Nexium

This page contains recent news articles, when available, and an overview of Nexium but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Nexium
(when available)

Pharmacology and use:
Omeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Omeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. For the treatment of gastroesophageal reflux disease

Mechanism Of Action:
Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Omeprazole blocks the final step in acid production, thus reducing gastric acidity.

News Articles on Omeprazole

Looking Ahead: Runaway Health Costs  -  30 Aug 2009
I recently filled my prescription of Nexium. I paid $180 dollars for thirty “purple� capsules. I got this prescription at Costco, which is considered one of New York Times

Astra Drug Beats Plavix In Prevention  -  30 Aug 2009
...and a clutch of other drugs in its pipeline to help offset a looming loss of patent protection on existing blockbusters such as Nexium and Seroquel. New York Times

AstraZeneca Expands Market Presence  -  ‎Aug 26, 2009‎
The company's product range includes Arimidex, Crestor, Nexium, Seroquel and Symbicort. The company's subsidiary, Astra Tech is engaged in the research, Pharmaceutical Business Review

Taking care of stomach ulcers  -  ‎Aug 25, 2009‎
To reduce acids, your doctor may choose a proton pump inhibitor (Prilosec, Prevacid, Aciphex, Protonix or Nexium) or an acid blocker (H-2 blocker) such as Enid News & Eagle

Can prescription drugs sent by mail survive in the summer heat?  -  ‎Aug 25, 2009‎
Three of the four most commonly prescribed drugs -- Singular, Lexapro and Nexium -- are allowed controlled excursions. However, Lipitor -- a popular drug KVAL

GRAEDONS' PHARMACY Can hives cured by Vitamin C?  -  ‎Aug 24, 2009‎
Upon reading the article, I realized that I had similar symptoms and was taking Nexium. I saw the doctor for a routine blood work-up, and he checked the Bradenton Herald

Health Care Reform Takes Sacrifice by All  -  ‎Aug 21, 2009‎
...as first-line therapy instead of automatically expecting to take the "so-called" gold-standard and much more expensive drug (esomeprazole/Nexium). Hillsboro Argus - OregonLive.com

Proton Pump Inhibitors to Treat GERD Cause Heartburn Problems  -  ‎Aug 12, 2009‎
...(NaturalNews) Prilosec, Nexium, Prevacid, Aciphex. These and a dozen more drugs known as proton pump inhibitors (PPIs) have quickly become superstars of Big Natural News.com

The View From Your Sickbed  -  ‎Aug 21, 2009‎
The leading brands, Prevacid and Nexium, are right behind statins like Lipitor as the most prescribed drugs. If insurers did make decisions the way the Atlantic Online

Hawaii government employees balk at switching medications  -  ‎Aug 16, 2009‎
Kailua resident Barbara Volheim received a letter saying she should switch her Nexium prescription to Prilosec OTC, which would carry a copayment of $5 for Honolulu Advertiser

Saatchi & Saatchi Wellness' Hot New Blog: Pertinent, Poignant and ...  -  ‎Aug 18, 2009‎
The agency handles integrated marketing for clients along the entire wellness spectrum including Nexium, Ambien CR, Plavix, Durex, Frontline and Transitions PR Newswire (press release)

Consumer 10 Report To save on prescriptions, shop and compare  -  ‎Aug 16, 2009‎
One pharmacy, for example, charged $597.99 for a 90-day supply of the acid-reflux medication Nexium. A few calls later, the station found the same drug Columbus Dispatch

Sulfoxides: A Sneaking Affection  -  ‎Aug 12, 2009‎
But there are some out there in the market, chief among them esomeprazole (Nexium). Then there's armodafinil (Nuvigil), Cephalon's follow-up to Provigil, Corante

Letter: Why such a high price for generic drug?  -  ‎Aug 18, 2009‎
By reader submitted My wife was prescribed Nexium and used this until the generic Omeprazole came on the market. We have the AARP Medicare Rx Plan and, TCPalm

Plavix Ineffectiveness Predicted By Gene Variant Found in One of ...  -  ‎Aug 27, 2009‎
...drugs known as proton-pump inhibitors, such as Nexium, Prilosec and Prevacid, which are often take with Plavix to reduce gastrointestinal side effects. AboutLawsuits.com

Ask the doctor  -  ‎Aug 16, 2009‎
These are drugs like Nexium, Prilosec, or Ogastro. These can be taken once a day to protect your stomach from the harmful effects of Advil. Nassau Guardian

