Pravastatin

This page contains recent news articles, when available, and an overview of Pravastatin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Pravastatin (when available)

Pharmacology and use:
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation. For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.

Mechanism Of Action:
Like lovastatin and simvastatin, pravastatin inhibits hydroxymethylglutaryl-CoA (HMG-CoA) reductase. As HMG-CoA is necessary for the intracellular synthesis of cholesterol, its inhibition results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.

News Articles on Pravastatin

No benefit to intensive statin therapy in ACS patients with low ...  -  Sep 1, 2008
Boston, MA - An analysis of one of the pivotal "lower-is-better" cholesterol trials—Pravastatin or Atorvastatin Evaluation and Infection TheHeart.Org,

Clinical Trial: No  -  Sep 1, 2008
Conclusions: A progressive reduction in the benefit of intensive LLT with atorvastatin 80 mg over pravastatin 40 mg occurred in statin-naïve ACS patients as Cardiosource,

Statin pioneer, gene experts win US medical awards  -  Sep 13, 2008
N: Quote, Profile, Research, Stock Buzz) under the brand name Lipitor; pravastatin or Pravachol, made by Bristol-Myers Squibb (BMY. Reuters

Statin drugs: Benefits versus risks  -  Aug 26, 2008
Subjects in the west of Scotland study who took pravastatin had a reduced incidence of diabetes compared to those taking placebo. And women taking statins Enid News & Eagle,

Can Drug Therapy Prevent Parkinson’s Disease?  -  Aug 25, 2008
In the current study, each of these drugs, except pravastatin, was associated with a 60 to 70% decreased risk of Parkinson’s disease. GNIF Brain Blogger,

Key Issues in the Developing Synergism Between Cardiovascular ...  -  Sep 14, 2008
Recent data suggest that lipoprotein-associated phospholipase A2 (LpPLa2) (28) may have a role in this area, and data from the PROVE-IT (Pravastatin or RedOrbit,

Survey Among European Cardiologists Points To A Gap In ...  -  Sep 3, 2008
Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the prospective Pravastatin Pooling Project. Circulation. Medical News Today (press release),

Diapharm Starts GMP Audit Service for Active Pharmaceutical ...  -  Sep 11, 2008
...pravastatin, propyphenazone, rizatriptan, rosiglitazone, rosuvastatin, simvastatin, sotalol, sumatriptan, theophylline, trimethoprim and zolmitriptan. Newswire Today (press release),

Key words: Cholesterol - Coronary disease - Hydroxymethylglutaryl ...  -  Aug 28, 2008
Under this formulation, a daily dose of 10 mg simvastatin, 20 mg pravastatin, or 40 mg fluvastatin is considered low equipotency; 5 mg rosuvastatin, RedOrbit,

Statins fight stroke in older people too  -  Sep 3, 2008
They include atorvastatin, made by Pfizer Inc under the brand name Lipitor; pravastatin or Pravachol, made by Bristol-Myers Squibb; fluvastatin, Reuters

Statins: use and effectiveness  -  Sep 3, 2008
Having claudication I was prescribed Pravastatin which removed the effect but which made me feel tired. Various US sites suggested taking Q10 as a Times Online,

Medicare's Poison Pill  -  Sep 3, 2008
I must keep my blood pressure and bad cholesterol way down, he said, so I started taking Diovan for the former and Pravastatin for the latter. Mother Jones,

The war on drugs  -  Aug 24, 2008
Cincinnati-based Kroger added 11 prescriptions – six medications, some offered in varying dosages – including the cholesterol-lowering drug Pravastatin. Fort Wayne Journal Gazette,

Cholesterol Drug used to treat various cancers  -  Aug 21, 2008
...‘Using laboratory cultures of esophageal cancer cells, the researchers found that adding simvastatin (Zocor), lovastatin (Mevacor), and pravastatin Justice News Flash,

Direct Determination of Lipoprotein Particle Sizes and ...  -  Sep 5, 2008
Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of RedOrbit,

Effects of Statin Treatment in Men and Women With Stable Coronary ...  -  Aug 18, 2008
Effect of pravastatin on cardiovascular events in women after myocardial infarction: the Cholesterol and Recurrent Events (CARE) trial. RedOrbit,

Keep taking statins after heart attack - study  -  Aug 27, 2008
Statins include atorvastatin, made by Pfizer under the brand name Lipitor; pravastatin or Pravachol, made by Bristol Myers Squibb; fluvastatin, guardian.co.uk,

