Prednisolone

This page contains recent news articles, when available, and an overview of Prednisolone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Prednisolone (when available)

Pharmacology and use:
Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Mechanism Of Action:
Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

News Articles on Prednisolone

Drug Could End Miscarriage Misery  -  Sep 10, 2008
In the preliminary trials of the steroid - Prednisolone, 30 of the 40 women suffering from repeated miscarriages, all with high NK levels, went on to have TheMedGuru,

Data Support Prednisolone Use For Gout  -  Aug 25, 2008
In their clinical trial, prednisolone proved as effective as naproxen while averting the GI, renal, and cardiovascular complications that NSAIDs can cause. Renal and Urology News,

Sun Pharmaceuticals gets USFDA nods for Alendronate Sodium tablets  -  Sep 13, 2008
The drug also finds use for both men and women who have suffered from any form of osteoporosis sometimes caused by steroid medications such as prednisolone. Stock Watch,

Drug Prevents Miscarriages  -  Sep 11, 2008
Prednisolone's side effects include mood swings and increased appetite. However, most women would only need to take it for three months. Sky News,

Asthma drug could help cut miscarriages, researchers claim  -  Sep 12, 2008
And they believe treatment with the common steroid Prednisolone, traditionally used for asthma and allergies, could curb this response and protect unborn Medical Laboratory World,

‘Once A Month’ Pill To Combat Miscarriages  -  Sep 11, 2008
The introductory trials of this steroid – ‘Prednisolone’ – have shown promising results. In the words of Quenby herself: “I have already treated 40 women TopNews,

Steroid Can End Series Of Repeated Miscarriages  -  Sep 12, 2008
Researchers gave Prednisolone to 40 women suffering from repeated miscarriages along with all with high NK levels in the preliminary trials of the steroid. Visit Bulgaria,

MEDICINAL DRUGS  -  Aug 27, 2008
...of steroid tablet when the cheap tablet of prednisolone is equally effective ( are they trying to cover the fear of some patients for prednisolone ? The Island (subscription),

Taxotere® Injection (docetaxel hydrate) approved in Japan for the ...  -  Sep 1, 2008
TAX327 and on a Japanese Phase II clinical trial. prednisolone combination therapy significantly increases the overall survival versus mitoxantrone + PharmiWeb.com (press release),

Steroid Could Prevent Miscarriages  -  Sep 14, 2008
Women's hospital have helped six women who have a condition called "killer womb syndrome" by giving them an inexpensive steroid called prednisolone. RedOrbit,

Thalidomide available in the UK  -  Aug 28, 2008
Thalidomide Pharmion has been granted a licence for use in combination with melphalan and prednisolone as first-line treatment for patients with untreated Healthcare Republic

City breakthrough helps defeat the ‘killer wombs’  -  Sep 12, 2008
But taking the steroid, called prednisolone, reduces the amount of immune cells in “killer wombs�? that stop embryos from implanting. Liverpool Daily Post,

Veteran insists age no problem  -  Sep 7, 2008
...enough bouts to defend his Paralympic title in Athens, but was later stripped of his gold after testing positive for the banned steroid prednisolone. China Daily,

Disseminated cutaneous herpes simplex virus-1 in a patient with ...  -  Aug 26, 2008
Following the discontinuation of etanercept, our patient required high doses of oral prednisolone to control her inflammatory arthritis. 7thSpace Interactive (press release),

Childbirth pioneer hosts ‘Womb Wars’  -  Sep 9, 2008
..."We are now trialling a steroid treatment, called prednisolone, which we found to significantly reduce the number of these cells. Liverpool Daily Post,

DXEK exchanges corneal disc after failed penetrating keratoplasty  -  Sep 10, 2008
Postoperatively, a topical steroid, Pred Forte 1% (prednisolone acetate 1%, Allergan), and levofloxacin 1.5% are used four times daily. OSN SuperSite (subscription),

Fatal Oseltamivir-Resistant Influenza Virus Infection  -  Sep 3, 2008
One week before admission, he had received a course of cyclophosphamide, vincristine, and prednisolone chemotherapy. At admission, his white-cell count was New England Journal of Medicine (subscription),

