Propoxyphene

This page contains recent news articles, when available, and an overview of Propoxyphene but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Propoxyphene (when available)

Pharmacology and use:
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. For pain relief

Mechanism Of Action:
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Propoxyphene

Pharmacokinetic Drug Interactions of Synthetic Opiate Analgesics  -  ‎Apr 17, 2009‎
This review will focus on the pharmacokinetic drug–drug interactions of methadone, propoxyphene, levomethadyl, meperidine, other phenylpiperidines (such as Psychosomatics (subscription)

Civil suits await Mann  -  ‎Apr 9, 2009‎
Kowalski claimed Curry was prescribed Norflex, Zoloft, Valium, Oxycontin, Percocet, Lorazepam, Methadone, Propoxyphene and Doxepin by Mann on Aug. Russellville Courier

Drug testing pegged at $6500  -  18 Mar 2009
...benzodiazepines (Valium), cocaine, Marijuana, methadone, opiates such as Oxycontin and Vicodin, phencyclidine and propoxyphene such as Darvon. Keyser Mineral Daily News Tribune

Mass Torts Inevitable In Wake Of FDA Urged To Pull Popular ...  -  ‎Mar 6, 2009‎
Propoxyphene, the exclusive medication in Darvon and one of the two medications used in Darvocet, has been linked to over 7000 deaths in the 1980’s and 90’s Justice News Flash

Multi-modal, Pre-emptive Analgesia Decreases the Length of ...  -  ‎Mar 4, 2009‎
It had no effect on the need for additional oral narcotics (hydrocodone or propoxyphene). Although our data was combined from 2 populations (THA and TKA Ortho SuperSite

Treatment of restless legs syndrome with iron infusion therapy  -  ‎Mar 9, 2009‎
Tramadol, hydromorphone, propoxyphene HCl, oxycodone, and hydrocodone/acetaminophen are just a few examples. The fourth category of pharmacologic agents Journal of the American Academy of Physician Assistants

Cosco Busan Pilot Had Health Problems, Taking Lots Of Meds  -  ‎Mar 1, 2009‎
Cota had filled prescriptions for 90 sertraline tablets, 180 lorazepam tablets, 120 diazepam tablets, 190 propoxyphene tablets, 90 modafinal tablets, Cunningham Report

Death of attorney's wife shrouded in mystery  -  04 Feb 2009
Or it could be a pain-killing medication -- propoxyphene -- that was found at the house. Neither agency has ruled out the possibility that Steve Brady Orlando Sentinel,

FDA Panel Urges Ban of Pain Drug  -  Feb 3, 2009
The drug, called propoxyphene, has been sold in US pharmacies for more than 50 years and today is used in dozens of generic pain medications. Medscape

FDA advisers to decide on continued sale of 2 pain drugs  -  Jan 30, 2009
The drugs contain propoxyphene, which has been linked to 3028 cases of adverse events between 1957 and Sept. 24, 2008, according to the FDA. SmartBrief,

FDA Panel To Consider Fate Of Pain Pills Darvon, Darvocet  -  Jan 29, 2009
Darvon, which contains the active ingredient propoxyphene, has been on the US market for more than 50 years and was developed by Eli Lilly & Co (LLY). CNNMoney.com

Exploring the Palette of Pain Control: A Colorful Array of Options  -  Feb 1, 2009
Propoxyphene (a mild analgesic with a long half life), meperidine (which breaks down into toxic metabolites that can accumulate and cause seizures), Oncology Nursing News,

Drug testing not meant to punish, parents told  -  Jan 29, 2009
...includes alcohol, marijuana, amphetamines, barbiturates, benzodiazapens, cocaine, Ecstasy, methadone, opiates, phencyclidine (PCP), and propoxyphene. Clay Center Dispatch,

An Appraisal of Potential Drug Interactions in Cigarette Smokers ...  -  Jan 13, 2009
14 Observational studies showed that heavy smokers (>20 cigarettes per day) who received propoxyphene required higher dosages to achieve the same analgesic Journal of the American Podiatric Medical Association (subscription)

Попул�?рный анальгетик может и�?чезнуть из продажи  -  Feb 3, 2009
Пропок�?ифен (propoxyphene) продавал�?�? в американ�?ких аптеках на прот�?жении 50 лет и многократно и�?пользовал�?�? дл�? �?н�?ти�? при�?тупов боли. МЕДСТРИМ.РУ - кон�?ультации врачей, ново�?ти медицины,

What is the cause of my black stool?  -  Dec 3, 2008
I'm on enalapril, HCTZ, Requip, simvastatin, terazosin, temazepam, propoxyphene, aspirin, fish oil and calcium daily. What is causing the problem? GoErie.com,

