Procaine

This page contains recent news articles, when available, and an overview of Procaine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Procaine
(when available)

Pharmacology and use:
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine. Used as a local anesthetic primarily in oral surgery

Mechanism Of Action:
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

News Articles on Procaine

Fennel seeds stopped heartburn, successful wart remedy  -  May 12, 2008
Benzonatate (Tessalon) is not appropriate for anyone allergic to local anesthetics like procaine (Novocain). An iron supplement also may help with this kind Seattle Times,

FUNABASHI, Chiba -- A horse trainer accused of giving a winning ...  -  May 7, 2008
Investigators accuse Tate of administering procaine to the 4-year-old female racehorse Top Feeling, which came in first in the No. Mainichi Daily News,

“remind me - which naked lady is your daughter again?â€?  -  May 12, 2008
...you may want to go wash your hands. And begin consecutive daily intramuscular injections with procaine penicillin to combat syphilis.� Macleans.ca,

Impaired At The Helm  -  May 4, 2008
At the time of the Bay of Pigs, JFK was regularly taking at least a dozen prescription medicines, including testosterone, corticosteroids and procaine, Hartford Courant,

Vitamin B-12 deficiency linked to acid reducers  -  May 12, 2008
Benzonatate (Tessalon) is not appropriate for anyone allergic to local anesthetics such as procaine (Novocain). An iron supplement also may help with this Los Angeles Times,

Koriner Gets 5-Day Ban in Procaine Case  -  Apr 12, 2008
Black Seventeen, winner of the fifth race at Hollywood Park May 1, 2007, exceeded the acceptable regulatory level for procaine in a post-race test sample BloodHorse,

California trainer Koriner suspended, fined  -  Apr 12, 2008
Procaine is a local anesthetic and a Class 3 drug violation. Santa Anita stewards stayed 35 days of Koriner’s suspension, provided the trainer has no Thoroughbred Times,

Koriner draws fine, ban  -  Apr 9, 2008
2007, tested positive for the anesthetic procaine, according to a stipulated agreement between Koriner and the California Horse Racing Board. CBSSports.com

Prognosis: Lack of Standards and Sheer Ignorance!  -  Apr 8, 2008
...that one of the rowdy Presidential Advisors is a chronic case of Syphilis, the type that cannot even respond to procaine penicillin and other hardcore Nyasa Times,

A doctor in the House  -  Apr 4, 2008
...in tandem with his complex medical history, including his iatrogenic addiction to steroids and procaine injections as well as to recreational drugs. Guardian,

Emerging Antimicrobial Resistance in Neisseria gonorrhoeae: Urgent ...  -  Apr 14, 2008
...in the recommended dose of intramuscular procaine penicillin (with probenecid) from 50 000 units in 1945 to 4.8 million units by the early 1970s (9). Annals of Internal Medicine

Capsaicin from Chili Peppers May Work as Potent Dental Anesthetic  -  Apr 11, 2008
...anesthetics such as Novocaine (procaine), according to a study conducted by researchers at Harvard Medical School and published in the journal Nature. Natural News.com,

Mushers confident Iditarod is '100% clean'  -  Feb 28, 2008
The drug was procaine, which is often used in combination with penicillin and could mask a dog's lameness. The drug could end up in a dog's system by eating USA Today

ORC Rules On Preszcator Appeal  -  Feb 19, 2008
On July 19, 2007, a horse trained by Preszcator (Real Model) that was racing at Mohawk Racetrack produced a positive test for the 'Class V' drug Procaine. Standardbred Canada,

Fake Doctor Arrested At Hohoe  -  Feb 12, 2008
Some of the items found in the suspect’s room were bottles of procaine penicillin, four vials of vitamin c, two vials of chloroquine, four vials of Modern Ghana,

Drinkable Tap Water May Be Suitable for Wound Cleansing  -  Jan 25, 2008
Procaine spirit is a mixture of procaine HCl 2% with spirit 70% and is commonly prescribed for wound cleansing following surgery. Medscape (subscription)

Ignorance no defence as FEI beef up war on doping  -  Dec 11, 2007
...treated Ballybolger Bushman with the antibiotic, Procaine, after a fall on the flat while competing at the CNC in Tyrella, Co Down in April 2006. Irish Independent,

Health & Science: Anesthetics are more dangerous than we think  -  Dec 6, 2007
Local anesthetics selectively block sensory feedback from a part of the body; procaine (Novacaine) at the dentist's office is a good example. The Heights (subscription),

