Renova

This page contains recent news articles, when available, and an overview of Renova but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Renova (when available)

Pharmacology and use:
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Mechanism Of Action:
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

News Articles on Tretinoin

Sulzer,Renova won't have to make buyout offer-EBK  -  02 Jun 2008
S: Quote, Profile, Research) and its shareholder Renova will not have to offer to buy out other shareholders in Sulzer as the two do not form a single group Reuters

DomainerMeeting to be Held in Paris  -  02 Jun 2008
EuroDNS, Domain Sponsor, EP Services, Fabulous, dotAsia, Renova, InterNetX, Namemedia, Namedrive, Fusu, dotMobi, Modern Domainer, Domain News, Realtime, WebHosting.Info,

TNK-BP Chief Refuses to Step Down  -  Jun 1, 2008
BP and the Alfa-Access-Renova, or AAR, shareholders met informally for talks on the island, however, and are set to continue their talks this week, The Moscow Times,

Renova biggest OC Oerlikon shareholder after buying 14.1 pct stake ...  -  May 12, 2008
ZURICH (Thomson Financial) - Renova Industries Ltd. has hiked its stake in Swiss technology group OC Oerlikon Corp AG. to 39.1 percent by acquiring a 14.1 Forbes,

UPDATE 1-Renova tightens grip on Oerlikon  -  May 9, 2008
ZURICH, May 9 (Reuters) - Investment group Renova increased its stake in OC Oerlikon Corp (OERL.VX: Quote, Profile, Research) to 39 percent of voting rights Reuters

Renova Energy shares suspended pending clarification of financial ...  -  May 20, 2008
LONDON (Thomson Financial) - Renova Energy Plc. said its shares have been suspended from trading on AIM at the company's request pending clarification of Hemscott,

Seeing is believing  -  May 11, 2008
Today, that house is the home of Albi Renova, the company that has grown to become one of the busiest in the city -- and now, the one that's been named the Calgary Herald,

Vekselberg denies Kremlin influence  -  May 27, 2008
Vekselberg's holding company, Renova, has sent shockwaves through the Swiss manufacturing sector in the past two years by snapping up established companies ISN,

Vekselberg Wins Control of Oerlikon  -  May 11, 2008
ZURICH -- Renova Industries, owned by billionaire Viktor Vekselberg, took control of Oerlikon, the world's largest maker of spinning machines, The Moscow Times,

TNK-BP Torn by Conflicts  -  May 28, 2008
The AAR consortium of Alfa Group, Access and Renova confirmed the conflict with the Brits that slow down the company’s development on fears of its emergence Kommersant,

New Challenges for BP in Russia  -  May 15, 2008
BP is partnered with a Russian consortium called Alfa Access Renova, headed by three well-known tycoons Mikhail Fridman, Len Blatvanik, BusinessWeek

EU inquiry deadline for Renova Industries buy of Oerlikon June 20  -  May 21, 2008
BRUSSELS (Thomson Financial) - The European Commission said the deadline for its inquiry into investment company Renova Industries Ltd.'s proposed Forbes,

State Says It Backs Ethics in Business  -  Jun 1, 2008
But the Kremlin's message appeared at odds with the backroom battle at TNK-BP, as the Russian shareholders -- Alfa Group, Access and Renova -- called Friday The Moscow Times,

Northstar Neuroscience, Inc. Adopts Shareholder Rights Plan  -  May 21, 2008
Northstar's proprietary Renova(TM) Cortical Stimulation System is an investigational device that delivers targeted electrical stimulation to the outer Business Wire (press release),

‘Russia keen to do business in Africa’  -  May 6, 2008
The deal was for the development of a 1 billion investment in South Africa to be made over five years by the Renova Group in a manganese mine, a smelter and Dispatch Online,

Round 32 preview  -  May 15, 2008
They are 4 points above the 9th position and, at the same time, they are on level points with Pobeda and Renova. If the visitors note a victory here, MacedonianFootball.com,

Dixie sounds right for Freeplay  -  May 13, 2008
Shares in Renova Energy, the American biofuel company struggling to raise new cash from its lenders, halved to 2.875p as it said that any deal would include Times Online,

