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PhenerganThis page contains recent news articles, when available, and an overview of Phenergan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Phenergan (when available) Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. For the treatment of allergic disorders, itching, nausea and vomiting Mechanism Of Action: Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. News Articles on Promethazine Big Pharma Swallows Bitter Pill - Aug 26, 2009 To combat nausea from her headache, medical staff administered a shot of Phenergan into one of Ms. Levine's arms using a method known as an "IV push. 24-7PressRelease.com (press release) 'Cowardly and selfish' - Aug 27, 2009 ...of the children and their father Gary Poxon (Bell) in June last year, stated that traces of the drug Phenergan were found in the children's stomachs. Bega District News The next generation of Kennedys - Aug 27, 2009 ...into a security barrier on Capitol Hill in Washington, and he claimed he was suffering a reaction to prescription drugs Phenergan and Ambien. Global Mistrial ruled in Hinson trial - Aug 28, 2009 He was also given the sleep medication Ambien and the anti-inflammatory pain medicine Toradol, as well as Phenergan, an antihistamine that can be used to Post Searchlight Physician, pharmacist arrested - Aug 28, 2009 ...the investigation revealed that LaFata backdated prescriptions for pharmacist Paul Nugent of Nugent Pharmacy for drugs like Dilaudid and Phenergan, Huron Daily Tribune Child killer mom deserves 25 years, says prosecutor - Aug 19, 2009 ...“Morgan obediently drank the Phenergan tablets her mother gave her believing them to be vitamins. Little did poor Morgan know that her mom was slowly Weekend Post An Unforgettable Salmonella Illness - Aug 7, 2009 Ron was re-hydrated with a liter of normal saline, and twenty-five milligrams of Phenergan, an anti-nausea medication, were introduced intravenously. Food Poison Journal Wyeth spent $901K in 2Q lobbying on health issues - Aug 21, 2009 ...jury award against Wyeth, to a Vermont professional musician who lost her arm to gangrene after an injection of Wyeth's anti-nausea drug Phenergan. Forbes A Sickly Medical Device Safety Act - Aug 10, 2009 Levine's gross professional misconduct involved the drug Phenergan, used since 1954 to control severe nausea. Its package warning stated that in routine Forbes Guest opinion: War on drugs picks wrong target in marijuana - Aug 7, 2009 Upon beginning use of marijuana, the patient was able to discontinue Neurontin (for nerve pain), Flexeril (for muscle spasm), Restoril and Phenergan (for Billings Gazette 'Manthe driven by devil to kill' - Aug 15, 2009 ...she had drugged them before suffocating Willow after she had succumbed to the Phenergan (an anti-histamine that induces sleep) tablets she had given her Weekend Post How to take a holiday from the kids! - Aug 7, 2009 Dose them liberally with Phenergan before take-off (it's antihistamine -- they'll need it with all that nasty circulated air) and allow them to run around Irish Independent Sá»± tháºt vá»? nám da - Aug 4, 2009 Do dược phẩm: Má»™t số thuốc khi sá» dụng có thể gây cảm ứng vá»›i ánh nắng nhÆ° Tetracyline, Sulfamid, thuốc lợi tiểu nhóm Thiazid, chống dị ứng Phenergan, 24 giờ Wohltätige Gehirnwäsche - Aug 8, 2009 Phenergan bestand. Ein anderer Mitarbeiter weckte die Patientin zwei- oder dreimal täglich und gab ihr Elektroschocks. In psychiatrischen Kliniken damals Telepolis A Brain Wider Than the Sky: A Migraine Diary - 14 Jul 2009 ...he sent me to the emergency room, where I began a ritual that continues to this day: a shot of Demerol piggybacked with the antiemetic drug Phenergan. PopMatters Arguments About Accountability May Have Dire Impacts for ... - Jun 19, 2009 She went to a clinic in Vermont for migraine treatment and was so nauseated that the clinicians administered Wyeth's Phenergan to help ease her discomfort, BioWorld Online Supreme Court decisions made in the 2008-09 term - Jul 1, 2009 The right arm of Diana Levine of Vermont was amputated after she was injected with Phenergan, an anti-nausea medicine made by Wyeth Pharmaceuticals. The Associated Press NEWS | SAN DIEGO Something to Share With You - Jun 22, 2009 Upon discharge a prescription for Ceclor and Phenergan was given. The discharge diagnosis was bronchitis. The father tells the ER physician in the second ER San Diego Daily Transcript (subscription) Patrick Kennedy Back to Work After Rehab - Jul 7, 2009 ...had appeared intoxicated when he crashed his car, but Kennedy claimed that he was merely disoriented from prescription medications Ambien and Phenergan. Politics Daily Alabama court upholds King license revocation - Jul 7, 2009 King administered intravenous injections of "Rocephin, Stadol, Totadol, Valium and Phenergan. RB immediately experienced burning pain in her arms and Charleston Gazette MARINA POLICE LOG: Presciption