OBS bans steroids in sale horses  -  Dec 5, 2007
The company also will forbid bronchodilators within 72 hours of an under-tack show or sale session and will ban furosemide (Lasix or Salix) and procaine CBSSports.com

OBS Limits Steroid Use at Sales  -  Dec 4, 2007
Additionally, furosemide (Salix) and procaine penicillin may not be administered to a sale horse while on the sales grounds. OBS will continue to perform BloodHorse,

Pain can radiate to other areas  -  Nov 26, 2007
If a patient complains of a severe trigger point, I will refer them to their medical doctor, who may inject procaine or some other type of medication into Pacific Daily News,

Cocaine purity at 25% as gangs add anaesthetic and painkillers  -  Nov 25, 2007
Benzocaine, a local anaesthetic, was found in 8% of samples (4% and 4%) and procaine, also an anaesthetic, was in 3% of samples (3% and less than 1%). Irish Examiner,

Golden Gate bars vet for 30 days  -  Dec 14, 2007
...unplaced in the second race at Bay Meadows on Sept. 26 because of an excessive level of procaine, a painkiller. Purse money of $7200 will be redistributed. CBSSports.com

Massive theft of government drugs  -  Dec 14, 2007
The stolen drugs include paracetamol (panadol), Procaine Penicillin(PPF), intravenous fluids, septrin. Also stolen were bandages, plaster adhesives and New Vision,

Vet Suspended for Lidocaine Offense  -  Dec 14, 2007
13, Golden Gate stewards fined trainer Greg Gilchrist $1500 after a post-race urine sample of a horse in his care revealed the presence of procaine in BloodHorse,

North Beach gives mare her third stakes winner  -  Nov 12, 2007
Procaine is used as a local anesthetic, often with an antibiotic. Sixteen runners were nominated to Saturday's Grade 3, $150000 All American at 1 1/8 miles Daily Racing Form (subscription),

Gilchrist Cited in CHRB Complaint  -  Nov 10, 2007
Industrial Laboratories confirmed the finding of procaine in the duplicate sample above the authorized level. Procaine is a local anesthetic but is also BloodHorse,

The Medical Ordeals of JFK  -  Nov 16, 2007
...an internist and pharmacologist who had been relieving Kennedy's back pain with injections of procaine (an agent similar to lidocaine). Atlantic Online

Removing Mercury From the Body - Are You Being Poisoned?  -  Oct 21, 2007
MD, Ph.D. a specialist in neural therapy, a process using local injections of anesthetics, such as lidocaine or procaine, to remove interferences in the RINF.COM,

Wise Use of Antibacterial Drugs  -  Oct 6, 2007
For example, some horses react to an injection of procaine penicillin by collapsing or becoming hyperexcitable. Others may develop severe diarrhea and TheHorse.com,

Doping probe hits second Irish rider  -  Oct 2, 2007
Already listed on the FEI's Case Table was Sam Watson whose horse, Ballybolger Bushman, tested positive for Procaine while competing at the CIC 2-Star in Irish Independent,

King Pharmaceuticals Announces That It is Now Distributing ...  -  Aug 15, 2007
Bicillin(R) CR Pediatric 900/300 is comprised of 900000 units of penicillin G benzathine and 300000 units of penicillin G procaine. Bicillin(R) CR Pediatric PharmaLive.com (press release),

ORC Denies James, Macri Appeals  -  Aug 22, 2007
In an ORC ruling dated May 2, 2007, Macri had been handed a 15-day and $1500 fine for a positive Class 5 test for Procaine in the horse Dawnbrae Echo, Standardbred Canada,

Scientific method turns crime fighter  -  Aug 26, 2007
The pink tablet with the bunny imprint, which Yohannan tested last week, contained MDMA, methamphetamine and procaine, commonly called novocaine. Baltimore Sun,

Special to Page 2  -  Aug 14, 2007
Lidocaine, Procaine, Carbocaine: The numbing chemicals used by dentists and for ambulatory surgery might have been shot directly into his knee or elbow. ESPN

Robert Kidd, MD, CM, Offers Sept. 14-15 Neural Therapy Course in ...  -  Aug 18, 2007
Neural therapy treats interference fields by injecting them with a local anesthetic such as procaine. "Local anesthetics have an interesting property apart PR-GB.com (press release),