Simple ways to help stave off skin cancer  -  May 12, 2008
Here's the latest: In your cosmetics case: Prescription retinoids (such as Retin-A and Renova), potent versions of vitamin A creams, have been proven to MSNBC

DGAP-Adhoc: OC Oerlikon announces Annual Information Update  -  May 28, 2008
...integrated thin film solar production line 2008 April OC Oerlikon Board of Directors provisionally refuses Renova 29, Industries' applications for entry Vereinigte Wirtschaftsdienste,

Northstar Neuroscience to Present at Bank of America 2008 ...  -  May 7, 2008
Northstar's proprietary Renova(TM) Cortical Stimulation System is an investigational device that delivers targeted electrical stimulation to the outer PharmaLive.com (press release),

Last rounds preview  -  May 30, 2008
Cementarnica against Renova in a match that doesn't holds much pressure. Cementarnica are last on the table and will be playing in second league in the next MacedonianFootball.com,

Oerlikon Elects New Board Of Directors  -  May 14, 2008
Vladimir Kuznetsov, chief investment officer of Renova Management Ltd., and Dr. Hanno M. Bastlein, CEO of Constantia Packaging AG, were re-elected to terms Solar Industry,

Fun in the sun is good but remember to protect your skin.  -  May 20, 2008
My skin-care maintenance routine includes tretinoin cream (like Renova) alternating with topical Vitamin C serum nightly. Daily Press,

Round 31 preview  -  May 9, 2008
Sileks against Renova and Napredok against Pobeda are looking like two similar matches. Both the hosts are fighting for avoiding the 9th place that leads to MacedonianFootball.com,

New Picture For Norwich Hospital  -  Jun 1, 2008
On Friday, Michael Singer, the project manager for PGP, and John Hanselman, the managing partner for Renova Partners LLC - one of the companies that makes TheDay,

UK smallcap opening - Cagney falls as chief exec goes  -  May 13, 2008
Also on the downside, Renova Energy dropped 1-1/4 to 4-1/2 after the ethanol producer -- currently in talks with its lenders and creditors -- warned that Interactive Investor,

Is Business Hitting Bottom?  -  May 12, 2008
For only $20 for three rolls, you can buy Renova's top of the line TP and feel like a million bucks. Join Hoofy and Boo as they look at how toilet paper Minyanville.com,

Supreme Court Justice James Graves Jr. to speak at CCC commencement  -  May 8, 2008
Brittney Arrayanna Jackson of Renova; Lameka Lashae Jackson of Clarksdale; Marion B. Jackson of Pace; LaShannon R. James and Angel Denise Jamison, Clarksdale Press Register,

Renovation spending across 10 major centres up by $2 billion in 2007  -  May 22, 2008
...bought renovated $1000 or intend to intend to a home more on buy a spend (per cent) renova- home $1000 or (per cent) tions more on (per cent) renova- Canada NewsWire (press release),

Green Expo to Feature Eco-Exhibitors and Environmentally-friendly ...  -  May 29, 2008
...on easy recycling; Henry?s Market featuring natural and organic food samples and prizes; and, solar energy information from Renova, among many others. The Desert Sun,

BP Offices Searched By FSB Agents  -  May 20, 2008
The Russian shareholders — Mikhail Fridman and German Khan of Alfa Group, Viktor Vekselberg of Renova and Len Blavatnik of Access Industries — have denied The Moscow Times,

Belarus’ President: cooperation with Korea in high technology has ...  -  May 27, 2008
Receiving the letters of credence of Ambassador Extraordinary and Plenipotentiary of the Republic of Burundi to Belarus (on concurrent) Renova Ndaiirukii, National Legal Internet Portal,

The Valley's priciest home sales.  -  May 13, 2008
Tom Mauro is the owner and chairman of Albi Homes Ltd., Albi Renova and Mauro Realty, and the founder and president of Modena Financial in Calgary. Arizona Republic,

What the Russian papers say  -  May 26, 2008
Any plans for TNK-BP's Russian shareholders (the Alfa Group consortium, Access Industries, Renova and AAR) to invest abroad have been blocked by BP to RIA Novosti,

