Nifedipine

This page contains recent news articles, when available, and an overview of Nifedipine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Nifedipine (when available)

Pharmacology and use:
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure. For the management of vasospastic angina, chronic stable angina and hypertension

Mechanism Of Action:
Nifedipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

News Articles on Nifedipine

Myocardial Infarction In Pregnancy  -  20 Apr 2009
...fetal renal abnormalities and death.7 Nifedipine has been used in the treatment of hypertension, preeclampsia and myocardial ischemia during pregnancy, ADVANCE for Physician Assistants

防早产�?�使你比早产更痛苦  -  20 Apr 2009
...香港沙田�?尔斯亲王医院早�?进行研究，�?�现203�??有早产迹象的孕妇，在�?用抑制�?宫收缩�?�物“�?苯地平�?(Nifedipine)�?�，4人出现低血压�?��?�红，需�?�时�?��?�，�?�有两�??孕妇新浪网

Zenerx - Is Zenerx a Safe Selection For ED?  -  ‎Apr 3, 2009‎
Such as, the nifedipine medication you are taking could develop into ED. Masturbation is not a motive for erectile dysfunction. 마인드스포츠올림피아드

A pill for migraines  -  ‎Apr 14, 2009‎
High blood pressure medications like Calcium Channel Blockers (verapamil and nifedipine) and ACE Inhibitors like lisinopril are good at 'preventing' Jamaica Gleaner

Treatment and Survival in Children With Pulmonary Arterial ...  -  ‎Apr 6, 2009‎
...responsive to vasodilator testing, whereas 6% of patients with APAH were responsive; all patients responsive to vasodilators were started on nifedipine. Cardiosource

Postlithotripsy Agents Improve Stone Outcomes  -  ‎Apr 2, 2009‎
MET agents used in the trials were tamsulosin, nifedipine, and Phyllanthus niruri extract. Trevor D. Schuler, MD, and colleagues at St. Michael's Hospital Renal and Urology News

09年执业西�?�师�?��?�学辅导：第二�??一章第三节常用钙拮抗�?�  -  ‎Apr 15, 2009‎
...�?苯地平（nifedipine），�?��??心痛定。「�?��?�作用�?�?苯地平的作用与维拉帕米�?�?�，它对窦房结房室结�?�心收缩性的抑制作用较弱，对血管的舒张作用明显。青年人

09年执业西�?�师�?�物化  -  ‎Apr 16, 2009‎
...常用的�?�物例如：�?苯地平（Nifedipine）为第一代钙拮抗剂；第二代钙拮抗剂扩张冠状动脉作用更强，作用维�?时间长，例如尼�?�地平（Nicardipine）�?尼群青年人

Risico's van weeënremmers  -  ‎Apr 16, 2009‎
Veiligste geneesmiddelen zijn atosiban, indometacin en nifedipine. Bepaalde typen weeënremmers, zoals beta-agonisten, vergroten de kans op complicaties Gezondheid.be

Zenerx - Is Zenerx a Safe Selection For ED?  -  18 Mar 2009
Such as, the nifedipine medication you are taking could develop into ED. Masturbation is not a motive for erectile dysfunction. Depok Metro

Buyer Class Still Valid In Nifedipine Antitrust Suit  -  ‎Feb 24, 2009‎
PLC and Teva Pharmaceuticals Ltd. of conspiring to restrain the sale of nifedipine, a generic version of hypertension drug Adalat CC. Competition Law 360 (subscription)

Safety of Labor-Delaying Drugs Questioned  -  ‎Mar 6, 2009‎
The most widely used tocolytic drugs include beta agonists and nifedipine (which relax smooth muscles, including the uterus), and atosiban and indometacin U.S. News & World Report

Pre-Term Labor Meds Linked to Complications  -  ‎Mar 9, 2009‎
The most popular tocolytics include beta agonists and nifedipine—a smooth muscle relaxer, which works on the uterine muscles—atosiban, and indometacin—a Newsinferno.com

