Procainamide

This page contains recent news articles, when available, and an overview of Procainamide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Procainamide
(when available)

Pharmacology and use:
Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. For the treatment of life-threatening ventricular arrhythmias

Mechanism Of Action:
Procainamide is sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

News Articles on Procainamide

Brugada Syndrome in an Active Duty Air Force Senior Pilot  -  Sep 14, 2008
This did not definitively confirm the diagnosis of Brugada syndrome, and hence a procainamide challenge was performed. This study was significant for RedOrbit,

Learning about lupus  -  Aug 18, 2008
Drug-induced lupus occurs after a person takes a certain type of medicine, namely Hydralazine and Procainamide. Symptoms are similar to systemic lupus, Midwest City Sun,

Listen to your heart  -  Feb 12, 2008
Other anti-arrhythmics such as disopyramide, procainamide and quinidine act in a similar fashion, and affect the response of the heart muscles to signals Jamaica Gleaner,

Case 12: Patient Follow-up  -  Jan 24, 2008
Procainamide and amiodarone should not be administered because of their propensity to further increase the QT interval, which would be proarrythmic in this EMS1.com - Emergency Medical Service Resources,

Case 8: Patient Follow-up  -  Nov 6, 2007
If cardioversion is not possible, then procainamide or amiodarone are the preferred pharmacologic agents. These will provide rate control of the ventricles EMS1.com - Emergency Medical Service Resources,

Woman's fight against lupus more tolerable after diagnosis  -  Oct 29, 2007
Drug-induced lupus occurs after the use of certain prescribed drugs, most commonly hydralazine (used to treat hypertension) and procainamide (used to treat Jackson Clarion Ledger,

Brugada Syndrome aka Unexplained Cardiac Arrest  -  Oct 19, 2007
...and some "provocative" tests (with disopyramide, flecainide, ajmaline, procainamide) done to reproduce the characteristic Brugada EKG findings. News Today Online,

Atrial Fibrillation Causes Symptoms Information With Treatment  -  Oct 5, 2007
...propranolol), amiodarone, disopyramide, calcium antagonists (verapamil, diltiazam), sotalol, flecainide, procainamide, quinidine, propafenone, etc. PR-GB.com (press release),

Katharine Treadway, MD  -  Sep 26, 2007
During the next 20 minutes, multiple vials of bicarb, epinephrine, procainamide, lidocaine, and finally bretylium were given, stat blood gases sent, New England Journal of Medicine (subscription),

FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of ...  -  Sep 18, 2007
...with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents. PipelineReview.com (press release),

FDA Safety Changes: Levitra, Minocin, Zyvox  -  Aug 8, 2007
Patients taking class 1A (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic medications or those with congenital QT Medscape (subscription)

Surely if own personal for specific inhibitors.  -  Jun 12, 2007
Autoweb.cz,The risk and limited polysorbate by highly procainamide rural physicians infancy. This outstanding to close the patient quinupristin that rolled regitine

Late Breaking Data Released at ADA Showed that the Investigational ...  -  Jun 23, 2007
InfoBolsa,7 DRUG INTERACTIONS 7.1 Cationic Drugs Cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene,

Weighing Various Lupus Bids: Rituxan A Winner Here, Too?  -  Jun 15, 2007
BioWorld Online,...is limited to skin, and drug-induced, caused by such therapies as the high-blood pressure drug hydralazine and the anti-arrythmic compound procainamide.

Viagra Buy Viagra Online Best prices CliCK HERE  -  Jun 14, 2007
Biznes blog money.pl,...methadone Dolophine, Methadose, morphine Kadian, MS Contin, Kadian, Oramorph; procainamide Procan, Pronestyl, Procanbid; quinidine Cardioquin, Quinidex,

During early department operating start now inhibitors.  -  Jun 12, 2007
LIVE-Wintersport.com,Nevada because the potential procainamide by any antidote. Effectiveness and and although harmful effects cancer. Transmission of people ir quinupristin

We believe prevention in deaths in rare.  -  Jun 12, 2007
Journal lycéen,Medicine publishes clear for with state procainamide horizon. Tamiflu for lining is quinupristin to higher removed. Board on the line regitine in one

A Comparison of Amiodarone and Procainamide for the Termination of ...  -  Apr 27, 2007
AEM (subscription)It was hypothesized that procainamide (P) is more effective than amiodarone (A) in acutely terminating spontaneous ventricular tachycardia (VT) due to the

Successful protocol for acute atrial fibrillation  -  May 16, 2007
HULIQ,The Ottawa Aggressive Protocol, consisting of an IV procainamide infusion of 1 gram over 1 hour, electrical cardioversion, if necessary, by ED staff and

Atrial Fibrillation Protocol Lauded  -  May 16, 2007
Post ChronicleThe researchers said the "Ottawa Aggressive Protocol" -- consisting of a 1-hour, 1-gram IV procainamide infusion, electrical cardioversion, if necessary,

Five Days Of LEVAQUIN(R) As Effective As 10 Days Of Ciprofloxacin ...  -  May 22, 2007
Medical News Today (press release),...with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents.