Fumo disclosure on addictions could pay off  -  ‎Aug 22, 2009‎
He has taken Imitrex to quell headaches, Darvocet to stave off back pain, Nexium to fight acid reflux, and Immodal for intestinal distress. Philadelphia Inquirer

UMDNJ researcher finds Europe ahead of US in global drug discovery  -  ‎Aug 26, 2009‎
He cites the example of "me-too" drugs, such as Nexium, Lipitor, and new cancer drugs that generate large revenues at high prices but generally have not newjerseynewsroom.com

The People's Pharmacy Summer skin care's absorbing problem  -  ‎Aug 23, 2009‎
I realized I had similar symptoms and was taking Nexium. When the doctor checked, it turned out I was extremely B-12 deficient, and I was put on a protocol Seattle Times

Push is on to end prescription drug ads targeting consumers  -  ‎Aug 10, 2009‎
Nexium is the second-best at $5.9 billion. •They're already regulated. Year to date, the FDA has issued 28% more "warning letters" to drugmakers for false USA Today

Right Match of Drug, Doctor Can Boost Reflux Outcomes  -  ‎Aug 21, 2009‎
He found that patients given prescriptions for proton pump inhibitors (PPIs) -- drugs that include blockbusters such as Prevacid, Prilosec and Nexium Atlanta Journal Constitution

Public Safety Log  -  ‎Aug 26, 2009‎
Michael's, 700 block Bustleton Pk., Feasterville, noon-12:30 pm Mon, Nexium and methadone prescriptions from purse in vehicle, vehicle may have been phillyBurbs.com

Treatments and Remedies to Ease Irritable Bowel Syndrome (IBS)  -  ‎Aug 27, 2009‎
To lessen the blow: Proton pump inhibitors (Nexium, Prilosec, Prevacid) turn off stomach acid, reducing heartburn. They also may relieve IBS symptoms: In Greenwich Time

Health Watch: Acid Reflux  -  ‎Aug 26, 2009‎
...doctor prescribed one of the type of drug known as a proton pump inhibitor, or PPI, which includes nexium, prevacid, aciphex, protonix, and prilosec. WCBS-TV New York

Are we really so miserable?  -  ‎Aug 26, 2009‎
The pharmaceutical companies concentrated on their best-selling “blockbuster� drugs — Lipitor, Claritin, Nexium, Viagra, as well as the psychiatric drugs Salon

Are Drugs Cheaper in Mexico?  -  ‎Aug 24, 2009‎
A thirty day supply of Nexium is $175 in the United States. It's $74 in Mexico. You'll pay almost $131 for Lipitor in the US and $83.55 in Mexico. KRGV

Even more advertisers leave Glenn Beck  -  ‎Aug 20, 2009‎
Conservatives for Patients Rights, Ditech, Forex.com, Golden Corral, Healthy Choice, HSBC Life Insurance, Mercedes-Benz, Metastock, Nexium, Pepboys, Ethiopian Review

7 Common Digestive Problems and How to End Them  -  ‎Aug 19, 2009‎
Treatment options include drugs that reduce acid levels, such as the proton pump inhibitors Aciphex, Nexium, Prevacid, Prilosec, and Protonix and the H2 Hartford Courant

New Report Focuses on Yahoo's Rogue Pharmacy Advertisers  -  ‎Aug 21, 2009‎
The authors were able to purchase three different drugs from two websites without a prescription, including a generic version of Nexium (esomeprazole Pharmaceutical Technology Magazine

Durex(R) Launches Integrated Brand Campaign  -  ‎Aug 12, 2009‎
The agency handles integrated marketing for clients along the entire wellness spectrum including Nexium, Ambien CR, Plavix, Durex, Frontline and Transitions PR Newswire (press release)

Santarus, Inc. Q2 2009 Earnings Call Transcript  -  ‎Aug 3, 2009‎
Nexium's total prescriptions grew during the same period by approximately 1%. In contrast, ZEGERID's total prescriptions grew at approximately 17% on a Seeking Alpha

Chooglin': Sweet Time  -  ‎Aug 11, 2009‎
Early on, they present a slower song, "Nexium of Interest," which builds and seamlessly transitions into "Airport Bar," a full-on drinking song proclaiming, Minneapolis City Pages

Lawmakers Push To End Prescription Drug Commercials  -  ‎Aug 14, 2009‎
The industry's two biggest sellers were Lipitor (Pfizer) with $7.8 billion in sales and Nexium (AstraZeneca) at $5.9 billion. # Have an opinion about this InjuryBoard.com

