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RenovaThis page contains recent news articles, when available, and an overview of Renova but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Renova (when available) Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. Mechanism Of Action: Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown. News Articles on Tretinoin Living green - 30 Aug 2009 ...'Vince' is Vincent Battaglia, cofounder of Renova Solar in Palm Desert. Renova began with an energy audit on the house, showing what could be achieved by The Desert Sun Couture renova contrato com o UFC - 30 Aug 2009 Após o UFC 102, neste sábado, o americano revelou que renovou seu contrato por mais seis lutas com a organização. Os combates devem acontecer nos próximos UOL Esporte Escola Diocesana de Música renova plano de estudos - 30 Aug 2009 A renovação do plano de estudos ea alteração do horário das aulas são algumas das novidades do ano lectivo na Escola de Música da Diocese de Aveiro. Notícias de Aveiro Simpósio renova a esperança no tratamento de lesões incuráveis - 30 Aug 2009 O 1º Simpósio Internacional de Medicina Regenerativa em Ortopedia e Traumatologia reuniu médicos e pesquisadores de todo o Brasil e também do exterior, Jornal da Manhã - Uberaba Oerlikon CEO leaves after H1 loss, more job cuts - Aug 24, 2009 VX) main shareholder Renova pushed Chief Executive Uwe Krueger out of the Swiss technology group on Tuesday as it posted its latest set of disappointing Reuters Preview: Round 4 - Aug 29, 2009 Renova will host Vardar and Sloga Jugomagnat will be facing Teteks. Renova will be playing against Vardar in a match that will be televised live on national MacedonianFootball.com Russian Investor's Ally Dormann In As Sulzer Chairman - Aug 19, 2009 EB) after his investment firm Renova succeeded in getting Juergen Dormann elected as the Swiss machinery maker's new chairman. The appointment of Dormann at Wall Street Journal Joint Venture of Rusnano and Renova places 120 MW end-to-end line ... - Aug 27, 2009 Oerlikon Solar has announced that Nano Solar Technology Ltd. (NST), a newly formed Russian high-tech joint venture between Renova Group and the Russian Renewable Energy Magazine (press release) 6-Man South football preview - Aug 27, 2009 Noteworthy: The Cougars will be aiming for an 11th straight playoff appearance. A strong junior class will be led by Harrison, Renova and Ruth. Billings Gazette Group seeks energy grant - Aug 27, 2009 If the system is successful, Grimm said it could be adopted at the Renova site, located along Boyer Avenue and Larch Street, to fuel the site's future Bonner County Daily Bee Major Mongolian coal project could begin next fall - Report - Aug 28, 2009 A consortium of Russia Basic Element, Renova and Severstal bid in the first round. However Severstal said just over a month ago that it was pulling out of SteelGuru Loudoun County Animal Watch - Aug 8, 2009 ASHBURN, Renova Terr., Aug. 1. A cat was reported to have been hit by a car. An animal control officer met with the cat's pet sitter, who said the cat had Washington Post Renova to Triple Yekaterinburg Residential Construction in 2010 - Aug 10, 2009 10-08-09, 11:02, (Property Xpress) - Russian Renova-StroyGroup-Academy, part of Renova group, plans to launch 250000 sq. m of residential space in its Property Xpress (subscription) Vekselberg Company Orders Solar Modules Worth $277M - Aug 17, 2009 Nano Solar Technology, a joint venture between Vekselberg's Renova Group and Rusnano, ordered a 120-megawatt production line for thin-film solar modules, The Moscow Times Russian billionaire strengthens hold on Sulzer - Aug 18, 2009 Vekselberg's investment group Renova holds about 31 per cent of Sulzer. It already had two representatives on the board. Today's vote means that Vekselberg Swissinfo TNK-BP shakes up board - Aug 6, 2009 Officials at TNK-BP, a joint venture between BP and Alfa-Access-Renova group, have been