Procarbazine

This page contains recent news articles, when available, and an overview of Procarbazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Procarbazine (when available)

Pharmacology and use:
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division. For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Mechanism Of Action:
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA.

News Articles on Procarbazine

Inspired to help children abroad after cancer battle  -  Feb 18, 2008
At the moment, patients receive Procarbazine, an oral chemotherapy drug which can cause infertility, then large dozes of radiotherapy, which can cause Scotsman,

Chemotherapy for Hodgkin's Lymphoma Linked to Premature Menopause  -  Feb 18, 2008
The strongest associations were found with alkylating agents, especially procarbazine (HR 8.1) and cyclophosphamide (HR 3.5). The authors report that 10 Cancerpage.com,

High-dose Methotrexate Provides Long-term Results in Central ...  -  Feb 19, 2008
A regimen that included five cycles of high-dose methotrexate, Oncovin®, procarbazine, and intraventricular methotrexate resulted in a complete remission Cancer Consultants,

Phase 3 Trials Suggest Ways to Improve Current Hematologic Cancer ...  -  Feb 5, 2008
In the trial, each patient received 1 of 3 chemotherapy regimens: arm A received standard of care with COPP (cyclophosphamide, vincristine, procarbazine, Journal of American Medical Association (subscription),

Male Patients with Hodgkin Lymphoma Face High Risk of Infertility  -  Feb 4, 2008
...doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisone) therapy. The median age was 26; most patients were in clinical stage III. Cancerpage.com,

Escalated BEACOPP Chemotherapy Improves Long-Term Outcome in ...  -  Dec 10, 2007
Ten-year survival with standard BEACOPP was 80%; and it was 75% with a regimen based on COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) DG News

Research Provides Critical Insight into Improving Therapy for ...  -  Dec 9, 2007
Patients received one of three chemotherapy regimens: standard of care COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) alternating with Earthtimes,

Chemotherapy And Radiotherapy Should Be Standard Treatment For ...  -  Dec 3, 2007
The chemotherapy regimen used for all the groups was mechlorethamine, vincristine, procarbazine, and prednisone in combination with doxorubicin, bleomycin, Medical News Today (press release),

Chemotherapy Plus Radiation Recommended as Standard of Care in ...  -  Nov 15, 2007
...vincristine, procarbazine and prednisone)/ABV (doxorubicin, bleomycin and vinblastine) regimens plus radiation therapy to involved sites. Cancer Consultants (press release),

Chemotherapy plus Radiation Recommended as Standard of Care in ...  -  Nov 9, 2007
...procarbazine and prednisone); plus chemotherapy, referred to as ABV (doxorubicin, bleomycin and vinblastine); plus radiation therapy to involved sites. Cancer Consultants (press release),

Chemo plus involved-field radiation best for early Hodgkin's disease  -  Nov 9, 2007
Chemotherapy consisted of MOPP-ABV (mechlorethamine, vincristine, procarbazine, prednisone -- doxorubicin, bleomycin and vinblastine). Medicexchange,

Chemotherapy plus Involved-Field Radiation in Early-Stage ...  -  Nov 7, 2007
In the H8-F trial, we compared three cycles of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) combined with doxorubicin, bleomycin, New England Journal of Medicine (subscription),

Anti-Müllerian Hormone Is a Sensitive Serum Marker for Gonadal ...  -  Oct 12, 2007
...bleomycin, vinblastine and dacarbazine (ABVD) or EBVD with or without mechlorethamine, vincristine, procarbazine, and prednisone (MOPP). Journal of Clinical Endocrinology and Metabolism,

Barr Confirms Patent Challenge of TEMODAR(R)  -  Jul 24, 2007
CNNMoney.com...with refractory anaplastic astrocytoma, ie, patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine.

Recommendations for Treatment of Pleurisy  -  May 8, 2007
Medscape (subscription)...bromocriptine, cyclophosphamide, methotrexate, methysergide, minoxidil, mitomycin, oxyprenolol, practolol, procarbazine, and sclerotherapeutic agents.

131 Abstracts Evaluating Celgene Products to Be Presented at the ...  -  Dec 7, 2006
PR Newswire (press release),Thal & Metronomic Oral Chemotherapy with Prednisone, Etoposide, Procarbazine and Cyclophosph) in R/R Disease; Abstract 2751 Myelodysplastic Syndromes

Brand Names/Synonyms:
Procarbazine is also known by the following brand names and/or synonymsCCRIS 2389; CHEMBANK3199; HSDB 3250; IBZ; Ibenzmethyzin; Ibenzmethyzine; Ibenzmethyzine Hydrochloride; MBH; MIH; Matulane; Mih Hydrochloride; NSC-77213; Nathulane; Natulan; Natulan Hydrochloride; Natulanar; Natunalar; PCB; PCX; Pcb Hydrochloride; Procarbazin; Procarbazin [German]; Procarbazina [Inn-Spanish]; Procarbazine; Procarbazine Hydrochloride; Procarbazinum [Inn-Latin]; Ro 4 6467/1

Drug Category:
Procarbazine is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01XB01

Dosage Forms:
CAPSULE

Absorption:
Procarbazine is rapidly and completely absorbed.

Interactions:
Interactions for Procarbazine: To minimize CNS depression and possible potentiation, barbiturates, antihistamines, narcotics, hypotensive agents or phenothiazines should be used with caution. Ethyl alcohol should not be used since there may be an Antabuse (disulfiram)-like reaction. Because Matulane exhibits some monoamine oxidase inhibitory activity, sympathomimetic drugs, tricyclic antidepressant drugs (e.g., amitriptyline HCl, imipramine HCl) and other drugs and foods with known high tyramine content, such as wine, yogurt, ripe cheese and bananas, should be avoided. A further phenomenon of toxicity common to many hydrazine derivatives is hemolysis and the appearance of Heinz-Ehrlich inclusion bodies in erythrocytes. No cross-resistance with other chemotherapeutic agents, radiotherapy or steroids has been demonstrated.

Chemical IUPAC Name:
N-(1-methylethyl)-4-[(N'-methylhydrazino)methyl]benzamide

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