Experts Look for Ways to Lessen Impact of Drug Shortages and ...  -  Aug 14, 2007
Drugs that are discontinued or are in short supply range from trimethobenzamide suppositories (Tigan) for the treatment of nausea, to penicillin G procaine Journal of American Medical Association (subscription),

Syphilis - tertiary  -  Aug 9, 2007
Procaine penicillin 2.4 million units IM daily given with oral probenecid 500 mg 4 times per day -- both for 10 days. Penicillin is recommended as the only About - News & Issues,

Four individuals indicted by grand jury for armed robbery  -  Aug 9, 2007
David Beene, three counts of violation of the Georgia Controlled Substances Act (GCSA) (felony possession of methamphetamine, felony possession of procaine, Lincolnton Journal,

Clinical and Structural Outcomes of Nonoperative Management of ...  -  Sep 3, 2007
Procaine infiltration as a guide to treatment. J Bone Joint Surg Br. 1949;31:423 -5. Tabata S, Kida H, Takahara M, Yamaguchi S, Masuda K. A comparative Journal of Bone and Joint Surgery (subscription)

Journal of the National Association of Chiropodists, March 1955  -  Jul 27, 2007
Journal of the American Podiatric Medical Association (subscription)Steinberg also advocated the use of weekly interspace injections of procaine for patients with a syndrome he termed "forefoot rigidity" (personal

The SCPI Stem Cell Implant The Protocol  -  Jul 26, 2007
TransWorldNews (press release),With the patient on the operating table, after disinfecting the skin with an iodine solution, 10 cc of the local anesthetic procaine HCL 2% or analogs

Ask the Vet: Giving Intramuscular Injections  -  Jun 22, 2007
EquiSearch.com,The one exception to this rule is procaine penicillin, which currently is used much less commonly. In my opinion, we have much safer antibiotics than this,

Sherman, Koriner Face CHRB Complaints  -  Jun 17, 2007
BloodHorse,Koriner allegedly exceeded regulatory limits for procaine with his horse, Black Seventeen, also a Class 3 violation. A split sample confirmed the Maddy

Physician Assistant Probed For Puncturing Lung  -  Jun 26, 2007
CBS 2,State officials say that while injecting her with the anesthetic Procaine, John Harvey Cates accidentally punctured Foss' lung, causing a permanent injury

Physician assistant under scrutiny for patient's punctured lung  -  Jun 26, 2007
Fresno Bee (subscription),While injecting her with the anesthetic Procaine, John Harvey Cates accidentally punctured Foss' lung, causing a permanent injury that required

Buzzards Bay out of Gold Cup  -  Jun 19, 2007
ESPNProcaine, an anesthetic that is often used with an antiobiotic, is a Class 3 medication. Trainers with Class 3 violations are subject to fine and/or

Continuing Medical Education XVII  -  May 22, 2007
Newindpress (subscription),Penicillin: Examples include ben zylpenicillin, procaine penicillin, Amoxycillin, ampicillin, co-amoxiclav (Amoxycillin with clavulanic acid) and

Target 12 Investigators- Local Dentist Violations  -  May 16, 2007
Eyewitness News,Providing services outside the scope of dentistry, namely administering procaine injections for neck and back pain, and engaging in electrical conductivity

Montenegrin authorities seized 1.200 kg of drugs in 2006  -  May 2, 2007
Makfax,Additional five kilograms of substances used for mixing drugs, mainly paracetamol, procaine and caffeine, were also confiscated in the investigative

Horse strangles common this year  -  Jan 5, 2007
The Prairie Star,Streptococcus equi is very sensitive to a variety of antimicrobials, with procaine penicillin G the drug of choice. Mild cases usually resolve themselves

Clubs saddle up for prizemoney increase  -  Dec 15, 2006
The Age,The Smith-trained Arunluk was found to have procaine in his system after he won at Wyong on October 31 and the stewards accepted that the likely scenario

Drugs cloud: the fine line between fair and archaic  -  Dec 7, 2006
Sydney Morning Herald,Smith, a Broadmeadow trainer, was outed after his charge Arunluk returned a positive to Procaine after winning at Wyong on October 31.

