Nortriptyline

This page contains recent news articles, when available, and an overview of Nortriptyline but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Nortriptyline (when available)

Pharmacology and use:
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline. Depression

Mechanism Of Action:
It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.

News Articles on Nortriptyline

Nortriptyline for Idiopathic Gastroparesis  -  ‎Apr 1, 2009‎
From the American College of Gastroenterology and its member physicians, Digestive Health SmartBrief is a free, weekly newsletter. SmartBrief

The Anti-Cancer Properties Of Antidepressants: A Bibliography  -  ‎Apr 6, 2009‎
Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. eMaxHealth.com

Dear Dr. Levine,  -  ‎Apr 14, 2009‎
Some medications to consider include bupropion SR, varenicline, clonidine, and nortriptyline, as well as any formulation of nicotine replacement that seems Boca Raton News

Report: Andrea Lee Mura died of drug overdose  -  ‎Apr 8, 2009‎
The toxicology report reveals, in addition to heroin, Mura ingested three types of antidepressants: Fluoxetine, the generic form of Prozac; Nortriptyline, MLive.com

Prevention of first-episode depression: progress and potential  -  ‎Mar 31, 2009‎
For example, in a study of 104 patients with and without depression 11 with acute stroke given fluoxetine (20–40 mg/day) or nortriptyline (50–100 mg/day) British Journal of Psychiatry

Neuroanatomy of Pathological Laughing and Crying: A Report of the ...  -  ‎Apr 9, 2009‎
These limitations aside, these reports, suggest that tricyclic antidepressants such as amitriptyline 88 and nortriptyline, 15 and selective serotonin Journal of Neuropsychiatry (subscription)

심�?��?, '리리카캡�?' 요양급여 완전코드로 청구  -  ‎Apr 5, 2009‎
...심�?��? 관계�?는 "섬유근육통(fibromyalgia)�?는 섬유근육통으로 확진�?�고 삼환계 항우울제(TCA : amitriptyline, nortriptyline 등) �?는 허가사항 중 근골격계 질환 e-헬스 통신

Older drug seen better for Parkinson's depression  -  18 Mar 2009
To investigate, they compared the older "tricyclic" antidepressant nortriptyline with the newer "SSRI" agent paroxetine in 52 people with Parkinson's Reuters

Differential efficacy of escitalopram and nortriptyline on ...  -  ‎Feb 27, 2009‎
To test the hypothesis that escitalopram and nortriptyline differ in their effects on observed mood, cognitive and neurovegetative symptoms of depression. British Journal of Psychiatry

10-K: COMBINATORX, INC  -  ‎Mar 16, 2009‎
CRx-191 contains the mid-potency glucocorticoid, mometasone, and a low dose of the tricyclic anti-depressant, nortriptyline, co-formulated as a topical MarketWatch (press release)

The Pharmacological Management of Skeletal-Related Events From ...  -  ‎Mar 17, 2009‎
...gabapentin, lamotrigine, topiramate), tricyclic antidepressants (eg, amitriptyline, imipramine, desipramine, nortriptyline), venlafaxine, duloxetine, Ortho SuperSite

Highlights of this issue  -  ‎Feb 27, 2009‎
They found that the treatment effects of escitalopram and nortriptyline could be differentiated using dimensional measures of symptoms, with greater British Journal of Psychiatry

Persistent pain? Find help in traditional and nontraditional ...  -  ‎Mar 4, 2009‎
For Cynthia's fibromyalgia, she takes Flexeril, a muscle relaxant, and the sleep medicine nortriptyline because the lack of sleep and pain are related. PennLive.com

An assortment of drugs can be taken to treat RLS  -  Feb 1, 2009
A similar drug, Nortriptyline seems to work also and may be less likely to cause next-day drowsiness. Gabapentin (brand-name "Neurontin") has gone generic Hattiesburg American,

Other treatments  -  Jan 21, 2009
One other antidepressant, nortriptyline, also helps people stop smoking. If you take nortriptyline to help you stop smoking, your chance of success is guardian.co.uk,

What's the evidence for antidepressants plus lithium?  -  Jan 21, 2009
Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants. Journal of Clinical Psychopharmacology. 2003; 23: 92-95. guardian.co.uk,

