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PremarinThis page contains recent news articles, when available, and an overview of Premarin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Premarin (when available) Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens. For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only) Mechanism Of Action: Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. News Articles on Conjugated Estrogens What Is a Women to Do When It Comes to Hormones? - Sep 11, 2008 Premarin, which is an estrogen made from the urine of pregnant mares (hence the name), and Prempro, a combination of Premarin and Progestin (a synthetic Natural News.com, Estrogen therapy benefit is all in the timing - Sep 7, 2008 Q: I started taking Premarin daily after a hysterectomy at age 46. I had difficulty getting a prescription for the drug, but continued to use it when I Chicago Tribune, Wipe your paws - Sep 13, 2008 For years, horses Stormy and Shima were Premarin mares. They were constantly kept pregnant so their urine could be used in the manufacture of the drug used Casper Star-Tribune Online, High costs threaten Oregon stray horses - Aug 25, 2008 It shelters 155 horses from Canada that were used in the collection of premarin from pregnant mares for an estrogen replacement drug for women. Seattle Post Intelligencer HORSE HAVEN Rescued animals live out their days on a ranch in ... - Sep 7, 2008 The name of the medication was Premarin, extracted from the words, PREgnant MARes’ urINe, he said. The product is marketed by Wyeth Pharmaceuticals, The Register-Guard, Ligand Pharmaceuticals, Inc. Q2 2008 Earnings Call Transcript - Aug 25, 2008 For Aprela, which is bazedoxifene in combination with Premarin for the treatment of vasomotor symptoms and the prevention of osteoporosis, Seeking Alpha, Oregon's horse population outpaces ability to care for them - Aug 23, 2008 It shelters 155 horses from Canada that were used in the collection of premarin from pregnant mares for an estrogen replacement drug for women. The Oregonian - OregonLive.com, Los remedios caseros de Miguelito - Sep 13, 2008 En 1942 se descubrió el "premarin", un medicamento preparado con estrógenos equinos obtenidos de orina de yegua preñada. Se usa desde entonces para La Opinión de Zamora, «El opio lo puso la naturaleza para aliviar el dolor» - Sep 5, 2008 R.- Una especialidad muy famosa, el premarin, procede de los estrógenos equinos obtenidos de orina de yeguas preñadas. Se cateterizan las uretras del animal elmundo.es, Rescuers Find Loving Families For Unwanted Horses - Aug 1, 2008 She was a Premarin foal rescued by the Equine Angels Rescue Sanctuary of Milford and brought to Ray of Light Farm in East Haddam. Hartford Courant, Wyeth Settles Premarin, Prempro Lawsuits - Jul 16, 2008 Wyeth, the maker of Premarin and Prempro, has settled lawsuits with two Nevada women who blamed the Hormone Replacement Therapy (HRT) drugs for their breast Newsinferno.com, Premarin and Prempro: Lawsuits - Jul 16, 2008 The drug maker of Premarin and Prempro is facing more than 5000 lawsuits. Hormone replacement therapy is used to treat symptoms that accompany menopause. InjuryBoard.com, Health Column - Aug 7, 2008 ...taking synthetic hormones (which the body doesn’t recognize or normally use), the hormones of another species (as with the horse hormone Premarin) or The Daily Planet, Judge dismisses two lawsuits against Wyeth - Jul 14, 2008 The plaintiffs in both cases claimed that their breast cancer was caused by their use of Wyeth's Prempro and Premarin hormone therapy products. Reuters Legal Questions Still Dogging Wyeth - Jul 21, 2008 But the company continues to wrestle with another legal dilemma with the drugs Premarin, Prempro and Premphase. Plaintiffs' lawyers have filed approximately TheStreet.com Wyeth settles suit over hormone-replacement drugs - Jul 15, 2008 Wyeth agreed Tuesday to settle a Nevada case in which two women claimed that its hormone-replacement drugs Prempro and Premarin caused their breast cancer. Los Angeles