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PhenerganThis page contains recent news articles, when available, and an overview of Phenergan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Phenergan (when available) Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. For the treatment of allergic disorders, itching, nausea and vomiting Mechanism Of Action: Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. News Articles on Promethazine Reglan and Phenergan: What They Have In Common with Wyeth v. Levine - Aug 8, 2008 Diana Levine's arm was amputated after she developed gangrene from an injection of Wyeth's anti-nausea drug Phenergan. This week a brief was filed on Ms. InjuryBoard.com, Levine Files Preemption Brief With Supreme Court - Aug 8, 2008 During an emergency room hospital visit, Levine was given a Wyeth nausea med called Phenergan, which administered improperly and caused the Vermont musician Pharmalot, Judge Reverses Preemption Ruling In Paxil Case - Jul 22, 2008 Diana Levine who successfully argued before the Vermont Supreme Court that, even though labeling for Wyeth’s Phenergan complied with FDA requirements, Newsinferno.com, Gardasil Injection Followed by Stroke - Jul 21, 2008 Katherine began feeling dizzy and developed flu-like symptoms on February 1; on February 2, her family doctor gave her a phenergan shot for vomiting Newsinferno.com, Woman has stroke after shot - Jul 20, 2008 The next day, her family doctor assumed she had the flu and gave her a phenergan shot to stop her vomiting. The following day, Katherine lost feeling in the Frederick News Post (subscription), Varenicline safety concerns: An interview with Dr Serena Tonstad - Jul 16, 2008 Tonstad: In less than 3% of patients I've prescribed an antiemetic such as Phenergan (promethazine) or Zofran (ondansetron). I also ask them to take it on a TheHeart.Org, Ruling may aid drug firms - Jul 16, 2008 In the pharmaceutical case, a patient sued Wyeth, alleging the company was liable for injuries she suffered from its anti-nausea drug Phenergan. Philadelphia Inquirer, Entretien PPDA / Beigbeder (GQ) - Jul 24, 2008 Pour que le bébé ne crie pas, le père avait donné du Phenergan, mais ça n'avait pas marché. Il criait quand même, selon PPDA. "Je lui mets mon petit doigt Le Blog TV News, Why Doctors Should Worry about Preemption - 03 Jul 2008 Levine — which concerns a patient who lost her arm after an injection of Wyeth's antiemetic drug Phenergan — the Court will decide whether preemption of New England Journal of Medicine (subscription), Flying with children made easy - or slightly easier! - Jun 30, 2008 ...(Many people suggest dosing the babies with Phenergan to calm them but that's really up to you and it can sometimes have the opposite effect. Stuff.co.nz, People With Dementia Should Avoid Certain Drugs - Jun 27, 2008 Antiemetics (antivomiting agents) such as Cyclizine (Marezine), Dimenhydrinate Dramamine), Meclizine (Antivert), Promethazine (Phenergan) and RedOrbit, Fit man dies after shoulder surgery - Jun 11, 2008 The Melbourne Coroners Court today heard Mr Valentine was on a "cocktail" of medications when he died, including morphine, Phenergan and an anti-depressant The Australian, Unlicensed nurse had been fired for drug diversion - Jun 27, 2008 Wilbanks allegedly ordered three vials of Nubain, a narcotic analgesic, and five ampules of Phenergan. But when nursing supervisors checked, no patient had Tampa Bay's 10, Solicitor General Sides with Wyeth in Supreme Court Pre-emption Case - Jun 9, 2008 Levine involves a Vermont woman who alleged she lost her arm from adverse events tied to Wyeth’s nausea and motion sickness drug Phenergan. Newsinferno.com, Solicitor General Sides with Wyeth, FDA on Preemption - Jun 6, 2008 Diana Levine, a Vermont woman who alleged she lost her arm from adverse events tied to Madison, NJ-based Wyeth's nausea and motion sickness drug Phenergan TMCnet New Act to Protect Patients Could Cripple Preemption - Jul 1, 2008 In the case, patient Diana Levine lost her arm after being given Phenergan, an injectable nausea medication manufactured by Wyeth. PharmExec.com, Supreme Court cases could limit liability lawsuits - Jun 26, 2008 Wyeth knew that injecting Phenergan, instead of administering it intravenously, was riskier and should have foreclosed that option in its label. CNNMoney.com Pharmaceutical drug abuse increasing in India: UN0 - Jun 23, 2008 Pharmaceuticals like buprenorphine, dextropropoxyphene, diazepam, nitrazapam, codeine based cough syrups, phenergan and chlorpheniramine are commonly abused Economic Times, International day against drug abuse and Bangladesh - Jun 28, 2008 Sleeping Pill Available in Bangladesh are Tranquilizer, Seduxene, Diazapam, Enoctine, Phenergan, Stemetil, Laxatine. Others