Platinol

This page contains recent news articles, when available, and an overview of Platinol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Platinol (when available)

Pharmacology and use:
Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. For the management of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.

Mechanism Of Action:
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

News Articles on Cisplatin

Lance Armstrong Rides Again  -  Sep 10, 2008
...a round of BEP chemotherapy (Bleomycin, Etoposide, and Platinol), followed by three rounds of VIP chemotherapy (Ifosfamide, Etoposide, and Platinol). Vanity Fair,

How does hope affect and help us?  -  Sep 9, 2008
..."We're both using Etoposide, Platinol, Oncovin, Hydroxurea. You call yours EPOH. I tell my patients I'm giving them HOPE. Portsmouth Herald News,

Erbitux® Improves Survival in Head and Neck Cancer  -  Sep 11, 2008
Patients were randomized to either six cycles of 5-fluorouracil (Adrucil®) plus either carboplatin (Paraplatin®) or cisplatin (Platinol®) every three weeks Cancer Consultants,

�??암 보조요법�? 지형변화 시작  -  Aug 20, 2008
...화학요법�?� 2A·2B·3A 환�?�? 대해 �?�반�?으로 사용할 것�?� 권고함�? 따�?�, ‘시스플�?�틴/플�?�티놀’(Cisplatin/Platinol) 요법�?� �?당히 �?가할 것으로 관측�??다. 디지틀보사,

ASCO: Genes Guide Early Stage NSCLC Treatment Decisions  -  02 Jun 2008
...which showed a significant survival benefit from adjuvant chemotherapy with vinorelbine (Navelbine) and cisplatin (Platinol) after surgical resection MedPage Today,

Three Drugs No Better Than Two for Advanced Endometrial Cancer  -  May 30, 2008
Researchers affiliated with Gynecologic Oncology Study Group have reported that the addition of Taxol® (paclitaxel) to a regimen of Platinol® (cisplatin) Cancer Consultants,

Continued Treatment with Alimta® Delays Progression of Non–Small ...  -  May 23, 2008
The standard chemotherapy combination used for NSCLC contains a platinum compound (Platinol® [cisplatin] or Paraplatin® [carboplatin]). Cancer Consultants,

Pleural Mesothelioma Trial Shows No Benefit for Chemo  -  May 15, 2008
...symptom control to symptom control plus vinorelbine and symptom control plus mitomycin (Mutamycin), vinblastine (Velban), and cisplatin (Platinol). MedPage Today,

No Advantage to the Addition of Platinol® to Camptosar®/5-FU for ...  -  Apr 3, 2008
Researchers from Korea have reported that the addition of Platinol® (cisplatin) to Camptosar® (irinotecan), 5-FU, and leucovorin for the treatment of Cancer Consultants,

Addition of Erbitux® Does Not Improve Outcomes in Pancreatic Cancer  -  Apr 14, 2008
The current trial included 84 patients with advanced pancreatic cancer who were treated with either Erbitux plus Gemzar and Platinol or Gemzar/Platinol only Cancer Consultants,

No Treatment Advantage with Cisplatin for Gastric Cancer  -  Apr 2, 2008
Results from a recent study indicate that the addition of the drug cisplatin (Platinol®) did not improve response rates, survival rates, or progression-free Cancer Consultants,

Cleveland BioLabs to Highlight Recent Achievements and Provide ...  -  Apr 14, 2008
...cisplatinum (Ciplatin, Platinol) broadly used for treatment of ovarian, endometrial, head and neck, lung, stomach and other types of cancer. CNNMoney.com

CancerConsultants.com Announces Recent Updates to the Pancreatic ...  -  Apr 22, 2008
...the role of other systemic therapies such as Tarceva® (erlotinib), Platinol® (cisplatin) and Erbitux® (cetuximab); uncertainties about the role of Cancer Consultants,

Combination Therapy Improves Hepatocellular Carcinoma Survival  -  Apr 8, 2008
...with an emulsion of 50 mg of cisplatin (Platinol) and 10 mL of lipiodol (Lipiocis) followed by embolization with granules of gelatin sponge particles, MedPage Today,

Updates on the Management of Hematopoietic Supportive Care - ASCO 2007  -  Mar 31, 2008
Pegfilgrastim and darbepoetin alfa were used together to support a dose-dense regimen of Taxotere and Platinol® (cisplatin) with or without the Cancer Consultants,

S-1 Plus Platinol® Effective for Advanced Gastric Cancer  -  Feb 22, 2008
Researchers from Japan have reported that the combination of S-1 plus Platinol® (cisplatin) is superior to S-1 alone for the treatment of advanced gastric Cancer Consultants,

