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PhenerganThis page contains recent news articles, when available, and an overview of Phenergan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Phenergan (when available) Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. For the treatment of allergic disorders, itching, nausea and vomiting Mechanism Of Action: Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. News Articles on Promethazine A Destructive Court - 20 Apr 2009 The plaintiff in this case lost an arm to gangrene after she was injected with the Wyeth ( WYE - news - people ) drug Phenergan. Forbes Transcript: Nouriel Roubini - 20 Apr 2009 The plaintiff in this case lost an arm to gangrene after she was injected with the Wyeth drug Phenergan. The drug was clearly labeled with a warning that Forbes Changing the landscape for FDA approvals - Apr 7, 2009 Levine involved administering Wyeth’s anti-nausea drug Phenergan by the “IV-pushâ€? method. Susan Levine, a professional musician, suffered from migraines and Mass High Tech Supreme Court ruling could prove disastrous - Apr 3, 2009 Levine, the justices upheld a $6.7 million award to a Vermont woman who lost her lower arm because of a botched injection of the anti-nausea drug Phenergan. Buffalo News Man accused of possessing more than 200 grams of cocaine - Apr 15, 2009 Promethazine is also sold under the brand names Pentazine and Phenergan. McKinley remained in the Travis County Jail on Wednesday with bail set at $100000. Austin American-Statesman Medical Device Bill To Be Introduced Following Recent Supreme ... - Mar 31, 2009 Last Wednesday, the Court ruled against Wyeth’s contention that it should not be subject to lawsuits in state courts for Phenergan, its anti-nausea drug, InjuryBoard.com The Tragedy of Supremely Bad Law - Mar 30, 2009 The tragedy was that Diana Levine, a musician in Vermont, lost her arm due to gangrene after a physician's assistant injected her with Phenergan, American Spectator Altria, Wyeth Cases Mark Shift in US Court’s Course - Mar 31, 2009 The justices upheld a $7 million award to a musician who lost her arm after being injected with Wyeth’s Phenergan nausea treatment. Bloomberg Family sues hospital, doctor over woman's death - Apr 2, 2009 At that time, Dr. Abdeen prescribed Toradol for Pamela's pain and Phenergan for her nausea to be administered intravenously. West Virginia Record For the record - Apr 13, 2009 US$6.7 million to a musician whose arm was amputated after promethazine (Phenergan) was errantly injected into an artery instead of a vein (Wyeth v. CMAJ Deborah Hill Cone: Famous names branded with shame - Mar 29, 2009 But now I just meekly accept my lot and pack extra-strength Phenergan and every Thomas the Tank Engine DVD ever made. New Zealand Herald Judge, jury and medical practitioner - 18 Mar 2009 She was injected with an anti-nausea drug called Phenergan. The label on Phenergan says six times, in different ways, some of them in boldface capital The News Journal Health Buzz: Supreme Court Phenergan Ruling and Other Health News - Mar 5, 2009 The US Supreme Court ruled yesterday that the Food and Drug Administration's approval of the antinausea medication Phenergan and its warning label does not U.S. News & World Report A warning label warning - Mar 14, 2009 It's hard to imagine a more sympathetic victim than Diana Levine, a guitarist who lost her arm to gangrene after she was negligently injected with Phenergan Los Angeles Times The tragedy of Diana Levine - Mar 11, 2009 Her health clinic gave her intramuscular injections