Prevacid

This page contains recent news articles, when available, and an overview of Prevacid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Prevacid (when available)

Pharmacology and use:
Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori. For treatment of Acid-reflux disorders (GERD); Peptic Ulcer Disease, Duodenal ulcers and esophagitis; Zollinger-Ellison syndrome

Mechanism Of Action:
Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H₂-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H⁺,K⁺)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

News Articles on Lansoprazole

Eradicating Bacteria After Surgery Cuts Stomach Cancer's Return  -  Jul 31, 2008
...s Prevacid, one of several heartburn medicines. While scientists have known that removing the germ called Helicobacter pylori in laboratory animals can Bloomberg

Heartburn Drugs Can Speed Up Aging  -  Jul 25, 2008
Two types of drugs, proton-pump inhibitors (such as Prevacid and Prilosec) and H2 blockers (Tagamet, Zantac, and Pepcid) are very effective at reducing Stop Aging Now,

Toxins and Your Health  -  Jul 16, 2008
And Bea has another reason for taking this course of treatment, "I didn't want to spend the rest of my life on antacids or Prevacid. WKRG-TV,

Going-Concern Statement  -  Aug 6, 2008
Levitra(R) (vardenafil), Cialis(R) (tadalafil), Vfend(R) (voriconazole), AcipHex(R) (rabeprazole), Nexium(R) (esomeprazole), Prevacid(R) (lansoprazole), FOXBusiness

Dr. Mayer Eisenstein Offers a New Paradigm for Acid Reflux by ...  -  Aug 7, 2008
To relieve their symptoms people turn to Tums®, Rolaids®, Zantac®, Tagamet®, or the more dangerous, PPIs [Proton Pump Inihibitors] (Nexium®, Prevacid®, NewsReleaseWire.com (press release)

Takeda Raises Full-Year Profit Forecast on Millennium Purchase  -  Jul 30, 2008
...company's bestselling diabetes drug Actos and stomach-ulcer drug Prevacid face increased competition from lower-priced copies within three years. Bloomberg

Increasing M&A Activity in the Generics Industry: What happens next?  -  Aug 5, 2008
In 2009 for example, five major drugs lose patent protection (including Prevacid) in the US and seven drugs lose patent protection in at least one of the OBBeC.com,

Takeda May Post First Loss in 23 Years on Acquisition (Update1)  -  Jul 28, 2008
Millennium's Velcade cancer treatment will help Takeda as the Japanese company's best-selling diabetes treatment Actos and stomach-ulcer drug Prevacid lose Bloomberg

May Be Acid-Reflux Disease  -  Jul 21, 2008
Now age 11, Isaiah is taking Prevacid and has been diagnosed with a gluten intolerance. "When we went over the symptoms with him, he said he'd had this for Wall Street Journal

The Top Life Science & Health Deals of ‘08, So Far  -  Jul 14, 2008
Takeda’s hoping to compensate for coming generic competition against blockbusters Prevacid for heartburn and Actos for diabetes, both of which are expected Wall Street Journal Blogs,

Ebola virus may have a weak spot  -  Jul 12, 2008
Drugs that suppress the production of acid in the stomach -- Prevacid, Prilosec, Nexium and Protonix -- may avert bleeding for those most vulnerable and Los Angeles Times,

H. pylori Treatment Reduces Metachronous Stomach Cancer Risk  -  Aug 1, 2008
Patients assigned to prophylactic bacterial eradication received a combination of lansoprazole (Prevacid), amoxicillin, and clarithromycin (Biaxin) for a MedPage Today,

Takeda posts first-ever loss, interested in India’s Torrent?  -  Aug 1, 2008
Blood pressure drug Blopress (candesartan cilexetil) posted a 8.2% increase in sales to 59.9 billion yen, while gastrointestinal drug Prevacid/Takepron Pharma Times (subscription),

Severe GERD: Nexium 40mg Once Daily Vs Prevacid 30mg Twice a Day  -  Jul 23, 2008
Want to dig deeper? SmartBrief brings you news, research, and other information related to this issue. To track this topic, bookmark the page and return for SmartBrief,