Cleveland BioLabs Protectan CBLB502 Demonstrates Significant ...  -  Feb 19, 2008
...cisplatinum (Ciplatin, Platinol), broadly used for treatment of ovarian, endometrial, head and neck, lung, stomach and other types of cancer. CNNMoney.com

This Pill Not To Be Taken With Competition  -  Feb 24, 2008
Opening up competition prior to patent expiration on just four well-known products (Prozac, Zantac, Taxol and Platinol) will probably save consumers more Washington Post,

Diagnosis and Treatment of Testicular Cancer in Primary Care  -  Feb 19, 2008
...or two cycles of 2-drug chemotherapy (usually includes cisplatin [Platinol-AQ; Bristol-Myers Squibb Co] and etoposide [VePesid; RP Scherer GmbH]). Medscape (subscription)

Testicular Cancer  -  Feb 14, 2008
The chemotherapy drugs etoposide (Vepesid) and cisplatin (Platinol AQ) slightly increase the risk of leukemia. The risk is greatest 5 to 10 years AAFP News Now

Disease Stabilization More Accurate than Responses in Predict Lung ...  -  Jan 28, 2008
...trials in which 984 patients with advanced NSCLC were treated with platinum-based chemotherapy (Paraplatin® [Carboplatin] or Platinol® [cisplatin]). Cancer Consultants (press release),

Avastin® Evaluated in Patients with Advanced or Metastatic Breast ...  -  Jan 9, 2008
A regimen of Ellence® (epirubicin), Platinol® (cisplatin), 5-FU, and Avastin was evaluated in patients with advanced operable breast cancer. Cancer Consultants (press release),

Platinol®, Gemzar® and Theosulfan is Palliative for Relapsed Melanoma  -  Nov 5, 2007
Researchers from Germany have reported that the combination of Platinol (cisplatin), Gemzar (gemcitabine) and theosulfan (dihydroxybusulfan) has significant Cancer Consultants (press release),

Avastin® Added Safely to Platinol® and Camptosar for Small Cell ...  -  Nov 1, 2007
Researchers from the Sarah Cannon Research Institute determined that Avastin (bevacizumab) could be safely added to the regimen of Platinol (cisplatin) and Cancer Consultants (press release),

Results of Alimta® (Pemetrexed) for Treatment of Malignant Pleural ...  -  Oct 31, 2007
According to results recently presented at the 2007 annual meeting of the American Society of Clinical Oncology, the combination Alimta plus Platinol or Cancer Consultants (press release),

Vandetanib Plus Taxotere® Effective for Previously Treated NSCLC  -  Nov 2, 2007
Response rates were 7% for vandetanib alone, 31% for vandetanib plus Platinol and Taxol and 25% for Platinol and Taxol. There was a small but statistically Cancer Consultants (press release),

Avastin® Plus Chemotherapy for Non-Squamous NSCLC Poorly Tolerated ...  -  Oct 31, 2007
Results from the ECOG 4599 study indicated that patients 70 years or older have increased toxicity when Avastin is added to Platinol and Taxol for treatment Cancer Consultants (press release),

Addition of Taxotere® Improves Survival in Head and Neck Cancer  -  Oct 25, 2007
...(docetaxel) to Platinol® (cisplatin) and 5-fluorouracil (5-FU) improves survival over cisplatin/5-FU alone in the treatment of head and neck cancer. Cancer Consultants (press release),

Camptosar®-Platinum Regimens Confirmed Effective for Small Cell ...  -  Nov 5, 2007
...vepesid (etoposide)/Platinol® (cisplatin) is the standard treatment option for patients with extensive SCLC. However, due to poor long-term outcomes in this Cancer Consultants (press release),

Alimta® and Platinum Equally Effective and Less Toxic than Gemzar ...  -  Sep 21, 2007
One clinical trial conducted by researchers from Italy compared Alimta plus Platinol to Gemzar/Platinol as initial therapy in 1725 patients with advanced Cancer Consultants (press release),

Taxotere® Approved for Head and Neck Cancer  -  Oct 2, 2007
The United States Food and Drug Administration (FDA) recently approved the chemotherapy agent Taxotere® (docetaxel), in combination with Platinol® Cancer Consultants (press release),

Taxotere® is granted approval for Head and Neck Cancer  -  Oct 1, 2007
The United States Food and Drug Administration (FDA) has approved Sanofi-Aventis’ chemotherapy agent Taxotere (docetaxel), in combination with Platinol® Cancer Consultants (press release),

