Pravachol

This page contains recent news articles, when available, and an overview of Pravachol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Pravachol (when available)

Pharmacology and use:
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation. For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.

Mechanism Of Action:
Like lovastatin and simvastatin, pravastatin inhibits hydroxymethylglutaryl-CoA (HMG-CoA) reductase. As HMG-CoA is necessary for the intracellular synthesis of cholesterol, its inhibition results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.

News Articles on Pravastatin

Cholesterol kids: Rx or exercise?  -  Jul 16, 2008
Statin drugs - such as Lipitor, Zocor, Mevacor, Pravachol and Crestor - work by blocking the action of a liver enzyme that promotes cholesterol production. Globe and Mail,

Do cholesterol medicines really work?  -  Jul 28, 2008
...(Statins are: Zocor, Pravachol, Crestor, Lescol, Mevacor and Lipitor.) Muscle pain occurs in one in 1000 users. Muscle damage occurs in much fewer. Roanoke Times,

Myopathy From Statins Due To Rare Gene  -  Jul 23, 2008
Statin drugs (eg Lipitor, Crestor, Pravachol) are widely used to lower cholesterol but occasionally cause worrisome side effects including muscle pain and Methuselah Foundation,

Statins May Protect Against Dementia: Study  -  Jul 28, 2008
The pills included Zocor, Lipitor and Pravachol. During the five-year study, which was funded by the National Institute on Aging, 27 percent took a statin Pharmalot,

Listening to Lipitor  -  Jul 13, 2008
So-called statin drugs — the class that includes Lipitor and Pravachol — have been used for years in kids with certain genetic disorders that interfere with St. Louis Post-Dispatch,

Not all cholesterol drugs are harmful  -  Jul 20, 2008
...without a question, that the cholesterol medication known as a statin (Zocor, Simvastatin, Pravastatin, Pravachol, Crestor, Lipitor, Fluvastatin, News Chief,

The You Docs: Don't let latest study scare you off all multivitamins  -  Jul 16, 2008
...vitamins E and C. These can inhibit the anti-inflammatory component of cholesterol-clearing statins such as Mevacor, Lipitor, Crestor and Pravachol. IdahoStatesman.com,

Pfizer doubles profit on exchange rate, lower costs  -  Jul 23, 2008
...s Zocor and Bristol-Myers Squibb's Pravachol. Lipitor is slated to lose market exclusivity in late 2011. According to a recent note by Cowen & Co., MarketWatch

Pharma alliances, a shot in the arm  -  Jul 12, 2008
...a Japanese company, while Bristol Myers Squibb’s three biggest drugs — Pravachol, Glucophage and Taxol — are compounds developed by other companies. Sify,

Palpitations Over Pills for Kids  -  Jul 13, 2008
Already five statin drugs — Bristol-Myers Squibb’s Pravachol, Pfizer’s Lipitor, Merck’s Zocor and Mevacor, and Novartis’s Lescol — have been approved for New York Times,

Fitch Expects Bristol-Myers Squibb's Ratings to be Unaffected by ...  -  Jul 31, 2008
Leverage (total debt to EBITDA), which increased dramatically in 2006 due to generic competition to Pravachol starting in April 2006 and to Plavix in August PR-Inside.com (Pressemitteilung),

Do Cholesterol Medicines Really Work?  -  Jul 29, 2008
...(Statins are: Zocor, Pravachol, Crestor, Lescol, Mevacor and Lipitor.) Muscle pain occurs in one in 1000 users. Muscle damage occurs in much fewer. RedOrbit,

The Skinny on Heart Disease, Cholesterol  -  Jul 29, 2008
So Sinatra says if you're taking Zocor, Crestor, Pravachol or any of the statins, you should definitely take a coenzyme Q10 supplement to overcome the Christian Broadcasting Network,

Muscle pain can be side effect of Lipitor  -  Jul 28, 2008
Other statins include Crestor, Pravachol, Mevacor and Zocor. These are some of the most commonly prescribed drugs. The statins are used to treat high The Star-Ledger - NJ.com,

Genetic Variation Linked To Muscle Pain Due To Statins  -  Jul 24, 2008
...(both generated $33.7 billion in worldwide sales in 2007), Mevacor (lovastatin), Pravachol (pravastatin), Lescol (fluvastatin) and Baycol (cerivastatin) eFluxMedia

Natalie’s Orchid Island Juice Company confirms grapefruit juice ...  -  Jul 18, 2008
But those on Crestor®, Pravachol® or Zocor® need not refrain from refreshing with Natalie’s Orchid Island Grapefruit Juice. “People should consult with FreshPlaza,

Statins may help kidney transplant patients: study  -  Jul 23, 2008
Some statins include Pfizer Inc's Lipitor, Merck & Co's Zocor, AstraZeneca's Crestor and Bristol-Myers Squibb Co's Pravachol. The study was backed by grants Canada.com,

Traiter le cholestérol à 8 ans?  -  Aug 4, 2008
L'Agence américaine des aliments et des médicaments a déjà approuvé l'administration aux enfants de 8 ans et plus du Pravachol, un médicament à base de Cyberpresse,