Ask the doctor: What has caused my painful chilblains  -  ‎Mar 16, 2009‎
Medication is sometimes used to prevent recurring chilblains - the drug nifedipine opens the small blood vessels and so keeps the blood flowing; Daily Mail

Safety concerns over drugs for early labour  -  ‎Mar 6, 2009‎
The drugs most often used include ones called beta agonists and nifedipine (to relax the muscles in the womb) and atosiban and indometacin (to stop the guardian.co.uk

Some Tocolytics Carry High Risk of Adverse Reactions Combinations ...  -  ‎Mar 6, 2009‎
Of these women, 41.9 percent received atosiban, 34.3 percent received nifedipine, 13.8 percent were treated with ritodrine and fenoterol and 8 percent were Modern Medicine

Penwest Pharmaceuticals Q4 2008 Earnings Call Transcript  -  ‎Mar 4, 2009‎
...in Penwest receiving approximately $40 million from Mylan under our agreement with them for Nifedipine which has been on the market now for 10 years. Seeking Alpha

Police Torture Activist & Poet, Raul (Curly) Estremera  -  ‎Mar 1, 2009‎
I answered no to being diabetic and verbally spelled out the medications which I had just taken: Hydrochlorothyazide, fosinopril, nifedipine, for high blood Bay Area Indymedia

출산 지연 약물 �?�부, 심�?한 합병�? 위험  -  ‎Mar 8, 2009‎
...대체로 많�?� 사용�?�는 �?�? 수축 억제 약물�?� 베타 작�?�약과 니페디핀(nifedipine), 아토시반(atosiban)과 �?��?�메타신(indometacin)등�?�다. 그러나 �?�런 약물�?� 사용�? 데일리팜

“급여기준 30항목 변경�?…항�?제 �?�반�?칙 등  -  ‎Feb 23, 2009‎
...�?�성호 기�? 항�?제 �?�반�?칙 등 30항목�?� 변경�?�고 Nifedipine 경구제(품명: 니페드솔정 등)등 5항목�?� 신설�?�다. �?한 빈혈치료제 �?�반�?칙 등 10항목�?� 삭제�?�다. 메디포뉴스

니페드솔정 등 5품목 급여기준 신설  -  ‎Feb 22, 2009‎
...혈관확장제�?� Nifedipine경구제(품명 니페드솔정 등) 등 5품목�?� 요양급여기준�?� 새롭게 신설�?�다. 보건복지가족부는 21�?� �?�같�?� 내용�?� 담�?� 요양급여기준안�?� 메디게이트뉴스

En büyük suçlu tuz  -  ‎Mar 1, 2009‎
Tedavi olarak sadece Nifedipine (turuncu kapsüller) veya kaptopril tablet çiğnemek. * Kan basıncı yüksekliğini sadece strese bağlayıp tansiyon ilacı Türkiye Gazetesi - Avrupa

„Combinatie weeënremmers gevaarlijk�?  -  ‎Mar 10, 2009‎
Onderzoek waarin de effectiviteit van atosiban vergeleken wordt met het meest gebruikte alternatief, nifedipine, ontbreekt nog. De wetenschappers pleiten nu Reformatorisch Dagblad

What's the evidence for calcium channel blockers?  -  Jan 21, 2009
Two large studies have looked at the calcium channel blocker nifedipine.[2] [1] People who were given nifedipine didn't do any better than people given a guardian.co.uk,

What treatments work for Raynaud's disease?  -  Jan 21, 2009
A medicine called nifedipine can help prevent Raynaud's attacks. But it can cause side effects. Your doctor may try other medicines but there's not enough guardian.co.uk,

What treatments work for anal tears?  -  Jan 21, 2009
One study found that having Botox injections worked just as well as treatment with the drug nifedipine.[3] We need more research to know for certain how guardian.co.uk,

What's the evidence for drugs to lower very high blood pressure ...  -  Jan 21, 2009
This study showed that the drug nifedipine worked better for controlling blood pressure than the drug hydralazine. Duley L, Henderson-Smart DJ. guardian.co.uk,

