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PromethazineThis page contains recent news articles, when available, and an overview of Promethazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Promethazine (when available) Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. For the treatment of allergic disorders, itching, nausea and vomiting Mechanism Of Action: Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. News Articles on Promethazine Milford teens face drug charges - Aug 24, 2009 Mahan also found two white pills in a small plastic bag, which he later identified as Promethazine, an allergy medication known for its sedative effects, Milford Daily News Confessions of a Bo-Fessional - Aug 18, 2009 But Bo is more likley to kill you; promethazine causes extreme drowsiness and potentially, in large enough doses, heart attacks or respiratory failure. San Francisco Bay Guardian A primer on allergy medicines - 14 Jul 2009 Look for the words "pseudoephedrine" or "promethazine" on the label. Potential side effects include: These are not recommended if you have certain medical KTNV Las Vegas Drug Stash Found in 2003 Jackson Raid - Jul 10, 2009 TMZ reports the following was found: Versed (sedative), IV bags possibly containing anesthesias, Promethazine (strong anthistamine), Popeater Codeine abuse abounds in Houston - Jul 12, 2009 Known as Purple Drank, Lean or Sizzurp, mixing cough suppressant containing codeine and promethazine rose to prominence in Houston in the 1990s as its abuse Milwaukee Journal Sentinel Jackson's web of fraud and pill addiction is revealed - Jul 10, 2009 The police raid, for instance, found numerous medicines, including several vials of the sedatives Versed and Promethazine; a vial of the hospital-strength Scotsman Pill Popping in Pop Culture - Jun 30, 2009 But Penn's history of use with the prescription drug promethazine with codeine were listed as possible contributing circumstances. Brother Sean Penn said in ABC News Pain Management in Acute Care - Jul 13, 2009 Hydroxyzine or promethazine may add to the analgesic effect of an opioid while promoting relaxation and decreasing the incidence of nausea and vomiting. ADVANCE for LPNs Viral infection can trigger dizziness - Jul 6, 2009 And medicines like promethazine relieve dizziness and nausea, but they make some people so drowsy that they prefer the dizziness. DEAR DR. SouthCoastToday.com Cough, Cold Mixtures Unsuitable For Children Below Two - Jul 8, 2009 Clemastine, Dexbropheniramine, Diphenhydramine, Pheniramine, Promethazine dan Triprolidine), antitussives (such as Dextromethorphan and Diphenhydramine) Bernama 'Pill mill' doctors plead guilty - Jun 26, 2009 Van pleaded guilty to one misdemeanor involving promethazine with codeine, a narcotic cough syrup she prescribed for one of her husband's patients. SunHerald.com (registration) Repeated Episodes of Neutropenia Triggered by Mirtazapine - Jun 30, 2009 Although erythromycin, promethazine, pantoprazole, and metoclopramide have been associated with blood dyscrasias, these medications were longstanding Psychosomatics (subscription) Motorcyclist accused of popping wheelie on Center Street arrested ... - Jun 30, 2009 A search of her purse found four pills believed to be Alprazolam and seven pills believed to be Promethazine. She had a prescription for neither of the Kingsport Times News Weed in a can - Jun 19, 2009 The main ingredient in "Purple Drank" is prescription strength cough syrup containing the drugs codeine and promethazine. This cough syrup is then mixed Ponte Vedra Recorder Jackson's Death Could Be Ruled Homicide - Jul 10, 2009 TMZ also reports a 2003 raid on Jackson's home found a vial of Demerol, a bottle of the painkiller Percocet, a vial of the antihistamine Promethazine, ChartAttack Michael Jackson had more than one doctor who prescribed him drugs - Jul 7, 2009 The report found that Jackson had four substances in his system: Meperidine (Demerol), Normeperidine, promethazine (an antihistamine) and cocaine. HotIndieNews.com Un cocktail de médicaments pour Jackson - Jul 10, 2009 ...une fiole de Promethazine, un antihistaminique qui sert à combattre l'insomnie, ainsi qu'une bouteille d'Alprazolam, une drogue qui calme les troubles Canoë Foto's huiszoeking Michael Jackson - Jul 10, 2009 Promethazine, een anti-histamine met sterk verdovend karakter. - Alprazolam, een vorm van Xanax dat paniekaanvallen tegengaat. De Telegraaf Michael Jackson : prêt à tout pour se fournir des analgésiques - Jul 10, 2009 Prednisone (corticostéroïde), Promethazine (antihistaminique luttant contre des allergies et l'insomnie) ou encore du Percocet (antidouleur). Metro France AnchetaÅ£i pentru omucidere - Jul 10, 2009 Propofol (descoperit ulterior ÅŸi la reÅŸedinÅ£a cântăreÅ£ului din Los Angeles) ÅŸi alte anestezice de culoare albă, o sticluţă cu Promethazine (cu efecte Jurnalul Naţional Schools, Parents Respond After Pills Send 9 Students to The Hospital - 20 Apr 2009 Thursday as the semi-synthetic opioid painkiller hydrocodone, the allergy medication promethazine and the pain-reliever ibuprofen, the district said. KWTX Forged cough syrup prescription leads to Illinois man arrest in ... - Apr 13, 2009 Police said Leavy presented the pharmacy with a prescription for promethazine with codeine that was written on a prescription pad from a Chicago clinic. The Herald-Times (subscription) Pharmacies hot target for burglars in recent days - Apr 13, 2009 Burglars broke in about 3:15 am and took several bottles of promethazine with codeine from the CVS pharmacy in the 400 block of East Arrow Highway, San Gabriel Valley Tribune Man accused of possessing more than 200 grams of cocaine - Apr 15, 2009 Promethazine is also sold under the brand names Pentazine and Phenergan. McKinley remained in the Travis County Jail on Wednesday with bail set at $100000. Austin American-Statesman For the record - Apr 13, 2009 She successfully argued in a Vermont court that Wyeth had failed to properly inform doctors about the risk of administering promethazine via IV push. CMAJ UGK: UGK 4 Life - Mar 31, 2009 According to reports, he overdosed on “syrupâ€?—a mixture of promethazine and codeine. But now, nearly two years since his passing, Pimp C lives on. Vibe 8th-grader charged with distributing prescription drugs at GW Carver - Apr 17, 2009 Hydrocodone is a prescription-strength pain reliever, and promethazine is used to treat nausea and may cause drowsiness. The eight students who received and Waco Tribune Herald Mr. Ashok Shinkar, Director Corporate Finance, Wanbury Ltd - Apr 15, 2009 Wanbury boasts of a strong product portfolio which includes Salsalate, Glucosamine, Mefenamic Acid, Tramadol, Amitryiptyline, Promethazine, Sertraline, India Infoline.com Doctor Admits Illegally Dispensing Oxycodone - Mar 31, 2009 At his plea hearing, Agrawal admitted that between February 2005 and June 2008, he illegally sold bottles of promethazine cough syrup with codeine and Imperial Valley News Pills, ginger or a nap: Some useful remedies against sea sickness - Apr 19, 2009 For more severe symptoms, he recommends taking scopolamine or promethazine. If you have not taken anything, and you are hanging over the railing, TopNews Traffic stop yields drugs, cash, repeat offender - Apr 10, 2009 A suspected drug dealer and approximately $1000 worth of crack cocaine, $400 worth of Promethazine cough syrup and $5708 in alleged drug currency were all Jennings Daily News Summertime and living is agonising – for some - Mar 30, 2009 Associate director of pharmacy Anne Joshua said: “Antihistamines such as chlorphenamine and promethazine have been used for many years to treat adults, ChronicleLive 09年执业西è?¯å¸ˆè?¯ç‰©åŒ– - Apr 16, 2009 ...例如异丙嗪（Promethazine）和赛庚啶（Cyproheptadine）ç‰ã€‚ä¸?过这类è?¯ç‰©å¾€å¾€è¿˜æœ‰å…¶å®ƒè?¯ç?†ä½œç”¨ï¼Œå¼‚丙嗪结构与抗精神病è?¯æ°¯ä¸™å—ªç±»ä¼¼ï¼Œæœ‰æ˜Žæ˜¾çš„镇é?