UK small caps close flat; MicroEmissive plunges as profitability ...  -  May 13, 2008
Meanwhile, Renova Energy plunged 2.875 pence to 2.875 after the ethanol producer -- which is in talks with its lenders and creditors -- warned any Forbes,

Warimpex Interested in Bucharest, Kiev and Belgrade  -  May 26, 2008
...is interested, besides a EUR 12 mln 60 pct stake in an airport JV project together with the Renova Group of the Russian billionaire Victor Vekselberg in Property Xpress (subscription),

Applying a Balm to the Years  -  May 13, 2008
...and reverse the signs of photoaging by applying a prescription retinoid nightly like Renova or Retin-A, which is now available generically as tretinoin. New York Times,

Breakthrough on SA-Russian satellite at last  -  May 25, 2008
This involves the Renova group of companies, owned by Victor Vekselberg, who has publicly promised to invest $1bn in the project. However, according to the Business Day,

Complete list of SAM winners and finalists  -  May 11, 2008
Renovator of the Year: Albi Renova Ltd. (Finalists: Jameswood Homes, Laratta Homes, Litwiller Developments Ltd., Trademark Renovations, Calgary Herald,

RUSSIA DOMINATES MONGOLIA IN THE NEW “GREAT GAME�?  -  May 23, 2008
Russian business circles, represented by major corporations--Basic Element, Renova, Severstal, Rosatom, Polymetall, Gazprombank—show an interest in Eurasia Daily Monitor,

President Enkhbayar meets with Russian President to discuss ...  -  May 19, 2008
Russian business circles, represented by major corporations – Basic Element, Renova, Severstal, Rosatom, Polymetall, Gazprombank – display an interest in Mongolia Web News,

Examine the World Internet Protocol Television (iPTV) Markets  -  May 19, 2008
Systems II-49 Genband Inc Acquires Tekelec Unit II-49 Renova Group Acquires Moscow Cable II-49 Netifice Communications Acquires Megapath Networks II-50 Earthtimes (press release),

Vertical limit  -  May 15, 2008
...recordings of Over-Vert can currently be heard on the band’s Myspace page and a forthcoming, as-yet-untitled CD EP on a new local record label, Renova. Reno News & Review,

Indian telecom shut for Alfa Group  -  May 14, 2008
Alfa Group, together with Access Industries/Renova, holds a 50% stake in TNK-BP, one of the largest vertically integrated Russian oil and gas companies (in CNews,

TFN NEWS BRIEFING: Mergers and acquisitions highlights to 09:20 BST  -  May 13, 2008
ZURICH (Thomson Financial) - Renova Industries Ltd. has hiked its stake in Swiss technology group OC Oerlikon Corp AG. to 39.1 percent by acquiring a 14.1 Hemscott,

Smart and Savvy Skin Solutions Part 2  -  May 13, 2008
Prescription strength products go by the names Retin-A, Renova, Tazorac, and Avage. The active ingredient is tretinoin which is superior to the over the WKRG-TV,

Energy bill hearing stalled  -  May 13, 2008
Vincent Battaglia, president of Renova, an energy consulting firm in Palm Desert, called the bill "historic." "Once it gets implemented here, and folks see The Desert Sun,

Russian tycoons agree to set up mining giant  -  May 28, 2008
RUSAL's minority shareholders include investment vehicle Renova of billionaire Viktor Vekselberg and Swiss-based trader Glencore. guardian.co.uk,

Russia’s Private Sector joins UN Global Compact Network  -  May 12, 2008
Interros Group of companies, Renova, Sistema and the Russian Union of Industrialists and Entrepreneurs (RSPP), as well as non-governmental organizations UN Chronicle,

Scouts' Derby Day fundraiser lands in the winner's circle  -  May 9, 2008
Among those who showed up attired in a chapeau were Kelly Tye and Sue Howery of Southlake; Renova Williams and Colleen Meadows of Colleyville; Fort Worth Star Telegram,

Brand Names/Synonyms:
Renova is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid

Drug Category:
Renova is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22

Dosage Forms:
CAPSULE; CREAM; GEL; LIQUID

Absorption:
1-31% (topical);

Interactions:
Interactions for Tretinoin:

Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA.

RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity.

Chemical IUPAC Name:
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid

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