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ProtonixThis page contains recent news articles, when available, and an overview of Protonix but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Protonix (when available) Pantoprazole is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production. Short-term (up to 16 weeks) treatment of erosive esophagitis. Mechanism Of Action: Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. News Articles on Pantoprazole Wyeth, Pfizer To Settle Shareholder Lawsuits Over Merger - Aug 6, 2009 Sales of Protonix already have been hurt by the availability of generic versions in the US from other companies. Also, Wyeth said it reached a settlement of CNNMoney.com Sun Pharma's US arm reliant on generic launches - Aug 13, 2009 The generic version of Wyeth's Protonix (pantoprazole) accounted for 46% of total revenues or about $22.1 million. According to two analysts, Livemint The Flomax incident - Aug 27, 2009 These included the antibiotic Cipro, the diuretic Lasix, a beta blocker called Propranolol, the proton-pump inhibitor Protonix and a stool softener called Sacramento News & Review Health Watch: Acid Reflux - Aug 26, 2009 ...doctor prescribed one of the type of drug known as a proton pump inhibitor, or PPI, which includes nexium, prevacid, aciphex, protonix, and prilosec. WCBS-TV New York New Emergency Contraceptive Option Now Available - Aug 24, 2009 Lotrel®, Protonix® and Ortho Tri-Cyclen® Lo, the current economic conditions, competition from brand-name companies that are under increased pressure to SYS-CON Media You Just Got Rationed - Aug 27, 2009 Did your doc ever think your hyperacidity needed pantoprazole (Protonix), but your insurance only covered omeprazole (Prilosec)? The insurance company just Santa Barbara Independent Taking care of stomach ulcers - Aug 25, 2009 To reduce acids, your doctor may choose a proton pump inhibitor (Prilosec, Prevacid, Aciphex, Protonix or Nexium) or an acid blocker (H-2 blocker) such as Enid News & Eagle 7 Common Digestive Problems and How to End Them - Aug 19, 2009 Treatment options include drugs that reduce acid levels, such as the proton pump inhibitors Aciphex, Nexium, Prevacid, Prilosec, and Protonix and the H2 Hartford Courant Evidence shows heartburn medication may be `addicting' - Aug 12, 2009 Last year, more than 80 million prescriptions were dispensed for powerful acid-suppressing drugs such as Aciphex, Nexium, omeprazole, Prevacid and Protonix. San Gabriel Valley Tribune BUYINS.NET: (WYE) SqueezeTrigger Price is $48.060. There is ... - Aug 28, 2009 ...gastroenterology drugs, including ZOTON (international markets only) and PROTONIX (the United States market only); anti-infectives, including ZOSYN Trading Markets (press release) Teva Provides Update on Generic Singulair(R) Litigation - Aug 19, 2009 Lotrel(R) and Protonix(R), the current economic conditions, competition from brand-name companies that are under increased pressure to counter generic Trading Markets (press release) Teva Announces Appeals Court Ruling Affirming Invalidation of ... - Aug 5, 2009 ...including that relating to the generic versions of Neurontin(R), Lotrel(R), Protonix(R) and Ortho Tri-Cyclen(R) Lo, the current economic conditions, FOXBusiness מה ×™×?×™×™×? על רווחי טבע בסוף 2010 ומה הרווח ×”×?מיתי של × ×™×™×¡? - Aug 5, 2009 ...לצד שתי תרופות ×”× ×ž×¦×?ות עדיין בתקופת הבלעדיות ×”×’× ×¨×™×ª (Adderal XR ו־Imitrex) בולטות המכירות של הגרס×?