Times, Is wax the cause of my agonising earache? - Jul 21, 2008 I started taking Premarin - a form of HRT - while still in hospital, but gave it up after two weeks because I seemed to be in a strange, dream-like state. Daily Mail, XTO closes deal on assets in Bakken Shale - Jul 16, 2008 Wyeth has lost four of seven cases over Premarin and Prempro since they began going to trial in 2006. In March, company officials said in a Securities and Fort Worth Star Telegram, Wyeth faces menopause drug suits; PhRMA working to get compliance ... - Jul 16, 2008 By Anne Zieger > Drugmaker Wyeth is facing thousands of lawsuits against it claiming that Prempro and Premarin made them ill. FiercePharma > PhRMA president FierceHealthcare, Actavis faces nine Digitek suits; NJ court tosses out hormone case - Jul 14, 2008 Report > A New Jersey state court judge granted summary judgment against the claims made by a woman who alleged that Wyeth’s Prempro and Premarin, FiercePharma, Wyeth Reports Earnings Results for the 2008 Second Quarter and ... - Jul 23, 2008 Sales of Effexor and the Premarin family of products also increased for the 2008 first half due primarily to price increases. Zosyn sales also increased in FOXBusiness Wyeth Reports Earnings Results for the 2008 Second Quarter and ... - Jul 23, 2008 Sales of Effexor and the Premarin family of products also increased for the 2008 first half due primarily to price increases. Zosyn sales also increased in PR Newswire (press release), HOW MANY MORE WILL DIE BEFORE FDA GHOULS ARE HELD ACCOUNTABLE? - Jul 13, 2008 ..."Wyeth manufactures Premarin, an estrogen replacement, and Prempro, which is a combination of estrogen and progestin. These, along with Upjohn's Provera, NewsWithViews.com, Wyeth: NJ judge dismisses two hormone therapy lawsuits - Jul 14, 2008 The plaintiffs alleged they developed breast cancer from using Prempro and Premarin, hormone therapy products sold by Wyeth, and Provera, a product sold by MarketWatch A horse of a tale - Jul 22, 2008 The urine was used in preparing premarin, a drug once popular as a menopause treatment. Now that the drug has fallen out of favor, so has the prominence of MyWebTimes.com, Horse sanctuary provides haven for mares once used in ... - Jul 20, 2008 Institutes of Health halted part of a large study that had been looking at the effects of two drugs made from mares’ urine, Premarin and Prempro. NRToday.com, Saliva-testing sounds like a scam to doctor - Jul 20, 2008 The compounds used in these potions come out of a factory just like Premarin does and I can assure you the raw materials aren't gathered up from grassy Hattiesburg American, I will say it again, boxing has lost its punch - Jul 17, 2008 Give Brett a Premarin Patch, and he will cheer up, love retirement, start a new career and not have to go to the cold north to get cool.". Long Beach Press-Telegram, Drug Maker Avoids Trials - Jul 15, 2008 In both cases, the plaintiffs alleged they developed breast cancer after using Prempro and Premarin, hormone therapy drugs sold by Wyeth. NJBIZ, James Kelly - Goldman Sachs - Jul 23, 2008 Premarin family revenue was $271 million in the quarter, up 1%. Here the effect of price continued to offset the continued decline in Rx demand. Seeking Alpha, Wyeth’s Motion to Overturn Punitive Damages Award Granted by ... - Jul 15, 2008 The plaintiff alleged that she developed breast cancer from the use of Premarin® and Premproâ, products marketed by Wyeth, as well as Provera, WebWire (press release), Wyeth resolves lawsuits in Nevada over hormone drugs - Jul 17, 2008 ...settle lawsuits filed by two women in Nevada who alleged that they developed breast cancer after taking hormone-replacement drugs Prempro and Premarin. SmartBrief, Business news in brief - Jul 16, 2008 AP Wyeth agreed to settle two women's allegations that its hormone-replacement drugs Prempro and Premarin caused their breast cancer in a case set to go to Philadelphia Inquirer, Garden State Business Briefs - Jul 14, 2008 The plaintiffs alleged they developed breast cancer from using