Are older antidepressants better for depression in Parkinson's ...  -  Jan 19, 2009
In the study, scientists gave 52 people diagnosed with Parkinson’s disease and depression either nortriptyline, a tricyclic antidepressant (TCA), The Virtual Medical Centre,

5 patients died on his watch. Now his license is on the line.  -  Jan 24, 2009
He also prescribed a combination of antidepressants, including sertraline and nortriptyline. Two days later, on March 5, Patient M died. The Virginian-Pilot,

Tricyclics Top Other Antidepressants for Fibromyalgia  -  Jan 13, 2009
Amitriptyline was the agent tested in the seven included studies of tricyclics; one also included a nortriptyline arm. Dr. Hauser and colleagues found that MedPage Today,

Depression in adults  -  Jan 21, 2009
Examples of TCAs (and their brand names) include amitriptyline (Elavil), nortriptyline (Allegron) and imipramine. SSRIs boost the amount of a chemical guardian.co.uk,

What treatments work for tinnitus?  -  Jan 21, 2009
...[2] The drugs that were used in studies were nortriptyline (Allegron), trimipramine (Surmontil) and amitriptyline (Elavil). People in two studies said the guardian.co.uk,

Panic attacks  -  Jan 21, 2009
Other tricyclics include amitriptlyine, nortriptyline and clomipramine. You need to be careful not to take too much imipramine (or any other type of guardian.co.uk,

What treatments work for the menopause?  -  Jan 21, 2009
Some common ones (with some brand names) are imipramine, nortriptyline (Allegron), fluoxetine (Prozac) and sertraline (Lustral). More. guardian.co.uk,

Antidepressants plus pindolol  -  Jan 21, 2009
Some examples of TCAs are amitriptyline), doxepin (Sinepin), imipramine, nortriptyline (Allegron) and trimipramine (Surmontil). Monoamine oxidase inhibitors guardian.co.uk,

What treatments work for long-term back pain?  -  Jan 21, 2009
...of antidepressant called a tricyclic antidepressant for bad back pain. Examples of these are imipramine, amitriptyline, nortriptyline and doxepin. More guardian.co.uk,

The Military Family Network  -  Jan 15, 2009
Tricyclic antidepressants (TCAs): Examples are Elavil (amitriptyline), Tofranil (imipramine), and Pamelor (nortriptyline). Monoamine Oxidase Inhibitors eMilitary.org

What's the evidence for bupropion?  -  Jan 21, 2009
The research found that bupropion and nortriptyline help you stop smoking. But other antidepressant drugs, such as moclobemide and selective serotonin guardian.co.uk,

Amitriptylin versus nortriptylin til kroniske smerter  -  Jan 15, 2009
Klasco RK (Ed): Nortriptyline (Drug Evaluation). DRUGDEX(r) System (electronic version). Thomson MICROMEDEX, Greenwood Village, Colorado, USA. RELIS,

Nortriptyline Improves Depression Symptoms in Patients With ...  -  Dec 18, 2008
For the study, 52 patients with Parkinson's disease and depression were given either nortriptyline, paroxetine CR, or a placebo. Patients were tested for DG News

Medications That Can Help Smokers Quit  -  Dec 21, 2008
Nortriptyline, also known as Aventyl, is generally prescribed to treat depression; however nortriptyline has been prescribed to assist with smoking eMaxHealth.com,

Heartbeats: Older antidepressants might be better for Parkinson's ...  -  Dec 22, 2008
In the study, scientists gave 52 Parkinson's patients either nortriptyline, a tricyclic antidepressant; paroxetine CR, a selective serotonin reuptake Scarlet Scuttlebutt,

MEDICINE CABINET: Try antidepressants to help with nerve pain  -  Dec 16, 2008
Examples include amitriptyline, nortriptyline, desipramine and doxepin. I recommend starting with a very low dose, such as 10 milligrams of amitriptyline at Newsday,

Difficult-to-treat chronic pain syndromes  -  Dec 16, 2008
Instead, try the following: tricyclic antidepressants (eg, amitriptyline, nortriptyline, desipramine); selective serotonin and norepinephrine reuptake Clinical Advisor,