Drugs Available in Bangladesh: The New Nation, Lawmakers Seek to Upend Court Device Tort Shield - Jun 27, 2008 Diana Levine, a Vermont woman who alleged she lost her arm from adverse events tied to Madison, NJ-based Wyeth's nausea and motion sickness drug Phenergan TMCnet Is Your Headache A Migraine? - Jun 27, 2008 Nausea medications: These include Reglan, Compazine and Phenergan. Avoid triggers: Avoid certain foods if they have triggered migraines in the past. KMBC.com, High tech medical center focuses on complex digestive disorders - Jun 25, 2008 A prescription for Phenergan, an anti-nausea medication, helped curb the nausea but creates dizziness and lethargy. Meanwhile, my constant malaise worried Reno Gazette Journal, Physical therapy can treat symptoms of vertigo, other balance ... - Jun 24, 2008 Well-meaning doctors chock up vertigo to getting older (even though vertigo can happen at any age) and prescribe Valium, Antivert and Phenergan. Dothan Eagle, Gastrointestinal Complications of Diabetes - Jun 17, 2008 ...other drugs.7 Antiemetics, such as promethazine (Phenergan) and ondansetron (Zofran), may be prescribed for symptomatic relief of persistent nausea. RedOrbit, Area girl stricken by food poisoning in Texas - Jun 15, 2008 They gave her Phenergan (an anti-nausea allergy medicine). I didn't help a whole lot.â€? Later in the day, as the DeHaas family readied to board their flight Argus Press, What is a migraine and how can it be treated - Jun 16, 2008 Prochlorperazine (compazine) and promethazine (phenergan), mainly used for nausea, have an abortive or preventive effect on headaches as well. Australia.TO, Woman claims pharmacy mix-up caused wrecks - Jun 10, 2008 Patrick Kennedy blamed Ambien and anti-nausea medicine Phenergan for an early morning crash into a Capitol Hill security barrier. Log Cabin Democrat, Critiquing the economic argument for preemption - Jun 5, 2008 Wyeth was not at liberty to change the Phenergan label after its approval by the FDA. As the dissenting opinion explains, the applicable “regulation does Tort Deform, Doctor, Pharmacist Accused in Miss. Narcotics Distribution Denied Bond - Jun 14, 2008 The drugs in question are hydrocodone (Lortab), alprazalom (Xanax) and the cough syrup promethazine with codeine (Phenergan with codeine). RedOrbit, Police seize items from home of Morrisville woman - Jun 11, 2008 One of the drugs, promethazine, with the brand name Phenergan, is in the same class of anti-psychotic drugs as Thorazine and Stelazine, although it is not News & Observer, Alexander Pekelis And Drug Company Cases In Which Consumers Have ... - 02 Jun 2008 Moreover, on January 18th the Court had already agreed to hear another drug case, one involving a drug produced by Wyeth called Phenergan. OpEdNews, MOST-READ STORIES - May 22, 2008 ...symptoms of allergies or control nausea. Combines an antihistamine with a narcotic pain-reliever. Known by brand name as Phenergan with Codeine. Biloxi Sun Herald, What's new - May 22, 2008 Prescription drugs, such as Phenergan and Antivert, relieve nausea, but they'll probably make you sleepy, too (and cost more, even if you have insurance, Indianapolis Star, Victim's family: Hospital care killed man - May 21, 2008 ...improper traction and the overuse of pain and muscle-relaxing medications, including morphine, phenergan and valium, combined to asphyxiate Graves, Rutland Herald, The Preemption Clause - Apr 17, 2008 In that case, Diana Levine, a professional musician, was administered Phenergan to alleviate nausea caused by migraine headaches. After injecting the drug ADVANCE, Make it a family affair - Apr 20, 2008 You may want to consider giving your child a dose of Phenergan, a mild sleeping aid that can be prescribed to children aged two years and older. Sydney Morning Herald, Lawsuit filed by woman who said she was improprely injected with ... - Mar 28, 2008 She said in court documents that she went to the hospital and was improperly injected with Phenergan, causing permanent injury. San Luis Obispo Tribune, Local Doctor Arrested On Felony Charges - Mar 27, 2008 Dr. Zavaleta also prescribed 20 dosage units of a CDS Schedule IV narcotic (Xanax and six ounces of Phenergan w/ codeine syrup, a CDS Schedule V narcotic). KALB-TV Newschannel 5, Preemption Watch: Two Wins for Pharma - Apr 16, 2008 In that case, a woman lost her arm due to the onset of gangrene that was attributed to Wyeth's Phenergan. According to Wyeth, the nausea drug was properly PharmExec.com, Key Pharma Preemption Ruling in Third Circuit - Apr 16, 2008 In Levine, the plaintiff was injected with a drug, Phenergan, to relieve nausea and dehydration from a severe migraine headache. One of the plaintiff's two Mondaq News Alerts (subscription), How to sleep – a bedside guide - Mar 31, 2008 