Prednisolone acetate

This page contains recent news articles, when available, and an overview of Prednisolone acetate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Prednisolone acetate (when available)

Pharmacology and use:
Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Mechanism Of Action:
Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

News Articles on Prednisolone

DXEK exchanges corneal disc after failed penetrating keratoplasty  -  Sep 10, 2008
Postoperatively, a topical steroid, Pred Forte 1% (prednisolone acetate 1%, Allergan), and levofloxacin 1.5% are used four times daily. OSN SuperSite (subscription),

Amniotic membrane transplant key to pterygium surgical method  -  Aug 8, 2008
Pred Forte 1% drops (prednisolone acetate, Allergan) are used four times a day for 2 weeks, and then tapered off over the following 2 weeks. OSN SuperSite (subscription),

Ista conducting strategic review, may consider merger or buyout ...  -  May 14, 2008
Ista plans to launch three products in 2009: a revised label for Xibrom in a once-daily dose, T-Pred (prednisolone acetate 1%, tobramycin 0.3%) and once- OSN SuperSite (subscription),

Examine The Fastest Growing Biotechnology Companies: Growth ...  -  May 12, 2008
Xibrom(TM) (bromfenac) 109 Istalol® 110 Vitrase® 111 Product development programs 111 T-Pred (tobramycin and prednisolone acetate combination product) Earthtimes (press release),

Advanced surgical technique: Two-stage anterior lamellar keratoplasty  -  May 5, 2008
Postoperatively, a topical steroid, Pred Forte 1% (prednisolone acetate 1%, Allergan), and an antibiotic levofloxacin 1.5%, moxifloxacin 0.5% or OSN SuperSite (subscription),

Intracameral triamcinolone, prednisolone eye drops similarly ...  -  Apr 18, 2008
..."This makes it possible to decrease the dosage and duration of topical prednisolone acetate," the authors said. Aylin Karalezli, MD, and colleagues at OSN SuperSite (subscription),

Discussion: High-risk patients can pose problems for physicians  -  Apr 17, 2008
Once you have decided that everything inside the eye is as quiet as it can be, then I start topical steroids, prednisolone acetate 1%, as well as a topical OSN SuperSite (subscription),

Chronic inflammation presents after uncomplicated cataract surgery  -  Apr 17, 2008
He was started on Pred Forte (prednisolone acetate 1%, Allergan) and Vigamox (moxifloxacin 0.5%, Alcon) four times per day and atropine once daily in the OSN SuperSite (subscription),

Taro Provides Preliminary 2007 Full Year Results  -  Feb 19, 2008
A New Drug Application for Flo-Pred(tm) (prednisolone acetate oral suspension) was approved by the US Food and Drug Administration in the first quarter of Primenewswire (press release),

Taro Receives FDA Approval of New Drug Application for Flo-Pred TM ...  -  Jan 22, 2008
...has received approval from the US Food and Drug Administration for its New Drug Application (NDA) for Flo-Pred TM (prednisolone acetate oral suspension) Business Wire (press release),

Taro receives FDA approval for Flo-Pred NDA  -  Jan 23, 2008
The company said that the Flo-Pred (prednisolone acetate oral suspension) brand, for which there are no generic equivalents, will be sold by prescription as Trading Markets (press release),

Taro gets FDA nod for original asthma drug  -  Jan 23, 2008
...for the company's New Drug Application (NDA) for Flo-Pred (prednisolone acetate oral suspension) used in its NonSpil liquid drug delivery system. Globes,

TAROF: FDA Approval of NDA for Flo-Pred(TM)  -  Jan 22, 2008
Inc. has received approval from the FDA for its New Drug Application (NDA) for Flo-Pred(TM) (prednisolone acetate oral suspension) equivalent to 5 mg/5 Trading Markets (press release),

1 Department of Anesthesiology, Drum Tower Hospital, Nanjing ...  -  Nov 13, 2007
To elucidate how glucocorticoids affect this mechanism, we studied the effects of intrathecal (it) injection of prednisolone acetate (PA) on a nociceptive Annals of Clinical & Laboratory Science (subscription),

Eliminating intracameral medications reduces complications  -  Nov 13, 2007
Postop, they receive Pred Forte (prednisolone acetate 1%, Allergan) three times a day for 6 weeks and Acular three times a day for 6 weeks. OSN SuperSite (subscription),

Ista acquires North American rights to nasal formulation of ocular ...  -  Sep 28, 2007
..."As we now have four product candidates in our pipeline, T-Pred (prednisolone acetate 1%, tobramycin 0.3%), ecabet sodium, ophthalmic bepotastine and nasal OSN SuperSite (subscription),

Sutureless surgical technique can treat conjunctivochalasis  -  Jul 31, 2007
OSN SuperSite (subscription),An antibiotic eye drop (eg, ofloxacin) and a steroid eye drop (1% prednisolone acetate) should be used four times a day, tapered over 3 to 4 weeks.

