Orphenadrine Citrate

This page contains recent news articles, when available, and an overview of Orphenadrine Citrate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Orphenadrine Citrate (when available)

Pharmacology and use:
Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia. Indicated for the treatment of Parkinson's disease.

Mechanism Of Action:
Orphenadrine binds to both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

News Articles on Orphenadrine

Officer, kids wait 2 hours for mom's return  -  Jan 14, 2009
...a bottle of medicine containing 55 dosage units of 100 mg Orphenadrine Citrate, and a partially burned marijuana cigarette, according to the report. Daytona Beach News-Journal,

FDA Sends Warning Letter to Sandoz Regarding Manufacturing Facility  -  Aug 26, 2008
...your firm initiated an investigation of Orphenadrine Citrate ER 100 mg tablets, lot MK062041, which were rejected due to failing dissolution results. PharmaLive.com (press release),

FDA Inspection Prompts Recall of 55 Products  -  Sep 5, 2008
...drug finasteride, chemotherapy agent irinotecan HCl, anti-emetic ondansetron HCl and muscle-relaxant orphenadrine citrate were not affected by the recall. FDA news (subscription),

FDA finds Sandoz paperwork troubling: Letter cites quality control ...  -  Aug 27, 2008
The plant, which employs about 450, makes generic medicines, including the heart drug metoprolol succinate, muscle relaxer orphenadrine citrate and Trading Markets (press release),

Plant’s Emissions Will Be Focus Of Laurelton Hearing On Tuesday Feb 16, 2006
...drug distributor of its parent company, Novartis—is scheduled to end production in Laurelton of the popular muscle relaxant, orphenadrine citrate, by 2007. ... - Queens Chronicle,

Brand Names/Synonyms:
Orphenadrine Citrate is also known by the following brand names and/or synonymsAntiflex; BS-5930; Banflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Flexoject; Mephenamine; Mio-Rel; Myolin; Myotrol; Norflex; O-Methyldiphenhydramine; Orfro; Orphenadine; Orphenadrin; Orphenadrine; Orphenadrine Citrate; Orphenate; Orphenedrine; WS 2434

Drug Category:
Orphenadrine Citrate is categorized under the following by the FDA: Muscle Relaxants; Antiparkinson Agents; Antidyskinetics; Skeletal Muscle Relaxants; ATC:M03BC01; ATC:N04AB02

Dosage Forms:
TABLET (EXTENDED-RELEASE)

Absorption:
Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Interactions:
Interactions for Orphenadrine:

No information provided.

Chemical IUPAC Name:
N,N-dimethyl-2-[(2-methylphenyl)-phenyl-methoxy]-ethanamine

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