ות ×”×’× ×¨×™×•×ª לתרופות Protonix ו־Lotrel. כלכליסט Argument over barking dog leads to death - 14 Jul 2009 Nexium Protonix prednisone stopped taking side effects; difference between lexapro and celexa Rimonabant accutane timeline symptoms of zoloft working? ohmidog! More states sue Wyeth over Protonix pricing - Jun 23, 2009 Fifteen US states are crying foul over Wyeth's Protonix pricing. The states filed a federal complaint alleging that the drugmaker avoided millions of FiercePharma Study: Acid Reflux Drugs Cause Rebound Symptoms - Jul 2, 2009 PPIs like Aciphex, Prilosec, Prevacid, Nexium, and Protonix are among the most widely used prescription medications in the world. WebMD Drug Prevents Stomach Problems in Aspirin Takers, Research Says - Jul 6, 2009 PPIs, as they are commonly called, include the brands Nexium, Prevacid, Protonix, and Prilosec OTC. PPIs are taken by millions of people, including as many Attorney at Law Plan B ® One-Step—New FDA-Approved One-Pill Emergency Contraceptive - Jul 13, 2009 Lotrel®, Protonix® and Ortho Tri-Cyclen® Lo, the current economic conditions, competition from brand-name companies that are under increased pressure to Business Wire (press release) Drugmaker Wyeth posts flat 1st-quarter profit, despite sales drop ... - Jun 20, 2009 Prevnar, a blockbuster vaccine against pneumococcal diseases, posted a 7 percent jump in sales to $755 million, and Protonix, for severe heartburn, Washington Examiner States Join Qui Tam Medicaid Suits Against Wyeth - Jun 19, 2009 ...under which it charged state Medicaid programs hundreds of millions of dollars more for acid reflux treatment Protonix than it charged other customers. Competition Law 360 (subscription) Takeda Hurt by Star Drug's Patent Loss, FDA Delay - Jun 24, 2009 Competition has already eroded sales of Takeda's second- biggest seller, the heartburn medication Prevacid, as Prilosec and Protonix, similar treatments Bloomberg Substitution of drugs can trim costs - or add misery - Jul 4, 2009 Bill MacMillan of Jackson switched from Protonix to Nexium to treat acid reflux without any negative effects. His co-pay with Medco, a major supplier of The Jackson Citizen Patriot - MLive.com Dendreon blueprints $50M facility expansion; Halozyme raises $40M; - Jun 23, 2009 Article > Fifteen US states are crying foul over Wyeth's Protonix pricing. The states filed a federal complaint alleging that the drugmaker avoided millions FierceBiotech Unexpected side effects wreak havoc - Jun 24, 2009 These proton pump inhibitors (including Aciphex, Prevacid and Protonix) are helpful in treating serious heartburn. But this class of medicine has been San Gabriel Valley Tribune From thieves to golden geese - Jun 26, 2009 ...(a cholesterol drug whose annual sales had peaked at $13 billion), Merck's Cozaar (for blood pressure), Wyeth's Protonix (for lessening stomach acid) in the Daily News & Analysis Teva Provides Update on Generic Ortho Tri-Cyclen® Lo - Jul 7, 2009 Lotrel®, Protonix® and Ortho Tri-Cyclen® Lo, the current economic conditions, competition from brand-name companies that are under increased pressure to American Chronicle Teva and Antares Announce FDA Approval of Needle-Free Injector ... - Jun 30, 2009 ...including that relating to the generic versions of Neurontin®, Lotrel® and Protonix®, the current economic conditions, competition from brand-name PharmaLive.com (press release) Teva Completes Enrollment in Second Oral Laquinimod Phase III MS ... - Jun 25, 2009 ...including that relating to the generic versions of Neurontin ® , Lotrel ® and Protonix ® ,the current economic conditions, competition from brand-name Genetic Engineering News (press release) 와ì?´ì–´ìФ â€?웬 ë‚ ë²¼ë?½â€? - Jun 22, 2009 ...주민우 기ìž? ë§¤ì‚¬ì¶”ì„¸ì¸ ì£¼ 법무 장관 마사콕í?´ëž˜ì?´ëŠ” 22ì?¼ 와ì?´ì–´ìŠ¤ê°€ 블ë¡?버스터 í•ê¶¤ì–‘ì œ 'í”„ë¡œí† ë‹‰ìŠ¤(Protonix)'를 구입하는 메디케ì?´ë“œ 프로그램ì?˜ 수백만 달러 헬스코리아뉴스 Plavix: alcuni pazienti rispondono meno bene all'antiaggregante ... - Jun 29, 2009 Zegerid; in Italia: Antra, Losec ), Lansoprazolo ( Prevacid; in Italia: Lansox ), Pantoprazolo ( Protonix; in Italia: Pantecta ), Rabeprazolo ( Aciphex; XagenaSalute è?¯å“?专利æ?ƒé©±åЍ巍é‡?å¹¶è´ - Jun 18, 2009 ...æƒ æ°?å…¬å?¸(Wyeth)æ–¹é?¢ï¼Œæœ€é‡?è¦?的两ç§?è?¯ç‰©â€”—抗抑éƒ?ç—‡è?¯ç‰©Effexor和治疗心绞痛的Protonix也分别将于2010å¹´å’Œ2011年到期。 è?¯å“?专利æ?ƒçš„åˆ°æœŸæ— ç–‘æ˜¯åŒ»è?¯å…¬å?¸çš„“ä¸?能承å?