Phentolamine

This page contains recent news articles, when available, and an overview of Phentolamine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Phentolamine
(when available)

Pharmacology and use:
Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure. Female sexual dysfunction

Mechanism Of Action:
Phentolamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.

News Articles on Phentolamine

Malewezi sounds HIV/Aids advice  -  Jul 24, 2008
...the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. Nyasa Times,

Accelerated recovery after local anesthesia shown  -  Jun 16, 2008
A recent study in Anesthesia Progress has shown that phentolamine can reverse the effects of lidocaine 30?55% faster than your body can metabolize it Dental Economics,

Consumers Warned Not To Use Any Unauthorized Products Promoted To ...  -  Jun 10, 2008
Lot 0070263 of the product was found to contain the prescription drug phentolamine, which is not indicated on the label. Phentolamine is currently eMaxHealth.com,

Canada issues warning about 'Desire'  -  Jun 9, 2008
Health Canada said new lab results indicate two lots -- 84881 and 0070263 -- of the product contain phentolamine, which when used by patients with heart United Press International

Dentist turns the tables on anaesthetic  -  Jun 15, 2008
Oraverse, a phentolamine injection, reverses the local anaesthetic given for dental procedures. The drug opens the blood vessels only where the first Independent Online,

Patients alerted after Blackpool nurse found to have HIV  -  Jun 12, 2008
...sified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure. Blackpool Citizen,

Sex drug named Desire  -  May 24, 2008
Health Canada issued a warning Thursday about Desire, which was found to contain the prescription drug phentolamine, an ingredient not indicated on the Edmonton Sun,

Drug Promises to Restore Sensation After Dental Visit  -  May 11, 2008
OraVerse is a formulation of a decades-old drug, phentolamine mesylate, which is used to treat severe episodes of hypertension. New York Times,

Dental anesthesia reversal drug OK'd  -  May 10, 2008
He concluded that a drug called phentolamine would be a suitable candidate. It has been used for about 50 years to reverse the effects of epinephrine, San Diego Union Tribune,

Killer spared at death's door  -  May 23, 2008
Health Canada issued the warning in a release about a product called Desire, which was found to contain the prescription drug phentolamine -- something not Irish Independent,

Health Highlights: May 24, 2008  -  May 24, 2008
One lot of the product was found to contain the prescription drug phentolamine, which may be prescribed intravenously to prevent and control high blood Atlanta Journal Constitution,

Pacemaker for pup  -  May 24, 2008
Health Canada issued the warning in a release about a product called Desire, which was found to contain the prescription drug phentolamine, something not Winnipeg Sun,

Reuters Health News Summary  -  May 25, 2008
Health Canada issued the warning in a release about a product called Desire, which was found to contain the prescription drug phentolamine – something not San Diego Union Tribune,

Have fun and help African project  -  May 18, 2008
...sified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure. Congleton Guardian,

ALSO NOTED: FDA OKs Novalar therapy; StemCells files new patent ...  -  May 12, 2008
The FDA has OK'd Novalar's OraVerse (phentolamine mesylate) for the reversal of soft-tissue anesthesia and the associated functional deficits resulting from FierceBiotech,

Man claims god sent him cure for Aids  -  Apr 20, 2008
...and has a carbon-uranium-sulfur-(classified)-phentolamine configuration or structure. He added that AMBUSH has helped cure people with leukaemia, The Voice,

Case 14: Patient Follow-up  -  Apr 3, 2008
Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage. A study was set up to assess the effect on the clinical course EMS1.com - Emergency Medical Service Resources,

BUYINS.NET: RPRX, AKES, CARD, EDNE, IESV, MVOG Have Been On BUYINS ...  -  Jan 29, 2008
It also offers phentolamine-based products, such as VASOMAX for the treatment of male erectile dysfunction under the brand name, Z-Max, as well as Bimexes, Trading Markets (press release),

Sexual problems  -  Nov 3, 2007
There are also medications that may help, such as sildenafil, testosterone, phentolamine or hormone replacement therapy. You should only take these after Malaysia Star,

Pseudo : Mot de passe :  -  Nov 9, 2007
Phentolamine, Sildenafil, Tadalafil, at www.cialis.com · itraconazole (Sporanox) or seek immediate medical emergency, medical attention if you use. Journal lycéen,

Novalar Raises $30 Million in Series D Financing  -  Nov 1, 2007
Phentolamine mesylate (a vasodilator), the active ingredient in the investigational agent NV-101, has been approved and in use in specific medical PR Newswire (press release),

Senetek PLC Announces Update On Invicorp(R)  -  Jul 9, 2007
PR Newswire (press release),...at http://www.plethorasolutions.co.uk Invicorp(R) is a patented injectable combination of phentolamine mesilate and vasoactive intestinal polypeptide.