Smith suspension changed to fine  -  Dec 15, 2006
ThoroughbredNews.co.nz,His father Spencer, foreman of his stable at the time, administrered gave the procaine to Arunluk believing the horse to be Canny Shuffle, which was stabled

My son not to blame  -  Dec 5, 2006
Daily Telegraph,Longtime horseman Spencer Smith, 65, is still at a loss to explain how one of the stable's horses, Arunluk, returned traces of Procaine, a local anaesthetic

Trainer Smith fighting for his career after stewards impose ...  -  Dec 4, 2006
Sydney Morning Herald,Smith said the only explanation he had for Procaine being found in Arunluk was that his father, Spencer, who was his stable foreman at his Williamtown

Positive test for unplaced Victorian runner  -  Dec 14, 2006
ThoroughbredNews.co.nz,The analyst confirmed the presence of Procaine (used in penicillin preparations to prolong the action of penicillin, it is also a local anaesthetic) in the

Ban will ruin training career  -  Dec 4, 2006
Daily Telegraph,Yesterday he was outed because Arunluk, who won a race at Wyong on October 30, showed traces of Procaine, a form of penicillin that helps horses overcome

Court Command's Trainer Banned for Four Months  -  Dec 3, 2006
Virtual Form Guide,Racing NSW Stewards on Monday inquired into the Analyst's finding of the prohibited substance Procaine being detected in the urine sample taken from the

Bell's Suspension Halved On Appeal  -  Dec 12, 2006
Virtual Form Guide,Smith was outed after Arunluk tested positive to the prohibited substance Procaine after winning at Wyong in October.

NSW trainer advised of findings of prohibited substance  -  Nov 30, 2006
ThoroughbredNews.co.nz,Racing NSW Stewards on Thursday announced that Trainer Darren Smith has been advised of the Analyst's findings of the prohibited substance Procaine in the

Smith appeal date  -  Dec 7, 2006
ThoroughbredNews.co.nz,RNSW Stewards inquired into the Analyst's finding of the prohibited substance Procaine being detected in the urine sample taken from the racehorse Arunluk

'Target' ready for Hong Kong challenge, says Janiak  -  Dec 4, 2006
The Age,...who is stable foreman, gave Arunluk the therapeutic drug Procaine by mistake as the medication was meant for Canny Shuffle, who was stabled next door.

Newcastle Trainer Suspended  -  Dec 4, 2006
OzeformThe Smith trained Arunluk returned a positive urine sample to Procaine, following its win in the Peter Doyle Cellars Handicap run at Wyong on Tuesday,

Nkhata Bay Police sniffing Simama glory  -  Nov 29, 2006
The Nation, Malawi,Full results for the weekend games are as follows: Procaine Bombers 2, Mchenga 0, Ekwendeni Medicals 2 – Ekwendeni United 0, Eagle Strikers 3 – Embangweni 0

Recognize allergic reactions  Nov 7, 2006
...the muscle. An example would be hitting a vein when injecting procaine penicillin, which should only be given in the muscle. In ... -Thoroughbred Times, E-mail us your comments  Oct 27, 2006
...(The drugs that did not always remain stable included the antibiotic penicillin G procaine powder and the antimalarial mefloquine HC1 tablets.) Despite the ... -Newsweek Administering drugs in neonates  Oct 25, 2006
...is unwell but drug release from the IM "depot" is sometimes slow (a property that is used to advantage during treatment with naloxone, procaine, penicillin and ... -Express Pharma, Botulism Alert!  Oct 24, 2006
Antibiotics that have been associated with neuromuscular weakness should be avoided. These include aminoglycosides, tetracyclines, and procaine penicillin. ... -TheHorse.com, Brand Names/Synonyms:
Procaine is also known by the following brand names and/or synonymsAllocaine; Chloroprocaine Hcl; Diethylaminoethyl P-Aminobenzoate; Duracaine; Duracillin A.S.; Gerovital; Gerovital H-3; Jenacain; Jenacaine; Neocaine; Nesacaine; Nissocaine; Norocaine; Novocain; Novocaine; P-Aminobenzoyldiethylaminoethanol; Penicillin G Procaine; Pfizerpen-As; Procain; Procaine; Procaine Hcl; Procaine Hydrochloride; Procaine, Base; Scurocaine; Spinocaine; Vitamin H3

Drug Category:
Procaine is categorized under the following by the FDA: Anesthetics; Local Anesthetics; ATC:C05AD05; ATC:D04AB03; ATC:J01CE09; ATC:N01BA02; ATC:N01BA04; ATC:S01HA02; ATC:S01HA05

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
2-diethylaminoethyl4-aminobenzoate

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