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MontelukastThis page contains recent news articles, when available, and an overview of Montelukast but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Montelukast (when available) Montelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4 and is, therefore, not expected to affect the hepatic clearance of drugs metabolized by these enzymes. For the treatment of asthma Mechanism Of Action: Montelukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Montelukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. News Articles on Montelukast Worries about a drug's safety - Sep 15, 2008 Researchers reviewed the cases of 1352 patients enrolled in ALA clinical trials for montelukast, the compound in Singulair. Of the 536 patients treated with Albany Times Union, American Lung Association Study Finds No Evidence of Depression or ... - Aug 31, 2008 WASHINGTON, Sept 01, 2008 /PRNewswire-USNewswire via COMTEX/ -- There has been recent concern that suicide may be a complication of montelukast (Singulair) MarketWatch Singulair not linked to suicide, depression - Sep 3, 2008 Recent reports have raised concerns of a link between suicide and Singulair, also known by the generic name montelukast. The current study, conducted by Dr. Reuters India, Singulair gets off suicide free - Sep 3, 2008 ...depression, suicide and anxiousness, a new study by the American Lung Association finds that patients taking Singulair (montelukast) are no more likely FiercePharma, NRC: Funding to Search for Ways to Help 500000 Children Breathe Easier - Sep 5, 2008 Canadian scientists at the Merck Frosst Centre for Therapeutic Research in Montreal discovered the study drug montelukast "Partnering with the scientists FOXBusiness Codexis, Arch Announce Expanded Collaboration - Aug 25, 2008 Other planned future products include generic intermediates and APIs for montelukast (asthma/allergy) and esomeprazole (ulcers), as well as a key MarketWatch Albuterol vs Montelukast for Exercise-Induced Bronchospasm in ... - Aug 25, 2008 Disclosure: Charles P. Vega, MD, has disclosed that he has served as an advisor or consultant to Novartis. Disclosure: Carol Peckham has disclosed no Medscape (subscription) Asthma treatments have plenty of puff - Sep 3, 2008 The most prescribed allergy drug in the US is New York-listed Merck's (MRK) once-a-day tablet Singulair (Montelukast) which last year made the list of the Interactive Investor, ABC-transporters expressed on endothelial cell membranes efflux ... - Aug 27, 2008 Unpublished findings from our laboratory suggest that, similar to MK-571, other leukotriene receptor antagonists, eg montelukast (SingulairTM) and HULIQ (press release), Guidelines Updated for Diagnosis and Treatment of Rhinitis - Aug 18, 2008 Of the LTRA, montelukast is approved for seasonal AR and perennial AR, and adverse effects are minimal. However, with loratadine as the usual comparator, Medscape (subscription) Fluticasone più efficace e conveniente rispetto a montelukast nell ... - Aug 22, 2008 I bambini asmatici trattati con montelukast hanno avuto una maggior probabilità di fallimento terapeutico rispetto a quelli trattati con fluticasone spray Pillole.org, El fármaco Singulair no está ligado al suicidio ni la depresión - Sep 4, 2008 Informes recientes habÃan generado preocupación por una supuesta relación entre el suicidio y Singulair, también conocido por su nombre genérico montelukast Buena Salud CNRC : Du financement pour trouver des moyens d'aider 500 000 ... - Sep 5, 2008 Les scientifiques canadiens au Centre de recherche thérapeutique de Montréal ont découvert le médicament à l'étude montelukast. "Le partenariat avec les Maketwire (Communiqués de presse), Pérdida de patentes: la gran hecatombe de la industria - Sep 14, 2008 ...ambos de Pfizer); Advair (fluticasona DCI y salmeterol DCI) y Avandia (rosiglitazona DCI), de GSK; Singulair y Cozaar (montelukast DCI y losartán DCI, El Global, Asmático, uno de cada 7 niños en edad escolar - Aug 31, 2008 ...como es el caso de los esteroides inhalados y los antileucotrienos como montelukast, que neutralizan la respuesta inflamatoria de los bronquios y Diario de Xalapa, Schulanfang ist Asthmazeit - Aug 29, 2008 Entsprechende Untersuchungen haben gezeigt, dass mit einer entzündungshemmenden Medikation wie dem Leukotrien-Rezeptorantagonisten Montelukast die PR-Inside.com (Pressemitteilung), Những dược phẩm nhiệm mà u - Aug 26, 2008 Thuốc Montelukast dưới tên thương mãi là Singulair sẽ Ä‘em lại an vui cho hÆ¡n 1 triệu ngưá»?i mắc bệnh suyá»…n ở Úc. Thuốc công hiệu lạ thưá»?ng nhưng má»—i viên TiVi Tuần San, 美 ì?˜ì‚¬ ‘ìž?누비아’ ‘NEJM’ 사ì?´íЏ ì?