Industry news from the editorial staff at Proofs magazine, a ...  -  Jun 19, 2007
RDH,Phentolamine mesylate (a vasodilator), the active ingredient in the investigational agent NV-101, has been approved and in use in specific medical

Senetek PLC Reports Investor Conference Call  -  Apr 26, 2007
PR Newswire (press release),More importantly, you know, the fact of the matter is we ended up with a clinical hold on phentolamine, which, you know, on Invicorp(TM) which had nothing

A Possible Explanation for Penile Pain in Peyronie Disease Shown ...  -  Apr 25, 2007
Journal of Ultrasound in Medicine (subscription)This was followed by intracavernous injection of 0.1 mL of a trimix (2 mg of prostaglandin E 1 , 1.7 mg of papaverine, and 0.1 mg of phentolamine) and

Illumina Shuttering Connecticut Plant, Relocating 50 Employees  -  Apr 15, 2007
San Diego Business Journal,The active ingredient in NV-101 is phentolamine mesylate, which has been used for more than 50 years in other medical indications at significantly higher

A Milestone Change in Practice  -  Apr 11, 2007
EMS Magazine,Using low doses of phentolamine and high doses of epinephrine, adequate circulating epinephrine levels were achieved, leading to improved coronary perfusion

Novalar Pharmaceuticals submits NDA for dental anesthetic reversal ...  -  Apr 12, 2007
News-Medical.net,Phentolamine mesylate (a vasodilator), the active ingredient in the investigational agent NV-101, has been approved and in use in specific medical

Options for premature ejaculation  -  Mar 30, 2007
The Australian,Common ingredients include apomorphine and phentolamine. While these certainly may work, just be sure the doctors are aware of any other medical conditions

Study Unravels Inner Working of Bacteria  Jun 27, 2006
Once the infection-releasing receptor was identified, the researchers were then able to block the signals sent from the intestine using phentolamine, an alpha ... -Forbes

Bacteria, Beware: New Finding About E Coli Could Block Infections ...  Jun 28, 2006
...online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, researchers describe how they used phentolamine, an alpha ... -Medical News Today



Augmented Activity of Adenosine Triphosphate-Sensitive K ... Feb 21, 2006
...by the ATP-sensitive K + channel antagonist glibenclamide (10 –5 M). Droperidol (10 –7 M) and an -adrenergic receptor antagonist phentolamine (3 x 10 –9 M ... - Anesthesia & Analgesia (subscription),

Senetek Licenses Invicorp(R) Erectile Dysfunction Treatment to ...  Feb 21, 2006
Invicorp® is Senetek's patented injectable combination of phentolamine mesylate and vasoactive intestinal polypeptide for the treatment of ED. ... - Yahoo! News

Senetek Licenses Invicorp(R) Erectile Dysfunction Treatment to ... Feb 21, 2006
Invicorp(R) and the erectile dysfunction market Invicorp(R) is Senetek's patented injectable combination of phentolamine mesylate and vasoactive intestinal ... - PR Newswire,

Brand Names/Synonyms:
Phentolamine is also known by the following brand names and/or synonymsPhenotolamine; Phentalamine; Phentolamine Mesilate; Phentolamine Mesylate; Phentolamine Mesylate [Usan]; Phentolamine Methanesulfonate; Phentolamine Methanesulphonate; Phentolamine, Methyl Sulfonate; Regitin; Regitin Methanesulphonate; Regitine; Regitine Mesylate; Regitine Methanesulfonate; Regitipe; Rogitine

Drug Category:
Phentolamine is categorized under the following by the FDA: Antihypertensive Agents; Sympatholytics; ATC:C04AB01; ATC:G04BE05

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Interactions for Phentolamine: Diagnosis of pheochromocytoma - phentolamine blocking test. The test is most reliable in detecting pheochromocytoma in patients with sustained hypertension and least reliable in those with paroxysmal hypertension. False-positive tests may occur in patients with hypertension without pheochromocytoma.



Chemical IUPAC Name:
3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)-amino]phenol

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