|
 |
PremarinThis page contains recent news articles, when available, and an overview of Premarin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Premarin (when available) Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens. For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only) Mechanism Of Action: Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. News Articles on Conjugated Estrogens Don't underestimate the benefits of a good night's sleep - Mar 29, 2009 Q. My doctor recently prescribed Premarin Vaginal Cream. It has improved my life dramatically, reducing dryness and easing other symptoms of menopause. Houston Chronicle Animal cruelty must be punished - Apr 14, 2009 Here, Kachina (left) is introduced to Equine Voices' Premarin mares - horses rescued from farms where they were kept pregnant so their urine could be Tucson Citizen Abandoned Horse Grabs Public's Heart Strings - Apr 9, 2009 PREMARIN, an acronym for "Pregnant Mares Urine," is a hormonal drug commonly taken by women. Female horses are sometimes subjected to becoming pregnant Zootoo.com Cow Pee in Your Cola: Is This For Real? - Apr 2, 2009 Premarin, an estrogen drug made in America, is made from horse urine. If this cola becomes popular then look for Premarin-based cocktails at underground Digital City Were You Hurt By Hormone Replacement Therapy (HRT)? - Apr 6, 2009 Doctors believed until recently that long-term use of hormone replacement therapy (HRT) drugs such as Premarin, Depo Provera, and Prempro were safe. InjuryBoard.com Can cow urine be the perfect antidote of cancer? - Apr 4, 2009 Let me tell you Premarin, an estrogen drug made in America, is made from horse urine. Why can’t there be the precise application of cow urine then? Little About The People's Pharmacy - Mar 4, 2009 My doctor prescribed Premarin cream, and it works, but I am concerned... By Joe Graedon and Teresa Graedon‚ Ph.D. Q: Vaginal dryness has made relations Seattle Times Save the horses - Mar 13, 2009 ...race and performance horses that don't make the grade, foals from Premarin mares and wild horses kept in holding pens for excess time periods. Great Falls Tribune Federal judge moves suit against drug makers to state court - Mar 17, 2009 The Nevada lawsuit claims the drug companies' promotion and sale of a list of hormone replacement drugs -- including Premarin, Prempro, Premphase and Reno Gazette Journal Alternatives exist for hormone therapy - Mar 11, 2009 Prescription synthetic estrogen drugs like Premarin and newer drugs like raloxifene and alendronate have been proven to reduce the symptoms of menopause and Little About Hard Times for Horses - Feb 27, 2009 Since 2004 she focused on finding homes for unwanted foals that are an inevitable byproduct of the manufacture of Premarin, a hormone replacement therapy New York Times Mainstream Medicine Stunned by New Findings on Bioidentical ... - Mar 3, 2009 Synthetic forms of hormone replacement therapy prescribe substances such as Premarin, Provera and Prempro and present real health risks with increased risks MSNBC The Horse Whisperer - Feb 23, 2009 Since 2002, the founder and owner of Passion Horse Ranch in Joshua, Texas, has rescued more than 30 foals of so-called Premarin horses, saving them from Reader's Digest Women to pay more as HRT scripts go private - Mar 3, 2009 ...by Michael Woodhead Women using the oral HRT products Premia and Premarin will have to pay around $10 more prescription when the products are switched from 6minutes Hormone Replacement Therapy Linked to Skin Cancer - Feb 26, 2009 Hormone Replacement Therapy (HRT), including the drugs Premarin and Prempro, has long been linked to female cancers and fatal blood clots. Newsinferno.com Talk to clear up confusion about HRT - Mar 