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OndansetronThis page contains recent news articles, when available, and an overview of Ondansetron but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Ondansetron (when available) Ondansetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. For treatment of chemotherapy-induced nausea and vomiting Mechanism Of Action: Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT3 receptors located on vagal efferents to initiate the vomiting reflex. Therefore Ondansetron works by blocking the reception of serotonin at these 5-HT3 receptors. News Articles on Ondansetron Sagent Pharmaceuticals Launches Ondansetron in 5% Dextrose ... - Aug 4, 2009 Sagent's ondansetron in 5% dextrose injection in premix bags is the generic equivalent of GlaxoSmithKline's ZOFRAN(R) Injection Premixed. PR Newswire (press release) Drug Relieves Nausea, Vomiting Days After Chemotherapy - Aug 4, 2009 As antiemetics and serotonin receptor antagonists, dexamethasone and ondansetron greatly reduce CINV events up to 24 hours after chemotherapy, Oncology Nursing News Descending serotonergic facilitation and the antinociceptive ... - Aug 7, 2009 Two weeks later in vivo electrophysiology was performed, comparing the effects of spinal ondansetron (10- 100 mug/50mul) or systemic pregabalin (0.3 7thSpace Interactive (press release) Eurand NV Q2 2009 Earnings Call Transcript - Aug 6, 2009 Turning now to EUR-1025, our once-a-day proprietary formulation of the anti-emetic Zofran or ondansetron. We filed an IND with the FDA in December 2008 and Seeking Alpha Drug Manufacturers Trubion Pharmaceuticals (TRBN) and Eurand NV ... - Aug 28, 2009 EURX has EUR-1037, as an over-the-counter sleep-aid; EUR-1025, an oral formulation of ondansetron, an anti-emetic prescribed to prevent nausea and vomiting; Small Cap Network Fatalities Associated With Clozapine-Related Constipation and ... - Aug 17, 2009 For example, constipation is a common side effect of ondansetron, a 5-HT 3 antagonist used for chemotherapy-induced nausea. 12 Housing approximately 95% of Psychosomatics (subscription) Ask the Expert: Psychosomatic Medicine/Delirium - Aug 28, 2009 Serotonin antagonist (eg, ondansetron), to control toxic elevations of serotonin usually associated with hypoactive delirium, although some studies have Focus (subscription) NovaDel Pharma Inc Reports Operating Results (10-Q) - Aug 12, 2009 During the second quarter of 2008, we also entered into a European partnership for our ondansetron oral spray with BioAlliance, as a result of which we GuruFocus.com Par Pharmaceutical Reports EPS of $0.71 for Second Quarter 2009 - Aug 4, 2009 Strativa's New Drug Application (NDA) for ondansetron orally dissolving film strip (ODFS) has been accepted by the FDA for review. PR Newswire (press release) The Mothers Act Disease Mongering Campaign - Part V - Aug 28, 2009 Ms. Einarson has received unrestricted research grants from GlaxoSmithKline for studying ondansetron in pregnancy and from Organon for studying mirtazapine Natural News.com Eurand Reports Recent Developments and Second Quarter 2009 ... - Aug 8, 2009 ...a proprietary once-a-day oral modified-release formulation of ondansetron to an 8 mg dose of the anti-emetic drug Zofran® (ondansetron). PR-CANADA.net (press release) SciClone Reports Financial Results and Provides Pipeline Update ... - Aug 5, 2009 The recent licensing of the oral anti-nausea product, ondansetron RapidFilmâ„¢, shows further progress with our corporate strategy to broaden our product PR-CANADA.net (press release) Lack of Evidence - Aug 10, 2009 Similarly, the use of ondansetron (Zofran) in children with gastroenteritis has decreased hospitalization rates. Many such medications originally developed The Hospitalist Online INTERVIEW BioAlliance - La recherche de partenaire en bonne voie - Aug 26, 2009 Elle a précisé que BioAlliance présentait également à ces candidats le Setofilm (ondansetron RapidFilm), un produit destiné aux nausées et vomissements Euroinvestor Children's vomiting following