Phenergan is a babies' antihistamine and it causes drowsiness; it could be that that's all you need to get over the psychological hump of dropping off. Independent, Balance of justice - Mar 27, 2008 Levine, involves a professional pianist, Diana Levine, who lost her right arm eight years ago after the prescription drug Phenergan was administered through San Francisco Chronicle, Pre-emption For Real? - Apr 7, 2008 At issue is the labeling and usage of Wyeth's histamine antagonist Phenergan (promethazine), with the suit being brought by a patient who was injured after Corante, Cabell Huntington Hospital Named in Wrongful Death Complaint - Apr 6, 2008 ...allegedly injected Phenergan into an IV which caused her fingers, thumb and part of her right hand to die and the digits of her hand to be amputated. HNN Huntingtonnews.net, THIS JUST IN: Cabell County - Apr 4, 2008 While she was recovering, the suit claims a nurse entered the room and injected Miller with Phenergan into an IV in her right hand. West Virginia Record, Cough syrup complications - Mar 30, 2008 Phenergan with codeine and Robitussin ac are still hard to come by, but the shortage probably will be short-lived, he says. Sioux Falls Argus Leader, Search BostonHerald.com for Past 7 days Archives - Feb 26, 2008 Doctors had injected her with an antinausea drug called Phenergan, made by Wyeth, which if used improperly can cause gangrene. Levine sued and the Vermont Boston Herald, FDA supreme, for now - Mar 4, 2008 Miss Levine, a Vermont musician, received an anti-migraine drug (phenergan) in an emergency room — but it was injected into an artery instead of a vein, Washington Times, Justices Add Legal Complications to Debate on FDA’s Competence - Feb 20, 2008 In April 2000, Ms. Levine, a professional guitarist in Vermont, suffered a disabling migraine and went to a health clinic for a shot of Phenergan, New York Times, From the Blotter - Mar 4, 2008 Among the missing items were eight containers of prescribed medications including Phenergan, Lorcet, Xanax, Soma and Paxil. The victim said she needed a True Citizen (subscription), US Supreme Court to Hear Vt. Medical Liability Case - Feb 25, 2008 Since then the Vermont Supreme court awarded her $6.8 million dollars in damages against Wyeth, the maker of the drug Phenergan. WCAX, Supreme Court Rules to Limit Medical Device Suits - Feb 21, 2008 Last month the Court agreed to hear the case of Wyeth v Levine, in which the plaintiff argues that Wyeth's nausea drug Phenergan was unsafe, despite proper InjuryBoard.com, Medical Double Jeopardy - Feb 29, 2008 A Vermont patient contends that the warning label on the anti-nausea drug Phenergan was not specific enough about its risks. If FDA regulation fails -- as Wall Street Journal A Lifetime of Pain, and She Still Will Not Complain - Feb 28, 2008 9 over the counter pills, and weekly shots at the Diamond Headache Clinic of dolophine (Methadone) for pain and promethazine (Phenergan) for nausea. New York Times, Supremes Back Medtronic, Limit Suits Against Device Makers - Feb 20, 2008 It’s similar to the Medtronic case: The plaintiff argues the injected version of Wyeth’s nausea drug Phenergan was unsafe, even when used as described in Wall Street Journal Divided Supreme Court Affirms Decision In FDA Preemption Case - Mar 3, 2008 Levine, in which the Supreme Court has agreed to decide whether a musician who lost her arm after receiving the anti-nausea drug Phenergan via an off-label InjuryBoard.com, Purple drank: Prescription cough syrup key in drug abuse trend - Feb 20, 2008 ...the Houston area, but I am seeing quite an increase in the number of prescriptions written for Phenergan (promethazine) with codeine at the drug stores. Jackson Clarion Ledger, Savage Love Online Extra - Feb 20, 2008 ...a physician incur the wrath of the labor nurses, is the inclusion of a potent antinausea and antidiarrheal medicine—Phenergan and Lomotil respectively. PW-Philadelphia Weekly, Brand Names/Synonyms: Phenergan is also known by the following brand names and/or synonyms3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25 Drug Category: Phenergan is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05 Dosage Forms: Tablets, suppositories, opthalmic drops, syrup Absorption: On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance Interactions: -->Interactions for Promethazine: Injection: Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride. Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered. Syrup, Tablets and Suppositories: CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose. Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories. Chemical IUPAC Name: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine : |
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