9, 2009 For years, doctors prescribed synthetic hormones (such as Premarin, which is made from pregnant horse urine) - until the Women's Health Initiative (WHI) Surrey Now 10-K: LIGAND PHARMACEUTICALS INC - Mar 16, 2009 Wyeth is also developing bazedoxifene in combination with PREMARIN (Aprela) as a progesterone-free treatment for menopausal symptoms. MarketWatch (press release) Diana Levine Case Concludes Before Supreme Court In Ruling For ... - Mar 4, 2009 AstraZeneca's Seroquel, Wyeth’s Prempro and Premarin drugs are facing litigation which drug makers claimed was preempted by federal immunity. InjuryBoard.com Big Pharma Is Spending Big Bucks Hoping That You Have Fibromyalgia - Feb 28, 2009 Few even noticed the repeat offense as Pfizer acquired rival Wyeth at the same time whose Fen Phen and Premarin travail make Pfizer's profile look like Sir AlterNet New clinical guidelines say misconceptions have surrounded hormone ... - Mar 4, 2009 ...advisory board members or receiving research support from such firms as Wyeth Pharmaceuticals, which manufacturers Premarin (conjugated estrogen), CMAJ Pharmafirmen droht Klagewelle - Mar 6, 2009 Chancen auf Entschädigung haben nun auch die Opfer der Wyeth-Präparate Prempro und Premarin, die bereits vor anderen Gerichten Ansprüche wegen Financial Times Deutschland Breast Cancer Risk Drops One Year After End of Hormone Therapy - 04 Feb 2009 After the initial study report, use of Wyeth’s hormone replacement therapies Prempro and Premarin plummeted. The 61 million prescriptions written in 2001 Bloomberg Ending the Atrocities of the FDA; Life Extension Urges Immediate ... - 04 Feb 2009 ...(13) The FDA, however, has done nothing to remove Premarin® or Prempro®. Instead, the FDA openly seeks to protect Wyeth's market share by denying American Natural News.com, Retailers Nationwide Sell Wild West Company Chocolate Bars In ... - 04 Feb 2009 ...announced today the milestone of selling nearly 10000 "Hope" chocolate bars in the past year featuring a rescued Premarin Industry horse named Bozeman. PR Web (press release), Pfizer to buy Wyeth for $68 billion - Jan 26, 2009 Wyeth’s top selling drugs include the anti-depressant Effexor XR, the estrogen medicine Premarin and its arthritis drug Enbrel is co-marketed with Amgen. Bizjournals.com, Health Highlights: Jan. 26, 2009 - Jan 26, 2009 ...include the anti-depressant Effexor, acid reflux inhibitor Protonix, the pneumococcal vaccine Prevnar and the female hormone replacement drug Premarin. Forbes, Pfizer reportedly interested in Wyeth, for $60 billion - Jan 23, 2009 Among Wyeth's best-selling drugs are Prevnar, Enbrel, Effexor, Premarin and Protonix. The company had a market value of nearly $52 billion as of Thursday, TheDay, Brain Shrinkage Seen with Hormone Replacement Therapy - Jan 14, 2009 Much has come out about the risks of hormone replacement therapy (HRT) drugs like Premarin and Prempro, especially as a result of the massive Women’s Health Newsinferno.com, Hormone replacement therapy (HRT) - Jan 21, 2009 Some common brand names of oestrogen-only HRT are Estraderm, Evorel and Premarin. There are lots of HRT products. You can take it as a skin patch, guardian.co.uk, Martha Rosenberg: Drug firm’s sordid promotions - Jan 28, 2009 And its signature product line, the hormone drugs Prempro and Premarin, still kills. Since 70 percent of hormone-replacement therapy (HRT) patients quit Providence Journal, Customized hormones for treating menopause: Converts, concerns - Feb 1, 2009 Until recent years, menopause symptoms were commonly treated with manufactured hormone products such as Premarin (a conjugated estrogen product derived from Urbana/Champaign News-Gazette, Spin of the Week - Feb 1, 2009 Wyeth makes two hormone therapy