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PantoprazoleThis page contains recent news articles, when available, and an overview of Pantoprazole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Pantoprazole (when available) Pantoprazole is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production. Short-term (up to 16 weeks) treatment of erosive esophagitis. Mechanism Of Action: Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. News Articles on Pantoprazole Nycomed coping well with pantoprazole patent expiries - Aug 20, 2009 Pantoprazole sales slipped 1.4% to 316.2 million euros, given the loss of its substance patent in the major European markets in May (where sales fell 11.7%) Pharma Times Nycomed reports sustained momentum in second quarter 2009 - Aug 19, 2009 Pantoprazole turnover in Europe dropped only moderately after loosing patent protection in May. On a regional basis, most Nycomed markets performed in line PharmaLive.com (press release) Concomitant proton-pump inhibitors and clopidogrel associated with ... - Aug 21, 2009 Because pantoprazole is a much weaker inhibitor of cytochrome P450 2C19 than other PPIs, exposure to this agent was studied separately. Clinical Advisor You Just Got Rationed - Aug 27, 2009 Did your doc ever think your hyperacidity needed pantoprazole (Protonix), but your insurance only covered omeprazole (Prilosec)? The insurance company just Santa Barbara Independent Sun Pharma's US arm reliant on generic launches - Aug 13, 2009 The generic version of Wyeth's Protonix (pantoprazole) accounted for 46% of total revenues or about $22.1 million. According to two analysts, Livemint IOLCP to invest Rs 256 crore to expand chemicals and pharma operation - Aug 18, 2009 Besides, the company is also planning to foray into proton pump inhibitors business with a project to manufacture rabiprazole, omeprazole, pantoprazole, pharmabiz.com STADA with development as planned in H1/2009: Sales: EUR 755.2 ... - Aug 13, 2009 This also included generics with the active pharmaceutical ingredient Pantoprazole in time with the patent expiry in several EU countries, also including PharmaLive.com (press release) 9월부터 í??ê²½ 후 í˜¸ë¥´ëª¬ì œ 등 ì•½ì œ 5í•ëª© ê¸‰ì—¬ì‹ ì„¤ - Aug 27, 2009 ...프로톤 펌프 ì–µì œ ì£¼ì‚¬ì œ Omeprazole sodium(품명: 로섹주 등)·Pantoprazole sodium(품명: íŒ?í† ë¡?주 등)는 소화성 궤양으로 ì?¸í•œ 위장관 출혈환ìž? 중 활ë?™ì„± 메디포뉴스 간염약 내성치료ì—? 헵세ë?¼Â·ë°”ë?¼í?¬ë£¨ë“œ 급여 - Aug 27, 2009 ...프로톤 펌프 ì–µì œ ì£¼ì‚¬ì œ omeprazole sodium(로섹주 등), pantoprazole sodium(íŒ?í† ë¡?주 등) 등ì?€ 소화성 궤양으로 ì?¸í•œ 위장관 출혈환ìž? 중 활ë?™ì„± 출혈 ë˜?는 재출혈 데일리팜 美 í•ê¶¤ì–‘ì œ '오메프ë?¼ì¡¸' 주ë?„ì ? - Aug 19, 2009 ...ì?´ì–´ì„œ 'í”„ë ˆë°”ì‹œë“œ'(Prevacid, lansoprazole)ê°€ 18%, 'íŒ?í† í”„ë?¼ì¡¸'(pantoprazole)ì?´ 17%ë¡œ 많ì?´ 사용ë??다. ì œë„¤ë¦ ì˜¤ë©”í”„ë?¼ì¡¸ì?€ 미êµì—?ì„œ 2007ë…„ì—?야 ì œë„¤ë¦ìœ¼ë¡œ 출시 디지틀보사 ë ˆë³´ë¹„ë¥´ 내성치료 'ë°”ë?¼í?¬ë£¨ë“œ1mg' 급여 - Aug 10, 2009 ...소화성 ê¶¤ì–‘ìš©ì œì?¸ 프로톤 펌프 ì–µì œ ì£¼ì‚¬ì œ omeprazole sodium(로섹주 등), pantoprazole sodium(íŒ?í† ë¡?주 등) 등ì?€ ê³ ìœ„í—˜êµ°ì—? 급여가 확대ë??다. 데일리팜 HSE 'could save millions on drugs' - Jul 13, 2009 The other drugs highlighted by Dr Reilly which could reportedly be bought at a fraction of the current cost include Lansoprazole, Pravastatin, Pantoprazole, Irish Health Adverse Outcomes Associated With Use of Proton Pump Inhibitors and ... - Jun 30, 2009 Pantoprazole and esomeprazole, other PPIs also widely used in different institutions, do not inhibit CYP450 2C19. 