Prednisone

This page contains recent news articles, when available, and an overview of Prednisone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Prednisone (when available)

Pharmacology and use:
Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity. For the treatment of primary or secondary adrenocortical insufficiency. Also used in the treatment of several other conditions, including rheumatic disorders, collagen diseases, and dermatological diseases.

Mechanism Of Action:
Prednisone is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

News Articles on Prednisone

Data from Satraplatin SPARC Phase 3 Trial in Patients with Hormone ...  -  02 Jun 2008
The SPARC trial evaluated satraplatin plus prednisone versus placebo plus prednisone in 950 patients with hormone-refractory prostate cancer (HRPC) that had FOXBusiness

GPC Biotech Says Satraplatin Didn't Boost Survival in Study  -  02 Jun 2008
Patients who received satraplatin and the prednisone corticosteroid didn't live longer than patients who were given a placebo and prednisone, Bloomberg

Cougar Biotechnology Presents Positive CB7630 (Abiraterone Acetate ...  -  02 Jun 2008
In the trial, CB7630 in combination with low-dose prednisone was administered orally, once daily, to patients with castration resistant prostate cancer Business Wire (press release),

Poniard Presents Positive Results From Phase II Prostate Cancer Trial  -  02 Jun 2008
...in combination with docetaxel and prednisone, the standard of care for the first-line treatment of metastatic hormone-refractory prostate cancer. RedOrbit,

GPC Biotech presents New Data from Several Satraplatin Clinical ...  -  02 Jun 2008
The Sparc trial assessed satraplatin plus prednisone versus placebo plus prednisone in 950 patients with hormone-refractory prostate cancer that had RTT News,

Medicines are not usually culprit in gas production  -  02 Jun 2008
Prednisone — one of the cortisone drugs — treats both conditions effectively. With polymyalgia, symptoms disappear quickly. However, medicine might have to SouthCoastToday.com,

Immunomedics (IMMU) Receives Promising Phase II Results for ...  -  02 Jun 2008
...vincristine, and prednisone chemotherapy for the therapy of patients with newly diagnosed diffuse large B-cell lymphoma produced promising results. StreetInsider.com (subscription),

North Central Cancer Treatment Group Presents Phase II Study ...  -  02 Jun 2008
...today announced that adding epratuzumab to rituximab and combined cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (ER-CHOP) for Trading Markets (press release),

US Oncology Affiliated Physicians Make a Strong Showing in ASCO ...  -  02 Jun 2008
Multicenter, Phase I/II study of sunitinib in combination with docetaxel and prednisone in patients with metastatic castrate-resistant prostate cancer Earthtimes (press release),

Immunicon Corporation to Present at 2008 ASCO Annual Meeting  -  02 Jun 2008
...(Abstract No: 5072) -- Abiraterone acetate and prednisone in patients (Pts) with progressive metastatic castration resistant prostate cancer (CRPC) after Centre Daily Times,

Poniard Pharmaceuticals (PARD) Presents Data on Multiple ...  -  02 Jun 2008
2 trial of picoplatin in combination with docetaxel and prednisone demonstrated that picoplatin can be safely administered with full doses of docetaxel. StreetInsider.com (subscription),

ASCO Roundup  -  02 Jun 2008
Data from a separate Phase II trial showed that picoplatin in combination with docetaxel and prednisone resulted in a prostate-specific antigen response TMCnet

Market Report -- In Play (PARD)  -  02 Jun 2008
Co presents preliminary safety and efficacy data from its ongoing Ph. 2 clinical trial of picoplatin in combination with docetaxel and prednisone). MSN Money

Novel Chemo Drug Helps Treat Prostate Cancer  -  May 30, 2008
ScienceDaily (May 30, 2008) — Men with a certain type of prostate cancer have been shown to respond to a new chemotherapy drug, Sagopilone, plus prednisone Science Daily (press release)

Prostate Cancer Gets a New Chemo Drug  -  May 31, 2008
The new study showed that men with a certain type of prostate cancer responded well to new drug, Sagopilone, plus prednisone. To analyse the effectiveness MedIndia,

Fluticasone Spray for Allergic Rhinitis May Not Suppress ...  -  May 27, 2008
In this placebo- and active-controlled (prednisone), parallel-group study, outpatients aged 12 to 65 years with PAR for 2 years or more were enrolled from 1 Abkhazia,

People's Pharmacy: A Q&A about health matters  -  May 26, 2008
Recently, my internist put me on a 12-day tapered course of prednisone. Within days, I became extremely agitated and irritable. Seattle Times,

Black-Spot Poison Ivy  -  May 28, 2008
On day 8, she developed swelling in her left axilla and was treated at a local urgent care facility with oral prednisone (dose unknown). Abkhazia,