Perils of Intravascular Methylprednisolone Injection into the ...  -  Sep 1, 2008
...whereas seven animals received a non-particulate steroid (dexamethasone in four animals [Group 2] and prednisolone in three [Group 3]). Journal of Bone and Joint Surgery (subscription)

Yar’Adua: From Germany’s Horst Schmidt Klinik to Saudi’s King Fahd ...  -  Aug 29, 2008
Post-transplantation immunosuppresion in the patients comprised of prednisolone, azathioprine and cyclosporin. More recently, mycophenolate in place of Vanguard,

아급성 �?�?선염  -  Sep 10, 2008
...심한 �?�통과 고열�?� �?�반�?�어 non-steroidal anti-inflammatory drug과 prednisolone 45 mg/day(1mg/kg/day)�?� 약 1주간 투여한 후 �?차 줄여서 한 달 후�?는 완전히 디지틀보사,

La photosensibilité aux basses fréquences dans les épilepsies ...  -  Sep 8, 2008
Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis. Neurology 2008 ; 70 : 1218-20. Barthez-Carpentier et al, Épilepsies (Abonnement),

Sanofi-aventis : Taxotère approuvé au Japon pr cancer prostate  -  Sep 1, 2008
L'étude TAX327 a démontré que l'association Taxotere 75 mg/m² toutes les 3 semaines + prednisone /prednisolone, induisait une augmentation statistiquement Trading Sat,

Is Oral Prednisolone Effective in Weaning Infants With ...  -  Aug 1, 2008
When prednisolone was begun, the practitioners used a common approach -- 5 days at 2 mg/kg; then 3 days at 1 mg/kg; then 3 doses given every other day at 1 Medscape (subscription)

Drug Companies Get Healthy, but at Whose Expense?  -  Jul 23, 2008
The team turned up a study from the United Kingdom that gave infants high doses of prednisolone, a well-known, generic steroid. Prednisolone had been Wired News

TODAY ON PHARMALIVE.COM  -  Jul 24, 2008
The ‘gold standard’ in terms of efficacy is conventional oral prednisolone. However, this has significant adverse effects that limit its clinical use and PharmaLive.com (press release),

Prostate drug application withdrawn  -  Aug 6, 2008
Orplatna was expected to be used, in combination with prednisone and prednisolone, to treat patients with metastatic hormone-refractory prostate cancer who Pharmacy Europe,

TechMARK movers: Alizyme plunges on test results  -  Jul 24, 2008
The company said that that non-inferiority of efficacy of COLAL-PRED, its drug for the treatment of severe ulcerative colitis, to conventional prednisolone CITY A.M.,

Anti-inflammatory effects of ciprofloxacin in S. aureus Newman ...  -  Jul 29, 2008
Coincubation with prednisolone resulted in a significant reduction of IL-8 levels. Conclusion: Ciprofloxacin exerts anti-inflammatory effects in S. aureus 7thSpace Interactive (press release),

Alizyme says COLAL-PRED drug misses key efficacy goal in phase III ...  -  Jul 23, 2008
During the European phase III trial, the drug met its safety goal but missed its key efficacy goal of showing non-inferiority to conventional prednisolone. Hemscott,

Second pipeline blow for Alizyme  -  Jul 30, 2008
The ‘gold standard’ in terms of efficacy is conventional oral prednisolone, though this has significant adverse effects that limit its clinical use. Business Weekly,

Mycophenolate Mofetil Works As Well As Standard Therapy  -  Jul 22, 2008
The MMF-based regimen consisted of MMF 2 g/day for six months along with prednisolone at 0.5 mg/kg per day for two to three months. Renal and Urology News,

Amniotic membrane transplant key to pterygium surgical method  -  Aug 8, 2008
Pred Forte 1% drops (prednisolone acetate, Allergan) are used four times a day for 2 weeks, and then tapered off over the following 2 weeks. OSN SuperSite (subscription),