™å‰¯ä½œç”¨ã€‚ 青年人 Insomnia During Pregnancy - 18 Mar 2009 It would be safe enough for you to try them in modest amounts, the commonest being diphenhydramine and promethazine. Depok Metro Supreme Court Sends Suicide Case Back to Lower Court in Wake of ... - Mar 9, 2009 Wyeth, maker of promethazine, appealed the Vermont verdict and was supported in its appeal by the Bush administration. Their argument was that a warning MedPage Today Supreme Court Ruling Called "Major Win" for Patients - Mar 4, 2009 The case involved a former professional guitarist who was improperly injected with the anti-nausea medication Phenergan (promethazine), About - News & Issues Two Men Arrested For Allegedly Fleeing Longview Drug Bust - Feb 20, 2009 CODE investigators located quantities of promethazine, PCP, marijuana, illegal pills and a small quantity of cocaine during their search. Tyler Morning Telegraph Suspect captured fleeing scene of narcotics search - Feb 19, 2009 SWAT team members captured Smith and later found promethazine, PCP, marijuana, illegal pills and a small quantity of cocaine inside the residence, News-Journal.com Prescriptions written for Anna Nicole Smith - Mar 12, 2009 ..._ promethazine with codeine, an antihistamine and sedative. _ clonazepam, an anticonvulsant, muscle relaxant. _ chloral hydrate, a hypnotic sedative used to The Associated Press Carry warning labels on cold & cough medicines - Mar 11, 2009 In addition, cough and cold products containing promethazine (a commonly used antihistamine) should not be given to infants under 6 months because of the AsiaOne Unjust Equations: False Positives In Drug Testing - Mar 12, 2009 Over-the-counter allergy preparations, sleep-aids and anti-nausea medications that contain promethazine, Phenergan®, Promethagan® such as Claritin D will North Country Gazette Another Acid High ***** - Mar 5, 2009 ...“The Drop I Holdâ€? is something like a more ethereal version of early-period Wu-Tang; it’s garage rock as produced by GZA, dipped in promethazine, Daily Nexus Music review: Project Pat - Real Recognize Real - Mar 4, 2009 Also featuring Houston MC Bun B, the track glorified the woozy concoction of promethazine and codeine cough syrup that Lil’ Wayne gulps down like Kool-Aid. Advance Titan Parents told not to give cough and cold remedies - Feb 28, 2009 ...promethazine, triprolidine and doxylamine; the cough suppressants dextromethorphan and pholcodine, and the expectorants guaifenesin and ipecacuanha. Telegraph.co.uk Anna Nicole Smith's Boyfriend, Doctors Charged - Mar 13, 2009 ...a short term sleep aid; promethazine with codeine, an antihistamine and sedative; clonazepam, an anticonvulsant, muscle relaxant; chloral hydrate, AOL Canada Inside the GOP Hip-Hop Revival Tent - Feb 20, 2009 Sipping syrup, a combination made up chiefly of promethazine, codeine and Sprite. Steele plans on making Purple Drank the centerpiece of his healthcare Huffington Post 雪è¦æ?£å’³è?¯æ°´é›†å›¢åŒ»ç”Ÿä¹Ÿè?½ç½‘ - Mar 13, 2009 ...å? 沙表示，è¦æ–¹å…±èµ·èŽ·2å?ƒ932ç“¶åˆ¶é€ å’³å—½è?¯æ°´çš„异丙嗪（Promethazine）è?¯æ°´å’Œ8å?ƒ990颗å?Œæ°¢å?¯å¾…å› ï¼ˆDihydrocodeine）è?¯ä¸¸ã€?5ç“¶è‰²ç´ ã€?6瓶咳嗽è?¯æ°´ä»¥å?Šä¸€äº›å¤§å°?ä¸?一的空瓶。 光华日报 Henderson man jailed on manslaughter charge in 2007 Longview death - Feb 20, 2009 A Henderson man remained in the Gregg County Jail on Thursday, charged with manslaughter in the 2007 shooting death of a Longview woman. News-Journal.com Port Sanilac Physician Summarily Suspended - Feb 1, 2009 March 2007 and October 2008, Ebreo prescribed 207313 OxyContin tablets, 194514 Xanax tablets, 66529 Vicodin tablets and 2761 bottles of promethazine. Chicago Tribune, State yanks licenses of physician and pharmacist - Feb 3, 2009 ...and Oct. 2008, Ebreo, 68, prescribed 207313 OxyContin tablets, 194514 Xanax tablets, 66529 Vicodin tablets and 2761 bottles of promethazine. Michigan Messenger, Four key questions about promethazine-syrup-and-juice-sipping rap ... - Jan 22, 2009 Wayne has four tattoos on his face, including three teardrops. In