Promethazine

This page contains recent news articles, when available, and an overview of Promethazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Promethazine (when available)

Pharmacology and use:
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. For the treatment of allergic disorders, itching, nausea and vomiting

Mechanism Of Action:
Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.

News Articles on Promethazine

Anti-Energy Drink 'Drank' To Hit NYC Shelves  -  Aug 20, 2008
...concoction "Purple Drank," a mixture made with prescription strength cough syrup containing codeine and promethazine and popularized by hip-hop culture. WCBS-TV New York,

Anti-Energy "Drank" Set to Sedate NYC Tomorrow  -  Aug 19, 2008
Its main ingredient is prescription-strength cough syrup containing codeine and promethazine." Purple Drank was supposedly popularized by Houston's DJ Screw Gothamist,

Ondansetron Therapy May Improve Outcomes in Children With ...  -  Sep 2, 2008
Promethazine was found to be inferior to rectal pyrilamine-pentobarbital combination in 1 study with no adverse effects. Dexamethasone did not lower the Medscape (subscription)

School zone traffic stops put several persons in jail  -  Sep 11, 2008
There were three pills that included Zolpidem Tartrate, Promethazine Hydrochloride and an Acetaminopehn-hydrocodone. The three pills were labeled a Purcell Register,

Use of Antiemetic Agents in Acute Gastroenteritis A Systematic ...  -  Sep 1, 2008
...pyrilamine-pentobarbital (n = 2), metoclopramide (n = 2), dexamethasone (n = 1), and promethazine (n = 1). Meta-analysis of 6 randomized, double-masked, Archives of Pediatrics

Police looking for prescription forgers  -  Aug 29, 2008
The local store had earlier received an e-mail from their corporate offices warning them of forged prescriptions of promethazine, often used in cough syrups Galesburg Register-Mail,

Local drug investigations net arrests  -  Aug 27, 2008
Walters said officers confiscated $925 in cash, 82 hydrocodone pills and a pint of promethazine syrup. Monday, using information provided by a tip, Alexandria Town Talk,

insomnia during pregnancy  -  Aug 22, 2008
It would be safe enough for you to try them in modest amounts, the commonest being diphenhydramine and promethazine. Corsavoo.com,

NEJM Files Amicus Brief in Supreme Court Preemption Case  -  Aug 19, 2008
...award to Diana Levine after the firm’s anti-nausea drug Phenergan (promethazine HCl) was improperly administered, leading to the amputation of her arm. FDA news (subscription),

In Supreme Court Brief, Journal Editors Fault FDA Safety Record  -  Aug 18, 2008
Court in support of Diana Levine, a musician who lost her right arm to gangrene that developed after receiving promethazine (Phenergan) by IV push. MedPage Today,

Isopropyl Alcohol Poisoning from Cast Application  -  Sep 1, 2008
After having several episodes of small emesis approximately six hours after arrival on the ward, he was given 9 mg of Phenergan (promethazine) intravenously Journal of Bone and Joint Surgery (subscription)

美 제약사, 수천명 목숨 달린 안전성 정보 未제출  -  Aug 24, 2008
...�?� 소송�?� 와�?�어스�?� 항오심 약품 훼너간(Promethazine HCl)�?� 잘못 투여�?�어 레(Diana Levine)�?� 팔�?� 절단하게 �?� 사건으로, 배심�?들�?� 레빈�?게 680만 달러�?� 메디�?�뉴스,

Pill-mill suspects want bond set  -  10 Aug 2008
Drugs identified in the case are known by the generic names of hydrocodone, alprazalom and promethazine with codeine. A 22-count indictment includes the Biloxi Sun Herald,

Parents get 7 years in drugging death of infant  -  Aug 1, 2008
...in May to manslaughter, admitting that in April 2007, he gave the infant his own prescription medication Promethazine as well as adult-strength Tylenol. Newsday,

Buena pair get 7 years for baby's drug death  -  Aug 2, 2008
She admitted during the plea that she and her husband gave their baby adult-prescription Promethazine when they knew they should not have done so. Press of Atlantic City,

Routine patrol leads to drug arrests  -  Jul 18, 2008
Carlos Yates, 35, 173 St. Catherine St., was arrested on charges of felony possession of promethazine. He is being held on a $5000 bond. Natchez Democrat,

What the hell has Rakim been up to?  -  Jul 23, 2008
...which was problematic since I'd already spent the money on Hawaiian Punch and promethazine cough syrup in an effort to be more like Lil Wayne. Examiner.com