Families have yet to come to grips with fatal crash  -  Nov 30, 2008
What was found, he said, were trace elements of amitriptyline, an antidepressant; diphenhydramine, the active ingredient in Benadryl; and propoxyphene, Urbana/Champaign News-Gazette,

Lost Daughters – An ongoing tragedy in Nepal  -  Dec 5, 2008
Predominant drugs abused by trafficked girls working in Mumbai brothels includes cough syrup, cannabis, heroin and propoxyphene (Darvon), Women News Network,

High Growth Reported for the World Pharmaceuticals Market Brief  -  Nov 18, 2008
Ibuprofen, Levothyroxine, Metoprololtartrate, Albuterol nebulizer solution, Propoxyphene-N/APAP, Potassium chloride, Cephalexin, Amoxicillin/pot. MarketWatch

Belknap County indictments  -  Nov 18, 2008
4 East, Mendon, Vt., was indicted on special felony counts of possession of the drugs propoxyphene and alprazolam in Meredith in August. Laconia Citizen,

Mistakes in Medication  -  Nov 11, 2008
Listed as rarely appropriate includes Chlorodiazapoxide (Librium), Diazepam (Valium), Propoxyphene (Darvon), Carisoprodol (Soma) and more. Aiken Standard (subscription),

Cocaine, prescription drugs often found in autopsies  -  Nov 1, 2008
...also known as Xanax, diazepam, also known as Valium, oxycodone, methadone, morphine and propoxyphene, more commonly known as Darvocet, in autopsy cases. Ocala,

Pills, dope: Both lead to arrests  -  21 Oct 2008
...the vehicle and found a bottle that contained pills identified as acetaminophen and propoxyphene, Schedule 4 prescription medications, carisoprodol, Breckenridge American,

Convicted sex offender sentenced to 10 years  -  Sep 26, 2008
The prosecutor said toxicology tests showed Richmond had fatal levels of propoxyphene and acetaminophen, components of Darcovet, in his system when he died. The Star-Ledger - NJ.com,

Drug testing can avoid costly hires, reduce liabilities  -  Oct 13, 2008
There also is alcohol testing and testing for barbiturates, benzodiazepine, Ecstasy, methadone, propoxyphene and tricyclic antidepressants that employers Gazette Online,

Teva Neuroscience Launches Spanish Parkinson's Disease Patient and ...  -  Sep 29, 2008
Patients should not take AZILECT with tramadol, methadone, propoxyphene, dextromethorphan, St. John's wort, mirtazapine, or cyclobenzaprine. MarketWatch

Parents to get help detecting teen drug abuse  -  Oct 2, 2008
...cocaine, methamphtetamine, marijuana, opiates, methadone, methylenedioxymethamphetamine, oxycodone, phencyclidine, propoxyphene and alcohol. Tahlequah Daily Press,

Paging Dr. Alan Frischer...  -  Sep 25, 2008
...oxycodone (OxyContin, Percocet, Percodan, Tylox), methadone, clonazepam (Klonopin), propoxyphene (Darvocet and Darvon), amphetamine (Dexedrine), Downey Patriot,

Commonly Abused Prescription Medications-Painkillers  -  Sep 25, 2008
Other examples of opioids that can be prescribed to relieve pain include propoxyphene (Darvon); hydromorphone (Dilaudid); and meperidine (Demerol), TransWorldNews (press release),

Driver's fate is now in jury's hands as trial nears its end  -  Sep 3, 2008
Holmes told the jury the only drug charge Stotts was guilty of is the possession of propoxyphene, a painkiller for which he didn't have a prescription. Hutchinson News,

HEALTH MATTERS: Getting ‘unhooked’ from prescription meds  -  Sep 11, 2008
Roxicet, OxyContin), hydrocodone (Vicodin), and propoxyphene (Darvon, Darvocet). These drugs can produce drowsiness, nausea, constipation and, Lawrence Ledger,

Driver guilty of attempted murder charge  -  Sep 4, 2008
...possession of pseudoephedrine, lithium and drug paraphernalia with intent to manufacture, possession of propoxyphene, marijuana and drug paraphernalia, Hutchinson News,

Restless Legs: In Your Head Or In Your Genes?  -  Sep 4, 2008
For patients with more severe symptoms, opioids like codeine, propoxyphene or oxycodone may relieve pain and induce relaxation, but the side effects, WFtv.com,

Of 550 high school athletes drug-tested in Bullitt, one was positive  -  Sep 2, 2008
...hydrosol, PCP, methadone, barbiturates, benzodiaphine (such as Xanax), opiates, cocaine, propoxyphene (in painkillers such as Darvon) and alcohol. Louisville Courier-Journal,