4 Moreover, in a Canadian trial including Journal of American Medical Association (subscription) EMEA issues warning on possible clopidogrel-PPI interaction, but ... - Jun 19, 2009 Other PPIs available on prescription include esomeprazole, lansoprazole, pantoprazole, and rabeprazole. EMEA says the new concern "relates to several TheHeart.Org In the Literature - Jul 13, 2009 Subanalyses found similarly increased risk among patients prescribed omeprazole and rabeprazole, but those taking lanzoprazole and pantoprazole were not The Hospitalist Online Expect 20-25% upside in Cadila Healthcare: Parmar - Jun 25, 2009 It has JV with Hospira, which can compensate for the loss which it can have from Pantoprazole. Currently it has a margin of 20%, likely to have a PAT CAGR Moneycontrol.com H 2 antagonists an alternative to PPIs to prevent bleeds in ... - Jul 10, 2009 With regard to PPIs and their purported interaction with clopidogrel, he believes this is not a class effect: "Pantoprazole doesn't seem to interact, TheHeart.Org Nycomed receives Marketing Authorization for Pantoprazole 20mg OTC ... - Jun 17, 2009 Pantoprazole, the active ingredient of PANTOZOL Control®, is a well-established therapy for acid-related gastrointestinal diseases that has been used by PipelineReview.com (press release) Reducing bleeding risk in patients who need triple antithrombotic ... - Jul 8, 2009 I do give PPIs as prophylaxis to patients on triple antithrombotic therapy, but I tend to use pantoprazole and esomeprazole, which have the least TheHeart.Org Could heartburn drugs cause 'rebound' symptoms? - Jul 1, 2009 PPI drugs include omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. Most PPIs are only available on prescription, although omeprazole guardian.co.uk Repeated Episodes of Neutropenia Triggered by Mirtazapine - Jun 30, 2009 Although erythromycin, promethazine, pantoprazole, and metoclopramide have been associated with blood dyscrasias, these medications were longstanding Psychosomatics (subscription) Antacids are not meant as a long-term treatment - Jun 29, 2009 For example, proton pump inhibitors (dexlansoprazole, esomeprazole, lansoprazole, omeprazole, omeprazole/sodium bicarbonate, pantoprazole, and rabeprazole) Post-Bulletin Pharmaceutical industry: Duty slashed to 5% on import of raw ... - Jun 23, 2009 ...customs duty has been reduced on import of aflacalcidole, flurbiprofen, aspirin, amlodipine, loratadine, pantoprazole sodium, deferirone, lamivudine, Daily Times Milking Live Algae, No Half-appendectomies w/ Public Insurance ... - Jun 30, 2009 ...but by a "germ" called a "Helicobacter pylori", which can be cured by "Amoxicillin + Metronidazole + Pantoprazole (a Proton Pump Inhibitor)". American Chronicle Automédication : un IPP sans ordonnance - Jul 3, 2009 Pantoprazole 20 mg, propriété du laboratoire Nycomed, vient d'obtenir une AMM européenne et pourra bientôt être délivré sans ordonnance au comptoir Pharmaceutiques Új szer a láthatáron reflux-betegeknek - Jun 28, 2009 A svájci központú Nycomed az Európai Bizottságtól forgalmazási engedélyt kapott Pantoprazole-készÃtményének öt alkalmazására, melyeket ezentúl huszonhét Weborvos Generic Drugs Eat Away at Big Pharma - Caraco Pharmaceuticals (CPD ... - 20 Apr 2009 ...reflecting uncertainty over the at-risk launch of generic Protonix (pantoprazole) and lower sales of oxcarbazepine since the exclusivity period has Motley Fool Myocardial Infarction In Pregnancy - 20 Apr 2009 Her symptoms seemed to improve after taking ranitidine and pantoprazole, and she assumed the heartburn and GI upset were a normal part of pregnancy. ADVANCE for Physician Assistants Platelet-function test finds fault with omeprazole/clopidogrel ... - Apr 10, 2009 The study, published in the April issue of Thrombosis and Haemostasis, hints that other PPIs tested—pantoprazole and esomeprazole—might be a safer bet for TheHeart.Org Smokers’ Lung Treatment