ISTA Pharmaceuticals Reports Second Quarter 2008 Financial Results  -  Aug 8, 2008
...the additional T- Pred work required by the FDA for the testing of tobramycin and the pK study on the prednisolone component of the formulation. PharmaLive.com (press release),

ISTA Pharmaceuticals Reports Second Quarter 2008 Financial Results  -  Aug 7, 2008
...the additional T- Pred work required by the FDA for the testing of tobramycin and the pK study on the prednisolone component of the formulation. SunHerald.com,

Homeopathy Proven Better Than Conventional Medicine for Eczema  -  Jul 24, 2008
Corticosteroids, such as prednisone, prednisolone, and methylprednisolone, are fraught with risks, both short and long term. The study's authors noted only Natural News.com,

Pharmion Ltd Withdraws Its Marketing Authorisation Application For ...  -  Aug 5, 2008
Orplatna was expected to be used, in combination with prednisone and prednisolone, in the treatment of patients with metastatic hormonerefractory prostate PharmaLive.com (press release),

The alternative Holby City that treats 30000 patients a year  -  Aug 2, 2008
I was diagnosed with the autoimmune disease polymyalgia rheumatica and my GP prescribed prednisolone, a steroid. I was reluctant to take it because of the Daily Mail,

Prostate Cancer Vaccines with Subsequent Hormone Therapy Found to ...  -  Jul 23, 2008
Antiandrogens, such as bicalutamide or flutamide, oral glucocorticoids, high doses of estrogens, docetaxel and prednisolone, are some of the current Medi News Direct,

FAMU Receives $14 Million National Institute Of Health Grant  -  Jul 20, 2008
While at FAMU, in 1986, he received a patent for Anti-inflammatory Prednisolone Steroids and in 1998 for Anti-inflammatory Carboxy Pregnane Derivatives. Weekly Challenger,

FDA Approvals: Aciphex, Durezol, Aptivus  -  Jul 17, 2008
Difluprednate is a difluorinated derivative of prednisolone with potent anti-inflammatory activity, the company said in a news release, noting that its Medscape (subscription)

زيت السمك والقليل من الشحوم .. م�?يدان لمرضى الذئبة الحمراء  -  Jul 25, 2008
والدواء الشائع للعلاج هو البريدنوزولون Prednisolone))، وتختل�? الجرعة طبقاً لحالة نشاط المرض. الكورتيزون مادة طبيعية موجودة �?ي دم كل إنسان ولكن نحتاج إلى الوقت البحرينية,

Liệu có biệt dược giúp chống say rượu  -  Jul 21, 2008
...glucocorticoide (prednisolone và dexamethasone); indometacine; kayexalate; ketoconazole; thuốc an thần kinh nhóm phenothiazine; penicillamine; muối sắt. Nông Nghiệp,

Naproxen, Prednisolone May Be Effective First-Line Treatment of Gout  -  02 Jun 2008
Compare the efficacy of naproxen vs oral prednisolone as a first-line treatment of gout. Compare the safety and tolerability of naproxen vs oral Medscape (subscription)

Picture of the Month—Quiz Case  -  02 Jun 2008
In the week before evaluation, she had been started on a regimen of cephalexin; prednisolone, 15 mg/d with taper; and ibuprofen. Archives of Pediatrics

Oral Prednisolone and Naproxen (Aleve) Equal for Gout Pain  -  May 29, 2008
If patients ask, explain that prednisolone, a corticosteroid, was as effective as the commonly used nonsteroidal anti-inflammatory drug naproxen (Aleve) in MedPage Today,

Oral Prednisolone and Naproxen Found Equally Beneficial in the ...  -  May 29, 2008
LONDON -- May 29, 2008 -- A recent study, reported in The Lancet, finds that naproxen and prednisolone are beneficial alternatives for nonsteroidal DG News

Corticosteroid a safer and cheaper option for gout  -  May 30, 2008
One of the most common acutely painful conditions to present to GPs – gout – could be treated with the corticosteroid drug, prednisolone, rather than NSAIDs OnMedica,

