Picrotoxin

This page contains recent news articles, when available, and an overview of Picrotoxin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Picrotoxin
(when available)

Pharmacology and use:
Picrotoxin is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates. For the treatment of respiratory distress

Mechanism Of Action:
Binds to the GABAA and GABA-C receptors and blocks the action of the receptors.

News Articles on Picrotoxin

Development of herbal medicine  -  Aug 9, 2008
Some such compounds include for example, morphine, codeine (alkaloids) as analgesic, colchicine (alkaloid) as antigout, camphor and picrotoxin (mono and The New Nation,

Israeli researchers take first step toward live computer chip  -  Jul 29, 2007
Israel 21C,Baruchi and Ben-Jacob came up with the idea to suppress the inhibitory neurons with an injection of the chemical picrotoxin, which freed the excitatory

Creation of cyborg computer chips now closer to reality  -  Jun 9, 2007
DailyIndia.com,...in Israel have taught new firing patterns to a network of neurons by targeting specific points of the network with a chemical called picrotoxin.

Israeli boffins bring life to human neuron culture  -  Jun 7, 2007
Register,The scientists then injected the hapless culture with "picrotoxin, a cocktail of gamma-aminobutyric acid (GABA)." Apparently, "the cells on the electrode

A Step Toward a Living, Learning Memory Chip  -  Jun 6, 2007
Scientific AmericanThe pair chemically treated inhibitory neurons by injecting them with droplets of picrotoxin, a cocktail of gamma-aminobutyric acid (GABA),

News Tips From The Journal Of Neuroscience  Sep 1, 2006
Kcc-related seizure susceptibility was also reduced in flies treated with the GABAA receptor antagonist picrotoxin and in flies that expressed reduced levels ... -Medical News Today

Drug violations are Texas' top racetrack woe  Jul 1, 2006
Fluitt, 71, paid a $6,000 fine and was suspended six months after he was alleged to have been found at Retama Park with the Class 1 drug picrotoxin, a potent ... -San Antonio Express (subscription)

Brand Names/Synonyms:
Picrotoxin is also known by the following brand names and/or synonymsCOCCULINE; Cocculin; Cocculus; Coques Du Levant; Fish Berry; Indian Berry; Oriental Berry; PICROTOXIN; Picrotoxin; Picrotoxin of Fishberries; Picrotoxinin

Drug Category:
Picrotoxin is categorized under the following by the FDA: Anti-barbituates; Stimulants;

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
Not Available

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