May Fail to Fire Up Nycomed Bidders - Apr 8, 2009 Nycomed needs Daxas to offset sales that the company will lose when patent protection expires for its Pantoprazole heartburn remedy. Bloomberg The drug–drug interaction between proton pump inhibitors and ... - Mar 30, 2009 An exception was the proton pump inhibitor pantoprazole, which did not show the above associations. Juurlink and colleagues speculate as to why: unlike the CMAJ Pharma companies headed for slower earnings growth: analysts - Apr 19, 2009 ...in the 2008 January-March quarter by its six-month exclusive right in the US generic market for three drugs—Oxcarbazepine, Pantoprazole and Ethyol. Livemint Drug firms may exceed growth targets - Apr 19, 2009 Analysts feel Sun Pharma's performance in the fourth quarter will be affected due to diminishing sales for pantoprazole and production issues with Caraco, Business Standard Customs sacks NAIA-based employee for releasing P9 million worth ... - Apr 14, 2009 ...warehouseman III, will be investigated for the questionable release of 61 boxes of 21960 vials of 40-mg Pantoloc Pantoprazole that arrived in January. GMA news.tv Sector Watch - Apr 10, 2009 20 per cent-plus decline in net sales and profit in the fourth quarter due to the absence of exclusivity-based Pantoprazole and Oxcarbazepine supplies. Business Standard Customs warehouseman sacked over P9m in drugs - Apr 14, 2009 ...for his alleged involvement in clearing last January 61 boxes of 21960 vials of 40-mg Pantoloc Pantoprazole manufactured by Nicomed of Germany. Manila Standard Today Generic Version of Topamax® Will Save Upstate New Yorkers Millions - Apr 7, 2009 ...and also includes generic and over-the-counter omeprazole (brand-name Prilosec®) and generic pantoprazole (brand-name Protonix®). ReadMedia (press release) Medicines turn off acid pump - Mar 30, 2009 Other members are Prevacid (lansoprazole), Prilosec (omeprazole), AcipHex (rabeprazole) and Protonix (pantoprazole). These drugs pose a small risk of South Coast Today Customs recovers P9 million worth of missing anti-ulcer drugs - Apr 7, 2009 The shipment, which arrived in January, comprised of 61 boxes of 21960 vials of 40-milligran Pantoloc Pantoprazole. “If these were not recovered, GMA news.tv Managing acid reflux with less - Mar 31, 2009 Other proton pump inhibitors include generic omeprazole, generic pantoprazole, Prilosec, Protonix, Prevacid and Nexium. My recommendation depends on more Times Daily On the Pulse - 10th April 2009 - Apr 10, 2009 However, the absence of such an effect for pantoprazole, which does not inhibit cytochrome P450 and hence would not be expected to interact with clopidogrel OnMedica Acid reflux disease - 18 Mar 2009 Proton pump inhibitors like esomeprazole (Nexium), lansoprazole (Ogastro, Lanzap), omeprazole (Losec), pantoprazole (Pantecta), and rabeprazole (Pariet) are Jamaica Gleaner Acute allergic interstitial nephritis after use of pantoprazole - Mar 4, 2009 He had started taking oral pantoprazole (40 mg daily) 6 weeks earlier. The patient had a history of coronary artery disease and was taking acetylsalicylic CMAJ Font: smallerdefaultlargerlargest - Mar 10, 2009 Kidney disease: People with severe kidney disease should generally not take more than 20 mg of pantoprazole daily. People with severe kidney disease should Canada.com More evidence antacid meds reduce Plavix efficacy - Mar 3, 2009 Previous studies have suggested that PPIs, other than pantoprazole, prevent the liver from converting clopidogrel to its active form. CTV.ca A satisfactory 2008 for Nycomed - Feb 24, 2009 Key products developed strongly, with the exception of Pantoprazole sales in the United