PIMP C TO BE HONORED AT OZONE AWARDS: Late rapper to get musical ...  -  Aug 7, 2008
In December, Pimp C was found dead in his Hollywood hotel room due to a combination of sleep apnea and an accidental overdose of Promethazine and Codeine, Eurweb.com,

FDA, Federal Agents Seize $24.2 Million in Unapproved New Drugs  -  Jul 31, 2008
Ethezyme 650 Papain-Urea Ointment, Ethezyme 830 Papain-Urea Ointment, Hista-Vent DA Tablets, Meperidine/Promethazine Capsules, Pseudovent Capsules, Occupational Health Safety,

08-07-08 EUR ALL ON ONE PAGE  -  Aug 7, 2008
In December, Pimp C was found dead in his Hollywood hotel room due to a combination of sleep apnea and an accidental overdose of Promethazine and Codeine, Eurweb.com,

Woman to be sentenced today in fatal crash  -  Jul 28, 2008
...unit of what then was Columbus Children's Hospital. Drug tests taken the day of the crash showed Mattox had taken promethazine, meprobamate and Dilantin. The Newark Advocate,

-- Lil Wayne, aka Dwayne Michael Carter, aka Weezy F. Baby  -  Jul 20, 2008
Promethazine -- a heavy narcotic in some prescription cough syrups that has contributed to the death of several rappers -- is Weezy's drink of choice; RedOrbit,

Varenicline safety concerns: An interview with Dr Serena Tonstad  -  Jul 16, 2008
Tonstad: In less than 3% of patients I've prescribed an antiemetic such as Phenergan (promethazine) or Zofran (ondansetron). I also ask them to take it on a TheHeart.Org,

Sane in the Membrane  -  Jul 16, 2008
He may not have much of a lifetime if he continues to sip his noxious cocktail of choice (Hawaiian Punch and promethazine cough syrup) and smoke weed all Seattle Weekly,

FDA, 허가없�?� 제조한 �?�약품 무�?�기 압류  -  Jul 31, 2008
Meperidine/Promethazine Capsules, Pseudovent Capsules, Pseudovent 400 Capsules, Pseudovent PED Capsules, Tri-Vent DM Syrup, Tri-Vent DPC Syrup, Hydro-Tussin 메디�?�뉴스,

Major gang roundup nets 29 people in Longview  -  02 Jun 2008
..."The indictment alleges that each gang has maintained numerous drug houses in which crack cocaine marijuana, promethazine pills, and firearms were KSLA-TV,

Dozen arrested in Lawton drug bust  -  May 30, 2008
Oklahoma Bureau of Narcotics spokesman Mark Woodward says the nurse arrested is accused of supplying a party drug called promethazine with codeine. KFOR,

Two accused in theft of narcotic cough syrup  -  May 27, 2008
Shannon J. Broom said the syrups contain codeine, with the most popular brands being Tussionex with codeine, and Promethazine with codeine and Guifenesin. Biloxi Sun Herald,

Pair plead guilty in infant son's drug death  -  May 8, 2008
An autopsy determined that the baby died of promethazine intoxication. Promethazine is an allergy medication that should not be given to children younger Press of Atlantic City,

Bond denied for three of four in 'pill mill' case  -  May 22, 2008
Bottles of pre-mixed promethazine with codeine, a cough syrup, lined floor-to-ceiling shelves in the pharmacy. The drug sells for $10 to $15, he said, SunHerald.com,

Pimp C Died of Overdose, Coroner said  -  May 22, 2008
He cited that Promethazine/Codeine syrup and sleep apnea were factors involved in the untimely death of Pimp C, whose birth name is Chad Butler. NewsOXY,

Drugs, gun seized Thursday afternoon  -  May 23, 2008
Officers seized cocaine, marijuana, promethazine (an antihistamine) and a handgun. Allen remained jailed Friday on charges of manufacture/delivery of a News Journal,

MOST-READ STORIES  -  May 22, 2008
Promethazine with codeine: A syrup used to relieve coughs, symptoms of allergies or control nausea. Combines an antihistamine with a narcotic pain-reliever. Biloxi Sun Herald,

Region roundup Collings Lakes couple admit role in infant's death  -  May 14, 2008
He told the court that, between April 19 and April 20, 2007, he gave his infant son his prescription medication Promethazine as well as adult-strength The Hammonton News,

Broussard police says DNA evidence solves three-year-old burglary  -  May 20, 2008
Promethazine was stolen. The burglar cut himself and left blood at the scene. Broussard police sent the blood to the Acadiana Crime Lab for a DNA profile. The Daily Advertiser,

