달러 고소  -  Sep 30, 2008
...약물�?� OxyContin과 Vicodin, Valium and Xanax등과 같�?� 신경안정제, Restoril and Unisom같�?� 수면제. 수면 보조제로 사용�?�는 히스타민�?� �?�함하고 있다. 아�?�비타임즈,

Prescription Drugs More Deadly Than Cocaine, Heroin, Amphetamines  -  Sep 2, 2008
Diazepam (Valium) and Lorazepam (Ativan), the sleeping pill Zopiclone (Lunesta) and the sedative Temazepam (Restoril), which is also used for insomnia. Natural News.com,

Report: Case of Ledger's death is closed  -  Aug 6, 2008
Although Ledger had prescriptions for the Xanax, Valium and Restoril found in his system, he apparently did not have any for the OxyContin or Vicodin he had United Press International

Video: Put Your Sleep Issues To Bed  -  Aug 7, 2008
Twenty-four million prescriptions were written for the top four sleep drugs – Ambien (SNY), Lunesta (SEPR), Sonata (KG) and Restoril (COV) – in the last MainStreet,

Drug Testing 101  -  Aug 9, 2008
...such as Oxycodone, Oxymorphone, Hydrocodone, Hydromorphone, benzodiazepines (Valium, Xanax, Klonopin, Restoril), MDMA (ecstasy), GHB and barbiturates. AskMen

The Dark Night: Hollywood and Sleeping Pills  -  Jul 21, 2008
But there are many medications that are frequently given for insomnia, including Temazepam (Restoril), Clonazepam (Klonopin), Lorazepam (Ativan), PR Web (press release),

Caine talks about Ledger's death  -  Jul 14, 2008
...of six different medications, including the painkiller OxyContin, the anti-anxiety drugs Valium and Xanax and the sleeping pills Restoril and Unisom. TVNZ,

Benzodiazepines-Dangerous Drug Addiction  -  Jul 26, 2008
Shorter-acting benzodiazepines used to manage insomnia include estazolam (ProSom®), flurazepam (Dalmane®), temazepam (Restoril®), and triazolam (Halcion®). TransWorldNews (press release),

Accidental Overdose Killed Heath Ledger  -  Jul 18, 2008
...those drugs include the anti-anxiety medications Valium and Xanax, the painkillers OxyContin and Hydrocodone, and the sleeping aids Restoril and Unisom. Buzzle,

�?овый фильм о Б�?тмене бьет рекорды проката  -  Jul 20, 2008
а также �?нотворными — Ре�?торил (Restoril) и Юни�?ом (Unisom). Гидрокодон — болеутол�?ющие �?ред�?тво, которое врачи ча�?то пропи�?ывают пациентам. Ро�?балт.RU,

Use Caution When Stopping Meds  -  May 31, 2008
Sleeping pills: Ambien (zolpidem), Sonata, Lunesta and Restoril (temazepam) and Klonopin (clonazepam). Most sleepers are physically addictive, Best of Times,

Sepracor To Acquire Oryx Pharmaceuticals Inc. And Expand  -  May 5, 2008
The company's portfolio consists of 14 specialized products, including NIASPAN, ADVICOR, ANGIOMAX, NAPRELAN, CUBICIN, TRILEPTAL and RESTORIL and is Pharmaceutical Online (press release),

Heath Ledger Doctors Cleared After Investigation  -  Apr 7, 2008
Toxicology reports determined that the aforementioned drugs mixed with anti-anxiety drug Valium, sleep aid Restoril, anti-anxiety medication Xanax and sleep NewsOXY,

Can insomnia kill?  -  Mar 30, 2008
That might explain the variety of benzodiazepines he took that night -- Valium, Zanax and Restoril. All are effective at quieting a whirring mind. Los Angeles Times,

Use caution when stopping meds  -  Mar 25, 2008
Sleeping pills: Ambien (zolpidem), Sonata, Lunesta and Restoril (temazepam) and Klonopin (clonazepam). Most sleepers are physically addictive, Ocala.com,

Understanding Heath Ledger's death  -  Mar 5, 2008
Ledger's toxicology report revealed that he had ingested two sleep medications (Restoril and Unisom), two potent narcotics (oxycodone and hydrocodone) and Salon

Sleeping Pill Use Rises, Even for the Young  -  Mar 5, 2008
Two sleep aids were among the seven drugs in Heath Ledger’s system when he died at age 28: temazepam, sold as Restoril; and doxylamine, an ingredient in Wall Street Journal

2 doctors cleared of wrongdoing in Ledger's death  -  Feb 29, 2008
Toxicology reports determined that the aforementioned drugs mixed with anti-anxiety drug Valium, sleep aid Restoril, anti-anxiety medication Xanax and sleep Houston Chronicle,

Students speak about drug abuse  -  Feb 22, 2008
To put it in laymen's terms, he more than likely overdosed from mixing together OxyContin, Vicodin, Valium, Xanax and Restoril, but the report did not use The Reflector online,

LEDGER’S ACCIDENTAL DEATH HIGHLIGHTS POTENTIAL RISK OF DEPENDING ...  -  Feb 12, 2008
The three benzodiazepines on the list were diazepam (known to many as Valium), alprazolam (marketed as Xanax) and temazepam (often sold as Restoril or USPRwire (press release),

Prescription Drugs, Not Illegal Ones, Killed Heath Ledger  -  Feb 14, 2008
Of course, it has been joined by painkillers like Vicodin, sleeping pills like Restoril, anti-anxiety poppers like Valium and Xanax, and even antihistamines AlterNet,

Ledger's death turns a new spotlight on 'polypharmacy'  -  Feb 11, 2008
Ledger had taken three of them: Valium and Xanax for anxiety, and Restoril for sleep. It's possible, Lackner says, that Ledger forgot he already had taken USA Today

Three Actors to Assume Heath's Last Role in Magic Movie  -  Feb 18, 2008
OxyContin) and hydrocodone (Vicodin); the anti-anxiety and anti-insomnia drugs diazepam (Valium), temazepam (Restoril), and alprazolam (Xanax); The Money Times,

A Hollywood death spiral  -  Feb 14, 2008
He died of a lethal cocktail of prescription drugs -- among them medications that go by the brand names OxyContin, Vicodin, Valium, Xanax, Restoril and AZ Central.com,

Brand Names/Synonyms:
Restoril is also known by the following brand names and/or synonymsApo-Temazepam; Cerepax; Crisonar; ER 115; Euhypnos; Euipnos; Gelthix; Hydroxydiazepam; K-3917; Levanxene; Levanxol; Levanzene; Mabertin; Methyloxazepam; N-Methyloxazepam; Normison; Novo-Temazepam; Oxydiazepam; Perdorm; Planum; Remestan; Restoril; Signopam; Temaz; Temazepam; WY 2917; Wy-3917

Drug Category:
Restoril is categorized under the following by the FDA: Anti-anxiety Agents; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05CD07

Dosage Forms:
CAPSULE (7.5 mg, 15 mg, and 30 mg)

Absorption:
Well absorbed, minimal first-pass metabolism.

Interactions:
Interactions for Temazepam:

The pharmacokinetic profile of temazepam does not appear to be altered by orally administered cimetidine dosed according to labeling.

Chemical IUPAC Name:
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one

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