States and Canada, which is due to “at-riskâ€? launch and generic PharmaLive.com (press release) Is Esomeprazole The Best Choice For Reflux Esophagitis Patients? - Mar 4, 2009 The results indicated that esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and Medical News Today (press release) Jerry Springer Star William Windsor, aka, "Baby Man": The Cause of ... - Mar 16, 2009 An analysis of Windsor's liver showed him testing positive for 0.11 grams of ethyl alcohol, as well as pantoprazole, which treats acid reflux, Phoenix New Times Health insurers push generics, but what are patients getting? - Mar 8, 2009 Substitutes for the heartburn drug Nexium are omeprazole (generic for Prilosec) and pantoprazole (generic for Protonix). "A lot of people don't understand Chicago Tribune More Concern About Plavix and Proton-Pump-Inhibitors - Mar 9, 2009 PPIs available by prescription include omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), About - News & Issues Caraco Pharma Awaits FDA Inspection in May - Feb 25, 2009 ...reflecting uncertainty over the at-risk launch of generic Protonix (pantoprazole) and lower sales of oxcarbazepine since the exclusivity period has Seeking Alpha MoH suspends use, sales of Yixin Pharma injection - Mar 8, 2009 INTERFAX-CHINA - The Ministry of Health (MoH) has suspended the use and sales of pantoprazole sodium injections manufactured by Jilin Yixin Pharmaceutical Interfax China EMEA calls for Raptiva suspension, issues latest recommendations - Feb 20, 2009 The CHMP is also recommending approval for Nycomed’s over-the-counter versions of its own heartburn drug Pantozol (pantoprazole) and Teva’s generic version Pharma Times Brand Names/Synonyms: Pantoprazole is also known by the following brand names and/or synonymsBY 1023; CHEMBANK1787; Pantoloc; Pantoprazol [Inn-Spanish]; Pantoprazole; Pantoprazole Na; Pantoprazole Sodium; Pantoprazole [Usan:Ban:Inn]; Pantoprazolum [Inn-Latin]; Pantoprozole; Protonix; Protonix I.V.; Protonix Iv Drug Category: Pantoprazole is categorized under the following by the FDA: Anti-ulcer Agents; Proton-pump Inhibitors; ATC:A02BC02 Dosage Forms: TABLET (ENTERIC-COATED) Absorption: Pantoprazole is well absorbed; it undergoes little first- pass metabolism resulting in an absolute bioavailability of approximately 77%. Interactions: Interactions for Pantoprazole: Pantoprazole is metabolized through the cytochrome P450 system, primarily the CYP2C19 and CYP3A4 isozymes, and subsequently undergoes Phase II conjugation. Based on studies evaluating possible interactions of pantoprazole with other drugs, no dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam (and its active metabolite, desmethyldiazepam), diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, an oral contraceptive (levonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole, or amoxicillin. Clinically relevant interactions of pantoprazole with other drugs with the same metabolic pathways are not expected. Therefore, when coadministered with pantoprazole, adjustment of the dosage of pantoprazole or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. Because of profound and long lasting inhibition of gastric acid secretion, pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (eg, ketoconazole, ampicillin esters, and iron salts). Laboratory Tests There have been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving most proton pump inhibitors, including pantoprazole. An alternative confirmatory method should be considered to verify positive results. Chemical IUPAC Name: 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzoimidazole : |
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