Penciclovir

This page contains recent news articles, when available, and an overview of Penciclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Penciclovir (when available)

Pharmacology and use:
Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. Used to treat recurrent cold sores on the lips and face.

Mechanism Of Action:
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.

News Articles on Penciclovir

Evaluation of the in vitro skin permeation of antiviral drugs from ...  -  ‎Apr 2, 2009‎
This study evaluates the in vitro skin permeation and penetration of penciclovir and acyclovir from commercialized creams for the treatment of herpes 7thSpace Interactive (press release)

Topic of the week ¿ cold sores  -  ‎Apr 11, 2009‎
Creams containing the antivirals penciclovir or acyclovir are available from chemists. Apply as early as possible, at the first sensation of tingling. Melbourne Herald Sun

Lippenherpes, helfen die Cremes?  -  ‎Feb 22, 2009‎
Ein weiterer Wirkstoff ist Penciclovir. Cremes mit dem Inhalt heilen 0,7 Tage schneller. Dann dauert mein Herpes nicht 5,5 Tage sondern 4,8 Tage. Opinio

Institute for OneWorld Health Announces New Chief Medical Officer  -  04 Feb 2009
...quinolones), vaccines (Hepatitis A, Hepatitis B), antivirals (famciclovir, penciclovir, pleconaril), and topical antimicrobials (Bactoban). Business Wire (press release),

What treatments work for cold sores?  -  Jan 21, 2009
They include aciclovir (Zovirax) and penciclovir (Vetavir). It's possible that this treatment can make your cold sores less painful and help them heal more guardian.co.uk,

HERPES Was hilft, wenn’s juckt und brennt?  -  Jan 19, 2009
4 Euro), oder Penciclovir (Fenistil Pencivir) enthalten. Diese Wirkstoffe stoppen die Virusvermehrung. Auch gut: Creme mit Melissenextrakt (Lomaherpan, ca. Bild.de,

La riscossa dei farmaci generici  -  Dec 4, 2008
...ad agosto la crema antivirale Penciclovir ea settembre il Losartan (antipertensivo tra i più diffusi) e il Topiramate (usato nell'emicrania); La Repubblica,

Comparison Between Adenoviral and Retroviral Vectors for the ...  -  Nov 4, 2008
The efficacy and intensity of HSV1-sr39tk and HSV1-tk gene expression were determined by a direct comparison of [8- 3 H]-penciclovir ([8- 3 H]-PCV) cell Journal of Nuclear Medicine (subscription)

Herpes labialis Neues aus Therapie und Forschung  -  Nov 18, 2008
Die wichtigsten Substanzen in der Selbstmedikation sind die bewährten chemisch definierten Virustatika, das heißt die Nukleosidanaloga Penciclovir und Pharmazeutische Zeitung online,

Antivirale middelen bij Herpes simplex-virusinfecties  -  Nov 19, 2008
Voor lokaal toegepaste antivirale middelen (aciclovir, penciclovir) zijn de gegevens over doeltreffendheid tegenstrijdig: volgens sommige studies wordt de Gezondheid.be,

Antivirale middelen bij Herpes simplex-virusinfecties  -  Sep 29, 2008
In dit artikel wordt aandacht besteed aan de evidentie van doeltreffendheid van de antivirale middelen aciclovir, ganciclovir, penciclovir en valaciclovir, Medical facts,

Koortsblaasjes: hoe verzorg je ze zelf?  -  Aug 25, 2008
Het gaat om Aciclovir 5% (niet aangewezen voor kinderen onder 6 jaar) en Penciclovir 1% (niet aangewezen voor kinderen onder 15 haar). E-Gezondheid,

Soigner soi-même son bouton de fièvre  -  Aug 25, 2008
...directement sur le bouton et autour de celui-ci: Aciclovir 5% (contre-indiqué chez les enfants de moins de 6 ans) et Penciclovir 1% (contre-indiqué chez E-Santé.be,

PET Imaging of Cancer Immunotherapy  -  Jun 25, 2008
HSV1-tk converts thymidine to its phosphorylated form in addition to pyrimidine analogs such as acyclovir. ganciclovir. and penciclovir, leading to RedOrbit,

Management of Herpes Simplex Infections Reviewed  -  Jun 12, 2008
Topical regimens include penciclovir cream, 1% (apply every 2 hours during waking hours for 4 days) and acyclovir cream, 5% (apply 5 times a day for 4 days) Medscape (subscription)

Molecular-Genetic Imaging Based on Reporter Gene Expression  -  Jun 25, 2008
HSVI TK converts acycloguanosine prodrugs, such as acyclovir, ganciclovir, and penciclovir, into toxic compounds. Thus, HSVl TK kills target cells when RedOrbit,

Treating Herpes Naturally and with Fewer Side Effects  -  Mar 4, 2008
...antiviral medications for controlling herpes outbreaks, including aciclovir (Zovirax), valaciclovir (Valtrex), famciclovir (Famvir), and penciclovir. Natural News.com,

