Phenylephrine

This page contains recent news articles, when available, and an overview of Phenylephrine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Phenylephrine (when available)

Pharmacology and use:
Phenylephrine is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Phenylephrine is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Phenylephrine causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action. For the treatment of ophthalmic disorders (hyperaemia of conjunctiva, posterior synechiae, acute atopic), nasal congestion, hemorrhoids, hypotension, shock, hypotension during spinal anesthesia, paroxysmal supraventricular tachycardia. It is also used as an aid in the diagnosis of heart murmurs and for prolongation of spinal anesthesia

Mechanism Of Action:
Phenylephrine produces its ophthalmic and systemic actions by acting on alpha 1 adrenergic receptors in the pupillary dilator muscle and the vascular smooth musle, resulting in contraction of the dilator muscle and contraction of the smooth muscle in the arterioles of the conjunctiva and peripheral vasoconstriction. Phenylephrine decreases nasal congestion by acting on alpha 1 adrenergic receptors in the arterioles of the nasal mucosa to produce constriction.

News Articles on Phenylephrine

Chemists turn to Aussies for help  -  ‎Aug 29, 2009‎
However, research carried out by the British Pharmacological Society concludes phenylephrine, an alternative decongestant, is a poor substitute, Stuff.co.nz

Review urges cold medicine ban for kids  -  ‎Aug 19, 2009‎
One was a life-threatening case of fluid on the lungs in a 6-year-old boy who received an overdose of phenylephrine, a Nasal decongestant. New Zealand Herald

Topical antibiotics offer no additive benefit to povidone-iodine ...  -  ‎Aug 21, 2009‎
On the day of their surgery, all patients received one drop of proparacaine 0.5% (Akorn), one drop of tropicamide 1% (Akorn) and one drop of phenylephrine OSN SuperSite

Banning pseudoephedrine is not the answer to "P"  -  ‎Aug 18, 2009‎
...nasal decongestant than remedies made with an alternative ingredient, phenylephrine, there is a large amount of anecdotal evidence to support this view. Scoop.co.nz (press release)

执业西�?�师�?�物分�?辅  -  ‎Aug 13, 2009‎
...例如：去氧肾上腺素（Phenylephrine）�?异丙肾上腺素（Isoprenaline）�?克仑特罗（Clenbuterol）�?沙�?胺醇（Sulbutamol）�?氯丙那林（Clorprenaline）等。青年人

Cough, Cold Mixtures Unsuitable For Children Below Two  -  ‎Jul 8, 2009‎
...as Dextromethorphan and Diphenhydramine) and decongestants (such as Ephedrine, Phenylephrine and Pseudoephedrine) used to treat cough and cold ailments. Bernama

New iPhone IV Dosage Calculator  -  ‎Jul 6, 2009‎
Epinephrine, Flumazenil, Lidocaine, Magnesium sulfate, Mannitol, Naloxone, Phenylephrine, Procainamide, Vasopressin Continuous infusions: Epinephrine, Medgadget.com

Pols Cook Up Misguided Meth Bill  -  ‎Jun 25, 2009‎
Studies confirm what we all know: Drugs containing the "substitute" phenylephrine instead of ephedrine don't work as well and have to be taken more Examiner.com

Losartan counteracts the hyper-reactivity to angiotensin II and ...  -  ‎Jun 22, 2009‎
In aortic strips isolated from N, NL, D and DL rats we evaluated i) the isometric concentration-dependent contractile response to phenylephrine (Phe) and to 7thSpace Interactive (press release)

التهاب الأن�? التحسسي.. الأسباب والأعراض  -  ‎Jun 17, 2009‎
مضادات الاحتقان مثل «�?ينيلي�?رين» phenylephrine و«اوكسيميتازولين» oxymetazoline التي يلجأ إليها بعض الناس بهد�? التخ�?ي�? السريع من التهاب الأن�? التحسسي. عرب نت 5

Male Drugs for Female Sexual Dysfunction  -  20 Apr 2009
Arterial segments were contracted with phenylephrine then submitted to increasing concentrations of one of the PDE5 inhibitors. According to Dr. Allahdadi, PsychCentral.com

