Ondansetron

This page contains recent news articles, when available, and an overview of Ondansetron but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Ondansetron (when available)

Pharmacology and use:
Ondansetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Ondansetron is a highly specific and selective serotonin 5-HT₃ receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. For treatment of chemotherapy-induced nausea and vomiting

Mechanism Of Action:
Ondansetron is a selective serotonin 5-HT₃ receptor antagonist. The serotonin 5-HT₃ receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT₃ receptors located on vagal efferents to initiate the vomiting reflex. Therefore Ondansetron works by blocking the reception of serotonin at these 5-HT₃ receptors.

News Articles on Ondansetron

MonoSol Rx and Strativa file NDA for ondansetron orally dissolving ...  -  ‎Apr 10, 2009‎
The new drug application (NDA) is supported by positive data from completed pivotal studies in which ondansetron orally dissolving film strip (ODFS) Trading Markets (press release)

BioWorld Today April 10, 2009  -  ‎Apr 9, 2009‎
MonoSol Rx, of Warren, NJ, has submitted a new drug application to the FDA for the orally dissolving film strip (ODFS) formulation of ondansetron. TMCnet

PRX: Submits NDA to FDA for Orally Dissolving Film Strip Form of ...  -  ‎Apr 9, 2009‎
The NDA is supported by positive data from completed pivotal studies in which ondansetron ODFS demonstrated bioequivalence against GlaxoSmithKline's Zofran Trading Markets (press release)

Palonosetron "Preferred" 5-HT3 Antagonist for Emesis Prevention in ...  -  ‎Apr 2, 2009‎
Following the development of the first generation 5-HT3 receptor antagonists, such as ondansetron and granisetron, in the late '80s and early '90s, SYS-CON Media (press release)

美 경구 필름형 항구토제 승�?�신청  -  ‎Apr 13, 2009‎
...미국�?서 모노솔 Rx(MonoSol Rx)는 파 파마슈티컬(Par Pharmaceutical)과 경구 필름형 ‘온단세트론’(ondansetron)�? 대한 승�?��?� 신청했다. 디지틀보사

Leki przeciwwymiotne ułatwiają leczenie ostrego nieżytu żołądkowo ...  -  ‎Apr 6, 2009‎
Autorzy dokonali metaanalizy 6 badań z randomizacją, w których oceniano ondansetron. Pojedyncze badania dotyczyły pozostałych leków. Medycyna Praktyczna

Palonosetron "bevorzugter" 5-HT3-Rezeptorantagonist zur Vorbeugung ...  -  ‎Apr 3, 2009‎
Nachdem in den späten 80er- und frühen 90er-Jahren mit Ondansetron und Granisetron die erste Generation von 5-HT3-Rezeptorantagonisten entwickelt worden ist news aktuell (Pressemitteilung)

BioAlliance Pharma SA : Full-Year Accounts for 2008  -  ‎Mar 5, 2009‎
...the Phase III trial on acyclovir Lauriad® (BA021) and acquisition of Europe-wide licenses for two products (ondansetron Oral Spray and ondansetron Earthtimes (press release)

MonoSol Rx Achieves Milestones for Additional $2.5 Million Private ...  -  ‎Mar 12, 2009‎
Completed bioequivalence (BE) studies for a thin film formulation of ondansetron, an anti-emetic therapy, triggering a milestone payment to MonoSol Rx from PR Newswire (press release)

Common Nausea Drug May Reduce Opioid Withdrawal Symptoms  -  ‎Feb 20, 2009‎
The researchers found that drug ondansetron can block certain receptors involved in withdrawal symptoms. During the study, the researchers recruited eight MedIndia

Par Pharmaceutical Companies Inc Q4 2008 Earnings Call Transcript  -  ‎Mar 3, 2009‎
...in many of the company’s other generic product, as well as lower royalties which decline by $15 million, primarily from lower sales of ondansetron. Seeking Alpha

Skipping antiemetic medication on day 2 improves outcome  -  ‎Mar 10, 2009‎
Before receiving highly/ moderately emetogenic chemotherapy (day 1), patients were given IV ondansetron 16 mg, dexamethasone 20 mg, and ranitidine 50 mg. American Journal of Hemotology and Oncology

MDS Pharma Services Scientist named to Notable People in R&D list  -  ‎Mar 11, 2009‎
He was the lead US clinical pharmacology scientist for Glaxo’s Zofran (ondansetron), – an anti-emetic used to control post-operative and PharmaLive.com (press release)

Eurand NV Q4 2008 Earnings Call Transcript  -  ‎Mar 5, 2009‎
I’d now like to turn to EUR-1025, a once a day formulation of the anti-emetic real front or ondansetron. We filed an IND with the FDA in December and Seeking Alpha