High blood pressure  -  Jan 21, 2009
Calcium channel blockers: nifedipine (Adalat), amlodipine (Istin), diltiazem (Calcicard) and verapamil (Cordilox). Diuretics: bendroflumethiazide (Aprinox) guardian.co.uk,

Natural Help for Ovarian Cancer  -  Jan 23, 2009
Do not take quercetin with cyclosporine (Neoral, Sandimunne) or nifedipine (Procardia). Increases production of immune-system chemical interleukin-2 (IL -2) Natural News.com,

Stable angina  -  Jan 21, 2009
Examples include: diltiazem (Dilzem), nifedipine (Adalat) and verapamil (Cordilox). Calcium channel blockers can cause flushing, swelling of ankles, guardian.co.uk,

What treatments work for essential tremor?  -  Jan 21, 2009
Examples are nifedipine (brand names Adalat and Coracten SR), nicardipine (Cardene), and nimodipine (Nimotop). There have been two studies that used calcium guardian.co.uk,

What treatments work for unstable angina?  -  Jan 21, 2009
Common ones (and their brand names) include diltiazem (Adizem, Dilzem, Tildiem), felodipine (Plendil), nifedipine (Adalat, Coracten SR) and verapamil guardian.co.uk,

Painkillers can increase the risk of car crashes, a study finds  -  Jan 21, 2009
...data on who had a car crash while driving. certain drugs used to treat high blood pressure and other heart problems (such as felodepine and nifedipine). guardian.co.uk,

What's the evidence for beta-blockers?  -  Jan 21, 2009
Total Ischaemic Burden European Trial (TIBET): effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients guardian.co.uk,

Spironolactone alleviates late cardiac remodeling after left ...  -  Jan 21, 2009
...long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). The Journal of Thoracic and Cardiovascular Surgery

No Benefit Shown From Drug Widely Used To Prevent Premature Births  -  Dec 12, 2008
The new trial is the first-ever placebo-controlled test of nifedipine, a muscle relaxant originally developed to lower blood pressure, and its effect on Science Daily (press release)

Go easy on the sauce: and we don't just mean alcohol, we mean ...  -  Dec 22, 2008
And calcium channel blockers such as nifedipine increase the intoxicating effect of alcohol. Certain oral diabetes drugs mixed with alcohol cause facial Irish Times,

LVADs Do Not Improve Post-Surgery Survival, Continued Tocolysis ...  -  Nov 28, 2008
In a study of 68 women who were between 24 and 34 weeks' gestation, researchers found that continued treatment with nifedipine did not significantly improve Insidermedicine,

What you didn't learn in EMT School  -  Dec 17, 2008
Many spinal cord injury patients have nifedipine (Procardia) capsules, which they bite open and absorb in their mouth to quickly reduce their blood pressure EMS Magazine,

Read instructions that come with prescription meds  -  Dec 15, 2008
The blood pressure medications that interact with grapefruit juice all have generic names that end in "dipine" such as nifedipine, felodipine and isradipine Jackson Clarion Ledger,

�?�个�?�格病人�?��?�此�?彼忌  -  Dec 16, 2008
...宇暄医学中心主任陈镜洲医生说：“葡�?�柚�?�?适�?��?�?�物�?�，葡�?�柚�?�类黄酮，会抑制体内细胞的酶素作用，使�?些�?血压的�?�物，例如Nifedipine 中新网,

“고혈압약 드시는 분, �?�런 �?��?�?� 피하세요�?  -  Dec 2, 2008
...�?� 외�? 암로디핀(amlodipine),니페디핀(nifedipine), 니카르디핀(nicardipine) 등 ‘칼슘채�? 차단제’는 �?몽주스와 함께 먹으면 약 �?�성�?� 나타날 수 있으므로 주�?� 아�?�비타임즈,

פרויקט מיוחד: הכל על תרופות ליתר לחץ ד�?  -  Dec 2, 2008
...שמות מסחריי�? של תרופות מקבוצת חוסמי תעלות הסידן: AMLOW, DILATAM,ADIZEM, AMLODIPINE-TEVA, NORVASC, OSMO-ADALAT, PENEDIL,NIFEDIPINE-TEVA, IKAPRESS, VERAPRESS. BeOK פורטל ברי�?ות ויופי,