of Demerol (for her headache) and Phenergan (for her nausea). That treatment did not work. Chicago Tribune Business Highlights - Mar 4, 2009 Diana Levine's right arm was amputated after she was injected with Phenergan, an anti-nausea medicine made by Wyeth Pharmaceuticals, using a method that Forbes Preemption Watch: You've Been Warned - Mar 5, 2009 Well there are warnings, and there are warnings, so we took a look at the Phenergan PI to see what it had to say. It’ll no doubt make you feel even more PharmExec.com Nation & world business: Tyco to cut 20% of jobs - Mar 5, 2009 Her right arm was amputated after she was injected with Phenergan, an antinausea medicine made by Wyeth Pharmaceuticals, using a method that brings rapid Detroit Free Press Common drug causes spastic movements - Mar 3, 2009 These conditions also can happen with phenergan, a common medication used for nausea, because, like Reglan, it derives from the family of phenothiazine Great Falls Tribune Caloric deficit is key for a diet's success - Mar 10, 2009 In last week's article, "Common drug causes spastic movements," I remarked that the drug Reglan (as well as Phenergan) belonged to the phenothiazine class Great Falls Tribune One Down, One to Go: Could Pre-Emption for Medical Devices Be Next? - Mar 5, 2009 Diana Levine is the former Vermont musician who lost part of her right arm after suffering a botched injection of the anti-nausea drug Phenergan. Lawyers and Settlements Nation Briefly - Mar 4, 2009 Her right arm was amputated after she was injected with Phenergan, an anti-nausea medicine made by Wyeth Pharmaceuticals, using a method that brings rapid UT The Daily Texan Unjust Equations: False Positives In Drug Testing - Mar 12, 2009 Over-the-counter allergy preparations, sleep-aids and anti-nausea medications that contain promethazine, Phenergan®, Promethagan® such as Claritin D will North Country Gazette Wyeth/Pfizer Merger – Will Justice Roberts Recuse from Wyeth v ... - Feb 28, 2009 ...law preempts a state law tort action challenging the FDA labeling of the Wyeth drug Phenergan, known to cause gangrene when improperly administered. InjuryBoard.com National briefs - Mar 5, 2009 In a 6-3 decision, the court turned away Wyeth Pharmaceuticals' claim that federal approval of Phenergan and its warning label should have shielded the Dubuque Telegraph Herald Opposing view: Tragic injury makes bad law - Mar 5, 2009 Phenergan, the drug in question, had a label that was clear about the risks and contained warnings about its administration. It had been used beneficially USA Today Clarence Thomas, Supreme Court liberal? - Mar 7, 2009 She said drug maker Wyeth failed to fully warn the public about the danger of injecting the anti-nausea drug Phenergan. If it mixes with arterial blood, Los Angeles Times Supreme Court's new session to be devoted to business - Mar 13, 2009 ...was suffering from a migraine headache in April 2000 when a physician's assistant injected the potent anti-nausea drug Phenergan into her right arm. News & Observer Andreotti named BMS president; ExonHit looks for out-licensing deals; - Mar 4, 2009 Levine, the justices rejected Wyeth's claim that FDA approval of a drug--in this case, the anti-nausea treatment Phenergan--would pre-empt patient suits FierceBiotech 2009å¹´3月5日星期四01:47 BJT - Mar 4, 2009 Part of her arm had to be amputated after she was improperly injected with the anti-nausea drug Phenergan made by Wyeth as part of treatment for a migraine. 