Search this blog  -  Dec 8, 2008
...really any better than a combination of a medium-strength opioid, say hydrocodone, along with a norepinephrine reuptake inhibitor, say nortriptyline? ScienceBlogs

Police lift the lid on forensic work that cracked Vicky Hamilton case  -  Dec 5, 2008
Here we found traces of amitriptyline and nortriptyline, prescription anti-depressants which can have the side-effect of sedatives. Edinburgh Evening News,

'파킨슨병+우울�?' �?실 효과 없다  -  Dec 17, 2008
...�?�수차단제 우울�? 약물�?� 파킨슨병 환�?�?서 우울�?�?� 치료하는�?� 있어서 삼환계우울�? 약물�?� 노르트립틸린(nortriptyline) 보다 효과가 �?� 한 것으로 나타났다. 마�?��?��?�리,

Trial told there were drugs found in victim's body  -  Nov 20, 2008
She found the drugs amitriptyline and nortriptyline in her liver and a hematoma. She described amitriptyline as an anti-depressant with sedative stv.tv,

Court told of Vicky fingerprints  -  Nov 20, 2008
The jury heard nortriptyline - a substance produced when amitriptyline is broken down in the body - was also found. Ms Kerr said the presence of Fife Today,

Justin teen's death at party ruled accidental  -  Oct 30, 2008
...of hydrocodone and an antidepressant called nortriptyline, according to an autopsy completed Wednesday by the Tarrant County medical examiner’s office. Fort Worth Star Telegram,

BRIEFS: Justin teen died from mixture of drugs  -  Oct 31, 2008
...after a party died from a mixture of hydrocodone and an antidepressant called nortriptyline, according to the Tarrant County medical examiner’s office. Fort Worth Star Telegram,

Patients With Nonulcer Dyspepsia: Effect of Nortriptyline on ...  -  Oct 15, 2008
Want to dig deeper? SmartBrief brings you news, research, and other information related to this issue. To track this topic, bookmark the page and return for SmartBrief,

권�?진 "서울대병�? 금기약품처방 '최다'"  -  Oct 7, 2008
...�? 서울대병�?�?� 같�?� 복용할 경우 간질�?고혈압 등 부작용�?� �?�으킬 우려가 있어 병용처방�?� 금지�?� '노르트립틸린(nortriptyline)'과 '셀레길린(selegiline)' 성분�?� 매�?�경제,

Antidepressant Treatment of Caregivers of Children With Asthma  -  16 Sep 2008
...with a change to bupropion after 8 weeks if no response was observed, and switch to mirtazapine or nortriptyline after an additional 8 weeks if needed. Psychosomatics (subscription)

New drug to be made available to help smokers quit  -  Aug 3, 2008
Prateep Tanakitcharoen, deputy secretary-general of the National Health Security Office, said Nortriptyline would be added to the national drug list to help Bangkok Post,

治療�?��?�病患年耗515億銖  -  Aug 3, 2008
...宋詩會長表示，社會抓緊行動減少�?��?��?�象則具有極大的�?義，國家藥典還把戒�?�藥物收入其中，希望能幫助�?��?�人士進行有效的戒�?�，其中戒�?�藥Nortriptyline 泰國世界日報新�?�網,

Prescription drugs likely played a role in the death of a Goodyear ...  -  Jun 26, 2008
...died because of various concentrations of tramadol, oxycodone, nortriptyline and lorazepam combined with compression of the torso and cardiac disease. KSNT,

Commonwealth v. Ferola  -  Jul 2, 2008
The blood test also noted the presence of ">300 ng/ml nortriptyline, or one or more other tricyclics." Amitriptyline is a tricyclic. Based on his training, Massachusetts Lawyers Weekly,

Blog Entry 200 of 200 The Lakewood Zit Journal  -  Jun 9, 2008
I'm sure that the medication that JCMH wrote out for me was a form of sleeping pill (Nortriptyline hydrochloride) because that's almost all I did while I YourHub.com,

No benefit in combining NRT and nortriptyline  -  May 8, 2008
Nortriptyline and NRT are both useful in helping smokers to quit, but there does not appear to be any benefit in combining the two, UK researchers report. Pulse,