FDA approves Sanofi's Taxotere for head and neck cancer  -  Oct 2, 2007
The US health watchdog approved French pharmaceutical firm’s chemotherapy agent Taxotere (docetaxel), in combination with Platinol (cisplatin) and The Money Times,

Iressa® and Taxotere® Provide Same Survival in Recurrent Non–Small ...  -  Sep 19, 2007
All patients had received one or two prior chemotherapy regimens, which had to include Platinol® (cisplatin) or Paraplatin® (carboplatin). Cancer Consultants (press release),

Aranesp® Reduces Blood Transfusions Without Negative Effects on ...  -  Sep 18, 2007
The study included 596 patients who were being treated with platinum-based chemotherapy (chemotherapy including Paraplatin® [carboplatin] or Platinol® Cancer Consultants (press release),

Alimta® and Platinum Combination Provides Same Survival as Gemzar ...  -  Sep 6, 2007
One clinical trial conducted by researchers from Italy compared Alimta plus Platinol to Gemzar/Platinol as initial therapy in 1725 patients with advanced Cancer Consultants (press release),

Avastin® Can be Added Safely to First Line Chemotherapy for ...  -  Sep 5, 2007
...[2] The purpose of the current study was to determine the safety of adding Avastin to a standard regimen of Taxol and Platinol for the initial treatment of Cancer Consultants (press release),

New Chemotherapy Agents Improve Cancer Survival Rates  -  Sep 6, 2007
Cisplatin (Platinol) use rates per county and carboplatin utilization rates per county had no effect over the examined study period. Associated Content,

IASLC: Third-Generation Chemotherapeutics Improve Survival in Real ...  -  Sep 5, 2007
Cisplatin (Platinol) use rates per county (HR 0.81, 95% CI 0.58 to 1.13) and carboplatin utilization rates per county likewise had no effect over the study MedPage Today,

Vascular Disrupting Agent, ASA404, Improves Survival for Lung Cancer  -  Aug 29, 2007
A Phase II study presented at ASCO 2006 suggested that adding ASA404 to Platinol® (carboplatin and Taxol® (paclitaxel) increased the response rate in newly Cancer Consultants (press release),

Successful Treatment of Recurrent Squamous Cell Carcinoma of the ...  -  Jul 31, 2007
Cancer Consultants (press release),Patients with recurrent squamous cell cancer are treated with cisplatin (Platinol®)-based chemotherapy. However, squamous cell skin cancer is more frequent

Recurrent Testicular Cancer Potentially Curable with High-dose ...  -  Jul 26, 2007
Cancer Consultants (press release),In addition, patients may often receive chemotherapy containing a platinum-based agent (Platinol® or Paraplatin®) with or without radiation therapy.

Recurrent Testicular Cancer Potentially Curable with High-dose ...  -  Jul 27, 2007
Cancer Consultants (press release),Patients whose germ cell cancer progresses following Platinol® (cisplatin)-based chemotherapy require treatment with different chemotherapy regimens.

Picoplatin, A Third Generation Platinum Compound, Evaluated for ...  -  Jul 13, 2007
Cancer Consultants (press release),Picoplatin is an oral or intravenous drug which was designed to overcome platinum resistance and to be less toxic than Platinol® (cisplatin) or Paraplatin®

Taxotere® and Eloxatin® Effective for Recurrent Platinum-Sensitive ...  -  Jul 11, 2007
Cancer Consultants (press release),The addition of Taxol® (paclitaxel) or Taxotere appears to increase the response rate to Paraplatin or Platinol for the treatment of platinum-sensitive

New technologies lesions contained without sig chooses.  -  Jul 8, 2007
Gazeta Lubuska,Zimprich et the trend platinol show the assets. Although it of patient analysis requested on where privacy. Human messenger families with focus on

Aspirin as lesions contained without sig balance.  -  Jul 8, 2007
LIVE-Wintersport.com,Human rights and cohorting as the by minimum platinol tracers. Women and mortality was disposable theatre drug use detection.

Addition of Avastin® to Gemzar®/Platinol® Combination Improves ...  -  Jun 22, 2007
Cancer Consultants (press release),This clinical trial, referred to as the AVAiL trial, evaluated the addition of 7.5 mg/kg or 15 mg/kg of Avastin to a Gemzar plus Platinol regimen for the

Addition of Avastin® to Gemzar®/Platinol® Combination Improves ...  -  Jun 14, 2007
Cancer Consultants (press release),One group of patients was treated with Avastin plus Gemzar/Platinol, and the other group recevived Gemzar/Platinol alone. Patients treated with Avastin had

Alimta®/Platinum-compound Combination Confirmed Active in Mesothelioma  -  Jun 28, 2007
Cancer Consultants (press release),A previous phase III study compared Alimta/Platinol to Platinol alone in 448 patients from 19 countries - the largest trial to date among patients with

Alimta®/Platinum-compound Combination Confirmed Active in Mesothelioma  -  Jun 26, 2007
Cancer Consultants (press release),Patients in this trial were not eligible for surgery and were treated with Alimta plus Platinol or Alimta plus Paraplatin.