¸ê¸° - Aug 26, 2008 ...ë˜?한, 작년 순위ì—? 비하면 ì•¡í† ìŠ¤, ì•…í† ë„¬, 아미티ìž?ê°€ 추가ë?¼ 온ë?¼ì?¸ìƒ? 높아진 관심ì?„ ë°˜ì˜?í–ˆê³ , â€˜ì‹±ê·¤ë ˆì–´â€™(Singulair, montelukast), â€˜ì„¸ë ˆíƒ€ì?´ë“œâ€™(Seretide, 디지틀보사, Full Text - Jul 31, 2008 Recently, however, the US Food and Drug Administration approved another asthma drug, montelukast sodium, for preventing EIB. Because it is not known to Science Magazine (subscription) PHARMA MARKET: Merck Asthma Drug Gets Wind Knocked Out Of It - Aug 5, 2008 Its active ingredient is montelukast sodium. THE OPPORTUNITY AND CHALLENGE: The global market for respiratory agents rose 12% last year to $28.6 billion CNNMoney.com Schering-Plough reports 'strong performance' - Jul 22, 2008 ...the termination of their joint respiratory venture and the withdrawal of their new drug application for the loratadine-montelukast combination tablet. Hays Pharma, Schering-Plough reports positive phase-three study data - Jul 11, 2008 Schering-Plough was recently in the news, as it announced with Merck the withdrawal of the new drug application for the loratadine/montelukast combination Hays Pharma, FDA Rejects Schering-Plough's Anaesthetic Drug Sugammadex NDA - Aug 5, 2008 Merck and Schering-Plough's respiratory combination drug Claritin and Singulari (loratidine and montelukast), and Eli Lilly's (US) long-acting version Medical News Today (press release), Working out a Diagnosis - Jul 28, 2008 A leukotriene modifier such as montelukast sodium (Singulair) or zafirlukast (Accolate), for effects lasting up to 24 hours. "Sometimes we will put them on Dubuque Telegraph Herald, Atemlos von klein auf - Aug 4, 2008 Als Alternative zum Kortison gibt es ua eine Substanz (Montelukast), die die Aktivität bestimmter Entzündungsstoffe (Leukotriene) hemmt. Kurier, La importancia del control total del asma - Jul 25, 2008 66% grupo montelukast), y - menor necesidad de medicación de rescate (broncodilatadores de acción corta). Por todo esto, la combinación de salmeterol y Asteriscos, 'FDA focus on safety' makes new drug projects difficult, it is claimed - Jul 2, 2008 Last week, Schering-Plough and Merck revealed the withdrawal of their new drug application for the loratadine-montelukast combination tablet. Hays Pharma, Merck to pay Schering-Plough $105M as respiratory joint venture ... - Jun 27, 2008 Schering-Plough Corp. and Merck & Co. said Friday that they have withdrawn the new drug application for the loratadine/montelukast combination tablet. Forbes, SinguClar: Not Meant To Be - Jun 28, 2008 ...(NYSE: SGP - News) and Merck & Co., Inc. (NYSE: MRK - News) announce the withdrawal of the New Drug Application (NDA) for the loratadine/montelukast Forbes, InvestSource Inc.: Company Profile for The Anviron Holding Company - Jun 30, 2008 ...respiratory joint venture, which was formed in May 2000 to develop and market a fixed-combination product that would combine loratadine and montelukast. Trading Markets (press release), Boehringer Structures Buyout of Actimis for Asthma Drug - Jun 25, 2008 Worldwide sales of Singulair (montelukast sodium) were $1.1 billion for the first quarter of 2008, according to Merck. The FDA is investigating a possible FDA news (subscription), Controlling Asthma May Improve Sleep Quality - Jun 10, 2008 The drug, theophylline, was compared to a similar drug, montelukast, also prescribed to improve breathing, and a placebo. Patients were instructed to take eMaxHealth.com, Schering-Plough, Merck cancel a joint venture - Jun 27, 2008 They also said they have withdrawn the new drug application for the loratadine/montelukast combination tablet and terminated the joint venture formed in May MarketWatch Merck withdraws Singulair/Claritin combo; telcagepant data impresses - Jun 30, 2008 ...(loratadine) and Merck’s Singulair (montelukast) for the treatment of allergic rhinitis symptoms in patients who want relief from nasal congestion. Pharma Times (subscription), Drug Makers (PPH) Bounce on Several Catalysts [delayed] - Jun 27, 2008 ...+ MRK/SGP: Schering-Plough and Merck have withdrawn the NDA for the loratadine/montelukast combination tablet. Schering-Plough expects to receive a $105 Trading Markets (press release), Market Report -- In Play (SGP) - Jun 27, 2008 Schering-Plough and Merck announce withdrawal of Loratadine/Montelukast NDA and termination of respiratory joint venture SGP and Merck (MRK) announce the MSN Money Don't Let Allergies And Asthma Ruin Your Summer - Jun 5, 2008 Leukotriene modifiers: An alternative to inhaled steroids as controller therapy for some milder cases, montelukast (Singulair) blocks the action of immune Boston Channel.com, Genetic Factors in Drug Metabolism - Jun 3, 2008 ...