Herbal Supplements and Surgical Risks  -  ‎Apr 19, 2009‎
Of note, patients taking ephedra under general anesthesia can have severe hypotension that can be controlled with phenylephrine instead of ephedrine. eMaxHealth.com

Got snot? Help is behind the pharmacy counter  -  ‎Mar 29, 2009‎
As a result, Sudafed and other drug companies introduced a newly formulated version of their products (most containing phenylephrine) which could be sold on Examiner.com

Colorectal cancer misdiagnosed as hemorrhoids  -  ‎Mar 31, 2009‎
On the other, she was told to use phenylephrine suppositories and take a sitz bath. While taking the bath, Mrs. C thought she felt a vaginal tumor and went Clinical Advisor

Saving Lives through Quality Product  -  ‎Apr 13, 2009‎
Breaking down the components and its purpose, he said paracetamol is for fever and pain relief, while phenylephrine hydrochloride is to decongest the nose THISDAY

Health Watch: Make small changes for big savings on health-care costs  -  ‎Apr 13, 2009‎
Decongestants, such as pseudoephedrine and phenylephrine help temporarily relieve the stuffy nose of allergies. They are best used only for a short time. Utica Observer Dispatch

April showers bring spring allergies  -  ‎Apr 7, 2009‎
Decongestants — Pseudoephedrine and phenylephrine temporarily relieve the stuffy nose of allergies. Decongestants are found in many medicines and come as Northfield News (subscription)

Dr. Mallika's Files: Case Of 'Achoo Achoo'  -  ‎Apr 6, 2009‎
Decongestants, like phenylephrine (Sudafed), can also help if you tend to have a lot of congestion. If these medications don't do the trick, WBZ

Sorting Out Allergy Treatments  -  ‎Apr 8, 2009‎
Pseudoephedrine SUDAFED or phenylephrine also marketed as SUDAFED PE are two different decongestants. THE PACKAGING LOOKS THE SAME BUT THE MOST EFFECTIVE EmpowHer

It’s like punk rock, only it’sa pig  -  ‎Apr 3, 2009‎
I pointed at the implements of instruction and jabbered through a mental fog of phenylephrine and dextromethorphan: “What are those for? Brandeis Hoot

Common drugs can help allergic rhinitis  -  ‎Mar 29, 2009‎
...seen on the packaging as "D," such as Allegra-D, Zyrtec-D, and Claritin-D. The most commonly used decongestants are pseudoephedrine and phenylephrine. Daytona Beach News-Journal

التهاب الجيوب الأن�?ية.. أسبابه وعلاجه  -  ‎Apr 15, 2009‎
�?الحبوب الحاوية على مواد pseudoephedrine أو phenylephrine مساعدة جدا، إلا أنها تقود �?ي أحيان كثيرة إلى ر�?ع ضغط الدم، وتسريع نبضات القلب، أو تحدث التشويش عرب نت 5

Dùng thuốc trong thai kỳ  -  ‎Apr 10, 2009‎
Thai phụ nên thuộc nằm lòng hai độc chất (trong thai kỳ) là pseudoephedrine và phenylephrine. Nhất là trong 13 tuần đầu của thai kỳ. Thanh Niên

09年执业西�?�师�?��?�学辅导：第�??章第四节β�?�体激动�?�  -  ‎Apr 12, 2009‎
...�?酸去氧肾上腺素（phenylephrine hydrochloride）肌内注射，2～5mg/次；或10mg以葡�?�糖液100ml稀释�?��?�脉滴注。�?�?肌内注射10mg/次，�?�脉滴注�?分钟0.18mg. 青年人

Drixoral: Why the Allergy Medicine Isn't Available, and What to ...  -  ‎Mar 9, 2009‎
For the closest match to Drixoral, look for products that combine an antihistamine with a decongestant, such as pseudoephedrine or phenylephrine. U.S. News & World Report

Cold medicines 'no threat to children'  -  ‎Mar 3, 2009‎
..."All Lemsip products currently marketed in Australia that contain guaiphenesin and phenylephrine are not recommended for children 12 years and under," the Sydney Morning Herald

Collegiate athletes cautioned against effects of medicine  -  ‎Feb 26, 2009‎
Also reported on ncaa.org, Phenylephrine and Pseudoephedrine are stimulants that are not banned by the NCAA, which can commonly be found in nonprescription Famuan