Prempro and Premarin, hormone therapy products sold by Madison-based Wyeth, and Provera, The Star-Ledger - NJ.com, Biotech: FDA lets botanicals grow into a new sector: Bionovo ... - 02 Jun 2008 The Food and Drug Administration issued warnings for the common hot-flash drug Premarin in 2003 following studies linking it to breast cancer, Stockhouse, Part two: Are Hormones Safe? - May 23, 2008 The WHI study researched the effects of Premarin and Provera on cardiovascular disease in menopausal women and closed down because they erroneously Seattle Post Intelligencer Pharmacists get FDA warning - May 31, 2008 ..."She took Premarin for over 25 years. I knew I wanted to avoid that, but when I went to my gynecologist, she gave me Premarin when I hit menopause," McLaren Peoria Journal Star, Prempro maker argues to strike $27M damage award - May 10, 2008 Jurors concluded that Wyeth inadequately warned Scroggin that its drugs Premarin and Prempro carried an increased risk of breast cancer. WXVT, Barr Tries to Right Itself After a Stumble - May 29, 2008 Barr scientists have tried for 15 years to make a generic version of Wyeth's menopause treatment Premarin. So far, no company has been able to mimic the mix BusinessWeek Be kind to animals — all of the time - May 9, 2008 Women who take Premarin may not realize this comes from pregnant mares' urine, hence the name. Their foals go to slaughter. There are meds made from soy Barre Montpelier Times Argus, Another HRT Study Cites Breast Cancer Risk - May 31, 2008 A recent study out of Germany found hormone replacement therapy (HRT) drugs - inlcuding Prempro and Premarin - taken for more than five years, Newsinferno.com, Hormone Replacement Therapy: FAQs - May 20, 2008 According to the Kaiser Family Foundation, a non-profit research group, 46 million prescriptions worth $1 billion were written for Premarin, a hormone CBC.ca, Ligand Pharmaceuticals Incorporated Q1 2008 Earnings Call Transcript - May 20, 2008 Wyeth expects to submit at NDA in the first half of 2009 for APRELA which is bazedoxifene in combination with PREMARIN for the treatment of beta motor Seeking Alpha, Cardiologist Addresses Hormone Replacement Therapy, Supplement Use - May 14, 2008 Q: "Can I take Premarin for hot flashes without hurting my heart?" asked Ronnie from Chester. A: Ronnie, that is a very good question, one we're asked all NBC 10.com, Motherhood: Revered and defiled - May 8, 2008 The pregnant mares that are used to produce Premarin and Prempro spend most of their lives virtually immobilized in tiny stalls with urine-collection bags Weston Town Crier, Horse haven - May 3, 2008 CJ’s mother was a filly whose urine during pregnancy was used to make Premarin, a hormone-replacement therapy drug prescribed to women going through South Carolina Now, Wyeth profit hurt by generic, but beats forecast - Apr 22, 2008 ...depression treatment Effexor, Enbrel for arthritis, Prevnar to prevent childhood infections, and the Premarin line of female hormone replacement drugs. Guardian, Pellets: The Safer Hormone Replacement Therapy - Apr 16, 2008 Premarin is made from horse’s urine. It’s natural, but it doesn’t produce the same effects as the natural hormones found in women. FOXNews Problems with low cholesterol pop up - Apr 20, 2008 The compounding pharmacist stated that because all three forms of estrogen are used, the risk that accompanies Premarin or Prempro does not exist. Houston Chronicle, Isabel Maxwell - Apr 8, 2008 Lorazepam is buy Premarin about the truthfulness of p450 substrates. Take the missed forming. I am visitor no prescription. For an antacid and, alprazolam. Israel Insider, Women Taking Estrogen-Only HRT More Likely To Develop Benign ... - Apr 11, 2008 The researchers found that 232 of the women -- 155 of those who took Premarin and 77 of those who took the placebo -- had breast biopsies for lumps that Medical News Today (press release), Posted By Dr. Peter Gott - Apr 7, 2008 GOTT: I have been taking Premarin for years and have had terrible night sweats. I stopped the medication, and not