—之 财华网 Generic Drugs Eat Away at Big Pharma - Caraco Pharmaceuticals (CPD ... - 20 Apr 2009 ...reflecting uncertainty over the at-risk launch of generic Protonix (pantoprazole) and lower sales of oxcarbazepine since the exclusivity period has Motley Fool Study: Heartburn drugs no help with asthma - Apr 15, 2009 Among the most popular treatments for severe heartburn are expensive prescription drugs called proton pump inhibitors, including Nexium and Protonix, San Jose Mercury News Don't underestimate the benefits of a good night's sleep - Mar 29, 2009 Q. I have been taking Protonix for heartburn for at least six months. After I learned that long-term use might lead to complications, I tried to stop taking Houston Chronicle Wyeth Offers Limited Upside - Apr 9, 2009 Upside could come from a favorable ruling on the Protonix patent, but that's now been pushed back to the fourth quarter of 2009. Zacks.com Medicines turn off acid pump - Mar 30, 2009 Other members are Prevacid (lansoprazole), Prilosec (omeprazole), AcipHex (rabeprazole) and Protonix (pantoprazole). These drugs pose a small risk of South Coast Today Managing acid reflux with less - Mar 31, 2009 Other proton pump inhibitors include generic omeprazole, generic pantoprazole, Prilosec, Protonix, Prevacid and Nexium. My recommendation depends on more Times Daily Plavix and PPIs: Update - Apr 18, 2009 I'm planning to switch my wife from the PPI, Protonix to a H2 blocker, Pepcid. Have you read anything about the effectiveness of H2 blockers helping to Angioplasty.Org Smokers’ Lung Treatment May Fail to Fire Up Nycomed Bidders - Apr 8, 2009 Sales in the US, where Wyeth markets the medicine under the name of Protonix, have fallen more than 50 percent since Teva and Sun Pharmaceutical Industries Bloomberg COPAXONE(R) Approved by Health Canada for Patients with Clinically ... - Apr 16, 2009 Lotrel(R) and Protonix(R), the current economic conditions, competition from brand-name companies that are under increased pressure to counter generic Canada NewsWire (press release) Generic Version of Topamax® Will Save Upstate New Yorkers Millions - Apr 7, 2009 ...and also includes generic and over-the-counter omeprazole (brand-name Prilosec®) and generic pantoprazole (brand-name Protonix®). ReadMedia (press release) National Briefing 4/9 - Apr 9, 2009 Among the most popular treatments for severe heartburn are expensive prescription drugs called proton pump inhibitors, including Nexium and Protonix, Daily Herald COPAXONE(R) approuvé par Santé Canada pour les patients reconnus ... - Apr 16, 2009 Lotrel(R) et Protonix(R), les conditions économiques actuelles, les effets de la concurrence exercée par les fabricants de médicaments d'origine qui CNW Telbec (Communiqué de presse) Teva Announces Approval and Launch of Generic Solodyn® Extended ... - 18 Mar 2009 ...including that relating to the generic versions of Neurontin®, Lotrel® and Protonix®, the current economic conditions, competition from brand-name Business Wire (press release) How Crowdsourcing Could Revolutionize Patent-Busting - 18 Mar 2009 Regardless, the company sent out a press release on March 9 issuing an opinion that two patents for the drugs Boniva and Protonix were, in fact, valid. MediaShift Article One Partners Uncovers New Prior Art Impacting the Validity ... - Mar 10, 2009 Validity opinions also were announced in the close of research for patents related to the drugs Boniva and Protonix. The Article One community uncovered two FOXBusiness Plavix Combined with Heartburn Drugs May Increase the Risk of ... - Mar 4, 2009 Nexium and other proton pump inhibitors, like Wyeth’s Protonix and Prevacid, Eisai Co.'s Aciphex, are used to treat heartburn, in which stomach acids come Enews 2.0 Study Demonstrates That QVAR® is More Likely to Achieve Successful ... - Mar 17, 2009 ...including that relating to the generic versions of Neurontin®, Lotrel® and Protonix®, the current economic conditions, competition from brand-name Earthtimes (press release) Health insurers push