路透中国 Forged script arrest - Mar 8, 2009 ...the’re pretty good at picking up on forged ones and will contact law enforcement." Waugh said the prescription was for the pain killer phenergan-T codeine. San Marcos Daily Record AP Political NewsBrief at 11:14 am EST - Mar 4, 2009 In a 6-3 decision Wednesday, the court rejected Wyeth Pharmaceuticals' claim that federal approval of its Phenergan anti-nausea drug should have shielded TMCnet Doctor's quest changes lives for chronic vomiting sufferers - Mar 2, 2009 ...catheter) lines to administer nausea medication such as Phenergan, intravenous fluid to combat dehydration and antibiotics to ward off infections. Jackson Clarion Ledger AP Business NewsBrief at 10:35 am EST - Mar 4, 2009 In a 6-3 decision Wednesday, the court rejected Wyeth Pharmaceuticals' claim that federal approval of its Phenergan anti-nausea drug should have shielded TMCnet World Briefly - Mar 4, 2009 Her right arm was amputated after she was injected with Phenergan, an anti-nausea medicine made by Wyeth Pharmaceuticals, using a method that brings rapid Clanton Advertiser EDITORIAL: States of protection - Mar 8, 2009 The justices upheld a $6.7 million jury verdict in favor of a musician from Vermont whose arm had to be amputated after she was injected with Phenergan, Trading Markets (press release) Altria, Medtronic & Wyeth: Decisions that Concern Sales over ... - Mar 6, 2009 Musician, Diana Levine sued Wyeth in 2000 after a hospital gave her an IV push injection of Wyeth’s anti-nausea drug, Phenergan; she had gone to the InjuryBoard.com El Supremo de EEUU avala demanda al laboratorio Wyeth por un ... - Mar 5, 2009 Esta mujer, que se dedicaba a la música, habÃa sido amputada del antebrazo derecho en 2000 tras recibir, por vÃa intravenosa, una inyección de Phenergan, AFP USA: la Cour suprême donne raison à une victime contre un labo ... - Mar 4, 2009 Cette musicienne avait été amputée en 2000 de l'avant-bras droit après avoir reçu une injection par intraveineuse de Phenergan, censé soulager ses nausées. AFP 打錯é‡?é?æˆªè‚¢è—¥å» åˆ¤è³ 670è?¬ - Mar 5, 2009 ...一å??醫生助ç?†ç‚ºå¥¹æ³¨å°„防嘔å??è—¥ç‰©â”€æƒ æ°?è£½è—¥å» ç”Ÿç”¢çš„Phenergan。但是，這å??助ç?†æŠŠæ‡‰å?šé?œè„ˆæ³¨å°„çš„è—¥ç‰©èª¤æ³¨å°„é€²å‹•è„ˆï¼Œé€ æˆ?她的å?³è‡‚ç«‹å?³å£žç–½(gangrene)ï¼Œå¾Œä¾†å¿…é ˆæŠŠå?³ä¸‹è‡‚ 世界日報 WDHLG-US-Gericht - Pharmakonzerne für Gesundheitsschäden haftbar - Mar 4, 2009 Der Frau musste ein Teil ihres Arms amputiert werden, nachdem ihr zur Behandlung von Migräne unsachgemäß das Mittel Phenergan verabreicht worden war, Reuters Deutschland ç¾Žåœ‹æœ€é«˜æ³•é™¢åŠ å¯¬è²¬ä»»æ³•è¨´è¨Ÿç¯„åœ?Wyethåˆ¤è³ 740è?¬ç¾Žå…ƒ - Mar 5, 2009 ...她æŸ?å¤©å› ç‚ºå??é 痛而求診上門，當時醫師給她打了一é‡?æ¢æšˆè—¥ï¼Œè—¥å??為Phenergan，是由Wyeth (WYE-US;æƒ æ°?è—¥å» )å…¬å?¸è£½ä½œçš„è—¥å“?。 雖然該藥å“?上標註「使用é?œè„ˆæ³¨å°„ã€?，但å?Œ 鉅亨網 Baskytaristka bude žalovat výrobce léků, protože pÅ™iÅ¡la o ruku - Mar 4, 2009 Žena užÃvala kvůli migrénÄ› lék proti nevolnosti Phenergan, jehož základem je prometazin. Na klinice jà ho pÃchali do svalu, ale v dubnu 2000 jà ho poskytli Novinky BÄ™dzie wiÄ™cej pozwów ws. leków? - Mar 5, 2009 Osiem lat temu kobieta straciÅ‚a niemal poÅ‚owÄ™ ramienia (odcinek od Å‚okcia w dół) po podaniu leku Phenergan, stosowanego w celu leczenia nudnoÅ›ci. KopalniaWiedzy Usa,Corte suprema contro Wyeth in caso responsabilità su farmaci - Mar 4, 2009 ...del braccio dopo essersi impropiamente iniettata il farmaco anti-nausea Phenergan, prodotto dalla Wyeth, nell'ambito di una cura contro l'emicrania. Yahoo! Italia Notizie Gyógyszergyártók elleni perek özöne indulhat az Egyesült Ã?llamokban - Mar 4, 2009 A gyógyszergyártót beperlÅ‘ zenész, Diana Levine 2000-ben kapott intravénás injekciót a cég Phenergan nevű, migrén és hányinger elleni szerébÅ‘l úgynevezett Webradio 美대법ì›?, 와ì?