Actavis Establishes New R&D Labs in Florida  -  Nov 4, 2008
...the generic equivalents of Glaxosmithline's Wellbutrin XL and SR as well as Nifedipine ER, the generic equivalent of Bayer's Adalat CC. RedOrbit,

Actavis Opens Research and Development Labs in Florida  -  Nov 5, 2008
...the generic equivalents of GSK's Wellbutrin XL(R)* and SR(R)* as well as Nifedipine ER, the generic equivalent of Bayer's Adalat(R)** CC. PharmaLive.com (press release),

Slimming drug: Doctors warned off after links to suicide  -  Oct 28, 2008
Fda fingers heart drug - The calcium blocker nifedipine used to treat high blood pressure has been singled out by the US's Food and Drug Administration What Doctors Don't Tell You,

Actavis opens labs in Florida  -  Nov 3, 2008
States include Bupropion, the generic equivalents of GlaxoSmithKline’s Wellbutrin as well as Nifedipine, the generic equivalent of Bayer’s Adalat. IceNews,

Two erythematous leg rashes  -  Nov 19, 2008
She also had non-insulin-dependent diabetes, hyperlipidemia, and hypertension, which she managed with insulin, atorvastatin, and labetalol and nifedipine, Cortlandt Forum,

LifeCoach: Our experts answer questions  -  Nov 17, 2008
Drugs to open the blood vessels can be helpful, such as nifedipine (which is usually used to treat high blood pressure or angina). Surgery to cut the nerves Telegraph.co.uk,

Bayer earnings slip but firm says future looks bright  -  Oct 29, 2008
Sales of the hypertension treatment Adalat (nifedipine) were down 2.6% to 148 million euros, and the erectile dysfunction drug Levitra (vardenafil) fell Pharma Times (registration),

겨울철 다빈�?�질환 예방과 치료<4>  -  Nov 20, 2008
...�?�창�?� 발�?하면 병변부를 따뜻하게 하고 휴�?�?� 취하게 하며, nicotinic acid나 nifedipine�?� 투여하기�?� 한다. 추위�? 노출�?�면 그물 모양�?� 청�?색 반�?� �?겼다가 디지틀보사,

Academisch Medisch Centrum Universiteit van Amsterdam  -  Oct 30, 2008
Het medicijn Nifedipine ontspant de baarmoederwand, en daarom bestond het vermoeden dat het zou kunnen bijdragen aan een succesvolle versie. Nieuwsbank (persbericht) (abonnement),

Caso clínico: El paciente con hipocalcemia  -  Nov 18, 2008
Symptomatic hypocalcemia after tocolytic therapy with magnesium sulphate and nifedipine. Am J Obstet Gynecol 2004;190:1773-6. 48. Cooper MS, Gottoes NJ. Intramed.net (Suscripción),

「氰�?「石�?難安從三�?�氰胺談尿路�?石治療  -  Nov 11, 2008
...等，和鈣離�?阻斷劑Nifedipine 中時電�?報,

�?�个�?�格病人�?��?�此�?彼忌  -  Oct 29, 2008
...宇暄医学中心主任陈镜洲医生说：“葡�?�柚�?�?适�?��?�?�物�?�，葡�?�柚�?�类黄酮，会抑制体内细胞的酶素作用，使�?些�?血压的�?�物，例如Nifedipine �?��?�早报,

Common Medications Cause Elderly to Lose Thinking Skills  -  21 Oct 2008
The anticholinergics being taken included nifedipine (a blood pressure drug marketed as Adalat or Procardia), ranitidine (an acid reflux drug marketed as Natural News.com,

Male breast growth an embarrassment  -  Sep 25, 2008
Some medicines can be responsible for breast growth -- the water pill spironolactone and the blood pressure medicine nifedipine are two examples. The Beacon Herald,