Nausea Drug Shows Promise Against Opioid Addiction  -  ‎Feb 19, 2009‎
Initial tests in mice showed that the drug Ondansetron (Zofran) blocks certain 5-HT3 receptors involved in withdrawal symptoms, the researchers said. HealthCentral.com

Toddler prescribed wrong drug in Brighton  -  ‎Feb 19, 2009‎
But Ms Laker noticed the prescription was for two months worth of ondansetron, an anti-vomiting drug usually given to people before and after chemotherapy. The Argus.co.uk

Un medicamento para las nauseas promete contra la adicción a los ...  -  ‎Feb 23, 2009‎
Una investigación llevada a cabo por científicos de la Universidad de Stanford encontró que ondansetron podía aliviar los síntomas sin los efectos Info7

BioAlliance Pharma SA : Résultats annuels 2008  -  ‎Mar 5, 2009‎
...l’essai de phase III d’aciclovir Lauriad® (BA021) et l’acquisition des licences européennes des produits ondansetron Oral Spray et ondansetron RapidFilm Euroinvestor

Lista pod lupą aptekarzy  -  ‎Mar 16, 2009‎
Ondansetron kupujemy za 19,18 zł, a tropisetron za 51,22 zł. Z zadowoleniem Towarzystwo Farmaceutyczno-Ekonomiczne przyjęło natomiast wykreślenie ivabradiny NaszeMiasto.pl

GAZZETTA UFFICIALE: SOMMARIO (3)  -  ‎Mar 10, 2009‎
Autorizzazione all'immissione in commercio del medicinale per uso umano "Ondansetron Actavis". Autorizzazione all'immissione in commercio del medicinale per ANSA Valle d'Aosta

지연형 구토�? 카�?�트릴, 최대 10정까지 급여  -  ‎Feb 28, 2009‎
...개정내역�? 따르면 지연형구토�? 투여�?�는 ondansetron(최대 5�?�), dolasetron(최대 4�?�), tropisetron(최대 5�?�), ramosetron(최대 5�?�)�?� �?칙으로 하�?�, 메디게이트뉴스

[해외정보] �?�남아시아 시장정보  -  ‎Mar 1, 2009‎
...�?한 500개�?� 부�?합 �?�약품�?는 Viagra(sildenafil citrate), antibiotic moxclav, Ferogen syrup(ferrous fumarate)와 Generic anti-emetic ondansetron�?� �?해 디지틀보사

Prosecutions loom for 110 drugmakers in India  -  04 Feb 2009
...the antibiotic moxclav, Ferogen syrup (ferrous fumarate) and the generic anti-emetic ondansetron are among the 500 drugs found to be substandard. In-PharmaTechnologist.com,

Price checks brings PBS bill down  -  04 Feb 2009
From 1 August the NSAID meloxicam, along with ondansetron, doxorubicin and mitozanthrone, will have their prices reduced by up to two thirds. 6minutes,

Ondansetron for severe nausea and vomiting in early pregnancy  -  Jan 21, 2009
There isn't enough evidence from research to tell us whether ondansetron (brand name Zofran) reduces severe nausea and vomiting in pregnancy (called guardian.co.uk,

Late-night call leads to nightmare  -  Jan 10, 2009
He gave me something called Zofran (ondansetron) in case I felt nauseous from the pain medication,�? she said, weakly. “Okay,�? said Ms. J. “It's not uncommon Clinical Advisor,

BioAlliance Pharma Publishes Its 2009 Financial Calendar  -  Jan 15, 2009
In May and August 2008, the company expanded its product portfolio by acquiring the Europe commercial rights to, respectively, ondansetron Oral Spray (OS) WELT ONLINE,

Side effects of chemotherapy  -  Jan 21, 2009
It can be prevented by taking drugs such as ondansetron. Lorazepam, a type of tranquilliser, can also help you feel less sick. Fewer white blood cells: guardian.co.uk,

An Appraisal of Potential Drug Interactions in Cigarette Smokers ...  -  Jan 13, 2009
13 – 15 Other common drugs metabolized by CYP1A2 are cyclobenzaprine, duloxetine, lidocaine, melatonin, mirtazapine, ondansetron, ramelteon, ropinirole, Journal of the American Podiatric Medical Association (subscription)

Quando è colpa dei farmaci  -  Jan 21, 2009
La terapia antiemetica con ondansetron durante chemio-radioterapia da stipsi per il blocco dei recettori 5-HT3 serotoninergici. La Repubblica,

BioAlliance Pharma Adopts the AFEP-MEDEF Guidelines on Executive ...  -  Dec 23, 2008
In May and August 2008, the company expanded its product portfolio by acquiring the Europe commercial rights to, respectively, ondansetron Oral Spray (OS) PharmaLive.com (press release),