On the Pulse - 16th May  -  May 16, 2008
A study in the BMJ examines whether nortriptyline can help people to stop smoking. Participants (n=901) were allowed to use nicotine patches or not at will, OnMedica,

Incidence, Impact, and Current Management Strategies for Treatment ...  -  May 22, 2008
A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. Medscape (subscription)

Muscle syndrome may go undetected  -  May 27, 2008
Amitriptyline and nortriptyline are often used because they can also promote good sleep. Anti-inflammatories may reduce pain by reducing the levels of NewsOK.com (subscription),

Migraine treatment: Can antidepressants help?  -  Apr 4, 2008
Most effective are tricyclic antidepressants, such as amitriptyline, nortriptyline (Pamelor) and protriptyline (Vivactil). In fact, these medications are MayoClinic.com

Investigation Into the Cause of Death of a 56-Year-Old Man With ...  -  Apr 1, 2008
Evidence-based treatments for tobacco dependence include nicotine-replacement therapy, sustained-release bupropion, varenicline, nortriptyline, clonidine, Am J Psychiatry (subscription)

CombinatoRx Granted Broad Patent Covering TCA-Glucocorticoid ...  -  Feb 27, 2008
CRx-191 contains a mid-potency glucocorticosteroid, mometasone, and a very low dose of the tricyclic anti-depressant, nortriptyline. CRx-191 is thought to FOXBusiness

Correlation Between Denial of Illness and Executive Function ...  -  Feb 27, 2008
After 12 weeks of treatment (either nortriptyline, 100 mg/day maximum, fluoxetine, 40 mg/day maximum, or placebo), 44 patients were assigned to a 21-month Journal of Neuropsychiatry (subscription)

A Look at St. John's Wort  -  Feb 18, 2008
When compared with tricyclic anti-depressants such as imipramine, amitriptyline, doxepin, desipramine, and nortriptyline, St. John's Wort is equally HealthNewsDigest.com,

Antidepressants unproven as treatment for low back pain  -  07 Feb 2008
The majority of the studies looked at tricyclic antidepressants such as amitriptyline, nortriptyline and clomipramine. Two studies evaluated the Sun-Sentinel.com,

SSRIs Increase Risk of Nongastrointestinal Bleeding in Patients ...  -  Feb 1, 2008
For non-SSRI antidepressants nortriptyline and mirtazapine, no increased risk for hospitalization for either category of bleeding was observed. Medscape (subscription)

Depression relief exists, so keep looking for it  -  Jan 23, 2008
The third and fourth steps involved stronger antidepressants, such as nortriptyline (Aventyl and others), mirtazapine (Remeron) and lithium (Eskalith). Pioneer Press,

Batteries included  -  Jan 13, 2008
They used mixtures of five drugs as test analytes - pethidine, nortriptyline, methadone, haloperidol and loperamide. The compounds were dissolved in water separationsNOW.com (subscription),

combinatorx Announces Initiation of Phase 2a Clinical Study of crx ...  -  Nov 6, 2007
...crx-191 contains a mid-potency glucocorticosteroid, mometasone, and a very low dose of the tricyclic anti-depressant, nortriptyline. crx-191 is thought to Business Wire (press release),

Complicated Grief: A Case Series Using Escitalopram  -  Nov 1, 2007
Open-label bupropion showed modest effects for grief (3), but nortriptyline demonstrated no significant effect on grief in open-label (4) and randomized Am J Psychiatry (subscription)

Wal-Mart Launches Phase Two of Prescription Program With New $4 ...  -  Sep 27, 2007
2MG QTY 30 HALOPERIDOL 5MG QTY 30 HYDROXYZINE HCL10MG/5ML SYRUP QTY 120ML LITHIUM CARBONATE 300MG QTY 90* NORTRIPTYLINE 10MG QTY 30 NORTRIPTYLINE 25MG CNNMoney.com

Maintenance Antidepressant Treatment Improves Well-Being in Depression  -  Oct 1, 2007
69 patients required the addition of nortriptyline, bupropion, or lithium to achieve response. Randomization for the maintenance phase was stratified by the Medscape (subscription)