Couple sentenced for killing infant with adult medicine  -  May 7, 2008
...pleaded guilty to child endangerment. The father told a judge he gave the baby his prescription medication Promethazine as well as adult-strength Tylenol. Philadelphia Inquirer,

Crime and Court briefs: Saturday, May 31, 2008  -  May 31, 2008
Officers serving the search warrant found nearly five gallons of promethazine with codeine cough syrup, 3½ pounds of crack cocaine and a quarter-pound of NewsOK.com (subscription),

Huge Lawton Drug Bust  -  May 29, 2008
Police say they found guns, cash, more than $370000 worth of cocaine and five gallons of the prescription cough syrup Promethazine Codeine. KAUZ,

Suspected Longview drug gangs busted  -  May 29, 2008
..."Each gang is alleged to have maintained drug houses in which crack cocaine, marijuana, promethazine, pills and firearms were continually being sold," Marshall News Messenger,

Pharmacy burglary, thieves looking for  -  May 27, 2008
In a press release, Broom noted that the most popular brands targeted were "Tussionex, Promethazine with Codeine, and Guifenesin. MyFox Gulf Coast,

Bun B - II Trill Album Review  -  May 15, 2008
On December 4, 2007, Pimp C tragically passed away in a Los Angeles, CA hotel due to an overdose of Promethazine/Codeine syrup and a pre-existing medical UGO,

Compounding pharmacists are more than ordinary pill-pushers  -  May 10, 2008
He also has made promethazine gel, which can be applied to the wrist, for patients with nausea. He has even launched his own hand cream, Outdoor Hands, Augusta Chronicle (subscription),

Bun B Interview  -  May 5, 2008
...away on December 4, 2007 in Los Angeles, CA due to an overdose of Promethazine/Codeine syrup and a pre-existing medical condition called sleep apnea. UGO,

The Deregulatory Effects of Preempting Tort Litigation  -  May 20, 2008
Diana Levine developed gangrene and had her arm amputated after promethazine was administered for treatment of migraine and associated nausea through an Journal of American Medical Association (subscription),

Trial for area woman charged with vehicular homicide delayed  -  May 12, 2008
Court records show Mattox had taken some medication that day; Promethazine, mephrobamate and Dilantin. At the time of her original sentencing, Lewis ordered Zanesville Times Recorder,

Young Buck Leaves G-Unit Amid Rumors  -  Apr 21, 2008
Lastly, 50 also alleged that Young Buck is addicted to cocaine and syrup, a popular drink which mixes promethazine and codeine found in cough syrup – saying NobodySmiling.com,

50 Cent Blames Young Buck's Ousting On Erratic Behavior  -  Apr 21, 2008
50 Cent told MTV.com that Young Buck's behavior was erratic and that the rapper was using drugs -- in particular syrup (a mix of promethazine and codeine) KBS Radio,

Lil Wayne Addresses Syrup Addiction  -  Apr 5, 2008
Syrup is combination of Promethazine, Codeine and a mixer (usually juice or soda) that grew popularity in the south and was made famous by Wayne and other 411mania.com,

When the problem is Munchausen's  -  Apr 11, 2008
She had also been complaining of nausea but had refused to take Zofran, the usual anti-emetic, requesting promethazine instead, which accentuates the effect Los Angeles Times,

50 Cent Claims Young Buck Has A Drug Problem, Changes Title Of New ...  -  Apr 18, 2008
50 claims Buck uses cocaine and sips syrup (a mixture of promethazine and codeine) which played a role in Pimp C's death last year. Sixshot.com,

50 Cent Makes Shocking Allegations Against Young Buck, Says A Dis ...  -  Apr 18, 2008
...cocaine and sipping on syrup (commonly a mixture of promethazine and codeine), the latter of which played a role in Pimp C's death earlier this year. MTV News,

CPSO report  -  Apr 18, 2008
...as well as her primary care physician, over a four month period to obtain medications such as Hydrocodone, Promethazine, Oxycodone, and Butalbital. Sulphur Southwest Daily News,

Marietta police arrest 'King Kong,' seize $10K in drugs  -  Apr 2, 2008
...dextroamphetamine saccharate); the pain killers Lortab, Vicodin and meperidine; and promethazine, which is prescribed for motion sickness and allergies. Atlanta Journal Constitution,

Friday's Daily Rap  -  Apr 11, 2008
The notorious beverage used primarily by rappers in the Southern states is a dangerous combination of Promethazine, Codeine and a mixer of either soda or FemaleFirst.co.uk,

Pre-emption For Real?  -  Apr 7, 2008
At issue is the labeling and usage of Wyeth's histamine antagonist Phenergan (promethazine), with the suit being brought by a patient who was injured after Corante,