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...其中一�?他汀类�?胆固醇�?�物Pravachol �?��?,

Estados Unidos recomienda a los niños tomar medicamentos de adultos  -  Jul 22, 2008
De hecho una estatina, el Pravachol, ya ha sido aprobada por la FDA para su uso en niños de ocho años. “Extrapolamos la información que tenemos en adultos�?, La Gaceta de los Negocios,

El colesterol en los niños y sus medicinas  -  Jul 19, 2008
Hay cinco estatinas que han sido aprobadas para niños con trastornos genéticos de colesterol: Pravachol de Bristol-Myers Squibb, Lipitor de Pfizer, Diario El Heraldo de Honduras,

Remédios de colesterol para crianças de 8 anos?  -  Jul 15, 2008
Uma estatina, Pravachol, já foi aprovada pelo Food and Drug Administration para uso em crianças a partir dos 8 anos de idade. “Fizemos deduções a partir da O Estado do Maranhão (Assinatura),

¿Niños de ocho años tomando estatinas? El debate médico empieza  -  Jul 14, 2008
Una estatina, el Pravachol, ya ha sido aprobado por la Agencia de Alimentos y Medicamentos de Estados Unidos (FDA, por sus siglas en inglés) para su uso en Quinta Columna,

¿Drogas contra el colesterol para niños de 8 años?  -  Jul 13, 2008
Una estatina, el Pravachol, ya ha sido aprobada por la Administración de Alimentos y Drogas (FDA, por sus siglas en inglés) para ser utilizada en niños muy Actualidad Misiones,

Annual cholesterol check-ups 'excessive'  -  May 17, 2008
The authors examined data from patients who had taken pravastatin, which is sold in Australia under brand names such as Pravachol and Vastoran. The Age,

Cholesterol and statin drugs  -  May 23, 2008
Mevacor (lovastatin - 50 cents/pill), Pravachol (pravastatin - 39 cents/pill), Lescol (fluvastatin - 2.45 / pill), Zocor (simvastatin - 19 cents / pill), The Union of Grass Valley,

Lowering cholesterol: what the options are  -  May 6, 2008
There are six statins on the market: atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor) and Myrtle Beach Sun News,

Drug Spending Moves Up for Diabetes, Down for Cholesterol  -  May 15, 2008
But two big statins, Merck’s Zocor and Bristol-Myers Squibb’s Pravachol, went generic in 2006, driving prices through the floor. Use of Pfizer’s Lipitor, Wall Street Journal Blogs,

Generics Sharply Curbed '07 Drug Spending Growth: Medco  -  May 14, 2008
While use of cholesterol drugs continues to grow, spending fell 8.5% last year as lower-cost generic versions of the cholesterol medicines Pravachol, CNNMoney.com

Giant Eagle adds 90-day supplies to generic program  -  May 21, 2008
...$10 for a 90-day supply -- are the generic versions of Pravachol for treating high cholesterol, and Paxil and Prozac, both used in treating depression. Pittsburgh Tribune-Review,

Business news briefs  -  May 20, 2008
The grocer said additional drugs being added for either $4 for a 30-day supply or $10 for a 90-day supply include the generic versions of Pravachol, Pittsburgh Post Gazette,

KAI, BMS Join Forces in $227M Heart Drug Deal  -  May 13, 2008
While BMS has a long history of developing and commercializing cardiovascular medications, such as Pravachol (pravastatin sodium) and Plavix (clopidogrel TMCnet

Statins Found to Have Antihypertensive Effect  -  May 6, 2008
Statins, specifically simvastatin (Zocor®/Merck) and pravastatin (Pravachol® /Bristol-Mayer Squibb) may reduce blood pressure modestly, according to the Medi News Direct,

Squibs on buying Bristol-Myers Squibb shares  -  May 4, 2008
Even with brand names such as Bufferin, Enfamil, Ban, Capotin, Taxol, Glucophage, Coumadin and Pravachol, and a cornucopia of popular beauty aids, The Courier News,

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Relationships with health sciences courses at. Pharm techs do any better than nearly 200. He is also the knowledge and long-term survival and marketing. ZDNet

Cholesterol Drugs Reduce Blood Pressure  -  Apr 21, 2008
...another was treated with pravastatin (marketed as Pravachol®), and the last group was treated with a placebo pill. After six months of treatment, HealthandAge.com

How to buy Lipitor online?  -  Mar 28, 2008
24X7 Pharmacy is a fully licensed online pharmacy that functions on the round a clock basis and offers affordable medicines like lipitor pravachol, Free press releases (press release),

Statins May Take Blood Pressure Down a Notch  -  Apr 18, 2008
Simvastatin (Zocor) and pravastatin (Pravachol) achieved a small but significant reduction in blood pressure relative to placebo (P=0.02 for systolic MedPage Today,

The age of 'disease-mongering'  -  Apr 18, 2008
Bristol-Myers Squibb is also the maker of Pravachol, a cholesterol-reducing drug. According to the US Food and Drug Administration, American sales of National Post,

