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PlaquenilThis page contains recent news articles, when available, and an overview of Plaquenil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Plaquenil (when available) Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Being alkaline, the drug reaches high concentration within the food vacuoles of the parasite and raises its pH. It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids. For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis Mechanism Of Action: The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. News Articles on Chloroquine Bernie Mac had sarcoidosis, but what is it? - Aug 9, 2008 Occasionally, physicians prescribe drugs known as immune system suppressants (such as Plaquenil and Methotrexate). While sarcoidosis can be severe, Hartford Courant, Living with lupus - Jul 16, 2008 Her doctor has prescribed an antimalarial medication called Plaquenil to protect against ultraviolet light, improve skin lesions and help lower the dosage Mason City Globe Gazette, Immune Disorder Strikes Young Adults - Aug 5, 2008 Occasionally, physicians prescribe drugs known as immune system suppressants (such as Plaquenil and Methotrexate). While sarcoidosis can be severe, RedOrbit, Al Dente: When physicians and dentists talk - May 22, 2008 Medications that cause mouth irritation include Adriamycin, penicillamine, Plaquenil, Potaba, and many others. These are strong medications for serious Malden Observer, Woman's fight against lupus more tolerable after diagnosis - Oct 29, 2007 Although, if I run out of my Celebrex (an anti-inflammatory drug) or Plaquenil (a disease modifier) and don't refill the prescription soon, Jackson Clarion Ledger, Causes of Juvenile Rheumatoid Arthritis - Nov 1, 2007 If these prove ineffective, gold salts, Plaquenil, and Cuprimine may be tried. Because of side effects, corticosteroids are generally reserved for treatment American Chronicle, Mom with lupus hopes to educate others about disease - Oct 25, 2007 Ingram's lupus isn't rearing its ugly head now that she takes the prescription drug Plaquenil, originally developed as an anti-malaria drug, she said. KC Community News, What Are The Pitfalls Of Current Treatment For Rheumatoid Arthritis - Sep 29, 2007 Other DMARDS such as Plaquenil (hydroxychloroquine) and sulfasalazine (Azulfidine), and leflunomide (Arava) are also used. Over time (less than 3 months), PR-GB.com (press release), Plaquenil Safety is Important for Arthritis Patients - Aug 15, 2007 Plaquenil, generic drug name hydroxychloroquine, has been prescribed for years to treat rheumatoid arthritis patients as well as patients with lupus, About - News & Issues, Bariatric surgery an option of diabetics - Aug 22, 2007 Hydroxychloroquine, sold under the brand names Plaquenil ... > full story Alzheimer's may have diabetes link (June 28, 2007) -- US researchers say poorly Science Daily (press release) Investigators probe gene therapy death - Aug 17, 2007 Hydroxychloroquine, sold under the brand names Plaquenil ... > full story Analysis: Genes aimed at pancreatic tumors (July 9, 2007) -- Pancreatic cancer Science Daily (press release) Australia bans painkiller - Aug 15, 2007 Hydroxychloroquine, sold under the brand names Plaquenil ... > full story Stem cell transplants aid angina patients (June 26, 2007) -- US scientists have Science Daily (press release) Plaquenil May Reduce Diabetes Risk in Rheumatoid Arthritis Patients - Jul 11, 2007 About - News & Issues,Plaquenil (hydroxychloroquine), one of the older and less expensive treatments for rheumatoid arthritis and some other autoimmune diseases, Plaquenil may prevent Diabetes - Jul 11, 2007 Insider Medicine,July 11, 2007 (Insidermedicine) Plaquenil, a medication long used to treat rheumatoid arthritis, is showing potential for diabetes prevention, according to Anti-Malarial Drug May Lower Diabetes Risk for Rheumatoid ... - Jul 28, 2007 Diabetes Drug Report,Anti-malarial drug Plaquenil (hydroxychloroquine) may help reduce the risk of the development of type 2 diabetes in patients with rheumatoid arthritis, Arthritis drug averts diabetes - Jul 10, 2007 Pittsburgh Tribune-Review,Hydroxychloroquine, sold under the trade name Plaquenil, helps reduce joint inflammation in patients with rheumatoid arthritis, a painful autoimmune Malaria Drug May Cut Diabetes Risk - Jul 11, 2007 CBS News,It will take more work to figure out if hydroxychloroquine — which is sold generically and by the brand names Plaquenil and Quineprox — truly guards against Drug may prevent diabetes - Jul 10, 2007 Pittsburgh Post Gazette,Published today in the Journal of the American Medical Association, the study shows that hydroxychloroquine (HCQ), sold under the name of Plaquenil, Malaria Drug May Reduce Diabetes Risk - Jul 12, 2007 Post ChronicleBy Staff Hydroxychloroquine, sold under the brand names Plaquenil and Quineprox, was found to reduce the incidence of type 2 diabetes by 38 percent in a Patient dies during gene therapy trial - Jul 27, 2007 Science Daily (press release)Hydroxychloroquine, sold under the brand names Plaquenil ... > full story Analysis: Genes aimed at pancreatic tumors (July 9, 2007) -- Pancreatic cancer Common Rheumatoid Arthritis Treatment Shows Potential For Diabetes ... - Jul 12, 2007 Science Daily (press release)Hydroxychloroquine, marketed as Plaquenil ® is manufactured by Sanofi-Aventis. 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Swabs should bleeding quired pletal median incubation orally verifying ponstel diet Brand Names/Synonyms: Plaquenil is also known by the following brand names and/or synonyms3377 RP; 3377 RP opalate; Amokin; Aralen; Aralen HCl; Arechin; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chloroquina; Chloroquine; Chloroquine Phosphate; Chloroquinium; Chlorquin; Cidanchin; Clorochina; Cocartrit; Delagil; Dichinalex; Elestol; Gontochin; Heliopar; Hydroxychloroquine Sulfate; Imagon; Iroquine; Klorokin; Lapaquin; Malaquin; Malaren; Malarex; Mesylith; Neochin; Nivachine; Nivaquine; Nivaquine B; Nivaquine [as sulfate]; Pfizerquine; Plaquenil; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; RP 3377; Resochen; Resochin; Resoquina; Resoquine; Reumachlor; Reumaquin; Roquine; SN 6718; SN 7618; Sanoquin; Silbesan; Siragan; Solprina; Sopaquin; Tanakan; Tresochin; Trochin; W 7618; WIN 244; Chloroquine (VAN) Drug Category: Plaquenil is categorized under the following by the FDA: Antirheumatic Agents; Antimalarials; Amebicides; ATC:P01BA01; ATC:P01BA02 Dosage Forms: TABLET Absorption: Completely absorbed from gastrointestinal tract Interactions: Interactions for Chloroquine: Antacids and kaolin: Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed. Cimetidine: Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided. Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of this agent and chloroquine should be observed. Cyclosporin: After introduction of chloroquine (oral form), a sudden increase in serum cyclosporin level has been reported. Therefore, close monitoring of serum cyclosporin level is recommended and, if necessary, chloroquine should be discontinued. Chemical IUPAC Name: N'-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine : |
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