Analyst Comments: Emageon, Abbott Labs, Maguire Properties ...  -  Jul 17, 2008
Finally, the divestiture of the TAP JV, sheds Prevacid, and allows Abbott to focus on higher growth businesses including its oncology and lipid platforms. istockAnalyst.com,

Five Things You Need to Know: There May Be Strangers Among Us  -  Jul 16, 2008
...kinds of hearings essentially worry-free, with only minor facial twitches and occasional jitters caused by the interaction of Prevacid with Klonopin. Minyanville.com,

Zacks Equity Research Analyst Blog  -  Jul 17, 2008
Finally, the divestiture of the TAP JV, sheds Prevacid, and allows Abbott to focus on higher growth businesses including its oncology and lipid platforms. Zacks.com,

التخلص من بكتريا يحد من مخاطر الاصابة بسرطان المعدة  -  Jul 31, 2008
الحيويين اموكسيسيلين وكلاريثروميسين وعقار القرح لانسوبرازول "lansoprazole" الذي تسوقه شركة صناعة الادوية اليابانية "تاكيدا" باسم بري�?اسيد "Prevacid". رويترز العربية,

Un estudio relaciona una bacteria con el cáncer de estómago  -  Aug 2, 2008
...y claritromicina, además de lansoprazol, un medicamento contra las úlceras comercializado por la japonesa Takeda Pharmaceutical como Prevacid. Reuters España,

Deshacerse de bacteria reduce cáncer estomacal  -  Aug 1, 2008
...amoxicilina y claritromicina, además del medicamento contra úlceras lansoprazol, comercializado por la japonesa Takeda Pharmaceutical Co Ltd como Prevacid. La Prensa (Panamá),

Los antibióticos reducen cerca de un 65% la recurrencia del cáncer ...  -  Aug 3, 2008
...amoxicilina y claritromicina, además del medicamento contra úlceras lansoprazol, comercializado por la japonesa Takeda Pharmaceutical como 'Prevacid'. AZprensa,

Takeda heartburn drug beats Prevacid in studies  -  May 18, 2008
T: Quote, Profile, Research) experimental heartburn drug has proven more effective in healing inflammation of the esophagus than Prevacid, a blockbuster Reuters

Conn. AG says pharmaceutical distributor inflated prices  -  May 29, 2008
...and state-funded health care programs paying millions of dollars more than they should have for many brand-name drugs, including Lipitor and Prevacid. Hartford Courant,

Friday IP Round-Up  -  May 30, 2008
...largest pharmaceutical distributor, on allegations it illegally inflated wholesale drug costs for many brand-name drugs, including Lipitor and Prevacid. Patent Baristas,

Heartburn, hiatal hernia are not the same  -  May 27, 2008
Proton pump inhibitors — Nexium, Prevacid, Prilosec, Protonix and Aciphex — reliably cut back acid production and almost always can stop heartburn. SouthCoastToday.com,

Abbott pays $45 million for Lake Forest building  -  May 29, 2008
...a venture formed in 1977 that developed the heartburn medication Prevacid and Lupron, used in the treatment of prostrate and other forms of cancer. Crain's Chicago Business,

Positive Clinical Data with Santarus' ZEGERID Capsules in ...  -  May 24, 2008
The primary endpoint of the study was to evaluate the effects of pre-breakfast dosing of ZEGERID Capsules, Protonix tablets and Prevacid capsules on 24-hour Stockhouse,

Positive Clinical Data with Santarus' ZEGERID Capsules in ...  -  May 19, 2008
The primary endpoint of the study was to evaluate the effects of pre-breakfast dosing of ZEGERID Capsules, Protonix tablets and Prevacid capsules on 24-hour PR-Inside.com (Pressemitteilung),

AstraZeneca CEO-Nexium sales trend 'consistent'  -  May 6, 2008
..."If you exclude the generics and just look at the branded products like Prevacid, Nexium ... we're still gaining share," Brennan told reporters after Reuters

Santarus' study reveals ZEGERID produces notably greater and ...  -  May 19, 2008
ZEGERID capsules were compared with 40 mg of Protonix or pantoprazole sodium delayed-release tablets, and 30 mg of Prevacid or lansoprazole delayed-release RTT News,