Steroid Pill May Ease Gout Attack  -  May 30, 2008
By Miranda Hitti May 30, 2008 -- To treat gout attacks, prednisolone pills may be as good as the nonsteroidal anti-inflammatory drug naproxen. WebMD

Oral steroids first line for gout  -  May 29, 2008
...by Dr Linda Calabresi A five day course of oral prednisolone is as effective as naproxen in relieving acute gout, and should be considered first-line, 6minutes,

CombinatoRx Completes Enrollment In Phase 2B Clinical Trial Of CRx ...  -  May 29, 2008
CRx-102 contains the cardiovascular agent dipyridamole and a very low dose of the glucocorticoid prednisolone and is being developed in a uniquely Medical News Today (press release),

CombinatoRx Completes Enrollment in Phase 2B Clinical Trial of CRx ...  -  May 27, 2008
CRx-102 contains the cardiovascular agent dipyridamole and a very low dose of the glucocorticoid prednisolone and is being developed in a uniquely Business Wire (press release),

Lead Exposure May Induce Criminal Behavior, New Treatment for Gout ...  -  May 29, 2008
From the Netherlands - The corticosteroid drug prednisolone is just as effective at treating gout as the conventional treatment naproxen. Insider Medicine,

CombinatoRx completes enrollment in Phase IIb osteoarthritis trial  -  May 28, 2008
In the study, patients are randomized to three different doses of CRx-102 (2.7mg prednisolone and 360mg, 180mg or 90mg of dipyridamole), Stockhouse,

Alizyme Announces Commencement of Phase II Study for Colal-Pred in ...  -  May 21, 2008
Patients will be randomized to placebo or one of four doses of COLAL-PRED® (equivalent to 40, 60, 80, or 120 mg of prednisolone) for a treatment period of 4 Lifescience-online,

Gout Isn't Gone, Guys  -  May 30, 2008
Just yesterday, for example, a study appeared in Lancet suggesting that a corticosteroid called prednisolone may be the safest treatment choice for men who U.S. News & World Report,

'The heart of the team'  -  Jun 1, 2008
Later, the medical team switched her to prednisolone. "Six months to the day she stopped taking pregnisone, in 1995, her words started to come back," Nancy Glens Falls Post-Star,

Black-Spot Poison Ivy  -  May 28, 2008
She was treated with intravenous diphenhydramine, methyl prednisolone, and cimetidine. Since the last episode, she has strictly avoided poison ivy exposure Abkhazia,

Second revolution in arthritis antibody  -  May 27, 2008
During these 24 months the patients received basic treatment with DMARDs, partially in combination with prednisolone, or a TNF-alpha blocker. Laboratory Talk,

Sick to the stomach  -  May 13, 2008
Back to these drugs that either don't work or don't exist: there are two, basically nuclear, options, one a steroid, prednisolone, which is widely used in guardian.co.uk,

Prometheus fires pellets for colon treatment  -  May 26, 2008
By encasing a generic steroid (prednisolone sodium metasulfobenzoate) in Alizyme's delivery technology the drug is released only when it reaches the colon In-PharmaTechnologist.com,

First Jack’s now Hugo’s last ride…  -  May 24, 2008
For months at a time we tried one ear medication after another – from Prednisolone, Baytril, Synotic, Otimax to a smelly concoction created in-house by a In-Forum,

Martin Napp on good prescribing audits  -  May 19, 2008
I suggest that colcichine is preferable to treat acute gout, with short course prednisolone as an alternative if colchicine is not tolerated or is not 6minutes,

Mesenchymal stem cells might be the answer to Spinal Cord Injury  -  May 19, 2008
Currently, administration of methyl prednisolone at high doses within 6 hours after injury is the most effective therapy with recognized benefits; India PRwire (Press Release),

Ista conducting strategic review, may consider merger or buyout ...  -  May 14, 2008
Ista plans to launch three products in 2009: a revised label for Xibrom in a once-daily dose, T-Pred (prednisolone acetate 1%, tobramycin 0.3%) and once- OSN SuperSite (subscription),

