Montelukast

This page contains recent news articles, when available, and an overview of Montelukast but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Montelukast (when available)

Pharmacology and use:
Montelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4 and is, therefore, not expected to affect the hepatic clearance of drugs metabolized by these enzymes. For the treatment of asthma

Mechanism Of Action:
Montelukast selectively antagonizes leukotriene D₄ (LTD₄) at the cysteinyl leukotriene receptor, CysLT₁, in the human airway. Montelukast inhibits the actions of LTD₄ at the CysLT₁ receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

News Articles on Montelukast

Efficacy of Budesonide or Montelukast Treatment of Wheezing ...  -  ‎Apr 1, 2009‎
The remaining 238 children were randomized to one of the following three treatment groups: montelukast and a placebo aerosol (n=95); budesonide aerosol and AAP Grand Rounds (registration)

Sioux Falls Regional Competition Winners Announced  -  ‎Apr 15, 2009‎
The Jr. NBA/Jr. WNBA Skills Challenge, sponsored by Singulair® (Montelukast Sodium) is a free program for boys and girls ages 9 to 14 in which they compete OurSports Central (press release)

Allergic rhinitis: market evolution  -  ‎Apr 3, 2009‎
Schering–Plough and Merck partnered to develop a pill combining loratadine (Claritin) and montelukast (Singulair), with the expectation of providing Nature.com (subscription)

Common drugs can help allergic rhinitis  -  ‎Mar 29, 2009‎
Finally, Singulair (montelukast sodium) can block leukotriene effects and relieve allergic symptoms, but not as effectively as corticosteroid nasal sprays. Daytona Beach News-Journal

Article One Partners Uncovers New Prior Art Impacting the Validity ...  -  ‎Mar 10, 2009‎
A key paper authored by Dr. Robert Young (one of Merck's own scientists) provides a roadmap of how to construct montelukast sodium and was not before the FOXBusiness

Barclays sees court ruling against Teva on Merck patent  -  ‎Mar 8, 2009‎
If the court rules in favor of Merck, Teva will be unable to launch generic montelukast before the August 2012 patent expiry, barring appeal." Globes

Allergies and asthma can occur together  -  ‎Feb 20, 2009‎
Taken in pill form, montelukast (Singulair) is used to help with symptoms caused by both allergies and asthma. Called a leukotriene modifier, WWLP 22News

MicroMass Wins Seven RxClub Awards  -  ‎Feb 27, 2009‎
AIR Program (Asthma Information Resources), an education initiative developed in support of the Merck asthma medication Singulair® (montelukast sodium). PharmaLive.com (press release)

The budget's message to medical science: Quick! Get a shovel!  -  ‎Mar 4, 2009‎
Important medical treatments (recent examples include lamivudine for HIV/AIDS and montelukast for asthma) have been developed in Canada. CMAJ

Merck seeks to block Teva in US court  -  ‎Feb 24, 2009‎
The discovery of the compound montelukast, the active ingredient in Singulair, resulted from almost two decades of research by Merck scientists for an Jerusalem Post

Choix thérapeutiques et adaptations  -  ‎Feb 24, 2009‎
Les antileucotriènes constituent une nouvelle classe thérapeutique dont seul le montelukast (Singulair ® 5 mg ou 10 mg) a actuellement l’AMM pour les MT Pédiatrie (Abonnement)

Tra antistaminici e vaccini  -  ‎Feb 26, 2009‎
Di più recente introduzione sono gli antileucotrienici (es. montelukast o zafirlukast) che sono nati per la prevenzione e la cura dell' asma bronchiale ma La Repubblica

Merck & Co chief does not rule out big deals as earnings climb  -  04 Feb 2009
Sales of Vytorin (ezetimibe plus simvastatin) and Zetia (ezetimibe) sank 26% to $1.1 billion, while sales of the asthma drug Singulair (montelukast) slipped Pharma Times,

FDA: No Definitive Conclusion Reached Regarding Use of Montelukast ...  -  Jan 13, 2009
Merck submitted results from 41 placebo-controlled clinical trials in patients aged 6 years and older, of which 9929 were treated with montelukast and 7780 DG News