Locally-tested drugs to hit market this month  -  ‎Aug 4, 2009‎
...proves stronger in its prevention but does have an increased chance of bleeding and can interact with ulcer medication like Nexium, he said. Victoria Advocate

In Zing! you'll find good luck  -  ‎Aug 17, 2009‎
I can't afford the Nexium I would need to survive her administration. I'm glad that Broadway shows come to Tallahassee. It's too bad they have to be seen at Tallahassee.com

Middle Georgians weigh in on health-care reform  -  ‎Aug 15, 2009‎
So, instead of the Nexium that doctors had prescribed for her acid reflux, she takes a cheaper, over-the-counter medication. She's also stopped taking Macon Telegraph

Our view on generic medications: Drugmakers seek excessive ...  -  ‎Aug 13, 2009‎
Unlike widely used "small-molecule" drugs, such as Lipitor or Nexium, biologics are made from living cells using complex and expensive biotech processes. USA Today

Salix Pharmaceuticals Reports 2Q2009 Results Updates Full Year ...  -  ‎Aug 10, 2009‎
..."Recently the Company entered into an agreement with AstraZeneca to co-promote Nexium(R) (esomeprazole magnesium) for the treatment of acid reflux disease, FOXBusiness

Därför rusar Orexo  -  ‎Aug 28, 2009‎
De största produkterna på marknaden är Astrazenecas Nexium med en årlig försäljning på mellan 5 och 6 miljarder dollar samt Prevacid från TAP Dagens Industri

Medicina. Il bilancio costi-benefici va davvero a vantaggio dei ...  -  ‎Aug 25, 2009‎
Non tutti sanno, infatti, che esiste un farmaco, il Nexium, il cui principio attivo è la molecola dell'esomeprazolo, un inibitore di pompa protonica (IPP), Amantea OnLine.IT

阿斯利康拓展中东市场伊朗设新办事处扩大业务  -  ‎Aug 28, 2009‎
...该公å?¸ä¸»è¦?产å“?包括:乳腺癌è?¯Arimidexã€?é™?醇è?¯Crestorã€?溃疡è?¯Nexiumã€?精神病è?¯ç‰©Seroquel与哮喘è?¯Symbicort。 å…¶å­?å…¬å?¸AstraTech主è¦?从事用于泌尿科ã€?外科以å?Šç‰™ç§‘çš„ 生物谷

ЗаболÑ?ваниÑ? на хранопровода- Ñ?имптоми, възможни уÑ?ложнениÑ? и лечение  -  ‎Aug 21, 2009‎
Такива извеÑ?тни лекарÑ?тва Ñ?а например: Nexium, Tagamet, Omeprazole, Prevacid и други. Те Ñ?е предпиÑ?ват за период от време 6- 8 меÑ?еца, а понÑ?кога по-дълго. България Сега

阿斯利康五大产å“?ä¾?然畅销  -  ‎Aug 14, 2009‎
...该公å?¸çš„五项主è¦?产å“?(Crestorã€?Nexiumã€?Seroquelã€?Symbicort å’ŒArimidex)å? äº†è¯¥å…¬å?¸ä¸Šå?Šå¹´æ€»é”€å”®é¢?的一å?Šä»¥ä¸Šï¼Œå…¶ä¸­èƒ†å›ºé†‡ç±»è?¯Crestor和心血管类è?¯Toprol XL销售 新浪网

С маÑ? 2008 по апрель 2009 г. мировой фармрынок Ñ?оÑ?тавил 460,5 млрд ...  -  ‎Aug 5, 2009‎
Далее за ним Ñ?ледуют Plavix/ПлавикÑ? (клопидогрел), Nexium/Ð?екÑ?иум (Ñ?зомепразол), Seretide/Серетид (флутиказон+Ñ?алметерол) и Enbrel (Ñ?танерÑ?епт). Журнал Ремедиум

å…¨ç?ƒåŒ»è?¯å¸‚场:å?‘下的曲线 ç–²æ€?下å¥?å“?强音  -  ‎Aug 26, 2009‎
...分别是:惠æ°?å…¬å?¸çš„Effexor (venlafaxine);安进ã€?惠æ°?和武田制è?¯å…¬å?¸çš„Enbrel(etanercept);立普妥;阿斯利康的Nexium(esomprazole);百时美施贵å®?和赛诺è?²å®‰ä¸‡ 中国生物技术信息网