Health Corner  -  Oct 13, 2008
These include: * diuretics ('water tablets'), nifedipine, cimetidine, salbutamol, terbutaline, lithium, clofibrate, penicillamine, morphine (withdrawal), Mmegi Online,

Periodontitis Risk Factors  -  Oct 10, 2008
Some drugs, such as the anticonvulsant medication diphenylhydantoin and the anti-angina drug nifedipine, can cause abnormal growth of gum tissue. The Epoch Times,

READERS RESPOND  -  Sep 30, 2008
However, she developed a cough while taking ramipril and was switched to nifedipine extended release, 30 mg/d. On this regimen her blood pressure was well Journal of American Medical Association (subscription),

如何正确�?用中�?�  -  Oct 15, 2008
...当归有�?�能增加�?血压�?�（如：Nifedipine 大纪元

BUYINS.NET: AWYI, PPCO, ICRB Have Been Added To Naked Short List Today  -  Oct 8, 2008
...pain requiring continuous opioid treatment using its TIMERx drug delivery technology; and Nifedipine XL, for the treatment of hypertension and angina. Trading Markets (press release),

Do some foods stop drugs working?  -  Sep 12, 2008
...may affect the action of other drugs such as benzodiazepine (Valium) or nifedipine (in blood pressure and angina pills such as Adalat and Cardilate). Times Online,

Managing persistent hiccups in advanced cancer 2: treatment  -  Aug 29, 2008
Nifedipine is a calcium channel blocker that has been used successfully to end bouts of persistent hiccups (Quigley, 1997). Its mode of action is unclear Nursing Times,

Aanvullingen en verbeteringen  -  Sep 5, 2008
...oraal in te nemen middelen, zoals de cholesterolverlagers simvastatine (Zocor) en atorvastatine (Lipitor), de bloeddrukverlager nifedipine (Adelat), Volkskrant,

Brand Names/Synonyms:
Nifedipine is also known by the following brand names and/or synonymsAdalat; Adalat 10; Adalat 20; Adalat 5; Adalat Cc; Adalat Cr; Adalat Crono; Adalat Ft; Adalat Gits; Adalat Gits 30; Adalat La; Adalat Lp; Adalat Oros; Adalat Pa; Adalat Retard; Adalate; Adapine; Adapress; Alat; Aldipin; Alfadal; Alonix; Alonix S; Alpha-Nifedipine Retard; Angipec; Anifed; Anpine; Apo-Nifed; Aprical; BAY 1040; Bay a 1040; Bay-a 1040; Bonacid; CCRIS 6074; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardilate; Cardionorm; Chronadalate; Chronadalate Lp; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dilcor; Dipinkor; Duranifin; Ecodipi; Ecodipin; Ecodipin E; Fedcor; Fedcor Retard; Fenamon; Fenamon Sr; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Introcar; Kordafen; Macorel; Megalat; Myogard; N1fedilat; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifedicor; Nifedin; Nifedine; Nifedipine; Nifedipine Retard; Nifedipres; Nifedirex Lp; Nifelan; Nifelat; Nifelat Q; Nifelate; Nifensar Xl; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Procardia Xl; Sepamit; Tibricol; Zenusin

Drug Category:
Nifedipine is categorized under the following by the FDA: Tocolytic Agents; Vasodilator Agents; Calcium Channel Blockers; Dihydropyridines; ATC:C08CA05

Dosage Forms:
CAPSULE; TABLET; TABLET (EXTENDED-RELEASE)

Absorption:
rapidly and fully absorbed

Interactions:
Interactions for Nifedipine:

Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.

Long Acting Nitrates: Nifedipine may be safely co-administered with nitrates, but there have been no controlled studies to evaluate the antianginal effectiveness of this combination.

Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers. The average increase was 45%. Another investigator found no increase in digoxin levels in 13 patients with coronary artery disease. In an uncontrolled study of over 200 patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.

Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).

Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. However, the relationship to nifedipine therapy is uncertain.

Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. Ranitidine produced smaller, non-significant increases. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.

Chemical IUPAC Name:
dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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