FDA Continues to Review Link Between Montelukast and ...  -  Jan 14, 2009
The FDA has not yet reached a definitive conclusion regarding these clinical trial data on mood and behavioral adverse events associated with montelukast, Medscape

Leukotriene antagonist tablets as an extra treatment  -  Jan 21, 2009
All the research in children looks at montelukast. Your doctor or nurse may refer to these drugs as preventers. These drugs are designed to be used together guardian.co.uk,

What's the evidence for antihistamine tablets?  -  Jan 21, 2009
Nayak A, Philip G, Lu S, et al., and the Montelukast Fall Rhinitis Investigator Group. Efficacy and tolerability of montelukast alone or in combination with guardian.co.uk,

UW researcher in clinical trial consults for medical firm  -  Jan 10, 2009
The university would find people in the Madison area with asthma, deliberately infect them with cold viruses and give them the Merck asthma drug montelukast Milwaukee Journal Sentinel,

Drug and Therapeutics Update  -  Jan 23, 2009
Following concerns about a possible association between montelukast and behaviour/mood changes, and suicide, the FDA requested that Merck, Astra Zeneca, OnMedica,

What treatments work for asthma in older children?  -  Jan 21, 2009
Montelukast (brand name Singulair) can be used in children over 2 years old and zafirlukast (brand name Accolate) can be used only in children over 12 years guardian.co.uk,

What treatments work for bronchiolitis?  -  Jan 21, 2009
Montelukast (brand name Singulair) is a drug that's sometimes used to treat asthma. It's used to help calm down the airways to prevent children getting guardian.co.uk,

What treatments work for hay fever?  -  Jan 21, 2009
Two common ones (and their brand names) are montelukast (Singulair) and zafirlukast (Accolate). More... Nasal spray with ipratropium bromide: This drug may guardian.co.uk,

Krka Banned from Selling Monkasta in Poland  -  Jan 28, 2009
Novo mesto/Warsaw, 28 January (STA) - Krka Polska has been banned from producing and selling a drug containing the active ingredient montelukast. STA - Slovenska Tiskovna Agencija,

News Roundup - Wednesday, 28 January  -  Jan 28, 2009
NOVO MESTO/WARSAW, Poland - Krka Polska has been banned from producing and selling a drug containing the active ingredient montelukast. STA - Slovenska Tiskovna Agencija,

Merck apoya seguridad de Singulair  -  Jan 25, 2009
UU. en su revisión de la seguridad de montelukast. Merck apoya la eficacia y seguridad demostradas de montelukast, un medicamento que ha sido recetado a la estrella,

Psychische bijwerkingen montelukast  -  Jan 14, 2009
Over montelukast ontvingen zij 41 studies, waarbij één persoon van de 9.929 patiënten suïcidale gedachten had tegenover geen patiënten in de placebo groep apothekersnieuws.nl,

Allergisches Asthma: Suizidgefahr bei Eingriff in Leukotrien ...  -  Jan 19, 2009
Die FDA hat darauf hin die Daten aller kontrollierten klinischen Studien von Montelukast, Zafirlukast und Zileuton überprüfen lassen. Apotheker Zeitung,

Asthmamedikament weiter unter Suizidverdacht  -  Jan 14, 2009
Im März 2008 hatte die FDA eine Überprüfung von Montelukast und vergleichbaren Asthma- und Allergiemedikamenten begonnen, die auf den Leukotrienstoffwechsel Deutsches Ärzteblatt,

천�?·COPD 치료�? 세레타�?�드 밀리나  -  Jan 19, 2009
...montelukast)�?� 처방�?� 늘고 있으며, �?�후 단계�?선 ‘심비코트’(Symbicort, budesonide/ formoterol) 쪽으로 옮겨가고 있기 때문�?� 것으로 분�?�??다. 디지틀보사,

Variazioni interindividuali nella risposta ai farmaci broncodilatatori  -  Jan 18, 2009
...risposta broncodilatatoria media 9,68%±11,13%) arruolati nel Clinical Trial of Low-Dose Theopylline and Montelukast (LODO trial), condotto dall’American Pillole.org,