Vitamin B-12 deficiency linked to acid reducers  -  May 12, 2008
Acid-suppressing drugs such as Aciphex, Nexium, omeprazole, Prevacid, Prilosec and Protonix relieve reflux symptoms. But there is a downside. Los Angeles Times,

Santarus Inc. Q1 2008 Earnings Call Transcript  -  May 27, 2008
Excluding the Protonix brand, the remaining delayed-release branded PPI products, including Nexium, Prevacid and Aciphex as a group declined 7.0% in volume Seeking Alpha,

Takeda Expects Profit to Fall 55% on Takeover Costs (Update3)  -  May 9, 2008
TAP Pharmaceutical Products Inc., Takeda's former joint venture with Abbott Laboratories, applied for US approval to sell TAK-390MR, a successor to Prevacid Bloomberg

When is surgery advised to correct hiatal hernia?  -  May 7, 2008
Since the arrival of drugs that are such effective suppressors of stomach acid — Nexium, Prevacid, Prilosec, Protonix and Aciphex — the need for surgery has SouthCoastToday.com,

Drug that helps smokers quit triggers depression for some  -  May 12, 2008
A: Acid-suppressing drugs (PPIs) like Aciphex, Nexium, omeprazole, Prevacid, Prilosec and Protonix relieve symptoms of reflux. There is a downside, however. Jackson Clarion Ledger,

Stop-smoking drug triggered depression  -  May 13, 2008
Acid-suppressing drugs (PPIs) such as Aciphex, Nexium, omeprazole, Prevacid, Prilosec and Protonix relieve symptoms of reflux. There is a downside, however. Belleville News Democrat,

Add newborn to policy as quickly as possible  -  May 11, 2008
Protonix (heartburn/ulcers), Prevacid (heartburn/ulcers), Plavix (heart/stroke prevention), Enbrel (arthritis/psoriasis), Nexium (heartburn/ulcers), The Post-Standard - Syracuse.com,

Attorney General sues pharmaceutical company for inflating drug prices  -  May 29, 2008
Neurontin, Nexium, Prevacid and Valium. These drugs are used to treat a variety of ailments such as asthma, allergies, pain, arthritis and cholesterol. Stamford Plus Magazine,

CGCA hopefuls cover wide spectrum  -  May 7, 2008
The nominees are: Caroline Jacques, general counsel, Abbott Laboratories Ltd. Abbott has been locked in litigation over its lead drugs Prevacid and Biaxcin, Financial Post,

Digestive Disease Week (DDW) 2008  -  May 23, 2008
Lake Forest, Illinois) achieves better healing rates and maintains longer pH control than lansoprazole (Prevacid, TAP Pharmaceutical Products, Inc.). Medscape (subscription)

Techs lag blue chip advance  -  May 19, 2008
...rose 1.2% after studies showed its experimental heartburn drug was more effective in healing inflammation of the oesophagus than Prevacid, a blockbuster Ninemsn,

Acid reflux symptoms can be easily managed  -  May 20, 2008
Doctors can prescribe medications such as Prevacid or Nexium. "All (prescription-strength antacids) are equally effective, no significant clinical LubbockOnline.com,

DAILY CHECKUP  -  May 30, 2008
...and state-funded health care programs paid millions more than they should have for Celebrex, Lipitor, Prevacid, Flonase, Nexium and other medications. Kentucky.com,

News and notes on health  -  May 14, 2008
Protonix (heartburn, ulcers), Prevacid (heartburn, ulcers), Plavix (heart attack/stroke prevention), Enbrel (arthritis, psoriasis), Nexium (heartburn, Rochester Democrat and Chronicle,

Work with doctor to save money on drugs  -  May 13, 2008
Prevacid, another PPI, might be a Tier Two. A third PPI is Nexium, which could be Tier Three. Since they all address acid reflux, you might ask your doctor The Post-Standard - Syracuse.com,

Santarus Reports First Quarter 2008 Financial Results  -  May 7, 2008
...two other marketed PPIs, Prevacid ® (lansoprazole) delayed release capsules 30 mg and Protonix ® (pantoprazole sodium) delayed-release tablets 40 mg. Earthtimes (press release),