Statins don't cause cancer, study finds  -  Aug 20, 2008
Statins include atorvastatin, made by Pfizer under the brand name Lipitor; pravastatin or Pravachol, made by Bristol Myers Squibb; fluvastatin, National Post,

Persistence of Atorvastatin and Simvastatin Among Patients With ...  -  Aug 28, 2008
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia [West of Scotland Coronary Prevention Study Group]. RedOrbit,

Ngư�?i già cũng nên dùng thuốc statin để ngăn ngừa đột quị  -  Sep 6, 2008
Những thuốc statins thông dụng trên thị trư�?ng gồm có atorvastatin, do hãng bào chế Pfizer Inc sản xuất với nhãn hiệu Lipitor; thuốc pravastatin, Ngư�?i Việt,

Thuốc hạ thấp cholesterol không làm tăng nguy cơ mắc bệnh ung thư  -  Aug 23, 2008
...do hãng bào chế Pfizer sản xuất với tên riêng là Lipitor; thuốc pravastatin hoặc Pravachol, của hãng bào chế Bristol Myers Squibb; thuốc fluvastatin của Ngư�?i Việt,

Predictors of Uncontrolled Hyperlipidaemia in High-Risk Ambulatory ...  -  Aug 9, 2008
In addition, in both studies type and dosage of pre- treatment with statins (atorvastatin, simvastatin, lovastatin, pravastatin or fluvastatin) were RedOrbit,

Cost-Effectiveness of Statins in the Prevention of Coronary Heart ...  -  Aug 9, 2008
Cost-effectiveness of rosuvastatin, atorvastatin, simvastatin, pravastatin and fluvastatin for the primary prevention of CHD in the UK. RedOrbit,

Biocon: Hold  -  Aug 2, 2008
With Biocon right now participating in categories such as Simvastatin (the biggest contributor), Pravastatin and Lovastatin, where they continue maintaining Hindu Business Line,

Pharmacogenomics and Drug Toxicity  -  Jul 23, 2008
Polymorphisms in some solute transporter genes have been associated with altered hepatic uptake of pravastatin, another statin, 8 , 9 and some data indicate New England Journal of Medicine (subscription),

Statin drugs-benefits vs risks  -  Jul 30, 2008
Results from the ongoing West of Scotland Coronary Prevention Study found that men taking pravastatin had a reduced risk of having a heart attack or dying Casa Grande Valley Newspapers,

Intensive Lipid Lowering With Atorvastatin in Patients With ...  -  Aug 5, 2008
The current observations are in part consistent with data from the Pravastatin Pooling Project, which included 19737 high-risk patients treated with RedOrbit,

Pinpointing Genetic Variations In European Americans  -  Aug 7, 2008
Disorders and Stroke (NINDS) as well as the CAP (Cholesterol and Pharmacogenetics) and PRINCE (Pravastatin Inflammation/CRP Evaluation) studies. Science Daily (press release)

Not all cholesterol drugs are harmful  -  Jul 20, 2008
Multiple studies over the past many years have shown, without a question, that the cholesterol medication known as a statin (Zocor, Simvastatin, Pravastatin News Chief,

Sciele Pharma, Inc. Reports Results for the Second Quarter of 2008  -  Jul 30, 2008
Research and development expenses for the second quarter of 2008 were primarily related to the pivotal clinical trials of the pravastatin/fenofibrate Genetic Engineering News (press release),

Sciele Pharma Inc. Q2 2008 Earnings Call Transcript  -  Jul 30, 2008
In the second quarter of 2008, the company completed a Phase III efficacy clinical trial using pravastatin and fenofibrate to treat mixed dyslipidemia. Seeking Alpha,

Baby Boomer Nutrition High Priority for Food Processors  -  Aug 6, 2008
A group of pharmaceutical compounds – atorvastatin, fluvastatin, pravastatin, rosuvastatin, and simvastatin – statins are used commonly to reduce the level Food Processing,

Statins May Protect Against Memory Loss  -  Aug 5, 2008
Statins included in the study were atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, rosuvavstatin and simvastatin. eMaxHealth.com,

Peripheral Arterial Disease: Diagnosis and Management  -  Aug 5, 2008
Ridker PM, Cannon CP, Morrow D, et al; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI RedOrbit,

Statins Reduce Risk for Cognitive Impairment  -  Jul 31, 2008
...cerivastatin (0 participants), fluvastatin (6 participants), lovastatin (104 participants), pravastatin (28 participants), rosuvastatin (5 participants) Medscape (subscription)