BC construction workers face drug tests  -  Sep 2, 2008
The policy includes testing for alcohol and nine drugs: marijuana, barbiturates, amphetamines, cocaine, methadone, opiates, propoxyphene, phenocyclidine OHS Canada,

Opioid Painkillers Used by Nearly 5% of American Adults  -  Aug 29, 2008
Norco, Zydone, Panacet, Lortab, Lorcet, Co-gesic, Anexsia), tramadol (Ultram), propoxyphene plus acetaminophen (Darvocet), and hydrocodone. MedPage Today,

Mercer case goes back to high court  -  Aug 26, 2008
Prosecutors argued that tests show Sally Mercer - who died in 1968 but whose body was exhumed in 2003 - was killed by a lethal dose of propoxyphene, Lansing State Journal,

WLPD teams with site to offer free drug tests  -  Aug 21, 2008
...amphetamine, marijuana, opiates, methamphetamine, benzodiazepine, oxycodone, propoxyphene and MDMA, more commonly known by its street name, ecstasy. Journal and Courier,

New Drug-Testing Rules Lead to Confusion  -  Aug 7, 2008
It is more thorough than a five-panel screening, which doesn't look for barbiturates, benzodiazepines, methadone and propoxyphene. State Journal,

Sex offender pleads guilty to manslaughter in drug death  -  Jul 30, 2008
Toxicology tests show Richmond had fatal levels of propoxyphene and acetaminophen, components of Darcovet, in his system when he died, Valentin said. The Star-Ledger - NJ.com,

Mercer case sent back to Ingham judge  -  Jul 26, 2008
Prosecutors contend those tests show that Sally Mercer died from a lethal dose of propoxyphene, a pain reliever. Charles Mercer's attorneys have argued the Lansing State Journal,

Seabrook board denies methadone clinic plan  -  Aug 8, 2008
...treatment to persons addicted to the opiate/opiod class of drugs including heroin, Dilaudid, Percodan, Percocet, Propoxyphene and Oxycotin. York Weekly,

Restless Legs Syndrome may be mental or genetic  -  Aug 4, 2008
For patients with more severe symptoms, opioids like codeine, propoxyphene or oxycodone may relieve pain and induce relaxation, but the side effects, News 8 Austin,

Restless Legs Syndrome  -  Jul 16, 2008
A double- blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. Sleep. RedOrbit,

Deputies say 2002 prescription pills found at Harper Road hotel  -  Jul 26, 2008
Killen said the pills included the painkillers propoxyphene, hydrocodone, oxymorphone, oxycodone and morphine; methylphenidate, a stimulant often used to Beckley Register-Herald (subscription),

Acura Pharmaceuticals, Inc. Announces Action Regarding Notice of ...  -  Jul 21, 2008
...drugs including oxycodone, hydrocodone, oxymorphone, hydromorphone, morphine, codeine, tramadol, propoxyphene, and many other opioid analgesics. CNNMoney.com (press release)

Acura Pharmaceuticals, Inc. Announces Action Regarding Notice of ...  -  Jul 21, 2008
...drugs including oxycodone, hydrocodone, oxymorphone, hydromorphone, morphine, codeine, tramadol, propoxyphene, and many other opioid analgesics. Primenewswire (press release),

Man files suit over wife's death  -  May 21, 2008
That medicine then contributed to her death by "propoxyphene intoxication," Scanlan said. The suit was brought by Chris Dodaro, the woman's husband, Chicago Daily Herald,

Mifflin program alone in Berks  -  May 31, 2008
...barbiturates, benzodiazepine (tranquilizers), cocaine, opiate, methadone, propoxyphene (Darvon) and THC (the primary intoxicant in marijuana). Reading Eagle,

Pediatric TOXICOLOGY: Part 1  -  23 Apr 2008
Certain narcotics or narcotic combinations, such as propoxyphene (Darvon), diphenoxylate/atropine (Lomotil) and pentazocine (Talwin) may not cause the EMS Magazine,

Autopsy fails to determine cause of death for man whose skeleton ...  -  Apr 16, 2008
A prescription painkiller, Propoxyphene/APAP, was present at the scene, according to the report. Dorton's family had not heard from him in about two years Gaston Gazette,

Zollo files written not guilty plea  -  Apr 5, 2008
A search of Zollo's vehicle led police to discover Darvacet, which contains acetaminophen and propoxyphene, a controlled substance for which he did not have Iowa City Press Citizen,

Ex-sheriff's deputy pleads guilty to drug charges  -  Apr 1, 2008
The painkillers included Oxycodone, Tylenol 3 with codeine and propoxyphene napsylate, according to the affidavit. In an agreement filed March 24 in US Charlotte Observer,