The Aging Eye  -  ‎Mar 5, 2009‎
Some common ophthalmic solutions may include beta-blockers (timolol), adrenergics (epinephrine, phenylephrine), cholinergic/anticholinesterase (pilocarpine) ADVANCE for LPNs

Modest vasomotor dysfunction induced by low doses of C60 ...  -  ‎Feb 25, 2009‎
...vasorelaxation elicited by acetylcholine in aorta segments mounted in myographs and the phenylephrine-dependent vasoconstriction response was increased. 7thSpace Interactive (press release)

Diagnosis and Treatment of Sleep Disorders in Older Adults  -  ‎Feb 25, 2009‎
...corticosteroids, decongestants (eg, pseudoephedrine, phenylephrine, phenylpropanolamine), stimulating antidepressants (eg, protriptyline, bupropion, Focus (subscription)

英�?�咳藥無效且�?�害兒童  -  ‎Mar 1, 2009‎
...香港藥劑師學會藥物教育資�?中心總監崔俊明指，用作通鼻塞的多種�?分，包括麻黃鹼（ephedrine）�?苯腎上腺素（phenylephrine）等會令血壓上�?��?心跳加速等，氯苯那香港新浪網

Küçüklere ilaç verirken bir daha düşünün  -  ‎Mar 10, 2009‎
...soğuk algınlığı ilaçlarında bulunan dekonjestan özellikteki pseudoephedrine, phenylephrine ya da ephedrine maddelerine bağlı 54 çocuk ölümü bildirildi. İhlas.Net

Effects of streptozotocin-induced diabetes on the pharmacology of ...  -  Jan 21, 2009
Isometric tension responses to the vasoconstrictors phenylephrine, serotonin and PGF2alpha, and the vasodilators carbachol and glyceryl trinitrate, 7thSpace Interactive (press release),

How to halt the spread of a cold  -  Jan 21, 2009
Sprays containing phenylephrine (Neo-Synephrine) or oxymetazoline (Afrin) shrink swollen blood vessels in the lining of your nose, allowing mucus to drain. Salt Lake Tribune,

What treatments work for sinusitis?  -  Jan 21, 2009
Common decongestants (and their brand names) are pseudoephedrine pills (Sudafed), oxymetazoline (Vicks Sinex), phenylephrine (Fenox) and xylometazoline guardian.co.uk,

Treating coughs and colds in children  -  Jan 21, 2009
...[1] That includes cough and cold medicines containing the following ingredients: phenylephrine, pseudoephedrine, ephedrine, oxymetazoline and xylometazoline guardian.co.uk,

What treatments work for hay fever?  -  Jan 21, 2009
Drowsy Sudafed Decongestant Tablets), oxymetazoline (Vicks Sinex Nasal Spray), phenylephrine (Fenox) and xylometazoline (Otrivine, Sudafed Nasal Spray). guardian.co.uk,

Cold Weather Can Increase Heart Disease Risks  -  Jan 13, 2009
Some common decongestants in over-the-counter medications include pseudoephedrine and phenylephrine. If you have high blood pressure, talk to your doctor Boston Channel.com,

Research and Markets: Top Three Drugs by Sales in Kazakhstan were ...  -  Jan 27, 2009
Novartis' over-the-counter (OTC) flu treatment Theraflu (acetaminophen + chlorpheniramine + dextromethorphan + phenylephrine + pheniramine + MarketWatch (press release)

Failure to launch  -  Jan 20, 2009
About a third of men improve after treatment with medicines that close the bladder neck, such as pseudoephedrine, phenylephrine, chlorpheniramine, Malaysia Star,

التهاب الجيوب الأن�?ية.. أسبابه وعلاجه  -  Jan 17, 2009
�?الحبوب الحاوية على مواد pseudoephedrine أو phenylephrine مساعدة جدا، إلا أنها تقود �?ي أحيان كثيرة إلى ر�?ع ضغط الدم، وتسريع نبضات القلب، أو تحدث التشويش الشرق الاوسط,

�?�?�康醫點�?�】市售感冒藥的�?分與用途  -  Feb 1, 2009
...五�?解鼻充血劑：例如pheudoe-phedrine�?phenylephrine 人間�?報,