at odds over the direction of the board of executives since at least United Press International Preview: Round 4 - Aug 22, 2009 Only 4 matches to be played on Sunday, after the postponing of Renova - Vardar and Sloga Jugomagnat - Teteks. In Skopje table leaders Rabotnicki and MacedonianFootball.com Preview: Round 3 - Aug 15, 2009 Champions Makedonija Gjorche Petrov after a slow start with only 1 point won from the two matches played in Tetovo against Renova and Teteks will host MacedonianFootball.com Preview: Round 2 - Aug 8, 2009 Derby will be played in Tetovo between Renova and Makedonija Gjorce Petrov and in Skopje Vardar and Teteks will remind us on the good old times. MacedonianFootball.com Macedonian First League - Round 4 - Aug 23, 2009 The matches Renova-Vardar and Sloga-Teteks were postponed because of security reasons. Rabotnicki noted an easy 3:0 win in the duel between the two leading MacedonianFootball.com Oerlikon Expands Thin Film Line to Russia - Aug 20, 2009 NST is a Joint Venture between Renova Group and the Russian Corporation of Nanotechnologies (Rusnano). The order includes Oerlikon Solar's Micromorph Reuters Macedonian First League - Round 3 - Aug 16, 2009 On the other matches from the third round, Rabotnicki defeated Renova, Pelister, Teteks and Sileks also noted home wins, while Metalurg won the only point MacedonianFootball.com 3 points deduction for Pobeda - Aug 21, 2009 Renova against Vardar and Sloga Jugomagnat against Teteks will not be played this weekend because of safety reasons. The new dates are yet to be announced. MacedonianFootball.com Weekly Investor Round Up - Aug 21, 2009 Nano Solar Technology is a joint venture between Renova Group (W7A.BE) and the Russian Corporation of Nanotechnologies (Rusnano). If completed as planned, SustainableBusiness.com Dudnyk Announces Promotion Of Laurie Bartolomeo To Associate ... - Aug 26, 2009 Laurie has worked with a number of prominent healthcare brands, including Floxin, Glucovance, Levaquin, Pravachol, Propecia, Renova, and Retin-A Micro. PharmaLive.com (press release) Semi-Annual Results 2009 / Management Changes at OC Oerlikon - Aug 26, 2009 ...a newly-formed Russian high-tech firm which is a joint venture between Renova Group and the Russian Corporation of Nanotechnologies (Rusnano). ENF - PV Industry Info Jürgen Dormann new Chairman of the Board - Aug 21, 2009 The proposal of the Renova Group, the single largest shareholder, to de-elect Louis Hughes and Thor HÃ¥kstad was approved as well. Impeller.net (press release) Russian PVC producer expands with oven acquisition - Aug 25, 2009 The unit will be gas fuelled and employ technology from Vinnolit, part of the Russian industrial group Renova Orgsyntes Holding. Plastics & Rubber Weekly TNK-BP production reaches 1 million tons - Aug 21, 2009 TNK-BP is Russia's third largest oil company, 50% owned by BP and 50% owned by AAR (Alfa, Access Renova). TNK-BP also owns close to 50% of another Russian Oil and Gas Industry Latest News NST Places World's Largest Solar PV Equipment Order for 2009 - Aug 19, 2009 Renova Group and the Russian Corporation of Nanotechnologies (Rusnano) recently formed a joint venture company, Nano Solar Technology Ltd. (NST). Electric.co.uk Fire Cracker at Makedonija GP, Komiti cause trouble - Aug 16, 2009 Rabotnicki defeated a solid Renova team, while Sileks and Teteks wrapped up the wins for the home teams against Sloga and Pobeda respectively. MINA Seven Points: Ts.Elbegdorj and Mongolian-Russian Cooperation - Aug 6, 2009 Such Russian companies as Renova, The Base Element and Severstal have already shown interest in participating in this project and had united in the UB Post Macedonian First League - Round 2 - Aug 9, 2009 Renova defeated Makedonija, Pelister managed to surprise Metalurg, while Sloga and Turnovo played only 79 minutes as the match was interrupted because of MacedonianFootball.com Sulzer H1 shines, but downbeat on full year - Aug 24, 2009 Russian billionaire Viktor Vekselberg holds a 31 percent stake in Sulzer as well a controlling stake in Oerlikon through his holding company Renova. Forex Pros Benfica renova contrato do paraguaio Óscar Cardozo até 2014 - Aug 29, 2009 Lisboa, 29 ago (EFE).