Monosol Rx Successfully Completes Pivotal Bioequivalence Studies  -  Dec 3, 2008
The ondansetron thin film product is being developed for the prevention of chemotherapy-induced nausea and vomiting, prevention of nausea and vomiting Pharmaceutical Online (press release),

MonoSol Rx announces completion of Pivotal Bioequivalence Studies ...  -  Dec 2, 2008
...(RTTNews) - MonoSol Rx announced the completion of all pivotal bioequivalence studies for a thin film formulation of ondansetron. Subject to final review of RTT News,

Prostrakan and Paladin Complete Agreement for Abstral(R) and ...  -  Dec 22, 2008
The largest molecule in this category is ondansetron with approximately $19 million in sales. "It is our intention to submit these two innovative products Trading Markets (press release),

Squashing a Queasy StomachHow to avoid nausea and vomiting during ...  -  Dec 23, 2008
The regimen includes a 5-HT3 antagonist—Anzemet (dolasetron), Kytril/Sancuso (granisetron), Zofran (ondansetron), or Aloxi (palonosetron)—given before Curetoday.com (press release),

Non-Hodgkin Lymphoma & Supportive CareTreanda and Sancuso patch ...  -  Dec 23, 2008
Sancuso and other 5-HT3 inhibitors, such as Zofran (ondansetron) and Aloxi (palonosetron), interrupt that signal. Read more about management of nausea and Curetoday.com (press release),

GlaxoSmithKline cuts 200 jobs at County Durham factory  -  Dec 3, 2008
Zofran, or Ondansetron, was developed by Glaxo scientists in the 1980s, and is one of the drugs made by the factory. It is used to prevent nausea and The Observer,

Inventor Profile: Signaling the Decline of Alcoholism  -  Dec 18, 2008
...drugs topiramate, typically used to treat seizures and migraine headaches, and ondansetron, used to treat chemotherapy-induced nausea and vomiting. Media Newswire (press release),

A claim that the drug Baclofen can 'cure' alcoholism has received ...  -  Dec 15, 2008
He also says trials in the United States of the anti-convulsion drug Topiramate and Ondansetron, a drug given to patients undergoing chemotherapy, Irish Times,

GSK cuts jobs in Durham due to decline in demand for Zofran  -  Dec 4, 2008
However the site’s principal product is Zofran (ondansetron) for chemotherapy-induced nausea, which is already coming under pressure from generic Pharma Times,

Par Pharmaceutical Companies, Inc. - SWOT Analysis ...  -  Dec 9, 2008
...year (FY) ended December 2007, an increase of 6.1% over 2006 primarily due to new product launches and royalties on the sales of ondansetron tablets. Live-PR.com (Pressemitteilung),

BioAlliance va réduire ses coûts en 2009  -  Dec 3, 2008
Enfin, BioAlliance veut aussi se focaliser sur l'enregistrement en Europe de l'Ondansetron Rapidfilm, dont l'approbation en Europe est prévu au premier Le Point,

GSK 英 공장 200명 �?�?  -  Dec 3, 2008
...�?�는 항구토제 ‘조프란’(Zofran, ondansetron)�?� 제네릭 경�? 때문�? 매출�?� 급격히 �?소했기 때문�?�다. �?�와 관련, GSK는 지난달�?�?� ‘�?�믹탈’(Lamictal, 디지틀보사,

BioAlliance Pharma : va devoir réduire la voilure  -  Dec 3, 2008
...lancement de quatre produits : Loramyc aux Etats-Unis, ondansetron RapidFilmTM, ondansétron 0S (Oral Spray) et acyclovir Lauriad", rappelle le groupe. Boursier.com,

Groundbreaking Discovery May Lead to Stronger Antibiotics - 2008-11-16  -  Nov 16, 2008
Ondansetron, also known as Zofran, is typically used to prevent nausea and vomiting following surgery or chemotherapy. It works by blocking the hormone exduco.net,

BioAlliance Pharma SA : Q3 2008: Significant Progression and ...  -  Oct 29, 2008
The company continued to extend its product portfolio through the acquisition from Swiss company APR of a new anti-emetic containing ondansetron developed WELT ONLINE,

Eurand Reports Recent Developments and Third Quarter and Year-to ...  -  Nov 7, 2008
...six new collaborations; and * Met with FDA and defined clinical and regulatory development plans for EUR-1025 (once-daily formulation of ondansetron). MarketWatch

Par Pharmaceutical Companies Inc. Q3 2008 Earnings Call Transcript  -  Nov 7, 2008
Next our two Ondansetron development programs. Zensana, an oral spray formulation recently completed bioequivalency studies with mixed results. Seeking Alpha,