drugs, Prempro and Premarin. “The course material was developed largely by DesignWrite, a new Jersey-based firm paid by Guerrilla News Network Bioidentical Hormone Therapy - Jan 28, 2009 Like Premarin used to supplement estrogen comes from a pregnant horse’s urine.While Bioidentical Hormones are closer to nature they come from sources, CBS42, UW course for doctors pushed risky therapy - Jan 24, 2009 ...was funded entirely by a $12 million grant from Wyeth Pharmaceuticals, which makes the hormone therapy drugs used in the study, Prempro and Premarin. Milwaukee Journal Sentinel, Wyeth Reports Earnings Results for the 2008 Full Year and Fourth ... - Jan 26, 2009 301 13% 13% 1205 20% Nutritionals 385 (2)% 7% 1634 13% Zosyn/Tazocin 298 2% 8% 1264 11% Premarin family 261 (1)% 1% 1070 1% Protonix family(1) 185 (60)% PR Newswire (press release), EDITORIAL: Corporate influence: The school should tighten rules ... - Jan 26, 2009 Wyeth makes Prempro and Premarin, the hormone therapy drugs used in the study. UW and Wyeth, along with a New Jersey firm, formed the Council on Hormone TMCnet A look at drugmakers Pfizer and Wyeth - Jan 23, 2009 ...$1.7B Xalatan, glaucoma, $1.8B Zosyn, antibiotic, $1.3B Detrol, bladder trouble, $1.2B Premarin, menopause, $1.1B Sources: Companies, analyst reports. The Associated Press For Pfizer, a Big Buy Could Be a Big Mistake - Jan 15, 2009 Wyeth is also defending approximately 8700 lawsuits alleging that its hormone-replacement therapy drugs -- Premarin and Prempro -- caused cancer and/or Motley Fool Oprah and Bio-Identical Hormones, the Truth is Finally Getting Out - Jan 15, 2009 ..."For decades, large pharmaceutical companies have manufactured and sold dangerous synthetic hormones, such as the popular Premarin and Prempro, PR Web (press release), Glance-STOCKS NEWS EUROPE-Stratex soars after Oksut drilling results - Jan 26, 2009 Wyeth faces significant claims by more than 10000 women in the US who allege that hormone replacement products Prempro and Premarin can cause breast cancer Interactive Investor, Pfizer pancreatic cancer drug fails, trial halted - Jan 31, 2009 ...for manufacturing the over-the-counter (OTC) drugs Robitussin and the analgesic Advil (ibuprofen), as well as the prescription drugs Premarin and Effexor. TheMedGuru, Hormone Therapy Influences Brain - Jan 13, 2009 CEEs, which are components of Premarinâ„¢ and PremProâ„¢, have been used extensively for treating menopausal symptoms. In the first of the two studies, PsychCentral.com, Der Zickzack-Kurs von Wyeth: Oft verlobt und nie verheiratet - Jan 27, 2009 Für einen wesentlichen Teil des Konzernumsatzes sorgen indes rezeptpflichtige Bestseller wie Premarin und Effexor. Das Hormonpräparat Premarin war das am Handelsblatt, Pfizer хочет купить Wyeth - Jan 25, 2009 обвинÑ?вшей Wyeth в Ñ?окрытии информации о Ñ?ерьезных побочных Ñ?ффектах гормональных препаратов Prempro и Premarin, вызвавших у пациентки рак груди. ГÐ?ЗЕТÐ?.GZT.ru, Avec Wyeth, Pfizer cherche à croître dans les biothérapies et les ... - Jan 27, 2009 ...juridiques liées aux médicaments de Wyeth, et notamment des plaintes concernant les effets potentiels de Prempro et Premarin sur la cancer du sein. Les Échos, Wyeth, l'entreprise qui revient de loin - Jan 25, 2009 Enbrel (polyarthrite rhumatoïde), Protonix (problèmes gastriques), Zosyn/Tazocin (maladies infectieuses) et Premarin (carences en Å“strogène). E24, Did Ghostwriters Promote Wyeth's Cancer-Associated HRT? - Dec 20, 2008 And its signature product line, the hormone drugs Prempro and Premarin, still kills. Since 70 percent of hormone replacement therapy (HRT) patients quit OpEdNews, Hormone Drugs Linked to Breast Cancer, Again - Dec 15, 2008 Hormone therapy drugs like Premarin, Prempro, Premphase and