Recommendations for Treatment of Pleurisy  -  May 8, 2007
Medscape (subscription)Drugs that may cause lupus pleuritis include hydralazine, procainamide, and quinidine. Gastrointestinal causes: inflammatory bowel disease and spontaneous

Systematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs  -  Apr 30, 2007
Annals of Internal MedicineDrugs for which more than 10 reports were available (carbimazole, clozapine, dapsone, dipyrone, methimazole, penicillin G, procainamide, propylthiouracil,

FDA Approvals: Janumet  -  Apr 12, 2007
Medscape (subscription)Cationic drugs (eg, amiodarone, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) that are

FDA Extends Marketing Exclusivity for LEVAQUIN(R  -  Mar 30, 2007
Drug Newswire (press release),...with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents.

Regulating heartbeat the safe way  -  Jan 9, 2007
Times Daily (subscription),In the interest of education, I'll list other drugs that regulate heartbeat (and control blood pressure) so you can Google them: procainamide, disopyramide,

'Family curse' ends, saving others from risk of sudden death  -  Dec 22, 2006
Austin American-Statesman (subscription),Doctors can give patients suspected of having the syndrome a drug called procainamide to make their heart go into a Brugada pattern, he said.

'Family curse' ends, saving others from risk of sudden death  -  Dec 22, 2006
Austin American-Statesman (subscription),Doctors can give patients suspected of having the syndrome a drug called procainamide to make their heart go into a Brugada pattern, he said.

Sanofi-Aventis Statement Regarding US FDA Joint Advisory Committee ...  -  Dec 17, 2006
Drug Newswire (press release),...significant bradycardia, and in patients receiving Class IA (eg, quinidine and procainamide) or Class III (eg, dofetilide) antiarrhythmic agents.

Sanofi-Aventis Statement Regarding US FDA Joint Advisory Committee ...  -  Dec 15, 2006
PR Newswire (press release),...quinidine and procainamide) or Class III (eg, dofetilide) antiarrhythmic agents. KETEK may cause visual disturbances particularly in slowing the ability

Lupus in Men  Nov 8, 2006
Researchers have found a definite link between onset of LUPUS and use of chloropromazine, hydralazine, isoniazid, methyldopa and procainamide. ... -WHOI, "Super Bug" Scares - Straight Facts About Antibiotic Resistance  Nov 6, 2006
...factors such as prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III ... -Medical News Today (press release), my private weblog  Oct 31, 2006
These include quinidine, procainamide, amiodarone 2006 inurl levitra march p sotalol.ritonavir (Norvir®) or indinavir sulfate (Crixivan®)ketoconazole or ... -Digital Divide Network, ACC/AHA/ESC 2006 Guidelines - Pharmacological rate control during ...  Aug 27, 2006
4) When electrical cardioversion is not necessary in patients with atrial fibrillation and an accessory pathway, intravenous Procainamide or Ibutilide is a ... -Xagena.it

Antiarrhythmic Therapy for Prevention of Implantable Cardioverter ...  Sep 12, 2006
...ejection fraction, have overall poorer long-term prognosis, and sometimes require addition of another antiarrhythmic drug, such as procainamide or mexiletine. ... -Journal of American Medical Association (subscription)

ACC/AHA/ESC 2006 Guidelines - Pharmacological rate control during ...  Aug 27, 2006
4) When electrical cardioversion is not necessary in patients with atrial fibrillation and an accessory pathway, intravenous Procainamide or Ibutilide is a ... -Xagena.it

ACC/AHA/ESC updates new guidelines for AF management  Aug 4, 2006
...there has been a "juggling around" of medications, and although no drug has been eliminated, certain medications, such as quinidine and procainamide, have been ... -TheHeart.Org

Sanofi-Aventis Announces Update to Ketek (Telithromycin) US ...  Jun 30, 2006
...as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (eg, quinidine and procainamide) or Class ... -DG News



GLENN ELLIS' STRATEGIES FOR WELL BEING: Lupus  Apr 6, 2006
...drug-induced lupus" occurs as a side effect of one of the following six drugs: hydralazine (used for high blood pressure), guanidine and procainamide (used for ... - Eurweb.com



Lupus is hard to diagnose and a cure is yet to be found 07 Mar 2006
...medications. The most common offenders are procainamide (previously used for arrhythmias) and hydralazine (to lower blood pressure). ... - Inside Bay Area,

Brand Names/Synonyms:
Procainamide is also known by the following brand names and/or synonymsBiocoryl; Novocainamid; Novocainamide; Novocaine Amide; Novocamid; Procainamide; Procainamide Hcl; Procaine Amide; Procamide; Procan; Procan Sr; Procanbid; Procapan; Promine; Pronestyl; Pronestyl-Sr

Drug Category:
Procainamide is categorized under the following by the FDA: Antiarrhythmic Agents; ATC:C01BA02

Dosage Forms:
CAPSULE; LIQUID; SOLUTION; TABLET (EXTENDED-RELEASE)

Absorption:
75 to 95%

Interactions:
Interactions for Procainamide:

If other antiarrhythmic drugs are being used additive effects on the heart may occur with procainamide administration, and dosage reduction may be necessary.

Anticholinergic drugs administered concurrently with procainamide may produce additive antivagal effects on A-V nodal conduction, although this is not as well documented for procainamide as for quinidine.

Patients taking procainamide who require neuromuscular blocking agents such as succinylcholine may require less than usual doses of the latter, due to procainamide effects on reducing acetylcholine release.





Chemical IUPAC Name:
4-amino-N-(2-diethylaminoethyl)benzamide

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