Merck & Co stock falls over disappointing 2009 guidance  -  Dec 5, 2008
Merck is also forecasting a slowdown in growth for the asthma drug Singulair (montelukast), with sales between $4.3-$4.5 billion this year and $4.4-$4.7 Pharma Times,

Montelukast dodany do glikokortykosteroidu wziewnego u chorych na ...  -  Dec 15, 2008
...natomiast leki przeciwleukotrienowe (głównie antagoniści receptora leukotrienowego - montelukast i zafirlukast) są lekami drugiego wyboru (p. Med. Medycyna Praktyczna,

"Me falta el aire"  -  Nov 28, 2008
Se dispone de Montelukast y Zafirlukast. -CROMONAS COMO EL CROMOGLICATO SÓDICO Y EL NEDOCROMIL SÓDICO: se suelen usar para controlar el asma persistente Las Provincias,

Kaarslicht taboe voor kinderen met astma  -  Dec 5, 2008
Feith pleit voor de juiste medicijnen en het naleven van een aantal leefregels. ,,Bij kinderen met astma kan een medicijn als montelukast uitkomst bieden. De Gooi- en Eemlander,

Fluticasone/Salmeterol Diskus Controls Asthma Better Than ...  -  Nov 2, 2008
..."Investigators wanted to compare fluticasone/salmeterol diskus versus montelukast sodium in controlling asthma in patients with both asthma and seasonal DG News

Obesity Affects Response to Asthma Treatments: Presented at ACAAI  -  Nov 10, 2008
The analysis pooled data from 2 previously published, double-blind, randomised, parallel-group, 12-week trials that compared fluticasone and montelukast in DG News

CHEST: Asthma Medications May Lend Small Benefit to COPD Patients  -  Oct 30, 2008
In an analysis of four placebo-controlled trials of COPD patients, treatment with the leukotriene antagonists zafirlukast (Accolate) and montelukast MedPage Today,

Warning after drugs stolen  -  Oct 30, 2008
...red/yellow capsules, Prednisolone 5mg - 48 small red tablets, Salmeterol inhaler 25mg, Fluticasone nasal spray and Montelukast 10g - 46 white tablets. Champion Newspapers,

Chronic disease: First check your denture adhesive  -  Nov 20, 2008
Can you tell me whether there is any research evidence that the asthma medications montelukast and zafirlukast can affect immunity? I suspect that tak. What Doctors Don't Tell You,

News Briefs Highlight Research In Pulmonary, Critical Care And ...  -  Oct 29, 2008
...the effect of increasing body mass index (BMI) on achieving asthma control with fluticasone propionate/salmeterol via Diskus compared with montelukast. Medical News Today (press release),

抗肿瘤�?�物�?�?�治疗领域�?�物总销售冠军  -  Nov 5, 2008
...该治疗领域的拳头产�?除了Advair/Seretide外，还包括默沙东的抗哮喘�?�孟�?�?�特（Montelukast 生物通,

Breathing easier  -  Sep 27, 2008
New therapeutic approaches include montelukast, which can control fibroblasts proliferation and their transformation in myofibroblasts. Malaysia Star,

Respiratory problems re-emerge as summer wanes  -  Oct 3, 2008
Sharing the findings of his recent research, Dr Osman, “While prescribing Montelukast for allergy and asthma patients, we found that patients taking this The News International,

En Melilla unos 1.470 menores de 15 años son asmáticos  -  Oct 18, 2008
En este sentido el fármaco montelukast -comercializado por MSD como SINGULAIR®- ha demostrado en un estudio de 549 menores de entre 2 a 5 años con Melilla Hoy,

En otoño, máxima incidencia de exacerbaciones en niños con asma ...  -  Oct 8, 2008
En concreto, montelukast -comercializado por MSD como SINGULAIR®- ha demostrado en un estudio de 549 menores de entre 2 a 5 años con antecedentes clínicos Portales Médicos (Comunicado de prensa),

NUEVO ESTUDIO CIENT�?FICO DEMUESTRA QUE ES M�?S EFECTIVA LA TERAPIA ...  -  Sep 26, 2008
Durante el estudio se usó salmeterol/propinato de fluticasona (terapia inhalada) vs. montelukast (terapia oral). El Dr. Jorge Máspero, Top Management Mexico,