Doctors say insurers step over the line  -  May 3, 2008
..."Then I took the prescription to the pharmacy and they gave me this letter that said I had to try Prevacid first," he said. Troxell said the substitute drug The Star-Ledger - NJ.com,

Nikkei at 4-mth closing high, buoyed by trading firms  -  May 19, 2008
...heartburn drug was more effective in healing inflammation of the oesophagus than Prevacid, a blockbuster older drug sold by the Japanese drugmaker. guardian.co.uk,

People's Pharmacy: Thyroid disease epidemic mystifies  -  May 12, 2008
A. Acid-suppressing drugs (PPIs) like Aciphex, Nexium, omeprazole, Prevacid, Prilosec and Protonix relieve symptoms of reflux. There is a downside, however. Houston Chronicle,

Upstate medicinal costs rise to $5.5B  -  May 5, 2008
...to treat heartburn/ulcers, $107 million; Prevacid, to treat heartburn/ulcers, $103 million; Plavix, to treat heart/stroke prevention, $96 million; Washington Business Journal,

Brand Names/Synonyms:
Prevacid is also known by the following brand names and/or synonymsAG 1749; Agopton; Amarin; Aprazol; Bamalite; Biuret; Biuret Gr; Biuret Reagent; Biuret Reagent Solution; Blason; CHEMBANK1503; Compraz; Dakar; HSDB 7204; Ilsatec; Ketian; Lancid; Lanproton; Lansopep; Lansoprazol [Inn-Spanish]; Lansoprazole; Lansoprazole [Usan:Ban:Inn]; Lansoprazolum [Inn-Latin]; Lanston; Lanz; Lanzol-30; Lanzopral; Lanzor; Lasoprol; Limpidex; Mesactol; Monolitum; Ogast; Ogastro; Opiren; Prevacid; Prevacid Iv; Prevacid Solutab; Prevpac; Prezal; Pro Ulco; Promp; Prosogan; Suprecid; Takepron; Ulpax; Zoprol; Zoton

Drug Category:
Prevacid is categorized under the following by the FDA: Anti-ulcer Agents; Anti-Infectives; Proton-pump Inhibitors; ATC:A02BC03

Dosage Forms:
Enteric coated capsules

Absorption:
The absorption of lansoprazole is rapid, with mean Cmax occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.

Interactions:
Interactions for Lansoprazole:

Lansoprazole is metabolized through the cytochrome P₄₅₀ system, specifically through the CYP3A and CYP2C19 isozymes. Studies have shown that lansoprazole does not have clinically significant interactions with other drugs metabolized by the cytochrome P₄₅₀ system, such as warfarin, antipyrine, indomethacin, ibuprofen, phenytoin, propranolol, prednisone, diazepam, clarithromycin, or terfenadine in healthy subjects. These compounds are metabolized through various cytochrome P₄₅₀ isozymes including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A. When lansoprazole was administered concomitantly with theophylline (CYP1A2, CYP3A), a minor increase (10%) in the clearance of theophylline was seen. Because the small magnitude and the direction of the effect on theophylline clearance, this interaction is unlikely to be clinical concern. Nonetheless, individual patients may require additional titration of their theophylline dosage when lansoprazole is started or stopped to ensure clinically effective blood levels.

Lansoprazole has also been shown to have no clinically significant interaction with amoxicillin.

In a single-dose crossover study examining lansoprazole 30 mg and omeprazole 20 mg each administered alone and concomitantly with sucralfate 1 gram, absorption of the proton pump inhibitors was delayed and their bioavailability was reduced by 17% and 16%, respectively, when administered concomitantly with sucralfate. Therefore, proton pump inhibitors should be taken at least 30 minutes prior to sucralfate. In clinical trials, antacids were administered concomitantly with lansoprazole delayed-release capsules; this did not interfere with its effect.

Lansoprazole causes a profound and long lasting inhibition of gastric acid secretion; therefore, it is theoretically possible that lansoprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g. ketoconazole, ampicillin esters, iron salts, digoxin).

Chemical IUPAC Name:
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzoimidazole

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