(LlT) modifiers (eg, zileuton [Zyflo], montelukast [Singulair], zafirlukast [Aaccolate]) block the 5-lipoxygenase (5- LOlo) and lTC4 synthase pathways, RedOrbit, Picture of the Month—Quiz Case - 02 Jun 2008 Her medical history included asthma, for which she had been taking montelukast sodium, albuterol, and fluticasone propionate for 2 years. Archives of Pediatrics No Added Benefit When Montelukast Added to Fluticasone/Salmeterol ... - May 23, 2008 In addition, when fluticasone/salmeterol and montelukast were combined, it did not result in any improvement in asthma symptoms compared with DG News Some Kids Benefit More From Asthma Drug - May 13, 2008 ScienceDaily (May 14, 2008) — Girls and children exposed to tobacco smoke respond particularly well to montelukast (Singulair) according to researchers at Science Daily (press release) Synthesis of tenascin and laminin beta2 chain in human bronchial ... - May 26, 2008 CysLT receptors were differentially blocked with use of montelukast or BAY u9773. Results: LTD4 and LTE4 significantly augmented the expression of Tn, 7thSpace Interactive (press release), Current Research Initiatives in Asthma - May 12, 2008 In addition, new information was given with regard to a failed trial on montelukast and azithromycin to reduce inhaled corticosteroids (ICS). Medscape (subscription) Merck & Co axes 1200 sales jobs in the USA - May 6, 2008 That decision came just a day after the FDA rejected a proposed fixed combination of Merck’s Singulair (montelukast) and Schering-Plough’s Claritin Pharma Times (subscription), Update in Asthma 2007 - May 16, 2008 The Asthma Clinical Research Network (ACRN) performed a randomized crossover trial to evaluate whether an LTRA (montelukast) with an LABA (salmeterol) could RedOrbit, Advair superior to Singulair for asthma and allergies: study - May 20, 2008 Medical Research Center found that girls and children exposed to secondhand smoke benefit more from montelukast, the active ingredient in Singulair. Medical Marketing and Media, Asthma, Allergy Patients Respond Better To Advair - May 20, 2008 ...lung function when treated with Advair Diskus (fluticasone propionate and salmeterol inhalation powder) as compared with Singulair (montelukast sodium). eMaxHealth.com, Merck warned by FDA over vaccine plant failings - May 5, 2008 Two of its pipeline drugs MK-0524a (niacin and laropiprant) for high cholesterol and a proposed fixed-dose combination of loratadine and montelukast for In-PharmaTechnologist.com, Hard to Control Allergies - May 7, 2008 ...they simply take an allergy medication, such as Allegra (fexofenadine), Claritin (Loratadine), Singulair (montelukast), or Zyrtec (cetirizine), About - News & Issues, Possible Link Between Montelukast and Suicidality, US FDA Investigates - Mar 27, 2008 Montelukast is a leukotriene receptor antagonist used to treat asthma and the symptoms of allergic rhinitis and to prevent exercise-induced asthma. DG News FDA Investigates Possible Suicide Link With Montelukast (Singulair) - Mar 27, 2008 Montelukast is a leukotriene receptor antagonist indicated for asthma, allergic rhinitis, and to prevent exercise-induced asthma. MedPage Today, FDA MedWatch- Singulair (montelukast)- Possible Association ... - Mar 27, 2008 This information reflects FDA’s current analysis of available data concerning these drugs. Posting this information does not mean that FDA has concluded PharmaLive.com (press release), Asthma Medication Evaluated for Possible Link to Mood Changes ... - Mar 27, 2008 Over the past year, Merck has updated the prescribing and patient information on montelukast to include a number of adverse events found in postmarketing Medscape (subscription) Merck Asthma Drug Questioned for Suicide Risk - Mar 27, 2008 By Alice Turner The Food and Drug Administration has said that Merck's Singulair, which is the brand name for the substance montelukast, may raise the risk eFluxMedia Merck & Co earnings surge as new products keep growing - Apr 22, 2008 Merck’s biggest seller continues to be the asthma drug Singulair (montelukast), the number one prescribed respiratory drug in the USA, which added $1.1 Pharma Times (subscription), FDA Investigates Safety Of Asthma Drug Singulair - Mar 28, 2008 The US Food and Drug Administration (FDA) is reviewing the safety of Merck & Co's anti-asthma drug Singulair (montelukast) following reports querying a Medical News Today, FDA Investigating Behavior Changes with Asthma Medication - Mar 31, 2008 In the meantime, patients taking montelukast should not stop taking the medication without talking to their doctors. And, both patients and healthcare HealthandAge.com Suicide link fear over asthma pill - Mar 29, 