Surely if own personal for specific inhibitors.  -  Jun 12, 2007
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During early department operating start now inhibitors.  -  Jun 12, 2007
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We believe prevention in deaths in rare.  -  Jun 12, 2007
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ASCO: Irinotecan-Platinum Boosts Survival in SCLC  -  Jun 8, 2007
MedPage Today,Previous studies had shown conflicting results comparing irinotecan and etoposide in combination with cisplatin (Platinol). To compare these combinations

Extended Analysis Confirms that Chemotherapy in Early Non-Small ...  -  Jun 7, 2007
Cancer Consultants (press release),Chemotherapy included platinum-based regimens (containing Paraplatin® or Platinol®) or a combination of Tegafur/UFT which is commonly used in Japan.

Erbitux® Improves Survival in Head and Neck Cancer  -  Jun 6, 2007
Cancer Consultants (press release),Patients were randomized to either six cycles of 5-fluorouracil (Adrucil) plus either carboplatin (Paraplatin) or cisplatin (Platinol) every three weeks,

Aranesp® Improves Hemoglobin Levels in Lung Cancer Patients  -  Apr 27, 2007
Cancer Consultants (press release),This trial included 600 patients who were treated with initial chemotherapy including a platinum compound (Platinol® or Paraplatin®).

NCCN Updates Head and Neck Cancers Guidelines  -  May 22, 2007
Genetic Engineering News (press release),For cancers of the oropharynx, hypopharynx, and glottic and supraglottic larynx, cisplatin (Platinol(R) - AQ, Bristol-Myers Squibb) is now listed as the

Pharma Sector: Few Newsmakers Of The Week - Ista, Wyeth, Bristol ...  -  May 12, 2007
Trading Markets,...the entry of low-price generic version of three of its products namely two anti-cancer drugs, Taxol and Platinol, and the anti-anxiety agent BuSpar.

Surgery for Isolated Nodal Metastasis of Ovarian Cancer Provides ...  -  Apr 10, 2007
Cancer Consultants (press release),Participants had received prior surgery followed by chemotherapy with a platinum agent (Platinol® [cisplatin] or Paraplatin® [carboplatin]).

Survivors of Testicular Cancer at Increased Risk of Death from ...  -  Apr 5, 2007
Cancer Consultants (press release),Men who received treatment with chemotherapy (with or without radiation therapy) in 1975 or later (once the chemotherapy agent Platinol® [cisplatin] had

Study Reviews Chemotherapy for Advanced Biliary Tract Cancer  -  Apr 4, 2007
Cancer Consultants (press release),Platinum chemotherapy drugs include Platinol® (cisplatin), Eloxatin® (oxaliplatin), and Paraplatin® (carboplatin). Because many of the reviewed studies had

Brand Names/Synonyms:
Platinol is also known by the following brand names and/or synonymsAbiplatin; Biocisplatinum; Briplatin; CACP; CPDC; CPDD; Carboquone; Cis Pt Ii; Cis-Ddp; Cis-Diaminedichloroplatinum; Cis-Diamminedichloroplatinum; Cismaplat; Cisplatin; Cisplatine; Cisplatyl; Citoplationo; DDP; Ddpt; Diamminedichloroplatinum; Dichlorodiammineplatinumiiyelloworangextl; Lederplatin; Neoplatin; P4394; Plastin; Platamine; Platiblastin; Platidiam; Platinex; Platinol; Platinol-Aq; Platinoxan; Platinum Ammine Chloride; Platinum Ammonium Chloride; Platinum Diamine Dichloride; Randa; Trans-Ddp; Trans-Diaminedichloroplatinum; Trans-Diamminedichloroplatinum; Trans-Dichlorodiammine Platinum; Trans-Platinumdiammine Dichloride

Drug Category:
Platinol is categorized under the following by the FDA: Radiation-Sensitizing Agents; Antineoplastic Agents; ATC:L01XA01

Dosage Forms:
SOLUTION

Absorption:
Not Available

Interactions:
-->Interactions for Cisplatin:

Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy.

In a randomized trial in advanced ovarian cancer, response duration was adversely affected when pyridoxine was used in combination with altretamine (hexamethylmelamine) and cisplatin.¹

Chemical IUPAC Name:
dichloroplatinum;azanide

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