Get in on this bike racket  -  May 12, 2008
But the other day I was snooping through a friend's medicine chest and saw a bottle of Prednisone pills. I looked up what Prednisone is for. Houston Chronicle,

Addition of Methotrexate to Infliximab Offers No Improvement for ...  -  May 21, 2008
Patients were also on prednisone therapy at the start of the study, but the dose was tapered gradually so that at 14 weeks the use of the corticosteroid was DG News

DDW: Methotrexate Adds No Benefit to Infliximab (Remicade) in ...  -  May 23, 2008
Treatment success was defined by three criteria: score of less than 150 on the Crohn's Disease Activity Index and no clinical need for prednisone MedPage Today,

Multiple Clinical Trials of VELCADE(R) (Bortezomib) for Injection ...  -  May 31, 2008
Following SCT, patients received lenalidomide at 25 mg/day on days 1 through 21 plus prednisone at 50 mg every other day for four, 28-day LP cycles. PR Newswire (press release),

Poniard Announces Positive First-Line Efficacy and Safety Data ...  -  May 31, 2008
...today presented preliminary safety and efficacy data from its ongoing Phase 2 clinical trial of picoplatin in combination with docetaxel and prednisone, Earthtimes (press release),

First Jack’s now Hugo’s last ride…  -  May 24, 2008
Hugo inherited half a bag of Hills Prescription ZD anti-allergy food, along with a hefty dose of Prednisone and Cephalexin pills. Over the years, Maggie and In-Forum,

Solution for behaviour problems  -  May 15, 2008
Consider the commonly prescribed medicine prednisone, an anti-inflammatory steroid. Side effects include increased water consumption and, as a result, Cayman Net News,

Cougar Biotechnology Announces Initiation of Phase III Trial of ...  -  May 6, 2008
The Phase III trial is a randomized, double-blind, placebo-controlled trial of CB7630 plus prednisone in patients with metastatic castration-resistant UroToday,

More news briefs  -  May 6, 2008
Adults who take glucocorticoids such as prednisone for conditions including asthma and rheumatoid arthritis are at risk for bone loss and broken bones if Rochester Democrat and Chronicle,

Being Thankful  -  May 21, 2008
That nasal drip type thing that scratches my throat and sends me to the doctors for prednisone, steroids etc, because I get it All Night and Can't Sleep. Geekzone,

Aspen’s water is drug-free  -  May 14, 2008
...the city’s water results were “non detects�? — meaning traces of pharmaceuticals such as prednisone and aspirin were not present in the water, Aspen Times,

Paws up for Pets  -  May 17, 2008
The Prednisone that he has been on has been upped. He is weak. She didn’t know what to do except to love him. Rather than e-mail her back, I phoned and said Today's Local News,

Osteoporosis a risk when taking steroids  -  May 5, 2008
Thousands of New Yorkers take oral steroid treatments like prednisone. It helps relieve the pain of such chronic conditions as rheumatoid arthritis, News 10 Now,

Healthy Habits 101  -  May 14, 2008
My doctor said it was stress and prescribed four medications: prednisone, Pepcid for my stomach, an anti-itch cream and some other drug (I forget the name). Ventura County Reporter,

PEOPLE'S PHARMACY Some drugs dull mental edge  -  May 17, 2008
The list is too long to reproduce here, but some of the medicines include scopolamine (Transderm Scop) for motion sickness, prednisone for inflammation, Houston Chronicle,

disabled forced to live apart; Housing backlog takes its toll on ...  -  May 31, 2008
...for more than three years, undergoing chemotherapy and being prescribed large doses of steroids like prednisone to boost her immune system. Standard Freeholder,

Immunicon Corporation to Present at 2008 ASCO Annual Meeting  -  May 30, 2008
...(Abstract No: 5072) -- Abiraterone acetate and prednisone in patients (Pts) with progressive metastatic castration resistant prostate cancer (CRPC) after StreetInsider.com (subscription),

Shelter From the Storm  -  May 20, 2008
She spent nine nights in the hospital, and was prescribed seven new medications, including Singulair, Prednisone and Arithromycin that she now carries PW-Philadelphia Weekly,

Tacrolimus: A New Therapy For Steroid Resistant Nephrotic Syndrome ...  -  May 30, 2008
All these patients were treated with a concomitant prednisone which was subsequently tapered off and completely stopped. Successful outcomes were those Medical News Today (press release),

Remember When You Could Concentrate Better?  -  May 29, 2008
A lot of drugs can make your brain fuzzy: acid blockers for heartburn, cold medicine, prednisone, statin cholesterol drugs, blood pressure pills and RedOrbit,

Two DOXIL(R) Studies to be Presented at American Society of ...  -  May 29, 2008
Rituxan, Cyclophosphamide, Vincristine, and Prednisone in Aggressive B-Cell Non-Hodgkin's Lymphoma (Abstract 8563) Presentation: Saturday, May 31, PR Newswire (press release),