Brass Hat Firing Bullets in Preparation for Return  -  Jun 29, 2007
BloodHorse,...from second in the $6-million Dubai World Cup (UAE-I) after a post-race test revealed trace amounts of the drug methyl prednisolone acetate.

ISTA Provides Regulatory Update on T-Pred NDA Filing  -  May 4, 2007
Earthtimes.orgAdministration (FDA) relating to its New Drug Application (NDA) for T-Pred(TM) (prednisolone acetate 1.0% and tobramycin 0.3% ophthalmic suspension).

Pharma Sector: Few Newsmakers Of The Week - Idenix, Nabi, CSL ...  -  May 5, 2007
Trading Markets,T-Pred is a combination product containing tobramycin and prednisolone acetate in a fixed combination intended to offer anti-inflammatory relief and

Keys to success with surface ablation  -  Apr 10, 2007
OSN SuperSite (subscription),Johnson & Johnson, New Brunswick, NJ) is applied, followed by moxifloxacin ophthalmic solution 0.5% and prednisolone acetate suspension 1% for 1 week

ISTA Pharmaceuticals Files New Drug Application With US Food And ...  Jul 7, 2006
NDA) with the US Food and Drug Administration (FDA) for its investigational ophthalmic product, T-Pred(TM), containing tobramycin and prednisolone acetate in a ... -Medical News Today

Emirates Racing Authority Panel Hears Appeal in Brass Hat Case  Jun 26, 2006
...forfeiture of the $1.2 million runner-up purse, and a $5,400 against trainer Bradley after tests revealed trace amounts of the drug methyl prednisolone acetate ... -BloodHorse

Ista Seeks Approval for Eye Drug  Jul 7, 2006
...ocular conditions. The drug combines the ophthalmic steroid prednisolone acetate with the antibiotic solution prednisolone. Both ... -International News Service

Emirates Appeals Panel Upholds Brass Hat Disqualification  Jun 27, 2006
Stewards later disqualified Brass Hat, and moved Wilko to second, after a post-race test detected a trace of the drug methyl prednisolone acetate. ... -BloodHorse

ISTA Pharmaceuticals to Issue $40 Million 8% Senior Subordinated ...  Jun 22, 2006
...to be applied to fund ISTA's future potential commercial launch of its fixed combination eye drop product containing prednisolone acetate and tobramycin. ... -Yahoo! News

ISTA Applies for Eye Treatment Approval  Jul 6, 2006
...fight ocular inflammation. The topical product, called T-Pred, is a combination of tobramycin and prednisolone acetate. The company ... -Houston Chronicle

Brass Hat's DQ in Dubai is upheld  Jun 27, 2006
Brass Hat's trainer, William "Buff" Bradley - the son of Fred Bradley - argued in his appeal that he administered methyl prednisolone acetate, a potent anti ... -MSNBC

ISTA Seeks FDA Approval For Investigational Eye Treatment - Update  Jul 6, 2006
...treatment for ocular inflammation. T-Pred contains tobramycin and prednisolone acetate in a fixed combination. The FDA filing is ... -Trading Markets

Ista Pharma Files NDA With FDA For T-Pred - Quick Facts  Jul 6, 2006
...ophthalmic product, T-Pred. T-Pred contains tobramycin and prednisolone acetate in a fixed combination. The company also stated ... -Trading Markets

ISTA Pharmaceuticals, Inc. Reports First Quarter 2006 Financial ...  May 8, 2006
We intend to further advance this goal by our planned filing in the second quarter of our NDA for our tobramycin and prednisolone acetate combination product.". ... - Yahoo! News

Appeal Filed in Brass Hat Disqualification  May 4, 2006
UAE-I). The stewards disqualified Brass Hat because post-race blood tests showed a trace level of methyl prednisolone acetate. The ... - BloodHorse

Brass Hat Disqualified From Second in Dubai World Cup  May 3, 2006
...second in the March 25 Dubai World Cup (UAE-I), has been disqualified because a post-race test revealed trace amounts of the drug methyl prednisolone acetate. ... - BloodHorse

Leparoux claims five more wins  May 5, 2006
...second in the March 25 Dubai World Cup, was disqualified because a postrace test revealed trace amounts of the drug methyl prednisolone acetate, according to a ... - Louisville Courier-Journal

ISTA Pharmaceuticals Q1 Net Loss Widens Despite Higher Revenues ...  May 8, 2006
...increase in expenses for the quarter to the completion and analysis of a Phase III clinical trial for tobramycin and prednisolone acetate combination product ... - Trading Markets

Prostaglandin Analog Improves Results of Selective Laser ...  May 3, 2006
After surgery, patients continued their regular glaucoma medications and used 1% prednisolone acetate 4 times a day for 3 days following the procedure. ... - DG News

When arthritis strikes children  Mar 27, 2006
Her first flare of uveitis was caught at age 4 during a monthly eye examination. Sarah uses prednisolone acetate, steroid eye drops, five time a day. ... - Washington Times