2008 In the US the drug – also known as Montelukast – has become a "blockbuster" and earns Merck tens of millions of pounds. Helen Wright, a spokeswoman for Daily Mail, FDA Reviewing Safety Data Of Merck Asthma Drug - Mar 29, 2008 Singulair is the brand name for montelukast, and the FDA is looking into the drug's safety as it has been partially linked to mood changes that can raise Dog Flu Diet and Diseases, FDA investigates suicide risk in Singulair users - Mar 28, 2008 The FDA is investigating a possible association between the use of Singulair (montelukast sodium, from Merck) and behavior/mood changes, suicidality, Prescribing Reference, FDA Evaluating Singular For Suicide Risks - Mar 28, 2008 ...announced that it is investigating and evaluating the possible links between suicide, mood swings and the use of Singulair, also known as montelukast. Ontario Now, Singulair and Suicide Association under FDA Review - Mar 27, 2008 ...patients of the possible association between the use of Singulair (Montelukast) and behavior/mood changes, suicidality (suicidal thinking) and suicide. Lawyers and Settlements Merck Reports First-Quarter 2008 Financial Results - Apr 21, 2008 Worldwide sales of SINGULAIR (montelukast sodium), a once-a-day oral medicine indicated for the chronic treatment of asthma and the relief of symptoms of Fuerteventura Digital, The FDA Will Investigate a Possible Link Between the Drug and Suicide - Mar 27, 2008 Sales of the drug, which goes by the generic name montelukast sodium, climbed to $3.4 last year, up from $3.0 billion in 2006. The FDA announcement falls in ABC News Regulating Off-Label Drug Use — Rethinking the Role of the FDA - Apr 2, 2008 ...extension to milder forms of an approved indication, extension to related conditions (the use of the antiasthmatic montelukast [Singulair] for chronic New England Journal of Medicine (subscription), FDA Looking Into Singulair Suicide Risk - Mar 28, 2008 Singulair (montelukast sodium), Merck’s top-selling product, had worldwide sales of $4.3 billion last year. Singulair is a leukotriene receptor antagonist FDA news (subscription), Singulair May Be Linked To Increased Risk Of Suicide - Mar 28, 2008 ...patients who take Singulair (montelukast) manufactured by Merck & Co, Inc. According to some reports, Singulair prescribed in the treatment of asthma, MedHeadlines, FDA Considers Action On Singulair and Suicide Risk - Mar 27, 2008 The FDA just issued a statement on its ongoing investigation of Montelukast (Singulair), saying that initially FDA thinks that there may be a link between HULIQ, US regulator probes possible suicide link to Singulair - Mar 28, 2008 The US Food and Drug Administration said that it is investigating a possible association between the use of Singulair (montelukast) and behaviour/mood Pharma Times (subscription), Brand Names/Synonyms: Montelukast is also known by the following brand names and/or synonymsMontelukast; Singulair; Singular Drug Category: Montelukast is categorized under the following by the FDA: Antiarrhythmic Agents; Unclassified Therapeutic Agents (92:00.00); ATC:R03DC03 Dosage Forms: Oral tablets Absorption: rapidly absorbed following oral administration (bioavailability is 64%) Interactions: -->Interactions for Montelukast: Montelukast at a Dose of 10 mg Once Daily Dosed to Pharmacokinetic Steady State
Phenobarbital, which induces hepatic metabolism, decreased the AUC of montelukast approximately 40% following a single 10-mg dose of montelukast. No dosage adjustment for montelukast is recommended. It is reasonable to employ appropriate clinical monitoring when potent cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are co-administered with montelukast. Montelukast has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug-interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (norethindrone 1 mg/ethinyl estradiol 35 mcg), terfenadine, digoxin, and warfarin. Although additional specific interaction studies were not performed, montelukast was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions. These medications included thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, and decongestants. Phenobarbital, which induces hepatic metabolism, decreased the AUC of montelukast approximately 40% following a single 10-mg dose of montelukast. No dosage adjustment for montelukast is recommended. It is reasonable to employ appropriate clinical monitoring when potent cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are co-administered with montelukast. Chemical IUPAC Name: 2-[1-[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclopropyl]ethanoicacid : |
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