Examine The Fastest Growing Biotechnology Companies: Growth ...  -  May 12, 2008
Xibrom(TM) (bromfenac) 109 Istalol® 110 Vitrase® 111 Product development programs 111 T-Pred (tobramycin and prednisolone acetate combination product) Earthtimes (press release),

Lenalidomide raises clot risk in multiple myeloma patients  -  May 9, 2008
Along with lenalidomide-based therapy, 52 received high-dose dexamethasone (40 mg 12 days a month) and 73 received prednisolone or dexamethasone 40 mg, Curetoday.com (press release),

More news briefs  -  May 6, 2008
...dexamethasone, DexPak, Entocort, etidronate, fludrocortisone, hydrocortisone, Medrol, methylprednisolone, Orapred, prednisolone, prednisone and Sterapred. Rochester Democrat and Chronicle,

Advanced surgical technique: Two-stage anterior lamellar keratoplasty  -  May 5, 2008
Postoperatively, a topical steroid, Pred Forte 1% (prednisolone acetate 1%, Allergan), and an antibiotic levofloxacin 1.5%, moxifloxacin 0.5% or OSN SuperSite (subscription),

Brand Names/Synonyms:
Prednisolone is also known by the following brand names and/or synonyms.Delta.-Cortef; .Delta.-Stab; A-Methapred; Ak-Pred; Ak-Tate; Alphadrol; Articulose-50; CCRIS 980; Chloroptic-P S.O.P.; Co-Hydeltra; Codelcortone; Cordrol; Cortalone; Cotogesic; Cotolone; Decaprednil; Decortin H; Delcortol; Delta F; Delta-Cortef; Delta-Stab; Deltacortenol; Deltacortril; Deltacortril Enteric; Deltahydrocortisone; Deltasolone; Deltisilone; Depo-Medrol; Derpo Pd; Dexa-Cortidelt Hostacortin H; Di-Adreson F; Dicortol; Donisolone; Dydeltrone; Eazolin D; Econopred; Econopred Plus; Erbacort; Erbasona; Estilsona; Fernisolone; Fernisolone P; Fernisolone-P; Flamasone; HSDB 3385; Hostacortin H; Hydeltra; Hydeltra-Tba; Hydeltrasol; Hydeltrone; Hydrodeltalone; Hydrodeltisone; Hydroretrocortin; Hydroretrocortine; I-Pred; Inflamase Forte; Inflamase Mild; K 1557; Key-Pred; Klismacort; Lentosone; Lite Pred; M-Predrol; Medrol; Medrol Acetate; Metacortandralone; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Meti-Derm; Meticortelone; Meticortelone;Sterolone; Metreton; NSC 9120; NSC9900; Nisolone; Nor-Pred T.B.A.; Ocu-Pred; Ocu-Pred Forte; Ophtho-Tate; Orapred; PRDL; Panafcortelone; Paracortol; Paracotol; Pediapred; Precortalon; Precortancyl; Precortilon; Precortisyl; Pred Forte; Pred Mild; Predair; Predair A; Predair Forte; Predalone 50; Predalone T.B.A.; Predate Tba; Predate-50; Predcor-25; Predcor-50; Predcor-Tba; Predisolone Sodium Phosphate; Predne-Dome; Prednelan; Predni-Dome; Prednicen; Predniliderm; Predniretard; Prednis; Prednisolona [Inn-Spanish]; Prednisolone; Prednisolone Acetate; Prednisolone Sodium Phosphate; Prednisolone Tebutate; Prednisolone [Ban:Inn:Jan]; Prednisolonum [Inn-Latin]; Predonin; Predonine; Prelone; Prenolone; Rolisone; Scherisolon; Solone; Solu-Medrol; Steran; Sterane; Sterolone; Supercortisol; Ulacort; Ultra Pred; Ultracorten H; Ultracortene H; Ultracortene-H; Ultracortene-Hydrogen

Drug Category:
Prednisolone is categorized under the following by the FDA: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA01; ATC:C05AA04; ATC:D07AA01; ATC:D07AA03; ATC:D07AC14;

Dosage Forms:
SOLUTION

Absorption:
Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration

Interactions:
Not Available

Chemical IUPAC Name:
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

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