East LA gang parlance, a teardrop is used to signify each person one has killed. The Province, Hi, I'm the doctor, and I won't be taking your order today - Jan 16, 2009 The cough syrup she wanted, promethazine with codeine, is no better than over-the-counter stuff, and the only reason it makes people sleep is because it Los Angeles Times, Antihistamine tablets for normal nausea and vomiting in early ... - Jan 21, 2009 The antihistamine used to treat nausea and vomiting in pregnancy in the UK is promethazine (the brand name is Phenergan). Another antihistamine, cyclizine guardian.co.uk, Lil Wayne Documentary at Sundance Reveals Dire Cough Syrup Addiction - Jan 22, 2009 Obvious lyrical references aside, he’s also spoken out to MTV News about his addiction to the concoction that includes codeine and promethazine. TwentyFourBit, Sun Pharma Receives USFDA Approvals For 4 Generic Products - Jan 9, 2009 In addition, approval was received for generic Phenargan tablets. promethazine hydrochloride USP. Generic Phenargan is an antihistamine/ antiemetic and is Pharmaceutical Online (press release), FDA Approves Four ANDAs for Sun Pharma - Jan 15, 2009 ...of Novartis’ Aredia (pamidronate disodium), Pfizer’s Lopid (gemfibrozil) and Wyeth’s Phenergan (promethazine HCl), India-based Sun says in a statement. FDA news (subscription), Antihistamine tablets - Jan 21, 2009 ...[9] An antihistamine called promethazine can cause dangerous breathing problems in very young children.[10] It isn't recommended for children under 2 years guardian.co.uk, THE CARTER - Jan 21, 2009 The film looks like is a commercial for Wayne’s new album and his favorite drug of choice: Promethazine and Codeine (prescription strength cough syrup) Film Threat, Sleep problems in children - Jan 21, 2009 Antihistamines which cause drowsiness as a side effect include promethazine (brand name Phenergan), alimemazine (Vallergan) and chlorphenamine (Piriton). guardian.co.uk, Magnesium sulphate for treating severe pre-eclampsia or eclampsia - Jan 21, 2009 ...[1] For example, it works better than the drugs phenytoin and diazepam and better than a mixture of meperidine, chlorpromazine and promethazine.[2] guardian.co.uk, Wanbury's a strong formulations shot - Jan 11, 2009 Apart from being the largest producer of Metformin, it is known for manufacturing of mefanimic acid, ibuprofen, glucosamine, promethazine, amitryptalline, Daily News & Analysis, Lil Wayne: sippin' on sizzurp at Sundance - Jan 21, 2009 ...to sonically replicate the state of a person who has imbibed a lot of perscription cough syrup fortified with codeine, hydrocodone and/or promethazine. Los Angeles Times, What's the evidence for magnesium sulphate for treating severe pre ... - Jan 21, 2009 ...[1] A combination of three drugs (meperidine, chlorpromazine and promethazine). Duley L, Gulmezoglu AM, Henderson-Smart D. Magnesium sulphate and other guardian.co.uk, La bronchite aiguë infectieuse - Jan 9, 2009 ...vous prescrire contre la toux des antitussifs sous forme de capsules (Atouxx capsules ®) ou de solution buvable (Toplexil ®, Rhinathiol Promethazine ®. Doctissimo, Brand Names/Synonyms: Promethazine is also known by the following brand names and/or synonyms3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25 Drug Category: Promethazine is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05 Dosage Forms: Tablets, suppositories, opthalmic drops, syrup Absorption: On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance Interactions: -->Interactions for Promethazine: Injection: Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride. Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered. Syrup, Tablets and Suppositories: CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose. Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories. Chemical IUPAC Name: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine : |
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