- O Benfica informou à comissão de valores mobiliários de Portugal que renovou o contrato do atacante paraguaio Óscar Cardozo até 2014, EFE A TARDE se renova com reforma gráfica e editorial - Aug 29, 2009 Desde a sua fundação por Ernesto Simões Filho, em 1912, e depois sob a liderança de Regina Simões de Mello Leitão e Renato Simões, uma das marcas de A TARDE A Tarde On Line No Palmeiras, Muricy Ramalho renova antigos laços e adota novos ... - Aug 28, 2009 O primeiro surgiu ainda na infância, quando a diversão era o futebol sem compromisso e os papos com os famosos rolavam solto na casa no bairro de Pinheiros, globoesporte.com OC Oerlikon/Renova begrüsst Ernennung von Hans Ziegler zum CEO - Aug 24, 2009 Zürich (awp) - Renova als grösster Aktionär der OC Oerlikon Corporation AG begrüsst die Ernennung von Hans Ziegler als Delegierten des Verwaltungsrates und Handelszeitung Online Crédito novo cai 8,7%, inadimplência renova recorde - Aug 26, 2009 BRASÃ?LIA (Reuters) - As novas concessões de crédito no Brasil registraram queda de 8,7 por cento em julho ante junho na comparação da média diária, O Globo Medio Ambiente. El Plan Renova sustituye los vehÃculos de Quito - Aug 21, 2009 Los transportistas escolares de Quito que se afiliaron al Plan Renova, que impulsa el Ministerio de Industrias, obtendrán sus vehÃculos nuevos el próximo El Comercio (Ecuador) Hungria renova por dois anos com técnico Koeman - Aug 26, 2009 A Federação Húngara de Futebol anunciou nesta quarta-feira a renovação de contrato por dois anos do técnico Erwin Koeman. Com isso, o holandês fica no cargo Terra Brasil LowLandLions renova line-up - Aug 28, 2009 Um dos principais times da Bélgica anunciou hoje uma completa renovação para as próximas competições. O LowLandLions, que pela primeira vez terá uma line Made in Brazil Kamali não renova com o Atlético-PR - Aug 25, 2009 O atacante Abdullah Al Kamali deixou o Atlético Paranaense nessa segunda-feira para voltar aos Emirados Ã?rabes. O jogador, de 19 anos, ficou no Furacão O Globo OC Oerlikon/Renova salue la nomination de Hans Ziegler comme CEO - Aug 24, 2009 Zurich (awp) - Renova, principal actionnaire d'OC Oerlikon Corporation AG, salue la nomination de Hans Ziegler comme administrateur-délégué et CEO du groupe Romandie.com Entroncamento renova-se para o Turismo - Aug 28, 2009 Acabou de ser inaugurado o monumento ao ferroviário, junto ao posto de turismo do Entroncamento, frontal à estação de caminhos de ferro, em plena Praça da Opção Turismo Avaà renova com Medina e outras duas promessas - Aug 25, 2009 Querendo manter suas principais revelações, o Avaà anunciou nesta terça-feira a renovação de três jogadores formados em suas categorias de base. Abril Verdão dispensa cinco e renova com Indinho - Aug 27, 2009 O Uberlândia Esporte Clube anunciou ontem a dispensa de cinco atletas do elenco profissional. Desde a desclassificação do time no Campeonato Brasileiro Correio de Uberlândia Plan Renova entregó busetas escolares - Aug 24, 2009 Seis buses de transporte escolar fueron entregados por el Ministerio de Industrias, como parte del Plan Renova. El Plan, en general, ha renovado unos seis El Telégrafo - Ecuador Brand Names/Synonyms: Renova is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid Drug Category: Renova is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22 Dosage Forms: CAPSULE; CREAM; GEL; LIQUID Absorption: 1-31% (topical); Interactions: Interactions for Tretinoin: Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA. RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity. Chemical IUPAC Name: 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid : |
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