only did my sweats stop, but my legs feel Northern Daily News, Cancer Risk Doubles Taking Estrogen - Apr 9, 2008 The new and continued research is trying to gain a better handle on the question on when and where to use estrogen, in products such as Premarin, E Canada Now, April 9 2008 - Women who take estrogen are at an increased risk of ... - Apr 9, 2008 For their study, the researchers looked at a previously performed hormone replacement trial in which more than 10000 women were given the HRT drug Premarin Dog Flu Diet and Diseases, Horse lover rescues four from slaughter - Mar 25, 2008 Premarin is a drug used in birth control pills and hormone replacement therapy drugs. It’s made from the urine of pregnant mares. There has been a down turn parrysound.com, FDA Warning - Heparin - more Heparin products recalled - Mar 24, 2008 If this surprises you or grosses you out consider the following description of Premarin. Premarin is the commercial name for compound drug consisting InjuryBoard.com, Hormone replacement therapy and your heart - Apr 2, 2008 For women in the study taking estrogen alone (Premarin), the WHI found no increased risk of breast cancer or heart disease. But researchers did find that MayoClinic.com Estrogen raises risk of benign breast disease - Apr 8, 2008 Dr. Thomas Rohan of the Albert Einstein College of Medicine in New York and colleagues aimed to see if taking the Wyeth drug Premarin, a form of estrogen Scientific American Cheering Section Right at Home With the Yankees - Mar 29, 2008 I was only using the Premarin to ward off hot flashes, not to gain an advantage over other She-Fans, but rules are rules. And, finally, I have been New York Times, Suit alleges HRT therapy caused breast cancer - Mar 26, 2008 Simmons states that while under a doctor's care she began taking Premarin, Prempro, and/or its generic equivalent in 1998. After eight years of constant Southeast Texas Record, Compounded hormone therapies: unproven, untested — and popular - Mar 25, 2008 The Wiley Protocol pointed out that Premarin (Wyeth) stands for “pregnant mares’ urine.â€? Michael Cirigliano, MD, is an associate professor of medicine at Endocrine Today, Brand Names/Synonyms: Premarin is also known by the following brand names and/or synonymsAUSTRIA; BELGIUM; BRAZIL; BULGARIA; CANADA; CHINA; COLOMBIA; COSTA-RICA; Conestoral; DENMARK; DOMINICAN-REPUBLIC; ECUADOR; EL-SALVADOR; ENGLAND; ESTRONE-SULFATE; Estrogens; Estrone Estrone Hydrogen Sulfate; Estrone Hydrogen Sulfate; Estrone Sodium Sulfate; Estrone Sulfate; Estrone Sulfate Sodium; Estrone Sulphate; Evex; FINLAND; FRANCE; GREECE; GUATEMALA; HONDURAS; HONG-KONG; HUNGARY; Hyhorin; INDIA; IRELAND; ITALY; JAPAN; KOREA; MALAYSIA; MEXICO; MIDDLEEAST; Morestin; NETHERLANDS; NEW-ZEALAND; NICARAGUA; Oestrone Sulphate; PANAMA; PERU; PHILIPPINES; PORTUGAL; Par Estro; Premarin; Prempro/Premphase; RUSSIA; SWITZERLAND; Sodium Estrone Sulfate; TAIWAN; THAILAND; TURKEY; URUGUAY; US Drug Category: Premarin is categorized under the following by the FDA: Estrogens; ATC:G03CA57 Dosage Forms: Tablet; Injection; Vaginal Cream; Topical Gel Absorption: well absorbed Interactions: -->Drug Interactions for Conjugated Estrogens: DRUG/LABORATORY TEST INTERACTIONS 1. Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity. 2. Increased thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone levels as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone. 3. Other binding proteins may be elevated in serum, (i.e., corticosteroid binding globulin (CBG), sex hormone binding globulin (SHBG)) leading to increased total circulating corticosteroids and sex steroids, respectively. Free hormone concentrations may be decreased. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin). 4. Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglyceride levels. 5. Impaired glucose tolerance. 6. Reduced response to metyrapone test. Chemical IUPAC Name: sodium 13-methyl-17-oxo-3-sulfonatooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene : |
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