FDA Safety Changes: Reyataz and Invanz  -  Jul 30, 2008
Atorvastatin or rosuvastatin may be used with caution at the lowest possible dose, and substitution of other HMG-CoA inhibitors such as pravastatin or Medscape (subscription)

Genetic Variation Linked To Muscle Pain Due To Statins  -  Jul 24, 2008
...(both generated $33.7 billion in worldwide sales in 2007), Mevacor (lovastatin), Pravachol (pravastatin), Lescol (fluvastatin) and Baycol (cerivastatin) eFluxMedia

Does Switching Statins Increase the Risk for Adverse Events?  -  Jul 16, 2008
Included within this class are several agents: lovastatin, pravastatin, simvastatin; and the newer agents -- atorvastatin, fluvastatin, and rosuvastatin. Medscape (subscription)

No more twinkies for the Japanese  -  Jul 15, 2008
To test the MS/waist-size-heart disease/diabetes link, Dr. Sattar used two prospective studies — the Prospective Study of Pravastatin in the Elderly at Risk Anchorage Times,

Vorsicht Statistik!  -  Aug 8, 2008
Ein anderes Beispiel: 1995 wurde in einer US-Pharmastudie behauptet, das Medikament »Pravastatin« senke bei Menschen mit hohem Cholesterinspiegel das Neues Deutschland,

Πολλαπλό «φά�?μακο» τα ψά�?ια  -  Aug 2, 2008
καθημε�?ινά χαμηλή δόση στατινών pravastatin ή simvastatin μόνες ή μαζί με 1.800 χιλιοστογ�?αμμά�?ια ΕΡΑ ημε�?ησίως και για διάστημα πε�?ίπου πέντε ετών. Η Καθημε�?ινή,

한국화�?��?， 리피토 고용량 80 mg 출시  -  Jul 27, 2008
...가�?�드�?��?� 개정�? �?향�?� 준 임�?시험�?� 하나�?� PROVE-IT TIMI22(Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial 쿠키뉴스,

Chữa cholesterol cũng như làm kinh tế  -  Jul 25, 2008
Dùng loại thuốc nào, Simvastatin, Lovastatin, Pravastatin, Fluvastatin, Atorvastatin, hay Rosuvastatin... là tùy kinh nghiệm của thầy thuốc, Th�?i báo Kinh tế Sài Gòn Online,

Experts warn that a single UK CVD assessment tool is needed  -  02 Jun 2008
If there are potential drug interactions, or simvastatin 40mg is contraindicated, a lower dose or alternative preparation such as pravastatin may be chosen. Healthcare Republic

Cadila gets US OK for cholesterol lowering pravastatin  -  May 6, 2008
BO: Quote, Profile, Research) cholesterol-fighter pravastatin sodium tablets in various strengths, the regulator's Web site showed on Wednesday. Reuters India,

Cadila gets FDA approval to market four drugs in US  -  May 15, 2008
The group has received the Food and Drug Administration (FDA) approval to market 10, 20, 40, 80 mg of Pravastatin Sodium tablets in the United States, Economic Times,

Cadila gets USFDA nod for cholesterol lowering pravastatin  -  May 7, 2008
The US Food and Drug Administration has approved Cadila Healthcare`s (Q, N,C,F)* cholesterol-fighter pravastatin sodium tablets in various strengths. Myiris.com,

Kroger expands $4 drug program  -  May 13, 2008
...are 11 more prescriptions available at $4 for a 30-day supply or $10 for a 90-day supply, including the key cholesterol-lowering drug, Pravastatin. Indianapolis Star,

Cholesterol and statin drugs  -  May 23, 2008
Lovastatin, pravastatin, and simvastatin are available in generic form and are cheaper (all prices are from Costco for roughly equivalent doses). The Union of Grass Valley,

Annual cholesterol check-ups 'excessive'  -  May 17, 2008
The authors examined data from patients who had taken pravastatin, which is sold in Australia under brand names such as Pravachol and Vastoran. The Age,

Monitoring Cholesterol Levels: Measurement Error or True Change?  -  May 5, 2008
Design: Analysis of cholesterol measurement data in the LIPID (Long-Term Intervention with Pravastatin in Ischaemic Disease) study. Annals of Internal Medicine

Statins Found to Have Antihypertensive Effect  -  May 6, 2008
A double-blind, placebo-controlled trial was conducted, involving 973 subjects who were either given simvastatin, pravastatin or placebo for a period of 6 Medi News Direct,