'Proud Hands' Book Released to Benefit the American Parkinson ...  -  Apr 21, 2008
Patients should not take AZILECT with tramadol, methadone, propoxyphene, dextromethorphan, St. John's wort, mirtazapine, or cyclobenzaprine. PR Newswire (press release),

MCHS to random drug test  -  Apr 18, 2008
...methamphetamines, opiates and propoxyphene, according to the proposed procedures. While school personnel will supervise students taking the test, Morgan County Citizen,

Leg problems keeping you up at night?  -  Apr 15, 2008
Gabapentin (Neurontin); Opiods, such as codeine or propoxyphene (Darvon), though generally as an option only if other medicines have failed. Times Daily (subscription),

Wide-Scale Student Drug Testing Proposed  -  Apr 7, 2008
...cocaine, ecstacy, marijuana, methadone, methamphetamine, morphine, opiates, oxycodone, phencyclidine, propoxyphene, and tricyclic antidepressants. Whitefish Free Press,

Voters turn down high school bond  -  Apr 3, 2008
...opiates, oxycodone, phencyclidine, propoxyphene, and tricyclic antidepressants will be among the substances for which student samples will be tested. Whitefish Pilot,

Fire, police departments test candidates for substance abuse on ...  -  Mar 27, 2008
...categories of drugs, including amphetamines, cocaine, marijuana, opiates, PCP, benzodiazepines, barbiturates, methadone, methaquaalone and propoxyphene. The Herald-Times (subscription),

Revised plans for methadone clinic  -  Apr 22, 2008
Percocet, Propoxyphene and Oxycotin. Sullivan said patients would be enrolled in a comprehensive program including individual and group counseling. Hampton Union,

Musician arrested for April drug incident  -  Feb 12, 2008
A search of Zollo's vehicle led police to discover Darvacet, which contains acetaminophen and propoxyphene, which is a controlled substance for which he did Iowa City Press Citizen,

Defense in Lewis murder case wants medications tested  -  Feb 27, 2008
22, asks that the contents of prescription bottles labeled propoxyphene, alprazolam, hydrocodone and flucanazole, all recovered from a pillow case on the Springfield State Journal Register,

The blunt reality  -  Feb 15, 2008
...heroin and other narcotics), methamphetamine, barbiturates, benzodiazepines, Oxycodone (including Oxycontin), MDMA or Ecstasy, and Propoxyphene. Shelby Township Source Newspapers,

Local school districts that test for drugs  -  Jan 25, 2008
Substances tested for: Illegal substances including but not limited to marijuana, cocaine, phencyclindine, propoxyphene, opiates, hallucinogens, Dallas Morning News,

How The FDA Has Done Nothing About An Unsafe Drug  -  Jan 15, 2008
I'm talking about a combination of propoxyphene and acetaminophen, also sold under the brand name Darvocet. It is a pain reliever related to Darvon Evening Bulletin,

Glasford man's death ruled accidental  -  Feb 1, 2008
The anti-depressants Amitriptyline and Fluoxetine, the muscle relaxant Cyclobenzaprine, and the pain relievers Propoxyphene and Oxycodone were found during Peoria Journal Star,

Anti-drinking medications for alcoholics  -  Jan 29, 2008
People who take opiate pain relievers (like hydrocodone, propoxyphene, oxycodone, tramadol, etc.) should not take ReVia or Vivitrol because it could spiral Ocala.com,

Police news for Jan. 25  -  Jan 25, 2008
Henry-Sacks was in possession of marijuana and a pipe, while the teen was in possession of marijuana and two Propoxyphene pills, which are narcotic pain phillyBurbs.com,

Merritt ordered into police custody  -  Jan 9, 2008
According to the petition, it was alleged Merritt tested positive for use of methadone and propoxyphene, a narcotic analgesic and had also failed to keep Parkersburg News,

Brand Names/Synonyms:
Propoxyphene is also known by the following brand names and/or synonymsAlgafan; Antalvic; D-Propoxyphene; Darvocet; Darvon; Darvon-N; Deprancol; Depromic; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Dolene; Dolocap; Doloxen; Doloxene; Erantin; Femadol; Harmar; Kesso-Gesic; Propacet; Prophene 65; Propoxychel; Propoxyphene; Propoxyphene Hcl; Propoxyphene Hcl 65; Proxagesic; SK 65

Drug Category:
Propoxyphene is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; ATC:N02AC04; ATC:N02AC54; ATC:N02AC74

Dosage Forms:
Tablets

Absorption:
Not Available

Interactions:
Interactions for Propoxyphene:

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

As is the case with many medicinal agents, propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur, the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Sever neurologic signs, including coma, have occurred with concurrent use of carbamazepine.

Chemical IUPAC Name:
(4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl) propanoate

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