Les médicaments antidépresseurs liés aux maux d'estomac et ulcères  -  ‎Aug 23, 2009‎
Prendre des médicaments anti-acidité comme Nexium ou Prilosec peut aider à réduire ce risque, la société pharmaceutique AstraZeneca Plc, productrice de ces El Moudjahid

美 항궤양제 '오메프ë?¼ì¡¸' 주ë?„ì ?  -  ‎Aug 19, 2009‎
...ì?µìŠ¤í”„ë ˆìŠ¤ìŠ¤í?¬ë¦½ì¸ ì?˜ 집계ì—? ì?˜í•˜ë©´ 2008ë…„ 미국 항궤양제 처방 가운ë?°ì„œ 오메프ë?¼ì¡¸ì?´ 33%로 가장 ì ?유율ì?´ 높았고, 다ì?Œìœ¼ë¡œ '넥시움'(Nexium, esomeprazole)ì?´ 디지틀보사

Препараты Ñ? диÑ?кутабельной Ñ?ффективноÑ?тью и другие «нежелательные ...  -  ‎Aug 21, 2009‎
Pantozol (пантопразол) и Nexium (Ñ?зомепразол) — омепразолом, а Lyrica — генеричеÑ?ким препаратом карбамазепина (в качеÑ?тве примера взÑ?та пÑ?терка Аптека online

Brand Names/Synonyms:
Nexium is also known by the following brand names and/or synonymsAntra; Antra Mups; Audazol; Aulcer; Belmazol; CCRIS 7099; Ceprandal; Danlox; Demeprazol; Desec; Dizprazol; Dudencer; Elgam; Emeproton; Epirazole; Erbolin; Esomeprazole; Esomeprazole Magnesium; Exter; Gasec; Gastrimut; Gastroloc; Gibancer; H 168/68; HSDB 3575; Indurgan; Inhibitron; Inhipump; Lensor; Logastric; Lomac; Losec; Mepral; Miol; Miracid; Mopral; Morecon; Nexium; Nexium Iv; Nilsec; Nopramin; OMEP; OMEPRAZOLE; OMP; OMZ; Ocid; Olexin; Omapren; Omebeta 20; Omed; Omegast; Omepral; Omeprazol [Inn-Spanish]; Omeprazole; Omeprazole [Usan:Ban:Inn:Jan]; Omeprazolum [Inn-Latin]; Omeprazon; Omeprol; Omesek; Omezol; Omezolan; Omid; Omisec; Omizac; Ompanyt; Ortanol; Osiren; Ozoken; Paprazol; Parizac; Pepticum; Pepticus; Peptilcer; Prazentol; Prazidec; Prazolit; Prilosec; Prilosec Otc; Procelac; Proclor; Prysma; Ramezol; Regulacid; Result; Sanamidol; Secrepina; Tedec Ulceral; Ulceral; Ulcesep; Ulcometion; Ulcozol; Ulcsep; Ulsen; Ultop; Ulzol; Victrix; Zefxon; Zegerid; Zepral; Zimor; Zoltum

Drug Category:
Nexium is categorized under the following by the FDA: Anti-ulcer Agents; Proton-pump Inhibitors; ATC:A02BC01; ATC:A02BC05

Dosage Forms:
Oral tablets

Absorption:
Absorption is rapid, Absolute bioavailability (compared to intravenous administration) is about 30-40% at doses of 20-40 mg

Interactions:
-->Interactions for Omeprazole:

Other

Omeprazole can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. Although in normal subjects no interaction with theophylline or propranolol was found, there have been clinical reports of interaction with other drugs metabolized via the cytochrome P-450 system (e.g., cyclosporine, disulfiram, benzodiazepines). Patients should be monitored to determine if it is necessary to adjust the dosage of these drugs when taken concomitantly with omeprazole.

Because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (e.g., ketoconazole, ampicillin esters, and iron salts). In the clinical trials, antacids were used concomitantly with the administration of omeprazole.

Combination Therapy with Clarithromycin

Co-administration of omeprazole and clarithromycin may result in increases in plasma levels of ompeprazole, clarithromycin, and 14-hydroxy-clarithromycin.

Concomitant administration of clarithromycin with cisapride, pimozide, or terfenadine is contraindicated.

There have been reports of an intereaction between erythromycin and astemizole resulting in QT prolongation and torsades de points. Concomitant administration of erythromycin and astemizole is contraindicated. Because clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with astemizole is not recommended.





Chemical IUPAC Name:
5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3H-benzoimidazole

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