Provera are used to treat the hot flashes and other symptoms that accompany menopause. Newsinferno.com, A gentle place to gallop - Dec 1, 2008 Buddy is the offspring of one such Premarin mare. For more information on the KISS Horse Center, visit www.kisshorses.com. "We're a rescue center. Stockton Record, Wyeth Paid for Favorable Drug Reports, Sen. Grassley Says - Dec 15, 2008 Wyeth makes the hormone replacement drugs Prempro and Premarin. Premarin, an estrogen replacement, and Prempro, a combination of estrogen and progestin, eFluxMedia 22 federal suits filed over hormone replacement drugs - Nov 29, 2008 The studies and findings came years after Premarin, the first Wyeth hormone replacement therapy drug, was placed on the market in 1942, the suit states. West Virginia Record, Hormone Replacement Therapy for Menopause Again Comes under Fire - Dec 19, 2008 Charles Grassley, R-Iowa, of Wyeth, the maker of Prempro and Premarin, two popular HRTs. Grassley is looking into Wyeth's practice of using ghostwriters to MarketWatch (press release) Hepatitis C drug for kids approved - Dec 12, 2008 ...to letters released yesterday from Senator Charles Grassley of Iowa to the companies. Wyeth makes the hormone replacement drugs Prempro and Premarin. The Star-Ledger - NJ.com, When Nature Heals - Dec 19, 2008 ...verapamil (Calan), ofloxacin (Floxin), levofloxacin (Levaquin) estrogens, conjugated/equine (Premarin)- may lead to a build-up of caffeine in the body Pakistan Daily, BioSante Enters $144.5M Deal with Azur for Hot Flashes Gel - Dec 4, 2008 ...but oral contraceptives led by Wyeth's Premarin pill hold the biggest chunk of the market for estrogen, Oppenheimer analyst Kevin DeGeeter, BioWorld Online, 76 life-saving medicines unavailable - Dec 5, 2008 Prograf 0.5 mg Cap, Prograf 1 gm Cap, Marevan Tab for heart, Premarin Tab for women harmon disturbances, Winstrol Injection, ACTH for paralysis, The News International, Brand Names/Synonyms: Premarin is also known by the following brand names and/or synonymsAUSTRIA; BELGIUM; BRAZIL; BULGARIA; CANADA; CHINA; COLOMBIA; COSTA-RICA; Conestoral; DENMARK; DOMINICAN-REPUBLIC; ECUADOR; EL-SALVADOR; ENGLAND; ESTRONE-SULFATE; Estrogens; Estrone Estrone Hydrogen Sulfate; Estrone Hydrogen Sulfate; Estrone Sodium Sulfate; Estrone Sulfate; Estrone Sulfate Sodium; Estrone Sulphate; Evex; FINLAND; FRANCE; GREECE; GUATEMALA; HONDURAS; HONG-KONG; HUNGARY; Hyhorin; INDIA; IRELAND; ITALY; JAPAN; KOREA; MALAYSIA; MEXICO; MIDDLEEAST; Morestin; NETHERLANDS; NEW-ZEALAND; NICARAGUA; Oestrone Sulphate; PANAMA; PERU; PHILIPPINES; PORTUGAL; Par Estro; Premarin; Prempro/Premphase; RUSSIA; SWITZERLAND; Sodium Estrone Sulfate; TAIWAN; THAILAND; TURKEY; URUGUAY; US Drug Category: Premarin is categorized under the following by the FDA: Estrogens; ATC:G03CA57 Dosage Forms: Tablet; Injection; Vaginal Cream; Topical Gel Absorption: well absorbed Interactions: -->Drug Interactions for Conjugated Estrogens: DRUG/LABORATORY TEST INTERACTIONS 1. Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity. 2. Increased thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone levels as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone. 3. Other binding proteins may be elevated in serum, (i.e., corticosteroid binding globulin (CBG), sex hormone binding globulin (SHBG)) leading to increased total circulating corticosteroids and sex steroids, respectively. Free hormone concentrations may be decreased. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin). 4. Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglyceride levels. 5. Impaired glucose tolerance. 6. Reduced response to metyrapone test. Chemical IUPAC Name: sodium 13-methyl-17-oxo-3-sulfonatooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |