Phenytoin

This page contains recent news articles, when available, and an overview of Phenytoin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Phenytoin (when available)

Pharmacology and use:
Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, Phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery

Mechanism Of Action:
Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

News Articles on Phenytoin

Epilepsy drug linked to bone loss  -  May 14, 2008
Phenytoin, a drug used commonly in the treatment of epilepsy, may cause bone loss in young women after only one year of use, according to recent data Endocrine Today,

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added ...  -  May 30, 2008
Increased seizure activity or decreased phenytoin levels have been reported in patients receiving phenytoin concomitantly with Welchol. Earthtimes (press release),

Use Caution When Stopping Meds  -  May 31, 2008
Anti-Seizure Drugs: These meds are also used for nerve pain and include Neurontin (gabapentin), Dilantin (phenytoin), Lamictal, Tegretol (carbamazepine) and Best of Times,

THIS JUST IN: Kanawha County  -  May 30, 2008
Ralph Clanton was prescribed Phenytoin, which helps control seizures. According to the suit, Clanton noticed skin disruptions on his body and his entire West Virginia Record,

District Courts  -  May 16, 2008
LAPAN, Michael J., 37, 43 Center St., Northampton, pleaded innocent to charges of three counts of possession of a class E drug (phenytoin, lisinopril, Daily Hampshire Gazette (subscription),

FDA to Take A, B, and C Out of Pregnancy Labeling  -  May 28, 2008
The letter D indicates there are some data from clinical trials that indicate a risk to the fetus (paroxetine [Paxil], phenytoin [Dilantin]). MedPage Today,

Data From Pooled Analyses Demonstrates Welchol, Combined With ...  -  May 16, 2008
Increased seizure activity or decreased phenytoin levels have been reported in patients receiving phenytoin concomitantly with Welchol. Earthtimes (press release),

New dosage strength reduces number of PREZISTA tablets taken daily  -  May 19, 2008
Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, PharmaLive.com (press release),

Halozyme Therapeutics Reports 2008 First Quarter Financial Results  -  May 8, 2008
Furosemide, the benzodiazepines, and phenytoin are incompatible with hyaluronidase. Please see accompanying package insert at http://www.hylenex.com/ for Earthtimes (press release),

Strength and Innovation of Novartis Oncology Products and Pipeline ...  -  May 15, 2008
Concomitant strong CYP3A4 inducers The concomitant use of strong CYP3A4 inducers should be avoided (including, but not limited to, dexamethasone, phenytoin, PR Newswire (press release),

Barcoded Medication Administration A Last Line of Defense  -  May 13, 2008
A warfarin dose could be automatically flagged when a late laboratory result demonstrates a high international normalized ratio (INR), a phenytoin dose Journal of American Medical Association (subscription),

AAN: Epilepsy Treatment No Obstacle for Breastfeeding  -  Apr 21, 2008
Children were most commonly exposed to lamotrigine (68) during pregnancy followed by carbamazepine (48), phenytoin (42), valproate (29). MedPage Today,

Breastfeeding While Taking Seizure Medicine Does Not Appear to ...  -  Apr 22, 2008
...cognitive development of 2-year-old children (N = 187) whose mothers were taking the epilepsy drugs lamotrigine, carbamazepine, phenytoin, or valproate. DG News

Sun to Market Generic Cerebyx  -  Mar 26, 2008
Sun’s fosphenytoin sodium injection USP is indicated for short-term parenteral administration when other means of phenytoin dosing are unavailable, FDA news (subscription),

Welchol(TM) Added to the American College of Endocrinology ...  -  Apr 15, 2008
Increased seizure activity or decreased phenytoin levels have been reported in patients receiving phenytoin concomitantly with Welchol. Earthtimes,

Breast-Feeding While on Seizure Meds Doesn't Harm Babies  -  Apr 17, 2008
The cognitive development of 187 2-year-old children whose mothers were taking the epilepsy drugs lamotrigine, carbamazepine, phenytoin or valproate were U.S. News & World Report,

Seizure Medicines Safe for Breastfeeding  -  Apr 17, 2008
...year olds whose mothers were taking the epilepsy drugs lamotrigine (Lamictal), carbamazepine (Tegretol), phenytoin (Dilantin) and valproate (Depacon). Ivanhoe,

Breastfeeding while taking seizure medicine does not appear to ...  -  Apr 17, 2008
Researchers tested the cognitive development of 187 two-year-old children whose mothers were taking the epilepsy drugs lamotrigine, carbamazepine, phenytoin EurekAlert (press release),

Hairy belle  -  Apr 5, 2008
There are some medications that can cause excessive hair growth in some women, including minoxidil, phenytoin, cyclosporine and anabolic steroids. Malaysia Star,

Antiepileptic Drugs for Brain Tumors  -  Apr 15, 2008
Some patients received common antiseizure drugs -- phenytoin (Dilantin), phenobarbital or divalproex sodium (Depakote) -- while others received a placebo or Ivanhoe,

New Abbott Kaletra(R) (lopinavir/ritonavir) Lower-Strength Tablet ...  -  Apr 6, 2008
...phenytoin, phenobarbital), warfarin, certain antibiotics (ie, rifabutin, clarithromycin), certain antidepressants (eg, trazodone) and voriconazole. PR Newswire UK (press release),

Delirium Tremens - Causes, Symptoms, Diagnosis and Treatment  -  Mar 31, 2008
This may include lifesaving or life-support measures, anticonvulsant medications such as phenytoin, or other medications. Los Angeles Chronicle,

Kinetico Water Systems Can Reduce Pharmaceuticals in Drinking Water  -  Mar 28, 2008
Ibuprofen, Meprobamate, Naproxen, Phenytoin, Prednisone, Roxithromycin, Sulfamethoxazole, Sulfathiozole, Tetracycline, Tylosin, and Virginiamycin. PR.com (press release),

Use caution when stopping meds  -  Mar 25, 2008
Anti-Seizure Drugs: These meds are also used for nerve pain and include Neurontin (gabapentin), Dilantin (phenytoin), Lamictal, Tegretol (carbamazepine) and Ocala.com,

Older epilepsy drugs do not prevent first seizure from brain tumors  -  Apr 16, 2008
Some received one of three common antiseizure drugs: phenytoin (Dilantin), phenobarbital or divalproex sodium (Depakote). Others patients received a placebo PhysOrg.com,

Erythema Multiforme - Causes, Symptoms and Preventions  -  Apr 1, 2008
Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex Los Angeles Chronicle,

Breastfeeding while taking seizure medicine may not harm children  -  Apr 17, 2008
...development of 187 two-year-old children whose mothers were taking the epilepsy drugs such as lamotrigine, carbamazepine, phenytoin, or valproate. Food Consumer,

Philly Finds 56 Drugs in Its Water  -  12 Mar 2008
...relieves premenstrual mood swings Meprobamate — for anxiety Phenytoin — controls epileptic seizures Risperidone — for schizophrenia, bipolar disorder, The Associated Press

Drugs Found in Watersheds of 28 Areas  -  Mar 9, 2008
2 (caffeine and sulfamethoxazole) Philadelphia: 63 (including amoxicillin, aspirin, atorvastatin, bacitracin, diclofenac, phenytoin and fluoxetine) Prince The Associated Press

Water authority official: Findings a 'non-issue'  -  Mar 11, 2008
Phenytoin (anti-epileptic), detected at 1.6 parts per trillion; health effects begin at 6800 parts per trillion. Carbamazepine (anti-convulsant), detected Las Vegas Review - Journal,

Government needs better handle on effects of pharmaceutical ...  -  Mar 11, 2008
The Las Vegas Valley’s water system tested positive for carbamazepine and phenytoin, both anti-seizure medications, and meprobamate, used to treat anxiety Las Vegas Sun,

California in Brief  -  Mar 10, 2008
The two drugs found in the Jensen plant's treated water -- phenytoin, prescribed for epilepsy, and the antianxiety drug meprobamate -- were found only in Los Angeles Times,

Morning Buzz: Monday 3.10.08  -  Mar 10, 2008
Orlov/DN Traces of meprobamate and phenytoin, anti-epileptic and anti-anxiety medications, were found in the treated drinking water of Los Angeles and Long LA Observed,

Poststroke Hallucination Delusion Syndrome  -  Feb 27, 2008
He responded to high dose phenytoin sodium and sodium valproate. There is little description of atypical psychosis following stroke. 2 Why a few patients, Journal of Neuropsychiatry (subscription)

State waters yield strange chemicals  -  Mar 10, 2008
The Louisville Water Co. said the chemicals found -- caffeine, carbamazepine and phenytoin -- were at extremely low levels. The company has produced a Kentucky.com,

"Christian" Home Endangers Seizure Victims  -  Mar 3, 2008
As to anti-seizure medication, Dr. Roberts says that Phenytoin (Dilantin) is a key drug in managing epilepsy. Whenconvulsions are associated with or Best Syndication,

FDA Approves New Drug Application (NDA) for LEVOleucovorin ...  -  Mar 7, 2008
Levoleucovorin for Injection may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone, and increase the frequency of seizures in InfoBolsa,

Childhood Migraines  -  Mar 6, 2008
...activities there doctor might prescribe some medication such as propranolol, phenytoin, phenobarbital, amitriptyline, cryoheptadine, and methysergide. Gather.com,

Epilepsy Drug Doesn't Prevent Migraines  -  Feb 11, 2008
..."The results are not that surprising, as drugs with related mechanisms of action such as carbamazepine or phenytoin have never been found to be efficacious Forbes,

Valproate-Induced Subclinical Hypothyroidism  -  Feb 27, 2008
3 Contradictory to this, some reports suggest that though antiepileptic drugs like carbamazepine and phenytoin have been found to induce hypothyroidism—due Journal of Neuropsychiatry (subscription)

This Just In: Monongalia County  -  Feb 22, 2008
B. Stone * Tara Vitatoe seeks judgment against Mylan Pharmaceuticals for side effects suffered from a drug, Phenytoin Sodium, her son Jacob had taken. West Virginia Record,

FDA Safety Changes: Aptivus  -  Feb 13, 2008
The FDA has advised caution when prescribing carbamazepine, phenobarbital, or phenytoin because of decreased TPV plasma concentrations and efficacy. Medscape (subscription)

Whatever else is in the glass is unclear  -  Mar 9, 2008
The study did not check for mebprobamatem or phenytoin, the two drugs noted in the MWD sample. The AP's investigation also indicates that watersheds, Long Beach Press-Telegram,

Drugs found in water  -  Mar 10, 2008
Caffeine, carbamazepine and the anti-convulsant phenytoin were found in Louisville's drinking water. The situation is undoubtedly worse than suggested by Kentucky.com,

New 48-Week Efficacy and Safety Data Presented for INTELENCE(TM ...  -  07 Feb 2008
...phenobarbital, phenytoin, rifampin, rifapentine, rifabutin (when part of a regimen containing protease inhibitor/ritonavir) or products containing St. Earthtimes,

More News related to Press Releases  -  07 Feb 2008
The impact of other inducers of drug metabolizing enzymes, such as phenytoin and phenobarbital, on UGT1A1 is unknown. Other less strong inducers (eg, StreetInsider.com (subscription),

Resveratrol lowers cholesterol  -  Jan 20, 2008
Q: I was taking phenytoin, an extended-release generic form of the anti-seizure drug Dilantin. On Sept. 19, I had a grand mal seizure, and upon admission to Houston Chronicle,

What are the chronic complications of diabetes?  -  Feb 6, 2008
The pain of diabetic nerve damage may respond to traditional treatments with gabapentin (Neurontin), phenytoin (Dilantin), carbamazepine (Tegretol), TamilStar.com,

Abbott's Kaletra(R) and Aluvia(R) (lopinavir/ritonavir) New Lower ...  -  Jan 28, 2008
...itraconazole), morphine-like medicines (eg, methadone) anticonvulsants (eg, carbamazepine, phenytoin, phenobarbital), warfarin, certain antibiotics (ie, CNNMoney.com

What is Diabetes and its Causes and Types  -  Feb 2, 2008
Certain medicinal drugs can also cause it: oral contraceptives, adrenal corticosteroids, phenytoin, or thiazide diuretics. A diet high in sugar and white American Chronicle,

Welchol(TM) (colesevelam HCl) Receives FDA Approval To Reduce ...  -  Jan 19, 2008
Increased seizure activity or decreased phenytoin levels have been reported in patients receiving phenytoin concomitantly with Welchol. Medical News Today (press release),

Halozyme Therapeutics Announces Peer-Reviewed Publications of the ...  -  Jan 8, 2008
Furosemide, the benzodiazepines, and phenytoin are incompatible with hyaluronidase. For more information about HYLENEX please visit www. Reuters

Abbott's Kaletra(R) and Aluvia(R) (lopinavir/ritonavir) New Lower ...  -  Jan 28, 2008
...phenytoin, phenobarbital),warfarin, certain antibiotics (ie, rifabutin, clarithromycin),certain antidepressants (eg trazodone) and voriconazole. Juraforum.de,

Etravirine (TMC125, Intelence) granted accelerated approval in US  -  Jan 21, 2008
In addition, etravirine should not be co-administered with carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, rifabutin (when part of a regimen Aidsmap,

WCE 2007 - Phenytoin Metabolite Renal Calculus  -  Nov 1, 2007
The authors described for the first time a possible causative mechanism for phenytoin in calculus stone formation. Although this is just a single case UroToday,

Prescription Drugs: Generic Vs. Brand-Name  -  Nov 14, 2007
..."The best example of that is the medicine called Phenytoin or Dilantin which is commonly used for seizures," Parrish said. In this instance, Dilantin, NBC Augusta,

About This Site  -  Nov 15, 2007
In animal models, the teratogenicity of agents like thalidomide, methamphetamine, phenytoin, benzo[a]pyrene and ionizing radiation can be modulated by News@UofT,

Caraco Pharmaceutical Laboratories, Ltd. Announces Tentative FDA ...  -  Nov 12, 2007
...is indicated for conversion to monotherapy in adults with partial seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, CNNMoney.com

Video and Photo: Tasigna(R) Receives US Approval Providing New ...  -  Oct 29, 2007
Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, warfarin, erythromycin, and phenytoin. CNNMoney.com

Halozyme Therapeutics Reports 2007 Third Quarter Financial Results  -  Nov 8, 2007
Furosemide, the benzodiazepines, and phenytoin are incompatible with hyaluronidase. Please see accompanying package insert at http://www.hylenex.com for CNNMoney.com

Caraco Pharma Gets FDA Approval For Its ANDA For Lamotrigine ...  -  Nov 12, 2007
...in adults with partial seizures, who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED. RTT News,

Abbott Receives US Food and Drug Administration Approval for New ...  -  Nov 12, 2007
Agenerase(R) (amprenavir), fosamprenavir, Viracept(R) (nelfinavir), phenobarbital, phenytoin (Dilantin(R)) or carbamazepine (Tegretol(R)). Canada NewsWire (press release),

Legal Persecution in Indiana Finally Ends  -  Nov 10, 2007
...regular check-ups to monitor effectiveness and any negative effects, as well as to get refills on the medication, which included Warfarin and Phenytoin. WEBCommentary

When things get hairy  -  Nov 5, 2007
It is stimulated by some drugs and toxins (such as mercury) as an occasional side-effect, including Phenytoin, used in treating epilepsy. Health24.com,

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for ...  -  Nov 8, 2007
Drugs that may decrease dasatinib concentrations are: Strong CYP3A4 inducers (eg, dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, Earthtimes,

Halloween special: The origin of werewolves?  -  Oct 30, 2007
Milder disorders that cause similar hair growth can develop as a side effect of medications such as phenytoin (an anticonvulsant used in the treatment of Cosmos,

Excessive hair growth, part 1  -  Oct 25, 2007
Often it affects those taking the following drugs: phenytoin, diazoxide, minoxidil, cyclosporine progestagens or danazol. Another division includes those Manila Times,

Gum Disease Linked to Heart Disease  -  Oct 23, 2007
...poorly controlled diabetes, smoking and certain medicines, notably: phenytoin, cyclosporin and the calcium channel blocker blood pressure medicines. Toronto Daily News,

Young Immunosupressed Male S/p Renal Transplant  -  Oct 7, 2007
In SCU he was treated with meropenam and acyclovir in renally adjusted dose, IV fluid and potassium and magnesium replacement, phenytoin and vancomycin PR-GB.com (press release),

(9º) First-in-Class Oral HIV-1 Integrase Inhibitor  -  Oct 12, 2007
The impact of other inducers of drug metabolizing enzymes, such as phenytoin and phenobarbital, on UGT1A1 is unknown. Other less strong inducers (eg, InfoBolsa,

Aptivus（R）（tipranavir） Capsules Granted Full Approval by the ...  -  Oct 5, 2007
Caution should be used when prescribing carbamazepine, phenobarbital and/or phenytoin. APTIVUS may be less effective due to decreased tipranavir plasma 金�?界,

Excess Caffeine May Make Seizure Control Tougher  -  Oct 1, 2007
His convulsions had been successfully controlled with the drugs phenytoin and primidone. The man began experiencing a sharp rise in the frequency of his PakTribune.com,

New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates ...  -  Sep 18, 2007
Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, PR Newswire (press release),

Not Nifonging in Indiana Too!  -  Sep 19, 2007
In a sworn declaration provided to Ms. Kirkwood he stated, 'Given the unexplained increase in Jessica’s Warfarin dose and the discontinuation of Phenytoin The Conservative Voice,

Journal of the American Podiatric Medical Association  -  Sep 27, 2007
...been used in the management of neuropathic pain for many years, but there is limited evidence to support the efficacy of phenytoin and carbamazepine. Journal of the American Podiatric Medical Association (subscription)

Report Questions Generic Antidepressant  -  Oct 12, 2007
Some doctors also are concerned about anti-seizure drugs, such as phenytoin (brand name Dilantin), carbamazepine (brand name Tegretol) and gabapentin (brand NBC6.net,

Brand Names/Synonyms:
Phenytoin is also known by the following brand names and/or synonymsAleviatin; Antisacer; Auranile; CCRIS 515; Causoin; Cerebyx; Citrullamon; Citrulliamon; Comital; Comitoina; Convul; DPH; Danten; Dantinal; Dantoinal; Dantoinal Klinos; Dantoine; Denyl; Di-Hydan; Di-Lan; Di-Phetine; Didan Tdc 250; Difenilhidantoina; Difenilhidantoina [Spanish]; Difenin; Difetoin; Difhydan; Dihycon; Dihydantoin; Dilabid; Dilantin; Dilantin Acid; Dilantin-125; Dilantine; Dillantin; Dintoin; Dintoina; Diphantoin; Diphantoine; Diphedal; Diphedan; Diphenat; Diphenin; Diphenine; Diphentoin; Diphentyn; Diphenylan; Diphenylan Sodium; Diphenylhydantoin; Diphenylhydantoine; Diphenylhydantoine [French]; Diphenylhydatanoin; Ditoinate; Ekko; Ekko Capsules; Elepsindon; Enkelfel; Epamin; Epanutin; Epasmir "5"; Epasmir &Quot;5&Quot;; Epasmir 5; Epdantoin Simple; Epdantoine Simple; Epelin; Epifenyl; Epihydan; Epilan; Epilan D; Epilan-D; Epilantin; Epinat; Epised; Eptal; Eptoin; Extended Phenytoin Sodium; Fenantoin; Fenantoin Mn Pharma; Fenidantoin "S"; Fenidantoin &Quot;S&Quot;; Fenidantoin S; Fenitoina; Fenitoina [Inn-Spanish]; Fentoin; Fenylepsin; Fenytoin Dak; Fenytoine; Fosphenytoin; Hidan; Hidantal; Hidantilo; Hidantina; Hidantina Senosian; Hidantina Vitoria; Hidantomin; Hindatal; Hydantal; Hydantin; Hydantoin; Hydantoinal; Hydantol; Ictalis Simple; Idantoil; Idantoin; Iphenylhydantoin; Kessodanten; Labopal; Lehydan; Lepitoin; Lepsin; Mesantoin; Minetoin; NSC 8722; Neos-Hidantoina; Neosidantoina; Novantoina; Novophenytoin; Om Hidantoina Simple; Om-Hydantoine; Oxylan; Phanantin; Phanatine; Phenatine; Phenatoine; Phenhydan; Phenhydanin; Phenitoin; Phentoin; Phentytoin; Phenytex; Phenytoin; Phenytoin Awd; Phenytoin Sodium; Phenytoin-Gerot; Phenytoine; Phenytoine [Inn-French]; Phenytoinum [Inn-Latin]; Prompt Phenytoin Sodium; Ritmenal; Saceril; Sanepil; Silantin; Sinergina; Sodanthon; Sodantoin; Sodanton; Sodium; Solantin; Solantoin; Solantyl; Sylantoic; TOIN; Tacosal; Thilophenyl; Toin Unicelles; Zentronal; Zentropil

Drug Category:
Phenytoin is categorized under the following by the FDA: Anticonvulsants; Hydantoins; ATC:N03AB02; ATC:N03AB04; ATC:N03AB05

Dosage Forms:
CAPSULE; LIQUID; SOLUTION; SUSPENSION; TABLET

Absorption:
Not Available

Interactions:
-->Interactions for Phenytoin:

There are many drugs which may increase or decrease phenytoin levels or which phenytoin may affect. Serum level determinations for phenytoin are especially helpful when possible drug interactions are suspected. The most commonly occurring drug interactions are listed below:

1. Drugs which may increase phenytoin serum levels include: acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, diazepam, dicumarol, disulfiram, estrogens, H₂-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone.

2. Drugs which may decrease phenytoin serum levels include: carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. Moban brand of Molindone Hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems.

3. Drugs which may either increase or decrease phenytoin serum levels include: phenobarbital, sodium valproate, and valproic acid. Similarly, the effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable.

4. Although not a true drug interaction, tricyclic antidepressants may precipitate seizures in susceptible patients and phenytoin dosage may need to be adjusted.

5. Drugs whose efficacy is impaired by phenytoin include: corticosteroids, coumarin anticoagulants, digitoxin, doxycycline, estrogens, furosemide, oral contraceptives, quinidine, rifampin, theophylline, vitamin D.

Drug/Laboratory Test Interactions

Phenytoin may cause decreased serum levels of protein-bound iodine (PBI). It may also produce lower than normal values for dexamethasone or metyrapone tests. Phenytoin may cause increased serum levels of glucose, alkaline phosphatase, and gamma glutamyl transpeptidase (GGT).

Chemical IUPAC Name:
5,5-diphenylimidazolidine-2,4-dione

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