´ì–´ìŠ¤ì—? 약물 부작용 ë°°ìƒ? íŒ?ê²° - Mar 4, 2009 ...지난 2000ë…„ 4ì›” ë ˆë¹ˆì?€ 와ì?´ì–´ìŠ¤ì?˜ í•ì˜¤ì‹¬ì œì?¸ ‘피너간(Phenergan)' ì£¼ì‚¬ì œë¡œ ì?¸í•œ ê´´ì € 현ìƒ?으로 팔ì?„ ì ˆë‹¨í•˜ì˜€ë‹¤. ì?´ëŸ° 합병ì¦?ì?€ 드물게 ë°œìƒ?하는 부작용. 데일리팜 Sentenza: case farmaceutiche responsabili dei danni da medicine - Mar 5, 2009 La causa riguarda una chitarrista cui e' stata amputata parte del braccio in seguito ai danni causati da Phenergan, prescritto impropriamente contro ADUC Salute Pharmafirmen droht Klagewelle - Mar 6, 2009 Die Frau hatte das Wyeth-Präparat Phenergan in falscher Dosierung eingenommen und mangelnde Warnhinweise des Herstellers beklagt. Wyeth hatte eine Haftung Financial Times Deutschland TAGESÃœBERBLICK - WIRTSCHAFT - Mar 5, 2009 Der Frau musste ein Teil ihres Arms amputiert werden, nachdem ihr zur Behandlung von Migräne unsachgemäss das Mittel Phenergan verabreicht worden war, Handelszeitung Online 美大法官：FDAæ ¸å‡†è¦èªžä¸?å…?é™¤è—¥å» å‘ŠçŸ¥è²¬ä»» - Mar 4, 2009 ...å?²è’‚文斯寫é?“ï¼Œã€Œæƒ æ°?應有能力在抗暈眩藥å“?『é?žé‚£æ ¹ã€?（Phenergan）的包è£?上，更明確指出é?œè„ˆæ³¨å°„的風險。è?¯é‚¦æ³•å¾‹å?ŠFDAè¦?å®šéƒ½æŒ‡å‡ºï¼Œè—¥å» æ‡‰å°?包è£?æ¨™ç¤ºçš„å…§å®¹è² å®Œå…¨ 新浪網 Pfizer to Pay $2.3 Billion for Bextra Off-Label Marketing - Jan 27, 2009 Earlier this week, Pfizer announced it would acquire drug rival Wyeth, maker of the drug Phenergan, for $68 billion. Phenergan garnered much negative InjuryBoard.com, The preemption question - Jan 22, 2009 Levine, a patient who developed gangrene and had her arm amputated due to an improper administration of the Wyeth sedative and nausea drug Phenergan won a Med Ad News (subscription), Preempting Your Right to Innovative Drugs - Jan 8, 2009 Approved in 1955 by the FDA, Phenergan is used to control severe nausea and vomiting. Over the past 50 years, millions of doses of Phenergan have provided The Epoch Times, Treatments for normal nausea and vomiting in early pregnancy - Jan 21, 2009 The antihistamine drug called promethazine (brand name Phenergan) may reduce your vomiting. We don't know yet whether medicines called phenothiazines work guardian.co.uk, Sleep problems in children - Jan 21, 2009 Antihistamines which cause drowsiness as a side effect include promethazine (brand name Phenergan), alimemazine (Vallergan) and chlorphenamine (Piriton). guardian.co.uk, FDA Approves Four ANDAs for Sun Pharma - Jan 15, 2009 ...of Novartis’ Aredia (pamidronate disodium), Pfizer’s Lopid (gemfibrozil) and Wyeth’s Phenergan (promethazine HCl), India-based Sun says in a statement. FDA news (subscription), Antihistamine tablets - Jan 21, 2009 Promethazine HCI (marketed as Phenergan) information. April 2006. Available at http://www.fda.gov/ (accessed on 1 July 2008). British National Formulary. guardian.co.uk, Supreme Court should protect public - Dec 19, 2008 Eight years ago, struggling from the pain of a migraine headache, Diane went to the hospital and was given Phenergan, a drug often used to reduce the Ironton Tribune, Tort Lawyers Try to Undermine the Constitution - Dec 11, 2008 The plaintiff, Diana Levine, was given Wyeth's anti-nausea drug Phenergan, then on the market for 45 years. In rare instances, Phenergan can cause gangrene Cherry Creek News, State, Federal Regulation at Stake in Wyeth Case - Dec 1, 2008 The Vermont courts said even though the Food and Drug Administration approved a warning label on Wyeth’s anti-nausea, Phenergan, the company should have NJBIZ, Supreme Court Decision in Wyeth Case Could Ignite Drug Labeling ... - Dec 8, 2008 The case involves Diana Levine, a plaintiff who