Annual cholesterol tests ‘not needed'  -  May 12, 2008
The analysis of serial cholesterol measurements in 9014 people, taking part in a long-term randomised controlled trial of pravastatin, showed monitoring was Pulse,

Check cholesterol every five years  -  May 5, 2008
Using data from LIPID (Long-Term Intervention with Pravastatin in Ischaemic Disease) study, researchers discovered it was not until three years that 6minutes,

Kroger Adds to Highly Successful Generic Drug Program  -  May 13, 2008
...are 11 more prescriptions available at $4 for a 30-day supply or $10 for a 90-day supply, including the key cholesterol-lowering drug, Pravastatin. Palladium-Item,

Sheriff ramps up prescription drug battle  -  May 31, 2008
Pravastatin is a cholesterol medication. Diclofenac sodium is an anti-inflammatory drug. Cymbalta treats depression. Strattera is a treatment for ADHD. Princeton Times Leader,

Pay attention to statin side effects  -  May 25, 2008
When you add these medications to other statin-type medicines like simvastatin, lovastatin, pravastatin, Crestor and Lescol, the total number of bottles Houston Chronicle,

Metabolic Syndrome Predicts Diabetes, Not Cardiovascular Disease ...  -  May 22, 2008
Professor Sattar and colleagues addressed these issues in 2 prospective studies in elderly populations -- the Prospective Study of Pravastatin in the DG News

NICE Issues Guidance on Lowering Cholesterol for People at High ...  -  May 29, 2008
If there are potential drug interactions, or simvastatin 40 mg is contraindicated, a lower dose or alternative preparation such as pravastatin may be chosen DG News

Metabolic Syndrome Foretells Diabetes in Elderly  -  May 21, 2008
The researchers analyzed data from 4812 non-diabetic people, aged 70 to 82, who took part in the Prospective Study of Pravastatin in the Elderly at Risk Forbes,

NICE moves to prevent heart attacks and strokes  -  May 28, 2008
...to attend their GP’s practice to confirm their risk and be given lifestyle advice and a prescription for simvastatin, or if not suitable, pravastatin. OnMedica,

Lowering cholesterol: what the options are  -  May 6, 2008
Generic statins (lovastatin, pravastatin and simvastatin) cost less. Experts agree that statins are the best cholesterol-lowering medications. Myrtle Beach Sun News,

Healthy partnerships  -  May 11, 2008
The company launched another FTF drug Pravastatin (80 mg) (reduces cholesterol) in June 2007, garnering 30 per cent of prescription marketshare in the Business Standard,

Metabolic Syndrome Not Useful in Predicting Cardiovascular Risk  -  May 23, 2008
They reported the results of two prospective studies -- the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) and the British Regional Heart MedPage Today,

Diabetes, Not Cardiovascular Disease, Linked To Metabolic Syndrome  -  May 22, 2008
Data from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) enabled the researchers to assess 4812 non-diabetic people from age 70 to 82 Medical News Today,

New dosage strength reduces number of PREZISTA tablets taken daily  -  May 19, 2008
Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, PharmaLive.com (press release),

Japan's Daiichi Sankyo FY net profit up 24.3 percent, but sees ...  -  May 12, 2008
Revenue fell 5.3 percent to 880.1 billion yen, hit by an 18.3 percent drop in the global sales of its Mevalotin/pravastatin anti-hyperlipidemia agent, Trading Markets (press release),

KAI, BMS Join Forces in $227M Heart Drug Deal  -  May 13, 2008
While BMS has a long history of developing and commercializing cardiovascular medications, such as Pravachol (pravastatin sodium) and Plavix (clopidogrel TMCnet

Statins Are Not Without Problems  -  May 27, 2008
When you add these medications to other statin-type medicines like simvastatin, lovastatin, pravastatin, Crestor and Lescol, the total number of bottles The Ledger,

Brand Names/Synonyms:
Pravastatin is also known by the following brand names and/or synonymsCCRIS 7557; Compactin; Elisor; Lipostat; Lovastatin; Mevalotin; Mevastatin; Mevinolin; Oliprevin; Pravachol; Pravaselect; Pravastatin; Pravastatin Sodium; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; Selectin; Selipran; Vasten

Drug Category:
Pravastatin is categorized under the following by the FDA: Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA03

Dosage Forms:
TABLET

Absorption:
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.

Interactions:
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Chemical IUPAC Name:
3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-heptanoicacid

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