called in by suspect, not filled - Jun 28, 2009 HE ATTEMPTED TO ORDER THE DRUG PHENERGAN WITH CODEINE COUGH SYRUP. THE SUSPECT SAID THE DRUG WAS PRESCRIBED BY DOCTORS AT THE MARINA HEALTH CLINIC. The Salinas Californian State Board Revokes License of Wildwood Physician - Jul 9, 2009 Fiorinal, Halcion, Inderal, Esgic, and Tylenol #4 with codeine, etc., for CH, and at various times he gave her injections of Demerol and Phenergan. Cape May County Herald Physician in drug probe gives up right to prescribe - Jun 24, 2009 ...medicine April 11, 2001, after admitting to the State Medical Board of Ohio that he was chemically dependent on alcohol, OxyContin, and Phenergan. Toledo Blade Street urchins sniffing glue - Jun 28, 2009 ..."We take ganja throughout the daytime and at evening we take Jhakki, (jhakki is a cocktail of drugs such as unoctin, seduxen, phenergan and citin). The Daily Star Manthe sobs in court, saying 'I'm sorry, daddy' - Jun 24, 2009 After fetching her girls from school and saying they were “bunking work for the dayâ€?, she bought six phenergan tablets – an anti-histamine that induces Weekend Post Killer mom's dad will stand by her forever - Jun 27, 2009 On the Thursday morning she decided to kill her children, Manthe picked up her daughters early at Cambridge Primary School, stocked up on over 30 phenergan Weekend Post Những Ä‘iá»?u cần biết khi bị nám da - Jun 22, 2009 Do dược phẩm: Má»™t số thuốc khi sá» dụng có thể gây cảm ứng vá»›i ánh nắng nhÆ° Tetracyline, Sulfamid, thuốc lợi tiểu nhóm Thiazid, chống dị ứng Phenergan, VNExpress Phòng tránh viêm há»?ng mùa hè - Jun 29, 2009 ...có thể dùng các thuốc giảm ho nhÆ°: Siro phenergan, ho bổ phế, theralen... Vá»›i viêm há»?ng do vi khuẩn, cần phải dùng kháng sinh theo chỉ định của bác sÄ©. 24 giờ A Destructive Court - 20 Apr 2009 The plaintiff in this case lost an arm to gangrene after she was injected with the Wyeth ( WYE - news - people ) drug Phenergan. Forbes Transcript: Nouriel Roubini - 20 Apr 2009 The plaintiff in this case lost an arm to gangrene after she was injected with the Wyeth drug Phenergan. The drug was clearly labeled with a warning that Forbes Changing the landscape for FDA approvals - Apr 7, 2009 Levine involved administering Wyeth’s anti-nausea drug Phenergan by the “IV-pushâ€? method. Susan Levine, a professional musician, suffered from migraines and Mass High Tech Supreme Court ruling could prove disastrous - Apr 3, 2009 Levine, the justices upheld a $6.7 million award to a Vermont woman who lost her lower arm because of a botched injection of the anti-nausea drug Phenergan. Buffalo News Man accused of possessing more than 200 grams of cocaine - Apr 15, 2009 Promethazine is also sold under the brand names Pentazine and Phenergan. McKinley remained in the Travis County Jail on Wednesday with bail set at $100000. Austin American-Statesman Medical Device Bill To Be Introduced Following Recent Supreme ... - Mar 31, 2009 Last Wednesday, the Court ruled against Wyeth’s contention that it should not be subject to lawsuits in state courts for Phenergan, its anti-nausea drug, InjuryBoard.com The Tragedy of Supremely Bad Law - Mar 30, 2009 The tragedy was that Diana Levine, a musician in Vermont, lost her arm due to gangrene after a physician's assistant injected her with Phenergan, American Spectator Altria, Wyeth Cases Mark Shift in US Court’s Course - Mar 31, 2009 The justices upheld a $7 million award to a musician who lost her arm after being injected with Wyeth’s Phenergan nausea treatment. Bloomberg Family sues hospital, doctor over woman's death - Apr 2, 2009 At that time, Dr. Abdeen prescribed Toradol for Pamela's pain and Phenergan for her nausea to be administered intravenously. West Virginia Record For the record - Apr 13, 2009 US$6.7 million to a musician whose arm was amputated after promethazine (Phenergan) was errantly injected into an artery instead of a vein (Wyeth v. CMAJ Deborah Hill Cone: Famous names branded with shame - Mar 29, 2009 But now I just meekly accept my lot and pack extra-strength Phenergan and every Thomas the Tank Engine DVD ever made. New Zealand Herald Brand Names/Synonyms: Phenergan is also known by the following brand names and/or synonyms3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25 Drug Category: Phenergan is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05 Dosage Forms: Tablets, suppositories, opthalmic drops, syrup Absorption: On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance Interactions: -->Interactions for Promethazine: Injection: Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride. Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered. Syrup, Tablets and Suppositories: CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose. Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories. Chemical IUPAC Name: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine : |
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