was given the Wyeth antinauseant drug promethazine (Phenergan) in the emergency department (ED) of a Vermont Psychiatric Times, Drug safety: Jurors shouldn't be practicing medicine - Dec 5, 2008 Approved in 1955 by the FDA, Phenergan is used to control severe nausea and vomiting. Over the past 50 years, millions of doses of Phenergan have provided Sun-Sentinel.com, Patrick Kennedy’s Psychedelic Freak Out! - Dec 9, 2008 If you’ll recall, Kennedy’s excuse for the accident was taking Phenergan in combination with Ambien. He’s not the first to mix that particular cocktail: My Wonkette (satire), Costly error for musician, packing in the parks and background checks - Dec 16, 2008 The FDA-approved label on the anti-nausea drug Phenergan contained prominent warnings: ?extreme care should be exercised to avoid ... inadvertent Austin American-Statesman, Wyeth Paid Ghostwriters to Write Drug Studies, and Doctors to Put ... - Dec 12, 2008 This week, we learned that Wyeth—the pharmaceutical maker of Phenergan, recently in the preemption spotlight for causing gangrene when administered InjuryBoard.com, Watching for Wyeth: High Court Decision Could Have Strong ... - Dec 1, 2008 Levine, the plaintiff Diana Levine claimed that she was injured by the inappropriate administration of Wyeth’s antinausea drug Phenergan, which caused her Medical Device Link (press release), Clear drug labels key to good health care - Dec 6, 2008 The aide then administered Phenergan to combat nausea brought on by the pain killer. The drug, however, was improperly injected, causing Levine to lose her Sun-Sentinel.com, Massachusetts woman who allegedly tried to fill forged ... - Dec 11, 2008 Court documents allege Rosenfeld went to the South Main Street Walgreens and attempted to acquire Ambien and Phenergan, both controlled drugs, by uttering a Foster's Daily Democrat, Adverse court ruling could doom vaccines - Nov 29, 2008 Levine - involves a Vermont woman who claims that the manufacturer of the anti-nausea drug Phenergan failed to sufficiently warn her doctor of the dangers Myrtle Beach Sun News, Regulating Good Government - Dec 17, 2008 After her arm developed gangrene and had to be amputated because of a known complication from Wyeth’s anti-nausea drug Phenergan, Diana Levine sued the drug In These Times, The Promethazine and Codiene Syrup Appreciation... - Dec 2, 2008 The generic Phenergan CV is allegedly flavored Peach-Mint and is a "Red-Purple" color, according to description. The drink is almost always falsely believed AllHipHop Los consumidores y los productos defectuosos - Dec 21, 2008 Diana Levine es una paciente que fue inyectada, por vÃa intravenosa, con una dosis de Phenergan, un remedio normalmente utilizado para aliviar estados Diario de Madryn, Brand Names/Synonyms: Phenergan is also known by the following brand names and/or synonyms3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25 Drug Category: Phenergan is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05 Dosage Forms: Tablets, suppositories, opthalmic drops, syrup Absorption: On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance Interactions: -->Interactions for Promethazine: Injection: Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride. Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered. Syrup, Tablets and Suppositories: CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose. Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories. Chemical IUPAC Name: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine : |
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