posterior fossa surgery: A ... - Jul 13, 2009 Children who had intraoperative ondansetron were more likely to vomit in the final multivariable model (perhaps because of its use, in the clinical judgment BMC Pediatrics New Drug Application Approved for MonoSol Rx's Ondansetron Orally ... - Jun 24, 2009 The US Food and Drug Administration (FDA) has approved MonoSol Rx's new drug application (NDA) for ondansetron orally dissolving film strips (ODFS) Cancer Consultants U.Va. researcher develops medical therapy for alcoholism - Jul 2, 2009 They have discovered that people with a particular variant of the serotonin transporter gene have a propensity for heavy drinking, and that ondansetron, Staunton News Leader Pain Management in Acute Care - Jul 13, 2009 Vomiting and nausea results from stimulation of the chemoreceptor trigger zone in the brain stem and can be managed with antiemetics such as ondansetron ADVANCE for LPNs APR Enters into Licensing Deal with Abdi Ibrahim for Ondansetron ... - Jun 26, 2009 Ondansetron Rapidfilm® with its unique delivery system will be part of Abdi Ibrahim's oncology portfolio and is in line with our overall aim to bring new Emediawire (press release) FDA wants more info on GSK's nausea drug casopitant - Jun 24, 2009 GSK already markets Zofran (ondansetron) to prevent nausea and vomiting caused by surgery or cancer medicines and data was recently published showing that Pharma Times Mr. Arjun Handa, Managing Director & CEO, Claris Lifesciences Ltd - Jun 24, 2009 When do you plan to launch Ciproflaxacin, Metronidazole and Ondansetron in the US market? How big is the market for these three products? India Infoline.com Second Generation 5-HT3 Antagonists Open New Perspectives in ... - Jun 25, 2009 Following the development of the first generation 5-HT3 receptor antagonists, such as ondansetron and granisetron, in the late '80s and early '90s, PR Newswire UK (press release) Research and Markets: Cipla Generics Company Intelligence Report - Jun 19, 2009 Other firsts have included propranolol, ondansetron, salmeterol, montelukast, fluticasone propionate and doxazosin. Cipla gained global recognition in 2001 American Chronicle FDA, GSK ì˜¤ì‹¬êµ¬í† ì™„í™”ì œ ë ˆì¡°ë‹‰ ì¶”ê°€ì •ë³´ 지시 - Jun 26, 2009 GSK는 ì?´ë¯¸ í•ì•”ì œ 투여나 ìˆ˜ìˆ í›„ ë°œìƒ?하는 오심 êµ¬í† ì˜ˆë°©ìœ¼ë¡œ 조프란(Zofran: ondansetron)ì?„ ì‹œíŒ?í•˜ê³ ìžˆê³ ìµœê·¼ 발표ë?œ ìž?료ì—? ì?˜í•˜ë©´ 조프란과 ë?±ì‚¬ë©”타ì†?ì—? 메디포뉴스 Expertos recomiendan el uso de 'Aloxi' (Italfarmaco) para prevenir ... - Jul 3, 2009 ...una clara superioridad frente a sus antecesores, granisetron, ondansetron y dolasetron, tanto en ensayos clÃnicos como en la práctica clÃnica. ADN.es COMUNICADO: Los antagonistas 5-HT3 de segunda generación abren ... - Jun 25, 2009 Tras el desarrollo del antagonista receptor 5-HT3 de primera generación, como ondansetron y granisetron, a finales de la década de los 80 y principios de Europa Press Nuovi farmaci per prevenire il vomito da chemioterapia - Jul 7, 2009 Dopo la messa a punto, verso la fine degli anni '80, inizio '90, dei 5-HT3 antagonisti di prima generazione, come ondansetron e granisetron, recentemente ne Sanihelp.it 5-HT3-Antagonisten der zweiten Generation eröffnen neue ... - Jun 30, 2009 Auf die Entwicklung von 5-HT3- Rezeptorantagonisten, wie Ondansetron und Granisetron, Ende der 1980er Jahre und Anfang der 1990er Jahre folgten in den news aktuell Schweiz (Pressemitteilung) La seconde génération des antagonistes des 5-HT3 ouvre de ... - Jun 30, 2009 Suite au développement à la fin des années 80 et au début des années 90 de la première génération d'antagonistes du récepteur 5-HT3, tels que l'ondansetron Presseportal.ch (Communiqué de presse) MonoSol Rx and Strativa file NDA for ondansetron orally dissolving ... - Apr 10, 2009 The new drug application (NDA) is supported by positive data from completed pivotal studies in which ondansetron orally dissolving film strip (ODFS) Trading Markets (press release) BioWorld Today April 10, 2009 - Apr 9, 2009 MonoSol Rx, of Warren, NJ, has submitted a new drug application