ISTA Pharmaceuticals Announces Positive Phase III Results for ... Feb 2, 2006
...a Phase III bioequivalence study of ISTA's proprietary investigational combination ophthalmic product containing tobramycin and prednisolone acetate for the ... - PR Newswire,

ISTA Pharmaceuticals, Inc. Reports Fourth Quarter and Year End ...  Feb 23, 2006
...due to the commencement and completion during the second half of 2005 of the fixed combination product tobramycin 0.3% and prednisolone acetate 1.0% Phase III ... - PR Newswire,

ISTA reports positive Phase III study for eye drug Feb 2, 2006
...in a statement it plans to submit a new drug application to the US Food and Drug Administration for its tobramycin and prednisolone acetate combination product ... - Reuters

(PRN) - Signet's Fourth Quarter Like for Like Sales Up 1.8% ... ...  Feb 2, 2006
...[+]. (PRN) - ISTA Pharmaceuticals Announces Positive Phase III Results for Tobramycin and Prednisolone Acetate Combination Product ... [+. ... - Bolsamania.com,

ISTA Pharmaceuticals Announces Positive Phase III Results for ...  Feb 2, 2006
...a Phase III bioequivalence study of ISTA's proprietary investigational combination ophthalmic product containing tobramycin and prednisolone acetate for the ... - PR Newswire

ISTA reports positive Phase III study for eye drug  Feb 2, 2006
...in a statement it plans to submit a new drug application to the US Food and Drug Administration for its tobramycin and prednisolone acetate combination product ... - Reuters

(PRN) - Signet's Fourth Quarter Like for Like Sales Up 1.8% ... ...  Feb 2, 2006
...[+]. (PRN) - ISTA Pharmaceuticals Announces Positive Phase III Results for Tobramycin and Prednisolone Acetate Combination Product ... [+. ... - Bolsamania.com

Brand Names/Synonyms:
Prednisolone acetate is also known by the following brand names and/or synonyms.Delta.-Cortef; .Delta.-Stab; A-Methapred; Ak-Pred; Ak-Tate; Alphadrol; Articulose-50; CCRIS 980; Chloroptic-P S.O.P.; Co-Hydeltra; Codelcortone; Cordrol; Cortalone; Cotogesic; Cotolone; Decaprednil; Decortin H; Delcortol; Delta F; Delta-Cortef; Delta-Stab; Deltacortenol; Deltacortril; Deltacortril Enteric; Deltahydrocortisone; Deltasolone; Deltisilone; Depo-Medrol; Derpo Pd; Dexa-Cortidelt Hostacortin H; Di-Adreson F; Dicortol; Donisolone; Dydeltrone; Eazolin D; Econopred; Econopred Plus; Erbacort; Erbasona; Estilsona; Fernisolone; Fernisolone P; Fernisolone-P; Flamasone; HSDB 3385; Hostacortin H; Hydeltra; Hydeltra-Tba; Hydeltrasol; Hydeltrone; Hydrodeltalone; Hydrodeltisone; Hydroretrocortin; Hydroretrocortine; I-Pred; Inflamase Forte; Inflamase Mild; K 1557; Key-Pred; Klismacort; Lentosone; Lite Pred; M-Predrol; Medrol; Medrol Acetate; Metacortandralone; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Meti-Derm; Meticortelone; Meticortelone;Sterolone; Metreton; NSC 9120; NSC9900; Nisolone; Nor-Pred T.B.A.; Ocu-Pred; Ocu-Pred Forte; Ophtho-Tate; Orapred; PRDL; Panafcortelone; Paracortol; Paracotol; Pediapred; Precortalon; Precortancyl; Precortilon; Precortisyl; Pred Forte; Pred Mild; Predair; Predair A; Predair Forte; Predalone 50; Predalone T.B.A.; Predate Tba; Predate-50; Predcor-25; Predcor-50; Predcor-Tba; Predisolone Sodium Phosphate; Predne-Dome; Prednelan; Predni-Dome; Prednicen; Predniliderm; Predniretard; Prednis; Prednisolona [Inn-Spanish]; Prednisolone; Prednisolone Acetate; Prednisolone Sodium Phosphate; Prednisolone Tebutate; Prednisolone [Ban:Inn:Jan]; Prednisolonum [Inn-Latin]; Predonin; Predonine; Prelone; Prenolone; Rolisone; Scherisolon; Solone; Solu-Medrol; Steran; Sterane; Sterolone; Supercortisol; Ulacort; Ultra Pred; Ultracorten H; Ultracortene H; Ultracortene-H; Ultracortene-Hydrogen

Drug Category:
Prednisolone acetate is categorized under the following by the FDA: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA01; ATC:C05AA04; ATC:D07AA01; ATC:D07AA03; ATC:D07AC14;

Dosage Forms:
SOLUTION

Absorption:
Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration

Interactions:
Not Available

Chemical IUPAC Name:
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

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