التهاب الجيوب الأن�?يّة... تخلّصوا منه قبل أن يت�?اقم  -  Jan 31, 2009
ولا تؤدي بخاخات الأن�? (سبراي) التي تدخل �?ي مكوناتها مادة الـ phenylephrine أو oxymetazoline إلى أعراض جانبية، لكن كثرة استعمالها ل�?ترات طويلة، قد تجرح الأن�? الجريدة,

GSK introduces Panadol Cold & Catarrh  -  Dec 22, 2008
...“Our new offering and solution contain three internationally proven active ingredients which are paracetamol, phenylephrine hydrochloride and Vanguard,

Warning Letter Focuses on Use of Wrong Identity Test  -  Dec 19, 2008
The company, based in Rosenberg, Texas, used the US Pharmacopeia (USP) <197k> infrared spectrophotometric identity test for incoming lots of phenylephrine FDA news (subscription),

4 Types of Allergy Medications: Which Is Right For You?  -  Dec 3, 2008
Another kind of decongestant is phenylephrine, which is available in many over-the-counter products like Tylenol Sinus. Unlike pseudophedrine, this drug is FOXNews

Revised policy on red reflex exam recommends earlier testing  -  Dec 1, 2008
...including sympathomimetic agents such as phenylephrine and anticholinergic agents such as cyclopentolate hydrochloride and tropicamide. AAP News (subscription)

Safe Cures for Kids’ Common Colds  -  Dec 9, 2008
Pseudoephedrine was removed and replaced with phenylephrine, and pharmaceutical companies voluntarily ceased marketing all cold-and-cough medications as BU Today,

Health warning issued under Section 98 of the Medicines Act 1981  -  Dec 9, 2008
This product is labeled as containing noscapine hydrochloride, a cough suppressant; phenylephrine hydrochloride, a decongestant; guaiphenesin hydrochloride, New Zealand Doctor Online,

Health Canada Releases Decision on the Labelling of Cough and Cold ...  -  Dec 18, 2008
...(used to treat ephedrine hydrochloride/sulphatecongestion) phenylephrine hydrochloride/sulphate pseudoephedrine International Business Times,

Sudafed launches two new decongestant products  -  Nov 6, 2008
New Non-Drowsy Sudafed Congestion & Headache Capsules (Paracetamol, Caffeine & Phenylephrine) has a new positioning in the decongestant category and for the Talking Retail,

Parents seek solution for coughs and colds  -  Nov 22, 2008
...and September 2006 found 54 reports of children’s deaths associated with decongestant medicines made with pseudoephedrine, phenylephrine or ephedrine. Times Daily,

Pharmacist weighs in on cold remedies  -  Nov 3, 2008
Decongestants, including pseudoephedrine and phenylephrine, may alleviate the symptom of nasal congestion and post-nasal drip. These products should not be News-Leader.com,

Diabetes and the pulmonary circulation  -  Nov 1, 2008
Using standard vascular ring studies, the investigators demonstrate a decrease in ACh-mediated vasorelaxation in phenylephrine-constricted pulmonary artery AJP-Lung Physiology (subscription)

Safety of Kids Cough and Cold Medicines Questioned  -  Oct 27, 2008
...that most deaths in children under the age of 2 were associated with decongestant medicines made with pseudoephedrine, phenylephrine or ephedrine. Natural News.com,

Epistaxis significa sangrado por la nariz  -  Nov 15, 2008
...mantener la cabeza erguida y apretar la nariz con dos dedos por 5 minutos; gotas nasales a base de 1/4% de phenylephrine (máximo 5 a 6 dias); Almomento.net,

Use of Dye Can Help Prevent Vasoplegic Syndrome After ...  -  21 Oct 2008
...(1) Once the team instituted the procedure, he said, "we found we were no longer giving phenylephrine [to patients] on bypass." To evaluate the effects of DG News

Thieves bungle pharmacy robbery  -  Oct 1, 2008
The thieves picked cold and flu tablets which contain phenylephrine instead of pseudoephedrine. "They're different things. Phenylephrine cannot be broken Tweed Daily News,

Should Kids Cold Meds Remain OTC?  -  Oct 2, 2008
Between 1969 and 2006, an FDA review found that 54 children’s deaths were associated with decongestant medications made with pseudoephedrine, phenylephrine InjuryBoard.com,