NovaDel Reports Financial Results for Third Quarter 2008  -  Nov 12, 2008
NovaDel's partner for its Zensana(TM) (ondansetron oral spray) product candidate, Par Pharmaceuticals, recently announced that it had completed MarketWatch

Par Pharmaceutical Reports Third Quarter 2008 Results  -  Nov 6, 2008
...product such as metoprolol, partially offset by lower royalties of ondansetron tablets and lower sales of higher margin products such as propranolol. MarketWatch

Ms. Einarson Replies  -  Nov 3, 2008
Ms. Einarson has received unrestricted research grants from GlaxoSmithKline for studying ondansetron in pregnancy and from Organon for studying mirtazapine Am J Psychiatry (subscription)

Par Pharmaceutical Companies, Inc. - SWOT Analysis ...  -  Nov 19, 2008
...year (FY) ended December 2007, an increase of 6.1% over 2006 primarily due to new product launches and royalties on the sales of ondansetron tablets. PR-Inside.com (Pressemitteilung),

SCOLR Pharma Inc (AMEX:DDD) to Hold Q3 2008 Earnings  -  Oct 31, 2008
The Company is engaged in development of CDT-based extended-release formulations of ibuprofen, pseudoephedrine, ondansetron, rivastigmine, and risperidone, TransWorldNews (press release),

Par Pharmaceutical Reports Third Quarter 2008 Results  -  Nov 6, 2008
...product such as metoprolol, partially offset by lower royalties of ondansetron tablets and lower sales of higher margin products such as propranolol. istockAnalyst.com (press release),

BioAlliance Pharma SA : Chiffre d’affaires du troisième trimestre 2008  -  Oct 29, 2008
Ce produit s’ajoute à l’acquisition du spray d’ondansetron, acquis au premier semestre auprès de la société NovaDel, et permet à BioAlliance de disposer de Business Wire (press release),

Oral Ondansetron Reduces Need for IV Fluids in Gastroenteritis  -  Oct 1, 2008
The role of oral ondansetron in children with vomiting as a result of acute gastritis/gastroenteritis who have failed oral rehydration threrapy: a AAP Grand Rounds (subscription),

Drug-Delivery Tech Firms Find Bright Spot in the Economy  -  Oct 13, 2008
Under the deal, Par got the exclusive rights in the United States to commercialize the thin-film version of ondansetron, a prescription drug to prevent NJBIZ,

BioAlliance Pharma Was Informed That a Civil Action Was Filed by ...  -  Oct 13, 2008
In May and August 2008, the company expanded its product portfolio by acquiring the Europe commercial rights to, respectively, ondansetron Oral Spray (OS) WELT ONLINE,

Breast cancer technology  -  Oct 18, 2008
...they require an antiemetic drug to reduce nausea and vomiting, compared to the 64 percent who received ondansetron and 42 percent who received nothing. Sampson Independent,

BioAlliance Pharma SA : acts in favour of patients' quality of ...  -  Oct 6, 2008
In May and August 2008, the company expanded its product portfolio by acquiring the Europe commercial rights to, respectively, ondansetron Oral Spray (OS) MarketWatch

An Update on Chronic Pain Treatments  -  Oct 14, 2008
Antiemetics include ondansetron and promethazine. Other pain medications include opioids, butalbital, and hydrocodone. Dr. Robbins uses steroids, Medscape (subscription)

Cost of perscriptions vary widely  -  Oct 4, 2008
The generic form of Zofran, called ondansetron, received FDA approval in December 2006. More curious than angry, Mr. Catalano, 70, said he called a regional Pittsburgh Post Gazette,

Acupuncture helps ease post-surgical ills  -  Sep 25, 2008
One group received acupuncture, another group was given an anti-nausea drug called ondansetron, sold by GlaxoSmithKline under the brand name Zofran, The News International,

Brand Names/Synonyms:
Ondansetron is also known by the following brand names and/or synonymsZophren; Zofran; Zudan; Zofran ODT

Drug Category:
Ondansetron is categorized under the following by the FDA: Anti-anxiety Agents; Antipsychotics; Antipruritics; Antiemetics; Serotonin Antagonists; ATC:A04AA01

Dosage Forms:
TABLET; LIQUID

Absorption:
Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism.

Interactions:
Interactions for Ondansetron: Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. On the basis of limited available data, no dosage adjustment is recommended for patients on these drugs. Phenytoin, Carbamazepine, and Rifampicin: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampicin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs.1,3 Tramadol: Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small studies indicate that ondansetron may be associated with an increase in patient controlled administration of tramadol.4,5 Chemotherapy: Tumor response to chemotherapy in the P 388 mouse leukemia model is not affected by ondansetron. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron. In a crossover study in 76 pediatric patients, I.V. ondansetron did not increase blood levels of high-dose methotrexate.

Chemical IUPAC Name:
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydrocarbazol-4-one

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