to the FDA for the orally dissolving film strip (ODFS) formulation of ondansetron. TMCnet PRX: Submits NDA to FDA for Orally Dissolving Film Strip Form of ... - Apr 9, 2009 The NDA is supported by positive data from completed pivotal studies in which ondansetron ODFS demonstrated bioequivalence against GlaxoSmithKline's Zofran Trading Markets (press release) Palonosetron "Preferred" 5-HT3 Antagonist for Emesis Prevention in ... - Apr 2, 2009 Following the development of the first generation 5-HT3 receptor antagonists, such as ondansetron and granisetron, in the late '80s and early '90s, SYS-CON Media (press release) 美 경구 필름형 í•êµ¬í† ì œ 승ì?¸ì‹ ì² - Apr 13, 2009 ...미êµì—?ì„œ 모노솔 Rx(MonoSol Rx)는 파 파마슈티컬(Par Pharmaceutical)ê³¼ 경구 필름형 â€˜ì˜¨ë‹¨ì„¸íŠ¸ë¡ â€™(ondansetron)ì—? 대한 승ì?¸ì?„ ì‹ ì²í–ˆë‹¤. 디지틀보사 Leki przeciwwymiotne uÅ‚atwiajÄ… leczenie ostrego nieżytu żoÅ‚Ä…dkowo ... - Apr 6, 2009 Autorzy dokonali metaanalizy 6 badaÅ„ z randomizacjÄ…, w których oceniano ondansetron. Pojedyncze badania dotyczyÅ‚y pozostaÅ‚ych leków. Medycyna Praktyczna Palonosetron "bevorzugter" 5-HT3-Rezeptorantagonist zur Vorbeugung ... - Apr 3, 2009 Nachdem in den späten 80er- und frühen 90er-Jahren mit Ondansetron und Granisetron die erste Generation von 5-HT3-Rezeptorantagonisten entwickelt worden ist news aktuell (Pressemitteilung) BioAlliance Pharma SA : Full-Year Accounts for 2008 - Mar 5, 2009 ...the Phase III trial on acyclovir Lauriad® (BA021) and acquisition of Europe-wide licenses for two products (ondansetron Oral Spray and ondansetron Earthtimes (press release) MonoSol Rx Achieves Milestones for Additional $2.5 Million Private ... - Mar 12, 2009 Completed bioequivalence (BE) studies for a thin film formulation of ondansetron, an anti-emetic therapy, triggering a milestone payment to MonoSol Rx from PR Newswire (press release) Common Nausea Drug May Reduce Opioid Withdrawal Symptoms - Feb 20, 2009 The researchers found that drug ondansetron can block certain receptors involved in withdrawal symptoms. During the study, the researchers recruited eight MedIndia Par Pharmaceutical Companies Inc Q4 2008 Earnings Call Transcript - Mar 3, 2009 ...in many of the company’s other generic product, as well as lower royalties which decline by $15 million, primarily from lower sales of ondansetron. Seeking Alpha Skipping antiemetic medication on day 2 improves outcome - Mar 10, 2009 Before receiving highly/ moderately emetogenic chemotherapy (day 1), patients were given IV ondansetron 16 mg, dexamethasone 20 mg, and ranitidine 50 mg. American Journal of Hemotology and Oncology MDS Pharma Services Scientist named to Notable People in R&D list - Mar 11, 2009 He was the lead US clinical pharmacology scientist for Glaxo’s Zofran (ondansetron), – an anti-emetic used to control post-operative and PharmaLive.com (press release) Eurand NV Q4 2008 Earnings Call Transcript - Mar 5, 2009 I’d now like to turn to EUR-1025, a once a day formulation of the anti-emetic real front or ondansetron. We filed an IND with the FDA in December and Seeking Alpha Nausea Drug Shows Promise Against Opioid Addiction - Feb 19, 2009 Initial tests in mice showed that the drug Ondansetron (Zofran) blocks certain 5-HT3 receptors involved in withdrawal symptoms, the researchers said. HealthCentral.com Toddler prescribed wrong drug in Brighton - Feb 19, 2009 But Ms Laker noticed the prescription was for two months worth of ondansetron, an anti-vomiting drug usually given to people before and after chemotherapy. The Argus.co.uk Un medicamento para las nauseas promete contra la adicción a los ... - Feb 23, 2009 Una investigación llevada a cabo por cientÃficos de la Universidad de Stanford encontró que ondansetron podÃa aliviar los sÃntomas sin los efectos Info7 BioAlliance Pharma SA : Résultats annuels 2008 - Mar 5, 2009 ...l’essai de phase III d’aciclovir Lauriad® (BA021) et l’acquisition des licences européennes des produits ondansetron Oral Spray et ondansetron RapidFilm Euroinvestor Lista pod lupÄ… aptekarzy - Mar 16, 2009 Ondansetron kupujemy za 19,18 zÅ‚, a tropisetron za 51,22 zÅ‚. Z zadowoleniem Towarzystwo Farmaceutyczno-Ekonomiczne przyjęło natomiast wykreÅ›lenie ivabradiny NaszeMiasto.pl GAZZETTA UFFICIALE: SOMMARIO (3) - Mar 10, 2009 Autorizzazione all'immissione in commercio del medicinale per uso umano "Ondansetron Actavis". Autorizzazione all'immissione in commercio del medicinale per ANSA Valle d'Aosta 지연형 êµ¬í† ì—? ì¹´ì?