Fck it I'm not even a rapper call me T-Wayne" - Lil Wayne  -  Mar 10, 2008
First, he let people in on a dependency issue he has with promethazine codeine cough syrup. "If I go off it," he admitted to the magazine, Sixshot.com,

Gym Class Hero Admits To Drug Addiction  -  Mar 10, 2008
In the past weeks it has been found that UGK rapper Pimp C's untimely death was partially due to mixing medications including 'syrup' , Promethazine HipHopDX,

Bun B Comments on Lil Wayne's Syrup Addiction  -  Mar 6, 2008
The above is a quote from Bun B, commenting on the New Orleans rapper’s addiction to promethazine codeine cough syrup. Pimp C, Bun B’s partner in the duo HipHopDX,

Lil Wayne Explains His Addiction  -  Feb 29, 2008
After it was revealed that the now infamous “syrup�? (promethazine and codeine mixed with soda or juice) may have played a part in Pimp C’s death, HipHopDX,

Purple drank: Prescription cough syrup key in drug abuse trend  -  Feb 20, 2008
The main ingredient of the drink is prescription-strength cough syrup that contains promethazine and codeine. Abusers mix it with another liquid such as a Jackson Clarion Ledger,

News - Music, movie, Entertainment LIL WAYNE ADDICTED TO 'SYRUP'?  -  Mar 1, 2008
...in recent months, reportedly developed a liking for "syrup", the potentially lethal mix of prescription codeine or promethazine with soda or juice. PR-Inside.com (Pressemitteilung),

Jimson Weed - Uses and Side Effects  -  Mar 10, 2008
...with phenothiazines such as prochlorperazine and promethazine; and with tricyclic antidepressants such as amitriptyline and imipramine. Los Angeles Chronicle,

City woman faces drug charges after police search home  -  Feb 21, 2008
Holder also had 22 Promethazine tablets that had been prescribed to someone else. Traces of drugs and drug paraphernalia were found in the kitchen, Sheboygan Press,

Other Types Of Pain Relief-Pregnancy  -  Mar 5, 2008
Since one of the side effects of narcotics is nausea, many care providers will automatically give you a sedative drug called promethazine together with your Los Angeles Chronicle,

A Lifetime of Pain, and She Still Will Not Complain  -  Feb 28, 2008
9 over the counter pills, and weekly shots at the Diamond Headache Clinic of dolophine (Methadone) for pain and promethazine (Phenergan) for nausea. New York Times,

Lil Wayne On Syrup: 'Everybody Wants Me To Stop ... It Ain't That ...  -  Feb 28, 2008
On Sunday night, during a concert in Newark, New Jersey, Wayne explained to the audience that sipping syrup — a combination made up chiefly of promethazine MTV.com

Don't drink the Kool-Aid  -  Mar 3, 2008
...drug popular in the hip-hop community in many southern states. Its main ingredient is prescription-strength cough syrup containing codeine and promethazine. The Massachusetts Daily Collegian,

Hot Off The Presses: Andre 3000, Nas, Diddy, Lil Wayne & More  -  Mar 1, 2008
...death of Texas rapper Pimp C. Lil Wayne recently revealed to MTV that he's addicted to syrup -- a combination concocted from promethazine and codeine, BallerStatus.com,

Bun B Plans First Album After Pimp C’s Death  -  Feb 29, 2008
David Banner, Rick, and the late Pimp C, UGK’s second-half, who died December 4, of an accidental overdose of Promethazine and Codeine, known as “syrup. Vibe,

Area Pharmacy Owner, Texas Physician Among Those Indicted for ...  -  Feb 15, 2008
...alprazolam, a sedative and anti-anxiety medication (in both its generic and brand name forms, such as Xanax) and promethazine with codeine, Kansas City infoZine,

Nashport couple subpoenaed to testify again on vehicular homicide case  -  Feb 14, 2008
Court records show Mattox had taken medication that day: Promethazine, meprobamate and Dilantin. Lona Shumaker lost her left leg in the crash, while Richard The Newark Advocate,

Brand Names/Synonyms:
Promethazine is also known by the following brand names and/or synonyms3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25

Drug Category:
Promethazine is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05

Dosage Forms:
Tablets, suppositories, opthalmic drops, syrup

Absorption:
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance

Interactions:
-->Interactions for Promethazine:

Injection:

Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride.

Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered.

Syrup, Tablets and Suppositories:

CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose.

Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution.

Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories.

Chemical IUPAC Name:
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

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