Mortality Risk in Patients With Dementia Treated With ...  -  Sep 26, 2007
Antidepressants (amitriptyline, clomipramine, doxepin, imipramine, trimipramine, desipramine, nortriptyline, protriptyline, amoxapine, maprotiline, Am J Psychiatry (subscription)

Clinically Identified Maternal Depression Before, During, and ...  -  Sep 26, 2007
Antidepressant medications included tricyclics (amitriptyline, clomipramine, desipramine, doxepin, imipramine, and nortriptyline), SSRIs (fluoxetine, Am J Psychiatry (subscription)

Is It Possible To Stop Smoking With Prozac  -  Sep 24, 2007
Another substance that is used for the cessation of cigarette smoking is nortriptyline. Although this is proven to be as ineffective as a placebo, PR-GB.com (press release),

Brand Names/Synonyms:
Nortriptyline is also known by the following brand names and/or synonymsAVENTYL HCL; Acetexa; Allegron; Altilev; Amitryptyline, Demethyl-; Ateben; Avantyl; Aventyl; Aventyl Hcl; Demethylamitriptylene; Demethylamitriptyline; Demethylamitryptyline; Desitriptilina; Desmethylamitriptyline; Lumbeck; Noramitriptyline; Noritren; Nortrilen; Nortriptyline; Nortriptyline Hcl; Nortryptiline; Norzepine; PAMELOR; Pamelor; Psychostyl; Sensaval; Sensival Ventyl; Sesaval; Vividyl

Drug Category:
Nortriptyline is categorized under the following by the FDA: Antidepressants; Norepinephrine-Reuptake Inhibitors; ATC:N06AA10

Dosage Forms:
Capsules

Absorption:
well absorbed from the GI tract

Interactions:
Interactions for Nortriptyline:

Steady-state serum concentrations of tricyclic antidepressants are reported to fluctuate significantly when cimetidine is either added or deleted from the drug regimen. Serious anticholinergic symptoms (severe dry mouth, urinary retention, blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressants when cimetidine is added to the drug regimen. In addition, higher-than expected steady-state serum concentrations of tricyclic antidepressants have been observed when therapy is initiated in patients already taking cimetidine.

In well-controlled patients undergoing concurrent therapy with cimetidine, a decrease in the steady-state serum concentrations of tricyclic antidepressants may occur when cime-tidine therapy is discontinued. The therapeutic efficacy of tricyclic antidepressants may be compromised in these patients when cimetidine is discontinued. Several of the tricyclic antidepressants have been cited in these reports.

There have been greater than 2-fold increases in previously stable plasma levels of other antidepressants, including nortriptyline, when fluoxetine hydrochloride has been administered in combination with these agents. Fluoxetine and its active metabolite, norfluoxe-tine, have long half-lives (4 to 16 days for norfluoxetine), that may affect strategies during conversion from one drug to the other.

Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a ìstimulatingî effect in some depressed patients. Close supervision and careful adjustment of the dosage are required when nortriptyline hydrochloride is used with other anticholinergic drugs or sympathomimetic drugs.

The patient should be informed that the response to alcohol may be exaggerated.

Drugs Metabolized by P450IID6 óA subset (3% to 10%) of the population has reduced activity of certain drug metabolizing enzymes such as the cytochrome P450 isoenzyme P450IID6. Such individuals are referred to as ìpoor metabolizersî of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants. These individuals may have higher than expected plasma concentrations of tricyclic antidepressants when given usual doses. In addition, certain drugs that are metabolized by this isoenzyme, including many antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and others), may inhibit the activity of this isoenzyme, and thus may make normal metab-olizers resemble poor metabolizers with regard to concomitant therapy with other drugs metabolized by this enzyme system, leading to drug interactions.

Concomitant use of tricyclic antidepressants with other drugs metabolized by cytochrome P450IID6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Therefore, co-administration of tricyclic antidepressants with other drugs that are metabolized by this isoenzyme, including other antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (eg, propafenone, flecainide, and encainide), or that inhibit this enzyme (eg, quinidine), should be approached with caution.

Chemical IUPAC Name:
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

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