Emergencias infantiles  -  Oct 2, 2008
También existe medicina preventiva para los ataques de asma como el montelukast, el cual evita que las crisis sean severas, pero debe ser prescrito por un Prensa Libre (Guatemala),

난치성 천�?�? �?신신약 요�?  -  Oct 14, 2008
Zafirlukast) �?�후 '싱귤레어'(Singulair, montelukast) 등 3개 치료제가 출시�??으나, 코르티코스테로�?�드와 달리 염�?�?� �?�부만�?� 막아주기 때문�? 1차 치료제로 디지틀보사,

Stria som bivirkning av steroider.  -  Oct 2, 2008
I tillegg har hun brukt montelukast (Singulair) 5 mg fast, i sommer økt til 10 mg, og cetirizin 10 mg i allergisesongen. Er denne dosen steroider nok til at RELIS,

Rezidivprophylaxe bei Nasenpolypen ratsam  -  Sep 24, 2008
Deswegen wurde die Patientin mit Montelukast, Fenoterol und Ipatropiumbromid behandelt. Acht Jahre zuvor sei außerdem eine Nasenpolypektomie beidseits Ärzte Zeitung,

Worries about a drug's safety  -  Sep 15, 2008
Researchers reviewed the cases of 1352 patients enrolled in ALA clinical trials for montelukast, the compound in Singulair. Of the 536 patients treated with Albany Times Union,

American Lung Association Study Finds No Evidence of Depression or ...  -  Aug 31, 2008
WASHINGTON, Sept 01, 2008 /PRNewswire-USNewswire via COMTEX/ -- There has been recent concern that suicide may be a complication of montelukast (Singulair) MarketWatch

Singulair not linked to suicide, depression  -  Sep 3, 2008
Recent reports have raised concerns of a link between suicide and Singulair, also known by the generic name montelukast. The current study, conducted by Dr. Reuters India,

Singulair gets off suicide free  -  Sep 3, 2008
...depression, suicide and anxiousness, a new study by the American Lung Association finds that patients taking Singulair (montelukast) are no more likely FiercePharma,

NRC: Funding to Search for Ways to Help 500000 Children Breathe Easier  -  Sep 5, 2008
Canadian scientists at the Merck Frosst Centre for Therapeutic Research in Montreal discovered the study drug montelukast "Partnering with the scientists FOXBusiness

Codexis, Arch Announce Expanded Collaboration  -  Aug 25, 2008
Other planned future products include generic intermediates and APIs for montelukast (asthma/allergy) and esomeprazole (ulcers), as well as a key MarketWatch

Albuterol vs Montelukast for Exercise-Induced Bronchospasm in ...  -  Aug 25, 2008
Disclosure: Charles P. Vega, MD, has disclosed that he has served as an advisor or consultant to Novartis. Disclosure: Carol Peckham has disclosed no Medscape (subscription)

Asthma treatments have plenty of puff  -  Sep 3, 2008
The most prescribed allergy drug in the US is New York-listed Merck's (MRK) once-a-day tablet Singulair (Montelukast) which last year made the list of the Interactive Investor,

ABC-transporters expressed on endothelial cell membranes efflux ...  -  Aug 27, 2008
Unpublished findings from our laboratory suggest that, similar to MK-571, other leukotriene receptor antagonists, eg montelukast (SingulairTM) and HULIQ (press release),

Guidelines Updated for Diagnosis and Treatment of Rhinitis  -  Aug 18, 2008
Of the LTRA, montelukast is approved for seasonal AR and perennial AR, and adverse effects are minimal. However, with loratadine as the usual comparator, Medscape (subscription)

Fluticasone più efficace e conveniente rispetto a montelukast nell ...  -  Aug 22, 2008
I bambini asmatici trattati con montelukast hanno avuto una maggior probabilità di fallimento terapeutico rispetto a quelli trattati con fluticasone spray Pillole.org,

El fármaco Singulair no está ligado al suicidio ni la depresión  -  Sep 4, 2008
Informes recientes habían generado preocupación por una supuesta relación entre el suicidio y Singulair, también conocido por su nombre genérico montelukast Buena Salud