Two DOXIL(R) Studies to be Presented at American Society of ...  -  May 29, 2008
Rituxan, Cyclophosphamide, Vincristine, and Prednisone in Aggressive B-Cell Non-Hodgkin's Lymphoma (Abstract 8563) Presentation: Saturday, May 31, Earthtimes (press release),

Poison ivy: Kill the beast in the back yard  -  May 21, 2008
Treatment, Dr. Cruz says, usually consists of a topical steroid cream or ointment plus prednisone, orally or by injection. If you're resistant or immune to Dallas Morning News,

Simple Case Management Cuts Pulmonary Disease Admissions  -  May 21, 2008
...description of symptoms of COPD exacerbations; and refillable prescriptions for antibiotics and/or short courses of prednisone to manage exacerbations. Washington Post,

Sanofi-aventis and Regeneron Update Aflibercept (VEGF Trap ...  -  May 20, 2008
1st-line treatment for metastatic androgen-independent prostate cancer in combination with docetaxel and prednisone. 2nd-line treatment for metastatic WELT ONLINE,

Miss. Supreme Court to Hear Doctor's Appeal of Malpractice Ruling  -  May 28, 2008
According to the court record, Cantrell had developed "bone death'' in her right hip as a result of regular injections of the steroid prednisone, Insurance Journal,

Human Genome Sciences Reports Progress With Late-Stage Products ...  -  May 28, 2008
Today's therapy for SLE patients involves a variety of immunosuppressive and cytotoxic agents, with prednisone as the mainstay. Earthtimes (press release),

GPC Biotech Announces Data from Several Satraplatin Clinical ...  -  May 28, 2008
May 30-June 3, 2008. the phase III satraplatin and prednisone against refractory cancer (SPARC) trial," (Abstract #5003), Presenter: A. Oliver Sartor, PR-Inside.com (Pressemitteilung),

GPC Biotech Announces Data from Several Satraplatin Clinical ...  -  May 28, 2008
...“Satraplatin in patients with advanced hormone-refractory prostate cancer: Overall survival results from the phase III satraplatin and prednisone against Business Wire (press release),

Biotech Stocks' Various Lupus Therapies: Opportunity or Lost Cause?  -  May 7, 2008
A total of 257 patients from approximately 55 sites (US and Canada) were randomized to receive rituximab plus prednisone or placebo plus prednisone in two Seeking Alpha,

Poniard Pharmaceuticals Reports First Quarter 2008 Financial ...  -  May 6, 2008
Picoplatin was safely administered in combination with full-dose docetaxel and prednisone, the current standard of care for first-line HRPC patients. CNNMoney.com (press release)

Cancer Treatment: Adding Epratuzumab To Standard Chemotherapy ...  -  May 16, 2008
R-CHOP combines three chemotherapy drugs (cyclophosphamide, doxorubicin and vincristine) with the steroid drug prednisone and rituximab, a monoclonal Science Daily (press release)

Brand Names/Synonyms:
Prednisone is also known by the following brand names and/or synonyms&Laquo;Delta&Raquo; E.; &Laquo;Delta&Raquo;-Cortelan; &Laquo;Delta&Raquo;-Cortisone; &Laquo;Delta&Raquo;-Cortone; &Laquo;Delta&Raquo;-Dome; &Laquo;Delta&Raquo;-E; .Delta. E; .Delta.-Cortelan; .Delta.-Cortisone; .Delta.-Cortone; .Delta.-E; .Delta.Sone; Adasone; Ancortone; Apo-Prednisone; Betapar; Bicortone; CCRIS 2646; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; DRG-0227; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dehydrocortisone; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Delta E.; Delta-Cortelan; Delta-Cortisone; Delta-Dome; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; HSDB 3168; Hostacortin; In-Sone; Incocortyl; Juvason; Liquid Pred; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; PRD; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisona [Inn-Spanish]; Prednisone; Prednisone Intensol; Prednisone [Ban:Inn]; Prednisonum [Inn-Latin]; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Reserpine; Reserpine Base; Reserpine Puriss; Retrocortine; Servisone; Sk-Prednisone; Sone; Sterapred; Supercortil; U 6020; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid; Zenadrid [Veterinary]

Drug Category:
Prednisone is categorized under the following by the FDA: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA03; ATC:H02AB07; ATC:H02AB15

Dosage Forms:
Tablets, Ointments, creams, oral liquids

Absorption:
readily absorbed from the gastro-intestinal tract

Interactions:
Interactions for Prednisone:

The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Chemical IUPAC Name:
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,11-dione

:

Web health.mongabay.com

Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com lead to other sites. health.mongabay.com does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com responsible for dead or misdirected links.