Hormones May Prevent Macular Degeneration, Statins Good for Blood ...  -  Apr 14, 2008
In a clinical trial of patients randomized to Zocor, Pravachol or placebo, those taking the statins had a reduction of 2-3 mmHg in both systolic and Insider Medicine,

Cholesterol drugs destroy esophageal cancer cells  -  Apr 21, 2008
...the researchers found that adding simvastatin (Zocor), lovastatin (Mevacor), and pravastatin (Pravachol) reduced the number of esophageal cancer cells Reuters

Issues and benefits of using statin drugs  -  Apr 8, 2008
They include lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor) and rosuvastatin (Crestor). Kentucky.com,

Dr. Malloy: What's New About Cholesterol?  -  Apr 7, 2008
...and therefore help prevent heart attacks. Research was presented that showed that the stain Crestor has this benefit as does Zocor, Pravachol and Lipitor. NBC5.com,

mediabistro.com: FishbowlDC  -  Apr 3, 2008
Pravachol, probably. If you could have one superpower, which one would it be? I thought the USA was the only superpower to choose from? Red or white wine? mediabistro.com,

Commonly Used Drugs May Have Additional Benefits for Men With ...  -  Mar 26, 2008
Some of the well known statins include Zocor, Lipitor, Pravachol, Crestor, Lescol, and Mevacor. Commonly used anti-inflammatory drugs include aspirin, NewsBlaze,

New Benefits From Old Heart Measures  -  Apr 14, 2008
It was a classic double-blind, controlled trial with some of the 973 participants taking either simvastatin (Zocor) or pravastatin (Pravachol), Washington Post,

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Use of Rx to OTC Switch as Product Management Tactic Enjoys Comeback  -  Apr 10, 2008
Some future potential switches include leading gastrointestinal drugs Prevacid, Protonix and AcipHex; antilipidemic agents Mevacor, Pravachol, FOXBusiness

Another Blow For Schering And Merck  -  Mar 31, 2008
First, it provides definitive proof Crestor has lifesaving benefits like other statin drugs, such as Lipitor, Zocor and Pravachol. Forbes,

Amid Bad Publicity, Drug Company Uses Progressive Union to Peddle ...  -  Mar 26, 2008
...which blew the lid off the theory that "statins" -- drugs like Lipitor, Crestor, Mevacor, Zocor and Pravachol -- can cut the odds that you will die of a AlterNet,

How Some Drugs Deliver Good Statistics, Not Good Health  -  Apr 2, 2008
...simvastatin (Zocor), pravastatin (Pravachol) or extended release niacin (Niaspan). All of these drugs have been shown to prevent heart attacks. Evening Bulletin,

Statin Drug Crestor Slows Artery Plaque  -  Apr 1, 2008
Statins with proven clinical benefit include Zocor, Pravachol, Mevacor; Lipitor, and Lescol. "Now we have a clear indication that Crestor also prevents WebMD

Vytorin’s Shortcoming a Boon for Statins  -  Mar 31, 2008
They include medications such as Zocor, Pravachol, Mevacor, Lipitor, Lescol, and Crestor. They work by actually blocking the body's ability to produce WebMD

Ending the Cholesterol-Heart Disease Myth  -  Apr 7, 2008
The statin drugs that doctors use to push cholesterol levels down are LIPITOR (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin), and Pravachol Natural News.com,

ACC: For ENHANCE Results, Let There Be Light  -  Mar 25, 2008
...fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravachol), as well as niacin because all claim they reduce LDL and cardiovascular events MedPage Today,

Statins may help control blood pressure  -  Apr 15, 2008
One group were given the statin drug simvastatin (Zocor), another group were given pravastatin (Pravachol) and a third group were given a placebo. News-Medical.net,

How Low Can Vytorin Go?  -  Apr 4, 2008
Proven statin drugs like Zocor and Pravachol seem to help heart transplant patients in ways that have nothing to do with LDL, Aaronson says, so it's no sure Forbes,

BIOTECH STOCKS Merck, Schering-Plough plunge on Vytorin study  -  Mar 31, 2008
...older cholesterol-controlling agents called statins, such as Lipitor from Pfizer Inc. (PFE: , , ) Pravachol, are also now available in generic form. MarketWatch

Statins found lowering blood pressure in US study  -  Apr 14, 2008
Another group got pravastatin or Pravachol, made by Bristol-Myers Squibb Co. A third group got a placebo. “In both statins the effect was beginning to Peninsula On-line,

Brand Names/Synonyms:
Pravachol is also known by the following brand names and/or synonymsCCRIS 7557; Compactin; Elisor; Lipostat; Lovastatin; Mevalotin; Mevastatin; Mevinolin; Oliprevin; Pravachol; Pravaselect; Pravastatin; Pravastatin Sodium; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; Selectin; Selipran; Vasten

Drug Category:
Pravachol is categorized under the following by the FDA: Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA03

Dosage Forms:
TABLET

Absorption:
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.

Interactions:
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Chemical IUPAC Name:
3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-heptanoicacid

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