CNRC : Du financement pour trouver des moyens d'aider 500 000 ...  -  Sep 5, 2008
Les scientifiques canadiens au Centre de recherche thérapeutique de Montréal ont découvert le médicament à l'étude montelukast. "Le partenariat avec les Maketwire (Communiqués de presse),

Pérdida de patentes: la gran hecatombe de la industria  -  Sep 14, 2008
...ambos de Pfizer); Advair (fluticasona DCI y salmeterol DCI) y Avandia (rosiglitazona DCI), de GSK; Singulair y Cozaar (montelukast DCI y losartán DCI, El Global,

Asmático, uno de cada 7 niños en edad escolar  -  Aug 31, 2008
...como es el caso de los esteroides inhalados y los antileucotrienos como montelukast, que neutralizan la respuesta inflamatoria de los bronquios y Diario de Xalapa,

Schulanfang ist Asthmazeit  -  Aug 29, 2008
Entsprechende Untersuchungen haben gezeigt, dass mit einer entzündungshemmenden Medikation wie dem Leukotrien-Rezeptorantagonisten Montelukast die PR-Inside.com (Pressemitteilung),

Những dược phẩm nhiệm màu  -  Aug 26, 2008
Thuốc Montelukast dưới tên thương mãi là Singulair sẽ đem lại an vui cho hơn 1 triệu ngư�?i mắc bệnh suyễn ở Úc. Thuốc công hiệu lạ thư�?ng nhưng mỗi viên TiVi Tuần San,

美 �?�사 ‘�?누비아’ ‘NEJM’ 사�?�트 �?�기  -  Aug 26, 2008
...�?한, 작년 순위�? 비하면 액토스, 악토넬, 아미티�?가 추가�?� 온�?��?��? 높아진 관심�?� 반�?했고, ‘싱귤레어’(Singulair, montelukast), ‘세레타�?�드’(Seretide, 디지틀보사,

Brand Names/Synonyms:
Montelukast is also known by the following brand names and/or synonymsMontelukast; Singulair; Singular

Drug Category:
Montelukast is categorized under the following by the FDA: Antiarrhythmic Agents; Unclassified Therapeutic Agents (92:00.00); ATC:R03DC03

Dosage Forms:
Oral tablets

Absorption:
rapidly absorbed following oral administration (bioavailability is 64%)

Interactions:
-->Interactions for Montelukast:

Montelukast at a Dose of 10 mg Once Daily Dosed to Pharmacokinetic Steady State

did not cause clinically significant changes in the kinetics of a single intravenous dose of theophylline (predominantly a cytochrome P450 1A2 substrate).
did not change the pharmacokinetic profile of warfarin (a substrate of cytochromes P450 2A6 and 2C9) or influence the effect of a single 30-mg oral dose of warfarin on prothrombin time or the INR (International Normalized Ratio).
did not change the pharmacokinetic profile or urinary excretion of immunoreactive digoxin.
did not change the plasma concentration profile of terfenadine (a substrate of cytochrome P450 3A4) or fexofenadine, its carboxylated metabolite, and did not prolong the QTc interval following co-administration with terfenadine 60 mg twice daily.

Montelukast at Doses of ³100 mg Daily Dosed to Pharmacokinetic Steady State:

did not significantly alter the plasma concentrations of either component of an oral contraceptive containing norethindrone 1 mg/ethinyl estradiol 35 mcg.
did not cause any clinically significant change in plasma profiles of prednisone or prednisolone following administration of either oral prednisone or intravenous prednisolone.

Phenobarbital, which induces hepatic metabolism, decreased the AUC of montelukast approximately 40% following a single 10-mg dose of montelukast. No dosage adjustment for montelukast is recommended. It is reasonable to employ appropriate clinical monitoring when potent cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are co-administered with montelukast.

Montelukast has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug-interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (norethindrone 1 mg/ethinyl estradiol 35 mcg), terfenadine, digoxin, and warfarin.

Although additional specific interaction studies were not performed, montelukast was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions. These medications included thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, and decongestants.

Chemical IUPAC Name:
2-[1-[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]ethanoicacid

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