Leading Homeopathic Medicine Provider, Hyland's Inc., Offers ...  -  Oct 9, 2008
The issue of children's OTC cough and cold medicines concerns the use of eight specific, active ingredients (phenylephrine, diphenhydramine, pseudoephedrine MarketWatch

Teva Neuroscience Launches Spanish Parkinson's Disease Patient and ...  -  Sep 29, 2008
...amphetamines, cold remedies containing decongestants and weight-reducing preparations containing pseudoephedrine, phenylephrine, phenylpropanolamine, MarketWatch

Notch activates cell cycle reentry and progression in quiescent ...  -  Oct 6, 2008
...neonatal mouse ventricular cardiomyocyte; NRVC, neonatal rat ventricular cardiomyocyte; P, postnatal day; PHE, phenylephrine; Rb, retinoblastoma protein Journal of Cell Biology (subscription)

Küçüklere İlaç İçirmeyin  -  Oct 20, 2008
...soğuk algınlığı ilaçlarında bulunan dekonjestan özellikteki pseudoephedrine, phenylephrine ya da ephedrine maddelerine bağlı 54 çocuk ölümü bildirildi. Yeni Bursa,

Sudafed extends range of decongestants this winter  -  Sep 1, 2008
New Non-Drowsy Sudafed Congestion & Headache Capsules (Paracetamol, Caffeine & Phenylephrine) has a new positioning in the decongestant category and for the Talking Retail,

Authorities charge homeless man with theft, vandalism  -  Sep 11, 2008
The medications reported stolen were Adencord Calcium Chl., Cordarone, Epinephrine, Flumazenil, Lanoxin, Levophed, Magnesium Sulfate, Narcan/Phenylephrine Maryville Daily Times,

Medicine Cabinet Must-Haves  -  Sep 6, 2008
Good things to have on hand in case that common cold or flu strikes include a decongestant (Sudafed, phenylephrine) and an antihistamine (Benadryl, CBS News,

Competing for the cure  -  Aug 28, 2008
Now, when he has the sniffles he takes Coldrex, a branded drug produced by pharmaceutical giant GlaxoSmithKline containing paracetamol, phenylephrine and Moscow News,

Brand Names/Synonyms:
Phenylephrine is also known by the following brand names and/or synonymsAdrianol; Ak-Dilate; Ak-Nefrin; Alcon Efrin; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Biomydrin; Dilatair; Dimetane; Dionephrine; Doktors; Duration; Fenilefrina [Inn-Spanish]; HSDB 3383; I-Phrine; Isophrim; Isophrin; Isopto Frin; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; M-Sympathol; M-Sympatol; M-Synephrine; Mesaton; Mesatone; Mesatonum; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasympatol; Metasynephrine; Metsatonum; Mezaton; Minims Phenylephrine; Mydfrin; Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Neofrin; Neophryn; Neosynephrine; Nostril; Nostril Spray Pump; Nostril Spray Pump Mild; Ocu-Phrin Sterile Eye Drops; Ocugestrin; Phenoptic; Phenylephrine; Phenylephrine, I-; Phenylephrine, L-; Phenylephrinhydrochlorid; Phenylephrinum [Inn-Latin]; Prefrin; Prefrin Liquifilm; Pyracort D; Relief Eye Drops for Red Eyes; Rhinall; Spersaphrine; Vicks Sinex; Visadron

Drug Category:
Phenylephrine is categorized under the following by the FDA: Adrenergic alpha-Agonists; Cardiotonic Agents; Nasal Decongestants; Sympathomimetics; Vasoconstrictor Agents; Mydriatics; ATC:C01CA06; ATC:R01AA04; ATC:R01AB01; ATC:R01BA03; ATC:S01FB01; ATC:S01GA05

Dosage Forms:
Ophthalmic Solution; Nasal Solution; Solution (IM, IV, IV infusion and subcutaneous); Gel; Cream; Ointment; Suppository

Absorption:
Not Available

Interactions:
-->Interactions for Phenylephrine:

Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all.

MAO Inhibitors

The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic antidepressants.

Chemical IUPAC Name:
3-(1-hydroxy-2-methylamino-ethyl)phenol

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