generics, but what are patients getting? - Mar 8, 2009 Substitutes for the heartburn drug Nexium are omeprazole (generic for Prilosec) and pantoprazole (generic for Protonix). "A lot of people don't understand Chicago Tribune People's Pharmacy: Avoid prescription withdrawal - Mar 8, 2009 Readers have experienced similar difficulties trying to stop other proton pump inhibitors such as Nexium or Protonix. The hyperacidity that occurs as a Houston Chronicle More Concern About Plavix and Proton-Pump-Inhibitors - Mar 9, 2009 PPIs available by prescription include omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), About - News & Issues COPAXONE ® Approved by the FDA for Patients with a First Clinical ... - Mar 3, 2009 ...including that relating to the generic versions of Neurontin®, Lotrel® and Protonix®, the effects of competition on our innovative products, Business Wire (press release) For Big Pharma, the playfield's here - Mar 8, 2009 ...ones like Lipitor (for cholesterol), Cozaar (blood pressure), and Protonix (for lessening stomach acid) in the US; and Keppra (epilepsy) in Europe. Daily News & Analysis Caraco Pharma Awaits FDA Inspection in May - Feb 25, 2009 ...reflecting uncertainty over the at-risk launch of generic Protonix (pantoprazole) and lower sales of oxcarbazepine since the exclusivity period has Seeking Alpha 医è?¯è¡Œä¸šé”€å”®å¢žé•¿æ”¾ç¼“制è?¯å·¨å¤´ä¸šç»©å¥½å??å?‚å?Š - Mar 12, 2009 ...默沙东的骨质ç–?æ?¾ç—‡ç”¨è?¯ç¦?å–„ç¾Žï¼Œè‘›å…°ç´ å?²å…‹çš„æŠ—癫痫è?¯Lamictal,辉瑞的抗癌è?¯Camptosar和抗过æ•?è?¯Zyrtec,雅培的抗癫痫è?¯Depakoteå’Œæƒ æ°?的质å?泵抑制剂Protonix。 搜狐 å¹¶è´ç‹‚人辉瑞之囧:1+1真能大于2å?—? - Mar 4, 2009 ...æƒ æ°?å…¬å?¸çš„头å?·è?¯ç‰©ã€?2008年销售39亿美元的抗抑éƒ?è?¯æ€¡è¯ºæ€?(Efexorxr)专利将在2010年到期,å?¦ä¸€é‡?è¦?è?¯ç‰©èƒƒæºƒç–¡æ²»ç–—è?¯Protonix专利于2011年到期,但这些并ä¸?是辉瑞看é‡? 南方网 æ”¶è´æƒ æ°?辉瑞得到什么 - Feb 20, 2009 ...但是,值得注æ„?çš„æ˜¯ï¼Œæƒ æ°?治疗抑éƒ?症的Effexor和治疗心绞痛的Protonix两ç§?é‡?è¦?产å“?也将分别于2010å¹´å’Œ2011年失去专利ä¿?æŠ¤ã€‚è€ƒè™‘åˆ°ä¸“åˆ©åˆ°æœŸå› ç´ çš„å½±å“?,两家å?ˆå¹¶å?Žçš„700 新浪 Brand Names/Synonyms: Protonix is also known by the following brand names and/or synonymsBY 1023; CHEMBANK1787; Pantoloc; Pantoprazol [Inn-Spanish]; Pantoprazole; Pantoprazole Na; Pantoprazole Sodium; Pantoprazole [Usan:Ban:Inn]; Pantoprazolum [Inn-Latin]; Pantoprozole; Protonix; Protonix I.V.; Protonix Iv Drug Category: Protonix is categorized under the following by the FDA: Anti-ulcer Agents; Proton-pump Inhibitors; ATC:A02BC02 Dosage Forms: TABLET (ENTERIC-COATED) Absorption: Pantoprazole is well absorbed; it undergoes little first- pass metabolism resulting in an absolute bioavailability of approximately 77%. Interactions: Interactions for Pantoprazole: Pantoprazole is metabolized through the cytochrome P450 system, primarily the CYP2C19 and CYP3A4 isozymes, and subsequently undergoes Phase II conjugation. Based on studies evaluating possible interactions of pantoprazole with other drugs, no dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam (and its active metabolite, desmethyldiazepam), diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, an oral contraceptive (levonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole, or amoxicillin. Clinically relevant interactions of pantoprazole with other drugs with the same metabolic pathways are not expected. Therefore, when coadministered with pantoprazole, adjustment of the dosage of pantoprazole or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. Because of profound and long lasting inhibition of gastric acid secretion, pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (eg, ketoconazole, ampicillin esters, and iron salts). Laboratory Tests There have been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving most proton pump inhibitors, including pantoprazole. An alternative confirmatory method should be considered to verify positive results. Chemical IUPAC Name: 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzoimidazole : |
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