´íŠ¸ë¦´, 최대 10ì •ê¹Œì§€ 급여 - Feb 28, 2009 ...ê°œì •ë‚´ì—ì—? 따르면 ì§€ì—°í˜•êµ¬í† ì—? 투여ë?˜ëŠ” ondansetron(최대 5ì?¼), dolasetron(최대 4ì?¼), tropisetron(최대 5ì?¼), ramosetron(최대 5ì?¼)ì?„ ì›?칙으로 하ë?˜, 메디게이트뉴스 [í•´ì™¸ì •ë³´] ë?™ë‚¨ì•„시아 ì‹œìž¥ì •ë³´ - Mar 1, 2009 ...ë˜?í•œ 500ê°œì?˜ 부ì ?í•© ì?˜ì•½í’ˆì—?는 Viagra(sildenafil citrate), antibiotic moxclav, Ferogen syrup(ferrous fumarate)와 Generic anti-emetic ondansetronì?´ ì†?í•´ 디지틀보사 Prosecutions loom for 110 drugmakers in India - 04 Feb 2009 ...the antibiotic moxclav, Ferogen syrup (ferrous fumarate) and the generic anti-emetic ondansetron are among the 500 drugs found to be substandard. In-PharmaTechnologist.com, Price checks brings PBS bill down - 04 Feb 2009 From 1 August the NSAID meloxicam, along with ondansetron, doxorubicin and mitozanthrone, will have their prices reduced by up to two thirds. 6minutes, Ondansetron for severe nausea and vomiting in early pregnancy - Jan 21, 2009 There isn't enough evidence from research to tell us whether ondansetron (brand name Zofran) reduces severe nausea and vomiting in pregnancy (called guardian.co.uk, Late-night call leads to nightmare - Jan 10, 2009 He gave me something called Zofran (ondansetron) in case I felt nauseous from the pain medication,â€? she said, weakly. “Okay,â€? said Ms. J. “It's not uncommon Clinical Advisor, BioAlliance Pharma Publishes Its 2009 Financial Calendar - Jan 15, 2009 In May and August 2008, the company expanded its product portfolio by acquiring the Europe commercial rights to, respectively, ondansetron Oral Spray (OS) WELT ONLINE, Side effects of chemotherapy - Jan 21, 2009 It can be prevented by taking drugs such as ondansetron. Lorazepam, a type of tranquilliser, can also help you feel less sick. Fewer white blood cells: guardian.co.uk, An Appraisal of Potential Drug Interactions in Cigarette Smokers ... - Jan 13, 2009 13 – 15 Other common drugs metabolized by CYP1A2 are cyclobenzaprine, duloxetine, lidocaine, melatonin, mirtazapine, ondansetron, ramelteon, ropinirole, Journal of the American Podiatric Medical Association (subscription) Quando è colpa dei farmaci - Jan 21, 2009 La terapia antiemetica con ondansetron durante chemio-radioterapia da stipsi per il blocco dei recettori 5-HT3 serotoninergici. La Repubblica, Brand Names/Synonyms: Ondansetron is also known by the following brand names and/or synonymsZophren; Zofran; Zudan; Zofran ODT Drug Category: Ondansetron is categorized under the following by the FDA: Anti-anxiety Agents; Antipsychotics; Antipruritics; Antiemetics; Serotonin Antagonists; ATC:A04AA01 Dosage Forms: TABLET; LIQUID Absorption: Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism. Interactions: Interactions for Ondansetron: Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. On the basis of limited available data, no dosage adjustment is recommended for patients on these drugs. Phenytoin, Carbamazepine, and Rifampicin: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampicin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs.1,3 Tramadol: Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small studies indicate that ondansetron may be associated with an increase in patient controlled administration of tramadol.4,5 Chemotherapy: Tumor response to chemotherapy in the P 388 mouse leukemia model is not affected by ondansetron. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron. In a crossover study in 76 pediatric patients, I.V. ondansetron did not increase blood levels of high-dose methotrexate. Chemical IUPAC Name: 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydrocarbazol-4-one : |
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