Cold sores are hard to keep under wraps  -  Feb 5, 2008
Treating sores with antiviral drugs, including acyclovir, valacyclovir, and penciclovir cream, can shorten their course by a day or two. Orlando Sentinel,

United States: Three Days In September: Generic Famvir ...  -  Sep 28, 2007
Novartis had argued that other prior art taught away from using penciclovir by reporting toxicity of penciclovir in humans. The district court rejected this Mondaq News Alerts (subcription),

Data on paid out low prevalence core.  -  Jun 14, 2007
Journal lycéen,Validation of ease of penciclovir of addictive pemoline zanamivir. Saharan countries partly shut in large noti. Premiums in paper which stilnoct personnel

Pharma Sector - Weekly Wrap-up: Will Merck's Vioxx Heir Arcoxia ...  Aug 25, 2006
Denavir or penciclovir cream 1% is a topical antiviral prescription medication indicated for the treatment of herpes labialis, also known as cold sores, in ... -Trading Markets

Treatment hits herpes with one-day wallop  Aug 26, 2006
...valacyclovir) and Famvir (famciclovir) - followed. An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs ... -Bradenton Herald

Barrier Therapeutics Launches Denavir(R) (Penciclovir Cream) in ...  Aug 23, 2006
...company developing and commercializing products in the field of dermatology, today announced the commercial launch of Denavir® (penciclovir cream) 1% in Canada ... -DG News

Pharma Sector - Weekly Wrap-up: Will Merck's Vioxx Heir Arcoxia ...  Aug 25, 2006
Denavir or penciclovir cream 1% is a topical antiviral prescription medication indicated for the treatment of herpes labialis, also known as cold sores, in ... -Trading Markets

Treatment hits herpes with one-day wallop  Aug 26, 2006
...valacyclovir) and Famvir (famciclovir) - followed. An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs ... -Bradenton Herald

Barrier Launches Denavir in Canada  Aug 23, 2006
Denavir (penciclovir cream) 1% is a topical antiviral prescription medication indicated for the treatment of herpes labialis, also known as cold sores, in ... -International News Service

Barrier Therapeutics Launches Denavir in Canada  Aug 23, 2006
...company developing and commercializing products in the field of dermatology, today announced the commercial launch of Denavir ® (penciclovir cream) 1% in ... -CCNMatthews

A one-day wallop for treating herpes  Aug 22, 2006
...and Famvir (famciclovir) -- followed. An ointment for cold sores, Denavir (penciclovir), is also available. Over the years, doctors ... -Miami Herald

Statistically Significant Phase IIb Clinical Results of ...  Aug 15, 2006
Currently approved treatments for herpes labialis are acyclovir cream, penciclovir cream, n-docosonal 10 percent cream, and the oral prodrug of acyclovir ... -Yahoo! News

FDA Approves Supplemental New Drug Application for Antiviral ...  Jul 31, 2006
...is Pregnancy Category B. Famvir is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir® (penciclovir cream). -DG News

Recent Developments in the Treatment of Cutaneous Viral Infections  Apr 20, 2006
Nucleoside analogues, including acyclovir, valacyclovir, penciclovir, and famciclovir, are currently the primary antiviral medications used in the management ... - Medscape (subscription)

Barrier Therapeutics Announces First Quarter 2006 Financial ...  May 2, 2006
Execution of an agreement with Novartis Consumer Health Canada, Inc., under which Barrier will market and distribute Denavir® (penciclovir cream) 1% in ... - Market Wire

Barrier Therapeutics Acquires the Canadian Distribution Rights For ...  Mar 15, 2006
...products in the field of dermatology, today announced that it acquired the exclusive rights to market and distribute Denavir ® (penciclovir cream) 1% in ... - PharmaLive.com

Barrier to distribute cold sore cream in Canada  Mar 16, 2006
Denavir (penciclovir cream) 1% is a topical antiviral prescription medication indicated for the treatment of herpes labialis, also known as cold sores, in ... - Pharmaceutical Business Review

Single-Dose Famvir(R) Treatment Found To Accelerate Healing Time ... Mar 3, 2006
Famvir, Pregnancy Category B, is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir(R) (penciclovir cream). ... - Finanzen.net,

Novartis: Strengthening Its Infectious Disease Portfolio  Feb 9, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - International News Service,

Novartis: strengthening its infectious disease portfolio  Feb 7, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - Pharmaceutical Business Review

Basic Science Investigation  Jan 20, 2006
...into different types of cells (293T, MCF7, MDA-MB-435, and U87MG) was analyzed and quantified by thymidine kinase (TK) assay using 8- 3 H-penciclovir (8- 3 H ... - Journal of Nuclear Medicine

Brand Names/Synonyms:
Penciclovir is also known by the following brand names and/or synonymsDenavir; PE2; Penciclovir; Penciclovir [Usan:Ban:Inn]; Penciclovirum [Inn-Latin]

Drug Category:
Penciclovir is categorized under the following by the FDA: Antivirals; ATC:D06BB06; ATC:J05AB13

Dosage Forms:
Topical cream

Absorption:
Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily.

Interactions:
Interactions for Penciclovir:

No information provided.

Chemical IUPAC Name:
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one

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